Yuankang Feng, Zhenlin Huang, Liang Song, Ningyang Li, Xiang Li, Huihui Shi, Ruoyang Liu, Fubo Lu, Xu Han, Yafei Ding, Yinghui Ding, Jun Wang, Jinjian Yang, Zhankui Jia
Cuproptosis is a new Cu-dependent programmed cell death manner that has shown regulatory functions in many tumor types, however, its mechanism in bladder cancer remains unclear. Here, we reveal that Phosphodiesterase 3B (PDE3B), a cuproptosis-associated gene, could reduce the invasion and migration of bladder cancer. PDE3B is downregulated in bladder cancer tissues, which is correlated with better prognosis. Conversely, overexpression of PDE3B in bladder cancer cell could significantly resist invasion and migration, which is consistent with the TCGA database results...
January 2, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology