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pulmonary large cell neuroendocrine carcinoma

B C M Hermans, J L Derks, E Thunnissen, R J van Suylen, M A den Bakker, H J M Groen, E F Smit, R A Damhuis, E C van den Broek, C M Stallinga, G M Roemen, E J M Speel, A-M C Dingemans
BACKGROUND: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare tumor with high mutational burden. Two subtypes of LCNEC are recognized, the co-mutated TP53 and RB1 group and the TP53 and STK11/KEAP1 group. We investigated PD-L1 and CD8 expression in a well characterized stage IV LCNEC cohort and compared expression in the two subtypes. METHODS: Immunohistochemical (IHC) analysis for PD-L1 and CD8 was performed on pathological reviewed pretreatment tumor samples for 148 stage IV LCNEC...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
In Young Jo, Seung-Gu Yeo
The incidence of large cell neuroendocrine carcinoma (LCNEC) of the lung is rare, and the treatment methods and prognosis for such patients are still subjects of debate. We report a case of a 78-year-old male LCNEC patient for whom stereotactic body radiation therapy was performed. A four-dimensional computed tomography scan was used for simulation, and radiotherapy was planned using the volumetrically modulated arc technique. A total of 55 Gy was delivered in five daily fractions. The treatment was safely completed, and the patient did not report any discomfort...
2019: OncoTargets and Therapy
Fengkai Xu, Ke Chen, Chunlai Lu, Jie Gu, Haiying Zeng, Yifan Xu, Yuan Ji, Di Ge
BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) was categorized into pulmonary neuroendocrine tumors (NETs) according to the World Health Organization classification guideline. However, LCNEC patients often received the chemotherapy regimens similar to non-small cell lung carcinoma (NSCLC) in advanced stage and the therapeutic effect was unsatisfactory. Therefore, this study aimed to investigate the hidden clinical features, prognosis and immunoprofile of the LCNEC, compared with carcinoid and SCLC, to explore whether LCNEC shares similarity with SCLC and potential treatment approaches could be revealed...
February 25, 2019: Translational Oncology
Hai-Yue Wang, Zhong-Wu Li, Wei Sun, Xin Yang, Li-Xin Zhou, Xiao-Zheng Huang, Ling Jia, Dong-Mei Lin
BACKGROUND: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. This study was to investigate the potentially diagnostic value of Ki-67 in pNETs...
March 5, 2019: Chinese Medical Journal
Hai-Yue Wang, Zhong-Wu Li, Wei Sun, Xin Yang, Li-Xin Zhou, Xiao-Zheng Huang, Ling Jia, Dong-Mei Lin
BACKGROUND: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. This study was to investigate the potentially diagnostic value of Ki-67 in pNETs...
February 20, 2019: Chinese Medical Journal
Andrzej Badzio, Piotr Czapiewski, Adam Gorczyński, Kamila Szczepańska-Michalska, Johannes Haybaeck, Wojciech Biernat, Jacek Jassem
INTRODUCTION: Small cell lung carcinoma (SCLC) is an aggressive pulmonary neoplasm of neuroendocrine origin. Keratins form a large group of intermediate filaments, which are major structural proteins in epithelial cells and carcinomas. SCLC shows a wide spectrum of keratin expression, from very strong to completely negative. A prognostic role of keratin expression in SCLC is unknown. MATERIAL AND METHODS: Tumor tissue microarray samples from a unique series of 82 SCLC patients who underwent pulmonary resection were stained with keratin specific antibodies AE1/AE3 and CAM5...
February 22, 2019: Acta Biochimica Polonica
James K Goddard, Eric S Nussbaum, Michael Madison, Jeff Lassig, Collin Torok, Dimitrios Giannakidis, Sandra Hanson, William McDonald, Kevin M Kallmes, Leslie A Nussbaum
Although cardiac myxomas have been known to cause acute ischemic stroke and other cerebrovascular complications, intracranial embolization of metastatic tumor fragments is rare. This is likely because venous emboli generally cause pulmonary embolism. Pulmonary vein metastases and patent foramen ovales have previously shown to propagate intracranial embolic carcinomas, but these events are very uncommon, and are not well characterized. We report a rare case of large-cell, high-grade neuroendocrine lung cancer embolus occluding the basilar artery, which likely detached into the bloodstream from the lung after intruding into a pulmonary vein...
