keyword
https://read.qxmd.com/read/38461085/mainstream-model-of-genetic-testing-for-prostate-cancer-at-a-large-tertiary-cancer-centre
#21
JOURNAL ARTICLE
Xin Wang, Larissa Waldman, Yael Silberman, Michael Wang, Caleb Tackey, Lilian Hanna, Danny Vesprini, Urban Emmenegger, Andrea Eisen, Martin Smoragiewicz
BACKGROUND: An estimated 20% to 30% of men with advanced prostate cancer carry a mutation in DNA damage repair genes, of which half are estimated to be germline. Eligibility criteria for germline genetic testing expanded significantly for Ontario patients in May 2021 and many centers adopted a "mainstream" model, defined as oncologist-initiated genetic testing. METHODS: We conducted a retrospective chart review to report on the first-year mainstream experience of a large tertiary oncologic center, the Sunnybrook Odette Cancer Centre...
February 12, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38458329/srt1720-inhibits-bladder-cancer-cell-progression-by-impairing-autophagic-flux
#22
JOURNAL ARTICLE
Lanlan Li, Shengjun Fu, Jianliang Wang, Jianzhong Lu, Yan Tao, Liangtao Zhao, Beitang Fu, Lanpeng Lu, Caifei Xiang, Xince Sun, Shanhui Liu, Degui Wang, Zhiping Wang
Bladder cancer (BC) is the most common cancer of the urinary tract, with poor survival, high recurrence rates, and lacking of targeted drugs. In this study, we constructed a library to screen compounds inhibiting bladder cancer cells growth. Among them, SRT1720 was identified to inhibit bladder cancer cell proliferation in vitro and in vivo. SRT1720 treatment also suppressed bladder cancer cells migration, invasion and induced apoptosis. Mechanism studies shown that SRT1720 promoted autophagosomes accumulation by inducing early-stage autophagy but disturbed the late-stage of autophagy by blocking fusion of autophagosomes and lysosomes...
March 6, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38455819/utility-of-ct-scan-in-detecting-bladder-involvement-among-patients-with-cervical-carcinoma
#23
JOURNAL ARTICLE
Rajni Agrawal, Ritika Agarwal
Background Cervical cancer is a widespread health issue in India, particularly affecting women as the second most common cancer. The burden of cervical cancer in the country necessitates accurate staging for treatment optimization. The revised International Federation of Gynecology and Obstetrics (FIGO) staging system is vital for this purpose, emphasizing the extent of parametrial and pelvic sidewall involvement. Cervical cancer's propensity to infiltrate neighboring pelvic organs, including the bladder, necessitates precise staging...
February 2024: Curēus
https://read.qxmd.com/read/38454087/progress-in-site-specific-cancer-mortality-in-canada-over-the-last-70%C3%A2-years
#24
JOURNAL ARTICLE
Matthew T Warkentin, Yibing Ruan, Larry F Ellison, Jean-Michel Billette, Alain Demers, Fei-Fei Liu, Darren R Brenner
In Canada, the absolute number of cancer deaths has been steadily increasing, however, age-standardized cancer mortality rates peaked decades ago for most cancers. The objective of this study was to estimate the reduction in deaths for each cancer type under the scenario where peak mortality rates had remained stable in Canada. Data for this study were obtained the Global Cancer Observatory and Statistics Canada. We estimated age-standardized mortality rates (ASMR, per 100,000) from 1950 to 2022, standardized to the 2011 Canadian standard population...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38443785/the-potential-mechanism-of-ursolic-acid-in-the-treatment-of-bladder-cancer-based-on-network-pharmacology-and-molecular-docking
#25
JOURNAL ARTICLE
Xiao-Long Huang, Yan Sun, Peng Wen, Jun-Cheng Pan, Wei-Yang He
OBJECTIVE: This study explored the potential molecular mechanisms of ursolic acid (UA) in bladder cancer treatment using network pharmacology and molecular docking. METHODS: The Traditional Chinese Medicine Systems Pharmacology and UniProt databases were used to screen potential targets of UA. Relevant bladder cancer target genes were extracted using the GeneCards database. All data were pooled and intercrossed to obtain common target genes of UA and bladder cancer...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38426435/causal-estimation-of-long-term-intervention-cost-effectiveness-using-genetic-instrumental-variables-an-application-to-cancer
#26
JOURNAL ARTICLE
Padraig Dixon, Richard M Martin, Sean Harrison
BACKGROUND: This article demonstrates a means of assessing long-term intervention cost-effectiveness in the absence of data from randomized controlled trials and without recourse to Markov simulation or similar types of cohort simulation. METHODS: Using a Mendelian randomization study design, we developed causal estimates of the genetically predicted effect of bladder, breast, colorectal, lung, multiple myeloma, ovarian, prostate, and thyroid cancers on health care costs and quality-adjusted life-years (QALYs) using outcome data drawn from the UK Biobank cohort...
March 1, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://read.qxmd.com/read/38423930/value-of-cystatin-c-based-sarcopenia-index-in-patients-undergoing-surgery-for-renal-tumors
#27
JOURNAL ARTICLE
Shugo Yajima, Yasukazu Nakanishi, Ryo Andy Ogasawara, Naoki Imasato, Kohei Hirose, Sao Katsumura, Madoka Kataoka, Hitoshi Masuda
INTRODUCTION: Sarcopenia is a condition of low muscle strength and quantity, severe if low physical performances. The sarcopenia index (SI), calculated by blood levels of creatinine and cystatin C, had been reported to be correlated with skeletal muscle mass and is a potential simple screening tool for sarcopenia. We hypothesized that patients with a low SI, meaning low muscle mass, would have an inflated estimated glomerular filtration rate (eGFR) value based on serum creatinine levels...
February 9, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38422601/analysis-of-aromatic-amines-in-human-urine-using-comprehensive-multi-dimensional-gas-chromatography-mass-spectrometry-gcxgc-ms
#28
JOURNAL ARTICLE
Nerea Lorenzo-Parodi, Susanne Moebus, Torsten C Schmidt
Several aromatic amines (AA) are classified as human carcinogens, and tobacco smoke is one of the main sources of exposure. Once in the human body, they undergo different metabolic pathways which lead to either their excretion or ultimately to the formation of DNA and protein adducts. The aim of this study was to investigate AA in 68 urine samples (aged 29-79, 47% female), including 10 smokers (S), 28 past-smokers (PS) and 30 never-smokers (NS), and to study if there was a relation between the smoking status and the amount of the AA present...
February 28, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38420800/-ppp3cb-inhibits-cell-proliferation-and-the-warburg-effect-in-bladder-cancer-by-blocking-pdhk1
#29
JOURNAL ARTICLE
Xiangmin Qiu, Ziqing Jiang, Yu Luo, Dayu Tian, Tao Song, Qianyin Li
BACKGROUND: Cancer treatment has recently shifted towards metabolic approaches aimed at enhancing therapeutic efficacy. Somewhat surprisingly, a known regulator of energy metabolism in normal tissues, PPP3CB , is down-regulated in bladder cancer. This suggests that PPP3CB could exert an inhibitory effect on bladder cancer through its role in energy metabolism. METHODS: To explore the above hypothesis, we employed non-targeted metabolism screening in bladder cancer cells with knockdown of PPP3CB ...
February 4, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38418269/functional-and-oncologic-outcomes-of-prostate-capsule-sparing-radical-cystectomy-a-systematic-review-and-meta-analysis
#30
REVIEW
Christopher P Dall, James B Mason, Charlotte C Goldman, Grant Fabrizio, Emily C Alagha, Jiling Chou, Keith J Kowalczyk, Piyush K Agarwal, Lambros Stamatakis, Ross E Krasnow
Radical cystectomy (RC) is the gold standard treatment for patients with organ-confined bladder cancer. However, despite the success of this treatment, many men who undergo orthotopic neobladder substitution develop significant erectile dysfunction and urinary symptoms, including daytime and nighttime urinary incontinence. Prostate-capsule-sparing radical cystectomy (PCS-RC) with orthotopic neobladder (ONB) has been described in the literature as a surgical technique to improve functional outcomes in appropriately selected patients...
February 27, 2024: Urologic Oncology
https://read.qxmd.com/read/38410113/exploration-of-potential-biomarkers-for-early-bladder-cancer-based-on-urine-proteomics
#31
JOURNAL ARTICLE
Xu Zhou, Fei Xue, Tingmiao Li, Jiangshan Xue, Siqi Yue, Shujie Zhao, Hezhen Lu, Chengyan He
BACKGROUND: Bladder cancer is a common malignant tumor of the urinary system. The progression of the condition is associated with a poor prognosis, so it is necessary to identify new biomarkers to improve the diagnostic rate of bladder cancer. METHODS: In this study, 338 urine samples (144 bladder cancer, 123 healthy control, 32 cystitis, and 39 upper urinary tract cancer samples) were collected, among which 238 samples (discovery group) were analyzed by LC-MS. The urinary proteome characteristics of each group were compared with those of bladder cancer, and the differential proteins were defined by bioinformatics analysis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38409085/comprehensive-analysis-of-mitochondria-related-genes-indicates-that-ppp2r2b-is-a-novel-biomarker-and-promotes-the-progression-of-bladder-cancer-via-wnt-signaling-pathway
#32
JOURNAL ARTICLE
Du Shen, Shaosan Kang
Bladder cancer (BC) is the fourth and tenth most common malignancy in men and women worldwide, respectively. The complexity of the molecular biological mechanism behind BC is a major contributor to the lack of effective treatment management of the disease. The development and genesis of BC are influenced by mitochondrial retrograde control and mitochondria-nuclear cross-talk. However, the role of mitochondrial-related genes in BC remains unclear. In this study, we analyzed TCGA datasets and identified 752 DE-MRGs in BC samples, including 313 down-regulated MRGs and 439 up-regulated MRGs...
