Lanlan Li, Shengjun Fu, Jianliang Wang, Jianzhong Lu, Yan Tao, Liangtao Zhao, Beitang Fu, Lanpeng Lu, Caifei Xiang, Xince Sun, Shanhui Liu, Degui Wang, Zhiping Wang
Bladder cancer (BC) is the most common cancer of the urinary tract, with poor survival, high recurrence rates, and lacking of targeted drugs. In this study, we constructed a library to screen compounds inhibiting bladder cancer cells growth. Among them, SRT1720 was identified to inhibit bladder cancer cell proliferation in vitro and in vivo. SRT1720 treatment also suppressed bladder cancer cells migration, invasion and induced apoptosis. Mechanism studies shown that SRT1720 promoted autophagosomes accumulation by inducing early-stage autophagy but disturbed the late-stage of autophagy by blocking fusion of autophagosomes and lysosomes...
March 6, 2024: Biochemical Pharmacology