Read by QxMD icon Read

GERD and pulmonary

Maria Malmlöf, Mattias Nowenwik, Kristof Meelich, Iwona Rådberg, Ewa Selg, John Burns, Hermann Mascher, Per Gerde
The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of aerosol medicines per interface surface area when administered via the inhalation route is always quite low. However, in most in vitro systems used for dissolution testing of dry powder inhalables, the dose per surface area is generally much higher. The aim of this study was to investigate in one in vitro lung dissolution system, the DissolvIt, the manner in which the deposited dose per test surface area of drug particles influences the simulated dissolution- and absorption rate...
March 9, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Charlotte Eitel, Hueseyin Ince, Johannes Brachmann, Karl-Heinz Kuck, Stephan Willems, Jin-Hong Gerds-Li, Juergen Tebbenjohanns, Gert Richardt, Matthias Hochadel, Jochen Senges, Roland R Tilz
BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare. METHODS AND RESULTS: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188)...
February 20, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Maria M Wertli, Tenzin D Dangma, Sarah E Müller, Laura M Gort, Benjamin S Klauser, Lina Melzer, Ulrike Held, Johann Steurer, Susann Hasler, Jakob M Burgstaller
BACKGROUND: Non-cardiac chest pain is common and there is no formal recommendation on what diagnostic tests to use to identify underlying diseases after an acute coronary syndrome has been ruled out. OBJECTIVE: To evaluate the diagnostic tests, treatment recommendations and initiated treatments in patients presenting with non-cardiac chest pain to the emergency department (ED). METHODS: Single-center, retrospective medical chart review of patients presenting to the ED...
2019: PloS One
Yu-Huei Lin, Chen-Liang Tsai, Lee-Ing Tsao, Chii Jeng
AIMS AND OBJECTIVES: To explore perceptions of experience exacerbations of chronic obstructive pulmonary disease among chronic obstructive pulmonary disease patients with comorbid gastrooesophageal reflux disease by focusing on unravelling how patients differentiate and react to symptoms of chronic obstructive pulmonary disease and gastrooesophageal reflux disease. BACKGROUND: While gastrooesophageal reflux disease has been suggested to be a risk factor for chronic obstructive pulmonary disease exacerbations, no study has explored perceptions of the symptoms leading up to severe exacerbation of chronic obstructive pulmonary disease events among chronic obstructive pulmonary disease patients with comorbid gastrooesophageal reflux disease...
January 30, 2019: Journal of Clinical Nursing
Peter C Taylor, Michael E Weinblatt, Gerd R Burmester, Terence P Rooney, Sarah Witt, Chad D Walls, Maher Issa, Claudia A Salinas, Chadi Saifan, Xin Zhang, Anabela Cardoso, Miguel A González-Gay, Tsutomu Takeuchi
OBJECTIVE: To assess cardiovascular and venous thromboembolic events in clinical studies of baricitinib, an oral, selective Janus kinase (JAK)1/JAK2 inhibitor approved in selected countries for treatment of moderately-to-severely active rheumatoid arthritis (RA). METHODS: Data were pooled from 9 RA studies. Placebo comparison included 6 studies up to 24 weeks. Randomized dose comparison used 4 studies including baricitinib 2-mg and 4-mg, and associated long-term extension (LTE) data...
January 21, 2019: Arthritis & Rheumatology
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B Rimm, Christopher Kabrhel, Bengt Zöller, Gerd Assmann, Vilmundur Gudnason, Aaron R Folsom, Volker Arndt, Astrid Fletcher, Paul E Norman, Børge G Nordestgaard, Akihiko Kitamura, Bakhtawar K Mahmoodi, Peter H Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Völzke, Jackie A Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Després, Leon Simons, Elizabeth Barrett-Connor, Cecilia Björkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E Sutherland, Johan Sundström, Jussi Kauhanen, John Gallacher, Joline W J Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F Deen, Agustín Gómez de la Cámara, Lewis H Kuller, Annika Rosengren, Peter J Svensson, Dorothea Nagel, Carlos J Crespo, Hermann Brenner, Juan R Albertorio-Diaz, Robert Atkins, Eric J Brunner, Martin Shipley, Inger Njølstad, Deborah A Lawlor, Yvonne T van der Schouw, Randi Marie Selmer, Maurizio Trevisan, W M Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon D O Lowe, Angela M Wood, Adam S Butterworth, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade
Importance: It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE). Objective: To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism. Design, Setting, and Participants: This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016)...
January 16, 2019: JAMA Cardiology
Fayez Kheir, Adnan Majid
Excessive central airway collapse (ECAC) is characterized by excessive narrowing of the airway lumen during exhalation leading to dyspnea, cough, mucostasis, recurrent respiratory infections, and poor quality of life. Tracheobronchomalacia and excessive dynamic airway collapse are heterogeneous entities of ECAC and are characterized by a diverse nonspecific symptom profile. Although the pathophysiology of airway mechanics as well as morphology in both entities is different, current evidence so far shows no practical benefit in making such distinction since both have similar symptoms and the diagnostic and therapeutic work-ups are the same...
December 2018: Seminars in Respiratory and Critical Care Medicine
Heidi Markussen, Sverre Lehmann, Roy M Nilsen, Gerd K Natvig
BACKGROUND: The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present study was to examine whether SRI sum scores and related subscales are associated with mortality in LTMV patients. METHODS: The study included 112 LTMV patients (non-invasive and invasive) from the Norwegian LTMV registry in Western Norway from 2008 with follow-up in August 2014...
January 11, 2019: BMC Pulmonary Medicine
Gerd Bordon, Sara Burguet Girona
OBJECTIVE: To review the complications associated with the minimally invasive retropleural approach used in the anterior approach to the thoraco-lumbar spine. MATERIAL AND METHOD: We present the MIS surgical technique and the evaluation of data collected prospectively from the initial series of 31 patients undergoing surgery. Pleural opening during the approach, lung complications derived, other surgical complications, time of intervention, intraoperative bleeding, need for transfusion and hospital stay are evaluated...
December 31, 2018: Revista Española de Cirugía Ortopédica y Traumatología
Ashley L Miller, Cheryl J Hersh, Kaalan E Johnson, Christopher J Hartnick
INTRODUCTION: Interarytenoid injection augmentation at the time of initial diagnostic endoscopy for aspiration and dysphagia may result in near-immediate improvement in swallowing function, potentially obviating the need for future formal endoscopic repair of type 1 laryngeal cleft. Interarytenoid injection augmentation may also address physiologic aspiration. Early treatment of type 1 laryngeal cleft may allow for expedited liberalization of feedings. The objective of this study was to evaluate the effect of interarytenoid injection augmentation (IIA) for type 1 laryngeal clefts (LC-1) on short-term swallowing function assessed by videofluoroscopic swallowing study (VFSS)...
January 2019: International Journal of Pediatric Otorhinolaryngology
Federica Novelli, Elena Bacci, Manuela Latorre, Veronica Seccia, Maria Laura Bartoli, Silvana Cianchetti, Federico Lorenzo Dente, Antonella Di Franco, Alessandro Celi, Pierluigi Paggiaro
Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma. Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. We collected demographic data, smoking habit, asthma history, and assessment of comorbidities...
2018: Clinical and Molecular Allergy: CMA
Houman Goudarzi, Satoshi Konno, Hirokazu Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M Ito, Masaharu Nishimura
BACKGROUND: Previous studies have shown the association of anthropometric measures with poor asthma symptoms, especially among women. However, the potential influence of visceral adiposity on asthma symptoms has not been investigated well. OBJECTIVE: In this study, we have evaluated whether visceral adiposity is related to poor adult asthma symptoms independent of anthropometric measures and sex. If this relationship presented, we investigated whether it is explained by influence on pulmonary functions and/or obesity-related comorbidities...
November 23, 2018: Journal of Allergy and Clinical Immunology in Practice
K El Chehadeh, F Becmeur, L Weiss
INTRODUCTION: Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) and digestive (gastroesophageal reflux disease [GERD])...
December 2018: Revue de Pneumologie Clinique
Linda Ejlskov, Henrik Bøggild, Claus D Hansen, Jesper Wulff, Steen M Hansen, Liis Starkopf, Theis Lange, Thomas Gerds, Christian Torp-Pedersen
Background: Early-life socioeconomic position (SEP) is associated with lifestyle-related diseases in adulthood. However, evidence is lacking on the extent to which adult SEP mediates this association. Methods: Time to either chronic obstructive pulmonary disease (COPD), cardiovascular disease or diabetes were assessed in the Danish population born between 1961 and 1971 (n = 793 674) from age 30 until 2015. Early-life position was assessed in 1981 (by parental) and again at age 30 (own) by four markers; income, occupation, education-divided into high, middle, low-and a combined score for all markers...
November 14, 2018: European Journal of Public Health
Simen A Steindal, Henny Torheim, Trine Oksholm, Vivi L Christensen, Kathryn Lee, Anners Lerdal, Heidi Øksnes Markussen, Gerd Gran, Marit Leine, Christine Råheim Borge
AIM: To critically review and synthesize the findings of studies that evaluated the effectiveness of nursing interventions for improving breathlessness in adults with chronic obstructive pulmonary disease. BACKGROUND: Systematic reviews of nursing interventions for breathlessness in people with chronic obstructive pulmonary disease have not been specifically addressed. DESIGN: Systematic review with meta-analysis. DATA SOURCES: A systematic search of Medline, CINAHL, PsycINFO and Embase was performed for studies published between January 2000 - June 2017...
November 5, 2018: Journal of Advanced Nursing
Jeffrey Wessler, David Kaye, Finn Gustafsson, Mark C Petrie, Gerd Hasenfuβ, Carolyn S P Lam, Barry A Borlaug, Jan Komtebedde, Ted Feldman, Sanjiv J Shah, Daniel Burkhoff
Background Interatrial shunt device (IASD) effects have been described in patients with heart failure and ejection fractions (EFs) ≥40%. However, baseline characteristics that correlate with greatest hemodynamic effects are unknown. On the basis of fundamental principles, we hypothesized that larger pressure gradients between left and right atria would yield greater shunt flow and greater hemodynamic effects. Methods and Results REDUCE LAP-HF (Reduce Elevated Left Atrial Pressure in Patients With Heart Failure) was a multicenter study that investigated IASD safety and performance...
August 2018: Circulation. Heart Failure
Marion Delcroix, Gerd Staehler, Henning Gall, Ekkehard Grünig, Matthias Held, Michael Halank, Hans Klose, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Joanna Pepke-Zaba, Christian F Opitz, J Simon R Gibbs, Tobias J Lange, Iraklis Tsangaris, Doerte Huscher, David Pittrow, Karen M Olsson, Marius M Hoeper
Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (World Health Organization Functional Class, 6-min walk distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation)...
November 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Alfredo D Guerron, Camila B Ortega, Hui-Jie Lee, Gerardo Davalos, Jennifer Ingram, Dana Portenier
INTRODUCTION: Asthma is an important healthcare problem affecting millions in the United States. Additionally, a large proportion of patients with asthma suffer from obesity. These patients exhibit poor asthma control and reduced therapy response, increasing utilization of healthcare resources. Pulmonary symptoms improve after bariatric surgery (BS), and we hypothesized that asthma medication usage would decrease following BS. METHODS: A retrospective data analysis was performed in adult patients from a single institution's database...
October 17, 2018: Surgical Endoscopy
Othmar Moser, Gerhard Tschakert, Alexander Mueller, Werner Groeschl, Max L Eckstein, Gerd Koehler, Richard M Bracken, Thomas R Pieber, Peter Hofmann
To investigate the heart rate during cardio-pulmonary exercise (CPX) testing in individuals with type 1 diabetes (T1D) compared to healthy (CON) individuals. Fourteen people (seven individuals with T1D and seven CON individuals) performed a CPX test until volitional exhaustion to determine the first and second lactate turn points (LTP1 and LTP2 ), ventilatory thresholds (VT1 and VT2 ), and the heart rate turn point. For these thresholds cardio-respiratory variables and percentages of maximum heart rate, heart rate reserve, maximum oxygen uptake and oxygen uptake reserve, and maximum power output were compared between groups...
2018: Frontiers in Endocrinology
David M Kaye, Mark C Petrie, Scott McKenzie, Gerd Hasenfuβ, Filip Malek, Martijn Post, Robert N Doughty, Jean-Noël Trochu, Finn Gustafsson, Irene Lang, Adam Kolodziej, Ralf Westenfeld, Martin Penicka, Mark Rosenberg, Jörg Hausleiter, Philip Raake, Guillaume Jondeau, Martin W Bergmann, Tim Spelman, Huseyin Aytug, Piotr Ponikowski, Chris Hayward
AIMS: Impaired left ventricular diastolic function leading to elevated left atrial pressures, particularly during exertion, is a key driver of symptoms and outcomes in heart failure with preserved ejection fraction (HFpEF). Insertion of an interatrial shunt device (IASD) to reduce left atrial pressure in HFpEF has been shown to be associated with short-term haemodynamic and symptomatic benefit. We aimed to investigate the potential effects of IASD placement on HFpEF survival and heart failure hospitalization (HFH)...
February 2019: ESC Heart Failure
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"