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Topical vitamin a

Sham AlZahabi, Omar S Sakr, Adham A Ramadan
BACKGROUND: Solid lipid nanoparticles (SLNs) are dispersions synthesized by replacing liquid lipid in an o/w emulsion with solid lipids. Nanostructured lipid carriers (NLCs) improve on some of the major limitations of the SLNs as NLCs use liquid lipids along with crystalline solid fatty acids to build the core. AIMS: This work aims to investigate the potential advantage of using Prickly Pear (PP) seed oil to develop NLCs for topical delivery of vitamin A. METHODS: Four PP-based NLC formulations with varying composition have been developed using the hot homogenization method and compared with a SLN formulation that is free of PP oil...
February 19, 2019: Journal of Cosmetic Dermatology
Parviz Farzadinia, Gholamhossein Mohebbi, Afshar Bargahi, Samad Akbarzadeh, Iraj Nabipour, Mohammadreza Abdi, Zeynab Hasanpour, Zahra Alipour, Adel Daneshi
Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200±5 grams were divided equally into three groups. The second-degree burning induced on all groups...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Esraa Salah Ali Ismail, Aikaterini Patsatsi, Wafaa Mohammed Abd El-Maged, Essam El-Din Abd El-Aziz Nada
BACKGROUND: Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging. OBJECTIVES: To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma. METHODS: Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks...
February 15, 2019: Journal of Cosmetic Dermatology
Hanaa A Abdel-Messih, Rania A H Ishak, Ahmed S Geneidi, Samar Mansour
The transdermal route is a convenient non-invasive way for drug delivery, however, the hydrophobic compact nature of stratum corneum (SC) forms an obstacle hindering the diffusion of drugs particularly hydrophilic ones. Hence, the purpose of this study was to develop novel soft nano-vesicles, entitled Flexosomes, amalgamating two penetration enhancers, ethanol and one edge activator (EA) from various types and different hydrophilic-lipophilic balances. The tailored vesicles were loaded with tropisetron hydrochloride (TRO), a potent highly-soluble anti-emetic, and compared with ethosomes...
February 9, 2019: International Journal of Pharmaceutics
E I Karpov
The interest in the prostate cancer prevention is associated with high incidence and slow growth of tumor. Despite the lack of clinical guidelines for prostate cancer prevention, more and more studies are carried out dedicated to this topic. Since prostate cancer prevention requires prolonged use, the substances derived from food are seems to be the most appropriate. The two most well-known and studied substances are indole-3-carbinol (I3C), obtained from cruciferous plants, and epigallocatechin-3-gallate (EGCG), contained in green tea...
December 2018: Urologii︠a︡
Chen-Yu Zhu, Yun Li, Qiu-Ning Sun, Ayaka Takada, Akira Kawada
BACKGROUND: Melasma is pale brown to dark brown hyperpigmentation of the facial skin that commonly affects women of reproductive age. Treatment methods for melasma include oral and topical use of vitamin C, hydroquinone ointment, and laser treatment, with unsatisfactory results. Tranexamic acid (TA) has been shown to be effective against melasma, however, the optimal dose has not been investigated. OBJECTIVE: To analyse the therapeutic effect of different doses of oral TA on melasma...
February 8, 2019: European Journal of Dermatology: EJD
Hans-Christoph Diener, Robert G Hart, Peter J Koudstaal, Deirdre A Lane, Gregory Y H Lip
Numerous vascular risk factors and vascular diseases contribute to cognitive impairment and dementia. Many studies and registries show an association of atrial fibrillation (AF) with cognitive impairment, cognitive decline, and dementia. This is true for vascular dementia and Alzheimer's disease. The assumed multifactorial mechanisms include ischemic stroke, both apparent and silent, cerebral microinfarcts, cerebral hemorrhage, and reduced cerebral blood flow. A number of retrospective observational and prospective studies support that anticoagulation in patients with AF may reduce the risk of cognitive decline and dementia...
February 12, 2019: Journal of the American College of Cardiology
Sum S Kwok, Kendrick C Shih, Yashan Bu, Amy C-Y Lo, Tommy C-Y Chan, Jimmy S-M Lai, Vishal Jhanji, Louis Tong
OBJECTIVES: To evaluate recent studies on available and experimental therapies in preventing or minimizing corneal stromal scarring after injury. METHODS: We performed an Entrez PubMed literature search using keywords "cornea," "scarring," "haze," "opacity," "ulcer," "treatments," "therapies," "treatment complications," and "pathophysiology" resulting in 390 articles of which 12 were analyzed after filtering, based on English language and publication within 8 years, and curation for relevance by the authors...
February 1, 2019: Eye & Contact Lens
Mark E Nunnally, Arpit Patel
PURPOSE OF REVIEW: Sepsis-3 guidelines have implications in a deeper understanding of the biopathology of the disease. Further, the review focuses on timely topics and new literature on fluid resuscitation, the value of steroids in sepsis, and new therapeutic options such as angiotensin II, vitamin C, and thiamine as well as the emerging role of procalcitonin (PCT) in managing antibiotics. RECENT FINDINGS: Traditional therapies such as type of crystalloid fluid administration and steroid therapy for sepsis are currently under re-evaluation...
January 31, 2019: Current Opinion in Anaesthesiology
Katia Falasca, Marta Di Nicola, Giuseppe Di Martino, Claudio Ucciferri, Francesca Vignale, Alessandro Occhionero, Jacopo Vecchiet
BACKGROUND: The correlation among high levels of total homocysteine, low levels of B12 vitamin, and neurocognitive impairment in HIV negative patients has been the main research topic in some of the latest reviews. The aim of this study was to examine if the alteration of homocysteine, B12 vitamin, and D vitamins plasma levels was present in HIV-positive, and their relationship with cognitive function. METHODS: 57 HIV infected were enrolled and underwent the serum measurement of homocysteine, B12 , and D vitamins...
February 4, 2019: BMC Infectious Diseases
L Solman, A Lloyd-Lavery, D J C Grindlay, N K Rogers, K S Thomas, K E Harman
This review is part of a series of annual updates summarizing the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2016 with a focus on treatment and prevention of AE. There is reasonable evidence of benefit for topical corticosteroids, calcineurin inhibitors, a glycyrrhetinic acid-containing preparation (Atopiclair® ), oral ciclosporin, oral azathioprine, narrowband ultraviolet B radiation and education programmes...
January 31, 2019: Clinical and Experimental Dermatology
Gerishom Gimaiyo, Jeffery McManus, Matt Yarri, Shiva Singh, Andrew Trevett, Grainne Moloney, Ann Robins, Lilian Lehmann
Introduction: In Kenya's Kitui County, 46% of children under 5 years are stunted. Sanitation and nutrition programmes have sought to reduce child undernutrition, though they are typically implemented separately. We evaluate the effectiveness of an integrated sanitation and nutrition (SanNut) intervention in improving caregiver sanitation and nutrition knowledge and behaviours. Methods: We conducted a cluster-randomised controlled trial to evaluate the impact of the SanNut intervention on caregiver knowledge, sanitary and hygiene practices, sanitation outcomes and nutrition outcomes...
2019: BMJ Global Health
Boni Elewski, Andrew F Alexis, Mark Lebwohl, Linda Stein Gold, David Pariser, James Del Rosso, Gil Yosipovitch
Psoriasis has historically been considered a nonpruritic dermatosis, in contrast with atopic dermatitis. Thus, itch has often been underappreciated and overlooked in psoriasis. However, increasing evidence over the past decade has shown that itch can be one of the most prevalent and burdensome symptoms associated with psoriasis, affecting almost every patient to some degree; it can involve the entire body, although it predominantly affects the legs, hands, back, body, and especially the scalp. Uncontrolled itch can significantly impact all aspects of the well-being and quality of life of the patient...
January 25, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Beatriz Germán, Ruicheng Wei, Pierre Hener, Christina Martins, Tao Ye, Cornelia Gottwick, Jianying Yang, Julien Seneschal, Katia Boniface, Mei Li
Psoriasis is one of the most common skin inflammatory diseases worldwide. The vitamin D3 analog calcipotriol has been used alone or in combination with corticosteroids in treating plaque psoriasis, but how it suppresses psoriatic inflammation has not been fully understood. Using an experimental mouse psoriasis model, we show that topical calcipotriol inhibited the pivotal IL-23/IL-17 axis and neutrophil infiltration in psoriatic skin, and interestingly, such effects were mediated through the vitamin D receptor (VDR) in keratinocytes (KCs)...
