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Vittoria Ravera, Cristina Bovone, Vincenzo Scorcia, Sergio DʼAngelo, Massimo Busin
PURPOSE: To evaluate the possibility of using the intrastromal corneal ring segments (ICRSs) previously implanted as a depth reference for performing pneumatic dissection in deep anterior lamellar keratoplasty (DALK). METHODS: The depth of placement of 2 symmetrical ICRSs placed in the superior and inferior midperipheral cornea of 4 eyes of 4 patients with keratoconus was measured by means of anterior segment optical coherence tomography. Because of irregular and/or high astigmatism, DALK using pneumatic dissection was performed in all eyes...
February 12, 2019: Cornea
Tomona Hiyama, Yosuke Harada, Yoshiaki Kiuchi
Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab. Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO...
June 2019: American Journal of Ophthalmology Case Reports
Zhiping Liu, Hua Wang, Hong Jiang, Giovana Rosa Gameiro, Jianhua Wang
Background: The goal was to quantitatively analyze the bulbar conjunctival microvascular density using optical coherence tomography angiography (OCTA) and compare it to the vessel density using functional slit-lamp biomicroscopy (FSLB). Methods: Temporal bulbar conjunctiva of 20 eyes (10 healthy subjects) was imaged using both OCTA and FSLB. Image processing was performed including equalization, de-noising, thresholding, and skeletonization. The vessel density was measured by fractal analysis (box counting, Dbox) and pixel counting (%)...
2019: Eye and Vision (London, England)
B Zhao, N Torun, M Elsayed, A-D Cheng, A Brook, Y-M Chang, R A Bhadelia
BACKGROUND AND PURPOSE: No MR imaging measurement criteria are available for the diagnosis of optic nerve atrophy. We determined a threshold optic nerve area on MR imaging that predicts a clinical diagnosis of optic nerve atrophy and assessed the relationship between optic nerve area and retinal nerve fiber layer thickness measured by optical coherence tomography, an ancillary test used to evaluate optic nerve disorders. MATERIALS AND METHODS: We evaluated 26 patients with suspected optic nerve atrophy (8 with unilateral, 13 with bilateral and 5 with suspected but not demonstrable optic nerve atrophy) who had both orbital MR imaging and optical coherence tomography examinations...
February 14, 2019: AJNR. American Journal of Neuroradiology
Adam Al-Diwani, Adam Handel, Leigh Townsend, Thomas Pollak, M Isabel Leite, Paul J Harrison, Belinda R Lennox, David Okai, Sanjay G Manohar, Sarosh R Irani
BACKGROUND: Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology of NMDAR-antibody encephalitis needs to be clearly defined to encourage accurate clinical identification and prompt treatment. METHODS: For this systematic review, we searched PubMed for all studies published in English between Jan 1, 2005, and Oct 7, 2017, to identify individually reported adult patients (≥18 years) who satisfied consensus criteria for definite NMDAR-antibody encephalitis...
February 11, 2019: Lancet Psychiatry
Augusto A L Motta, Maria Teresa B C Bonanomi, Daniel A Ferraz, Rony C Preti, Raafay Sophie, Maria F Abalem, Marcia S Queiroz, Sérgio L G Pimentel, Walter Y Takahashi, Francisco M Damico
AIMS: To analyze contrast sensitivity of intravitreal bevacizumab injections with optimizing glycemic control versus optimizing glycemic control (in combination with sham injections) in eyes with diabetic macular edema (DME) DESIGN: Prospective, interventional, masked, randomized controlled trial. METHODS: Forty-one eyes of 34 patients with type 2 diabetes mellitus and DME with glycated hemoglobin (HbA1c) <11% received either intravitreal bevacizumab injection (Group 1) or sham injection (Group 2) at 0 and 6 weeks along with optimizing glycemic control...