February 20, 2019: Interventional Neuroradiology
Maria Cattoni, Eric Vallières, Lisa M Brown, Amir A Sarkeshik, Stefano Margaritora, Alessandra Siciliani, Pier Luigi Filosso, Francesco Guerrera, Andrea Imperatori, Nicola Rotolo, Farhood Farjah, Grace Wandell, Kimberly Costas, Catherine Mann, Michal Hubka, Stephen Kaplan, Alexander S Farivar, Ralph W Aye, Brian E Louie
BACKGROUND: Minimal knowledge exists regarding the outcome, prognosis and optimal treatment strategy for patients with pulmonary large cell neuroendocrine carcinomas (LCNEC) due to their rarity. We aimed to identify factors affecting survival and recurrence after resection to inform current treatment strategies. METHODS: We retrospectively reviewed 72 patients who had undergone a curative resection for LCNEC in 8 centers between 2000 and 2015. Univariable and multivariable analyses were performed to identify the factors influencing recurrence, disease-specific survival and overall survival...
February 19, 2019: World Journal of Surgery
Yoshinobu Ichiki, Hiroki Matsumiya, Masataka Mori, Masatoshi Kanayama, Yusuke Nabe, Akihiro Taira, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Ayako Hirai, Naoko Imanishi, Kazue Yoneda, Hiroshi Noguchi, Shohei Shimajiri, Yoshihisa Fujino, Toshiyuki Nakayama, Fumihiro Tanaka
Background: Pulmonary neuroendocrine tumor (NET) occurs with 20% of all lung cancers, and there are a limited number of literatures about the molecular aberrations, treatment and prognosis; especially in resected cases, as the operation indication for large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) is rare due to their aggressive behaviors. We investigated the relationship between postoperative survival and molecular expression patterns of pulmonary NET to establish a more effective treatment strategy...
December 2018: Journal of Thoracic Disease
Qiao Yang, Zihan Xu, Xiewan Chen, Linpeng Zheng, Yongxin Yu, Xianlan Zhao, Mingjing Chen, Bangyu Luo, Jianmin Wang, Jianguo Sun
BACKGROUND: The study was conducted to compare the clinicopathological characteristics, survival outcomes, and metastatic patterns between pulmonary large cell neuroendocrine carcinoma (LCNEC) and other non-small cell lung cancer (ONSCLC), and to identify the prognostic factors of LCNEC. METHODS: Data of patients diagnosed with LCNEC and ONSCLC from 2004 to 2014 were obtained from the Surveillance, Epidemiology, and End Results dataset. Pearson's chi-square tests were used to compare differences in clinicopathological characteristics...
February 7, 2019: Thoracic Cancer
Rodney E Wegner, Shaakir Hasan, Richard W Williamson, Gene Finley, Russell Fuhrer, Athanasios Colonias, Stephen M Karlovits
OBJECTIVES: Large cell neuroendocrine carcinoma (LCNEC) of the lung is a rare pulmonary tumor, having similar natural history and management strategy as small cell lung cancer. Therefore, the management of brain metastases in these patients has mirrored that of SCLC through the use of whole brain radiation therapy (WBRT). We used the National Cancer Database (NCDB) to look at predictors of stereotactic radiosurgery (SRS) and any potential differences in outcomes for patients with brain metastases from LCNEC...
February 7, 2019: Acta Oncologica
Yicui Piao, Hongyu Guo, Zhibo Qu, Biao Zheng, Yong Gao
Dysregulated expression of the cell surface protein, CD146, has been implicated in various types of cancer in humans, including in lung cancer. The present study aimed to clarify the mechanism underlying abnormal CD146 expression in human pulmonary large cell neuroendocrine carcinoma (LCNEC) cell lines (NCI-H460 and NCI-H810). The functions of CD146 were investigated by measuring cell migration and viability following CD146 knockdown or overexpression via small interference RNA and plasmid transfection. The findings demonstrated that decreased protein expression of CD146 could inhibit migration and viability in LCNEC cells...
February 2019: Oncology Letters
Barbara Bromińska, Rafał Czepczyński, Piotr Gabryel, Donata Jarmołowska-Jurczyszyn, Małgorzata Janicka-Jedyńska, Nadia Sawicka-Gutaj, Paweł Gut, Gabriel Bromiński, Wojciech Dyszkiewicz, Marek Ruchała
OBJECTIVES: The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed. PATIENTS AND METHODS: We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution...
January 10, 2019: Nuclear Medicine Communications
Naoki Shimizu, Yusaku Akashi, Tomomi Fujii, Hiroyuki Shiono, Katsunari Yane, Tadashi Kitahara, Yoshio Ohta, Kennichi Kakudo, Tomoko Wakasa
BACKGROUND: Patients with adenocarcinoma of the lung are routinely screened for anaplastic lymphoma kinase (ALK) rearrangement because they can be treated by ALK-specific targeted therapy. The clinical and molecular characteristics of large-cell neuroendocrine carcinoma (LCNEC) associated with ALK rearrangement are still unclear. Herein, we assessed the ALK status in a series of patients with LCNEC by testing methods commonly used for adenocarcinoma. MATERIALS AND METHODS: ALK expression was first examined by immunohistochemistry...
January 2019: Anticancer Research
Juan Wei, Xiao Fang Dong, Zu Liang Hu, Sheng Tang, Yi Fang Lu
RATIONALE: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, and 40% of patients are in stage IV at initial diagnosis. It has an extremely poor prognosis with a 1-year survival rate of 27%. Patients with LCNEC are predominantly male, older, and heavy smokers. There has been no clinical trial conducted to determine the best treatment for advanced LCNEC. Temozolomide (TMZ) has been successfully used to treat a variety of malignancies, such as glioblastoma multiforme, astrocytoma, non-small-cell lung carcinoma...
December 2018: Medicine (Baltimore)
J L Derks, A-M C Dingemans, R J van Suylen, M A den Bakker, R A Damhuis, E C van den Broek, E J Speel, E Thunnissen
PURPOSE: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimen. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimen. METHODS: Using the Dutch pathology registry (PALGA) surgically resected LCNEC with matching pre-operative biopsy specimen were identified and Haematoxylin and IHC slides (CD56, Chromogranin-A, Synaptophysin) requested. Subsequently, three pathologists assigned 1) the presence or absence of the WHO 2015 criteria and 2) cumulative size of all (biopsy) specimen...
November 28, 2018: Histopathology
Kai Obayashi, Kimihiro Shimizu, Seshiru Nakazawa, Toshiteru Nagashima, Toshiki Yajima, Takayuki Kosaka, Jun Atsumi, Natsuko Kawatani, Tomohiro Yazawa, Kyoichi Kaira, Akira Mogi, Hiroyuki Kuwano
Background: Correlations between volume doubling time (VDT) of primary lung cancer (PLC), histology, and ground glass opacity (GGO) components remain unclear. The purpose of this study was to evaluate and compare VDT of PLC in terms of histology and presence or absence of GGO components. Methods: A total of 371 surgically resected PLCs from 2003 to 2015 in our institute were retrospectively reviewed. The VDT was calculated both from the diameters of the entire tumor and of consolidation by using the approximation formula of Schwartz...
September 2018: Journal of Thoracic Disease
Lorene M Yoxtheimer, Jonas J Heymann, Cynthia Cohen, Rema A Rao, Abha Goyal, Momin T Siddiqui
BACKGROUND: Homeobox transcription factors have demonstrated utility in diagnosing neuroendocrine tumors. Orthopedia homeobox protein (OTP) has a well-defined role in embryonic neurodevelopment and has also been described as a prognostic marker in lung neuroendocrine tumors (NET). Additionally, NK6 homeobox-1 (NKX6.1) has been described to be necessary for the development of neuroendocrine cells in the pancreas. We evaluated immunohistochemical (IHC) expression of OTP and NKX6.1 to determine their utility in the diagnosis of NETs from lung and pancreas fine-needle aspirations (FNA)...
October 3, 2018: Diagnostic Cytopathology
Orestis Ioannidis, Charis Chatzidelios, Ioannis Mantzoros, Dimitrios Tatsis, Loukiani Kitsikosta, Christos Chatzakis, Apostolos Makrantonakis, George Paraskevas, Efstathios Kotidis, Manousos G Pramateftakis, Konstantinos Tsalis
Neuroendocrine carcinoma (NEC) of the colon is a rare and very aggressive tumor with poor prognosis. The current case report presents a 53-year-old male with a 6 cm × 10 cm ascending colon carcinoma, causing large intestine obstruction, with simultaneous multiple hepatic metastases and peritoneal carcinomatosis. Surgical resection of the primary tumor was performed, because of the bowel obstruction, to ameliorate the symptoms before the onset of chemotherapy. Histopathology revealed that the tumor was a small-cell undifferentiated NEC...
2018: Cirugia y Cirujanos
Shinji Nakashima, Toshiyuki Maeda, Satoshi Muraki, Taku Sakurada, Hisayoshi Osawa, Atsushi Watanabe
A 64-year-old man with pulmonary non-tuberculous mycobacteriosis(pulmonary NTM) who had been treated by antituberculous chemotherapy, developed a new nodule of 8 mm in size in the segment 3 of the right upper lobe. The cavity of 4.0 cm in size in the segment 1+2 of the left upper lobe due to Mycobacterium avium infection was preexisted. Radiologically, new nodule of the right lung was suspected to be lung cancer. Left upper lobe apical trisegmentectomy was performed at first. Three months later, enlarging of the right lung nodule with increased fluoro-2-deoxy-D-glucose(FDG) activity was noted, and the diagnosis of lung cancer was made by transbronchial lung biopsy(TBLB)...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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