January 24, 2019: JCI Insight
Amir Makni, Sanaz Lolachi, Marc-André Raetzo
In recent years, the topic of vitamin D has been the subject of numerous publications covering a wide range of fields, with the corollary effect of overusing its routine dosage. However, substitution benefits only a small part of the population and systematic dosing of vitamin D outside risk situations is not recommended. This dosage of vitamin D is only useful if it results in effective treatment in case of deficiency. The purpose of this article is to provide a synthesis of current knowledge about vitamin D, in particular about the indications for its dosage in clinical practice...
January 23, 2019: Revue Médicale Suisse
Aolin Yang, Qingqing Lv, Feng Chen, Difei Wang, Ying Liu, Wanying Shi
BACKGROUND In recent years, many studies on vitamin D have been published. We combed these data for hot spot analyses and predicted future research topic trends. MATERIAL AND METHODS Articles (4625) concerning vitamin D published in the past 3 years were selected as a study sample. Bibliographic Items Co-occurrence Matrix Builder (BICOMB) software was used to screen high-frequency Medical Subject Headings (MeSH) terms and construct a MeSH terms-source article matrix and MeSH terms co-occurrence matrix. Then, Graphical Clustering Toolkit (gCLUTO) software was employed to analyze the matrix by double-clustering and visual analysis to detect the trends on the subject...
January 22, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sung Woo Cho, Yu Lian Zhang, Young Kyung Ko, Jae Min Shin, Jun Ho Lee, Chae Seo Rhee, Dong Young Kim
PURPOSE: Vitamin D is a potent immunomodulator. However, its role in the pathogenesis of allergic rhinitis is unclear. METHODS: The aim of this study was to evaluate the antiallergic effect of intranasally applied vitamin D in an allergic rhinitis mouse model. BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and alum before they were intranasally challenged with OVA. Then, they were intranasally administered 1, 25-dihydroxyvitamin D3 (0.02 μg) or solvent...
March 2019: Allergy, Asthma & Immunology Research
Dieter-Christian Gottschling, Frank Döring
The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the model has a discovery function. Worm research serves also in the identification of nutrition-dependent pathways that could be used for novel approaches in human nutritional studies. This heuristic function of the model guides the applied nutrition research in an innovative direction...
2019: Genes & Nutrition
Patrick J McCullough, Douglas S Lehrer, Jeffrey Amend
Vitamin D3 is a secosteroid hormone produced in the skin in amounts estimated up to 25,000 international units (IUs) a day by the action of UVB radiation on 7-dehydrocholesterol. Vitamin D deficiency is common due to both lack of adequate sun exposure to the skin, and because vitamin D is present in very few food sources. Deficiency is strongly linked to increased risk for a multitude of diseases, several of which have historically been shown to improve dramatically with either adequate UVB exposure to the skin, or to oral or topical supplementation with vitamin D...
January 3, 2019: Journal of Steroid Biochemistry and Molecular Biology
Amandine Darres, Ronan Delaval, Alain Fournier, Emilie Tournier, Olivier Cointault, Francoise Moussion, Dominique Chauveau, Bruno Seigneuric, Catherine Lumbroso, Nassim Kamar, David Ribes, Sylvie Leou, Antoine Huart, Pascale Testevuide, Stanislas Faguer
BACKGROUND: Calciphylaxis (CPX) is a rare and life-threatening disease characterized by vascular calcification and development of painful and necrotizing skin lesions with a challenging management. Mechanisms of CPX are complex and include an imbalance between vascular calcification promoters and inhibitors, and frequently vitamin K deficiency. OBJECTIVES: To describe the various presentations and identify predictive factors of death in patients with CPX. METHODS: In this multicenter retrospective study, we included 71 CPX patients followed in South-West France (n = 26) and in French Polynesia (n = 45), and who all received sodium thiosulfate (25 g thrice weekly for a median of 61 days)...
January 3, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
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