February 11, 2019: Diabetes Research and Clinical Practice
Keiko Azuma, Xue Tan, Shotaro Asano, Kimiko Shimizu, Asako Ogawa, Tatsuya Inoue, Hiroshi Murata, Ryo Asaoka, Ryo Obata
Pachychoroid neovasculopathy (PNV) shares some anatomical features with other pachychoroid spectrum diseases, but little is known about the characteristics on the treatment with anti-vascular endothelial growth factor (VEGF). We investigated the effect of choroidal structure and responses to anti-VEGF on the prognosis of pachychoroid neovasculopathy (PNV) and other types of neovascular age-related macular degeneration (non-PNV). Twenty-one eyes with PNV and 34 eyes with non-PNV who had anti-VEGF treatment were retrospectively reviewed...
2019: PloS One
Cem Alay, Oya Tekeli, Özge Yanık Odabaş, Feyza Çalış Karanfil
Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients Materials and methods: Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness...
February 11, 2019: Turkish Journal of Medical Sciences
Romain Deschamps, Vivien Vasseur, Natalia Shor, Catherine Vignal, Laurence Salomon, Olivier Gout, Martine Mauget-Faÿsse
BACKGROUND: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. METHODS: Patients with a first episode of optic neuritis were invited to participate in a study that involved optical coherence tomography evaluation at baseline and the following 1, 3, 6 and 12 months...
February 13, 2019: Acta Ophthalmologica
Nobuaki Kobayashi, Kuniya Asai, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Hiroki Goda, Saori Uchiyama, Kenichi Tani, Masamichi Takano, Wataru Shimizu
OBJECTIVES: We aimed to examine the relations of very high levels of serum uric acid (sUA) with features of culprit lesion plaque morphology determined by optical coherence tomography (OCT) and adverse clinical outcomes in patients with acute coronary syndrome (ACS). METHODS: We retrospectively compared ACS patients according to sUA levels of > 8.0 mg/dL (n = 169), 7.1-8.0 mg/dL (n = 163), 6.1-7.0 mg/dL (n = 259), and ≤6.0 mg/dL (n = 717). Angiography and OCT findings were analyzed in patients with preintervention OCT and the 4 sUA groups (> 8...
February 13, 2019: Cardiology
Mohammad Vahid Jorat, Reza Tabrizi, Fariba Kolahdooz, Maryam Akbari, Maryamalsadat Salami, Seyed Taghi Heydari, Zatollah Asemi
OBJECTIVE: Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD. METHODS: The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018...
February 13, 2019: Inflammopharmacology
Pascal M Schäfer, Paul McKeown, Martin Fuchs, Ruth D Rittinghaus, Alina Hermann, Johanna Henkel, Sebastian Seidel, Christoph Roitzheim, Agnieszka N Ksiazkiewicz, Alexander Hoffmann, Andrij Pich, Matthew D Jones, Sonja Herres-Pawlis
Non-toxic, highly active and robust complexes are the holy grail as ideal green catalysts for the polymerisation of biorenewable and biodegradable polylactide. Four new zinc guanidine complexes [ZnCl2(TMG4NMe2asme)], [ZnCl2(TMG5Clasme)], [ZnCl2(TMG5Measme)] and [ZnCl2(TMG5NMe2asme)] with different electron-donating and electron-withdrawing groups on the ligand's aromatic backbone have been synthesised. Ligands are derived from low-cost commercially available compounds and have been converted by a three- or four-step synthesis process into the desired ligand in good yields...
February 13, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Peter Cram, Lisa M Lix, Eric Bohm, Lin Yan, Leslie Roos, John Matelski, Rajiv Gandhi, Bruce Landon, William D Leslie
BACKGROUND: Nearly 30 years ago, a series of studies showed increased hip fracture mortality in Manitoba compared to the United States, but these data have not been updated. Our objective was to compare the organization of hip fracture care and short-term outcomes in Manitoba and New York State using contemporary data. METHODS: This was a retrospective cohort study of administrative data for all adults aged 50 years or more admitted to hospital with hip fracture between Jan...
January 2019: CMAJ Open
Claudio I Perez, Sunee Chansangpetch, Anwell Nguyen, Max Feinstein, Marta Mora, Mai Badr, Marisse Masis, Travis Porco, Shan C Lin
Purpose/Aim: To evaluate the best formula to predict intraocular pressure (IOP) reduction after cataract surgery. MATERIALS AND METHODS: Prospective longitudinal study. We included consecutive patients with or without glaucoma, either with open or narrow angles but without peripheral anterior synechiae, who underwent phacoemulsification. Clinical factors and anterior segment parameters measured with optical biometry and optical coherence tomography were evaluated as preoperative predictors for IOP reduction at 6 months postoperatively...
February 12, 2019: Current Eye Research
Travis W Sawyer, Photini F S Rice, David M Sawyer, Jennifer W Koevary, Jennifer K Barton
Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process of segmentation...
January 2019: Journal of Medical Imaging
Justis P Ehlers, Atsuro Uchida, Sunil K Srivastava, Ming Hu
Purpose: To establish a predictive model of macular hole (MH) closure speed. Methods: This study was a post hoc analysis of eyes that underwent full-thickness MH repair in the prospective PIONEER intraoperative optical coherence tomography (iOCT) study. The Bioptigen SDOIS system was used for iOCT imaging. All patients underwent standard small-gauge vitrectomy with internal limiting membrane (ILM) peeling, gas tamponade, and postoperative facedown positioning. Before vitrectomy and after ILM peeling, various quantitative OCT measures related to MH were obtained, including MH geometry alterations and outer retinal features...
January 2019: Translational Vision Science & Technology
Johann S de Bono, Nicole Concin, David S Hong, Fiona C Thistlethwaite, Jean-Pascal Machiels, Hendrik-Tobias Arkenau, Ruth Plummer, Robert Hugh Jones, Dorte Nielsen, Kristian Windfeld, Srinivas Ghatta, Brian M Slomovitz, James F Spicer, Jeffrey Yachnin, Joo Ern Ang, Paul Morten Mau-Sørensen, Martin David Forster, Dearbhaile Collins, Emma Dean, Reshma A Rangwala, Ulrik Lassen
BACKGROUND: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor. METHODS: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe...
February 7, 2019: Lancet Oncology
J Wang, J Zhao, X Cui, B A Mysona, S Navneet, A Saul, M Ahuja, N Lambert, I G Gazaryan, B Thomas, K E Bollinger, S B Smith
Sigma 1 receptor (Sig1R), a putative molecular chaperone, has emerged as a novel therapeutic target for retinal degenerative disease. Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profound rescue of cone photoreceptor cells in the rd10 mouse model of retinitis pigmentosa; however the mechanism of rescue is unknown. Improved cone function in (+)-PTZ-treated mice was accompanied by reduced oxidative stress and normalization of levels of NRF2, a transcription factor that activates antioxidant response elements (AREs) of hundreds of cytoprotective genes...
February 8, 2019: Free Radical Biology & Medicine
Jinhai Huang, Hao Chen, Yue Li, Zhongxing Chen, Rongrong Gao, Jinjin Yu, Yune Zhao, Weicong Lu, Colm McAlinden, Qinmei Wang
PURPOSE: To compare axial length measurements (and failure rate) of three swept-source optical coherence tomography (SS-OCT)-based biometers: IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany), OA-2000 (Tomey, Nagoya, Japan), and Argos (Movu Inc., Komaki, Japan) to those provided by a partial coherence interferometry (PCI)-based optical biometer (IOLMaster v5.4 [Carl Zeiss Meditec]). METHODS: A total of 119 patients (171 eyes) undergoing cataract surgery were enrolled...
February 1, 2019: Journal of Refractive Surgery
Jing Zhao, Yang Gao, Tian Han, Li Zeng, Huamao Miao, Dong Yang, Qizhi Zhou, Xingtao Zhou
PURPOSE: To investigate the characteristics and changes in microdistortions in Bowman's layer 3 years after small incision lenticule extraction (SMILE). METHODS: In this non-randomized, prospective study, 50 eyes of 28 patients who received SMILE with a mean spherical equivalent of -6.72 ± 1.41 diopters (D) were divided into a thin lenticule group (lenticule thickness ⩽ 135 µm) and a thick lenticule group (lenticule thickness > 135 µm). Examinations were performed preoperatively and 1 day, 1 month, and 3 years after SMILE...
February 1, 2019: Journal of Refractive Surgery
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