Paolo Graziano, Paola Parente, Flavia Centra, Massimo Milione, Giovanni Centonze, Marco Volante, Alberto Cavazza, Diego Urbano, Giuseppe Di Maggio, Teresa Balsamo, Concetta Di Micco, Giulio Rossi, Antonio Rossi, Lucia Anna Muscarella
The combination of neuroendocrine/non neuroendocrine lung tumors (CNNELT) mentioned in the last edition of the World Health Organization (WHO) of Thoracic Tumors refers to small cell carcinoma (SCLC) or large cell neuroendocrine carcinoma (LCNEC) mixed with any other non-small cell lung carcinoma (NSCLC). Typical Carcinoid (TC)/Atypical Carcinoid (AC) combined with NSCLC is not included among this category. However, case reports of TC/AC combined with NSCLC have been described. We previously reported 2 cases of lung adenocarcinoma (LUA) mixed with carcinoid sharing mutations in both components supporting the hypothesis of a clonal origin...
September 29, 2023: Virchows Archiv: An International Journal of Pathology