February 26, 2024: Biology Direct
https://read.qxmd.com/read/38408996/impact-of-a-mediterranean-diet-on-prevention-and-management-of-urologic-diseases
#33
REVIEW
Mark I Sultan, Shady A Ibrahim, Ramy F Youssef
Compared to a Western diet, the Mediterranean diet moves away from red meat and processed foods. Universally regarded as a healthier dietary alternative, the Mediterranean diet has garnered scientific endorsement for its ability to confer an array of compelling benefits. These health benefits encompass not only a lowered incidence of Type 2 diabetes with a reduction in obesity, but also a robust protective effect on cardiovascular health. Extensive literature exists to corroborate these health benefits; however, the impact of a Mediterranean diet on urologic diseases, specifically sexual dysfunction, lower urinary tract symptoms, stone disease, and urologic cancers are not well studied...
February 26, 2024: BMC Urology
https://read.qxmd.com/read/38400838/jam3-is-a-potential-risk-biomarker-for-predicting-prognosis-and-immune-cell-infiltration-by-regulating-epithelial-mesenchymal-transition-in-bladder-cancer
#34
JOURNAL ARTICLE
Zhong-Qi Pang, Jian-She Wang, Jin-Feng Wang, Ya-Xuan Wang, Bo Ji, Yi-Dan Xu, Jia-Xin He, Lu Zhang, Li-Qiu Zhang, Bei-Chen Ding, Yang Liu, Ming-Hua Ren
To identify novel biomarkers for predicting prognosis and immune function in bladder cancer (BC) patients, we combined weighted correlation network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression analysis by using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and finally screened the junctional adhesion molecule 3 (JAM3) as an independent risk factor in BC. High levels of JAM3 were linked to adverse clinical parameters, such as higher T and N stages...
February 23, 2024: Biomol Biomed
https://read.qxmd.com/read/38398192/new-perspectives-on-the-role-of-liquid-biopsy-in-bladder-cancer-applicability-to-precision-medicine
#35
REVIEW
Fernardo Alberca-Del Arco, Daniel Prieto-Cuadra, Rocio Santos-Perez de la Blanca, Felipe Sáez-Barranquero, Elisa Matas-Rico, Bernardo Herrera-Imbroda
Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures that may cause pain and infectious complications. Considering the limitations of both procedures, and the recurrence and resistance to BC treatment, it is necessary to develop a new non-invasive methodology for early diagnosis and multiple evaluations in patients under follow-up for bladder cancer...
February 16, 2024: Cancers
https://read.qxmd.com/read/38384713/a-novel-serum-m-7-g-harboring-microrna-signature-for-cancer-detection
#36
JOURNAL ARTICLE
Yaxin Chen, Yufang Xie, Liyun Bi, Hang Ci, Weimin Li, Dan Liu
Background: Emerging evidence points to the exceptional importance and value of m7 G alteration in the diagnosis and prognosis of cancers. Nonetheless, a biomarker for precise screening of various cancer types has not yet been developed based on serum m7 G-harboring miRNAs. Methods: A total of 20,702 serum samples, covering 12 cancer types and consisting of 7,768 cancer samples and 12,934 cancer-free samples were used in this study. A m7 G target miRNA diagnostic signature (m7 G-miRDS) was established through the least absolute shrinkage and selection operator (LASSO) analyses in a training dataset ( n = 10,351), and validated in a validation dataset ( n = 10,351)...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38383173/urinary-exosomal-mir-17-5p-accelerates-bladder-cancer-invasion-by-repressing-its-target-gene-arid4b-and-regulating-the-immune-microenvironment
#37
JOURNAL ARTICLE
Hejia Yuan, Tianqi Wang, Peng Peng, Zhunan Xu, Fan Feng, Yuanshan Cui, Jian Ma, Jitao Wu
BACKGROUND: Urothelial bladder cancer (BCa) is a common malignant tumor of the urinary system. It has been identified that exosomal miRNAs contribute to the development of BCa. However, its significance and mechanism in the malignant biological behavior of BCa remain unclear. In this study, the influence of exosomal miRNAs on BCa progression was investigated. METHODS: High-throughput sequencing was conducted to analyze the microRNA-expression profile in urinary exosomes to screen out the key miRNA of muscle-invasive bladder cancer (MIBC)...
January 22, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38373783/macroscopy-of-specimens-from-the-genitourinary-system
#38
REVIEW
Murali Varma, John Dormer
Macroscopic specimen examination is often critical for accurate histopathology reporting but has generally received insufficient attention and may be delegated to inexperienced staff with limited guidance and supervision. This review discusses issues around macroscopic examination of some common urological specimens; highlighting findings that are critical for patient management and others that are clinically irrelevant. Macroscopic findings are of limited value in completely submitted radical prostatectomy specimens but may be critical in orchidectomy specimens where identification of focal non-seminomatous components can significantly impact patient management...
February 19, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38370377/prognostic-and-chemotherapeutic-response-prediction-by-proliferation-essential-gene-signature-investigating-pole2-in-bladder-cancer-progression-and-cisplatin-resistance
#39
JOURNAL ARTICLE
Liying Yu, Na Lin, Yan Ye, Shuang Zhou, Yanjuan Xu, Jiabi Chen, Wei Zhuang, Qingshui Wang
Background: Bladder cancer (BLCA) is the most common genitourinary malignancy. Proliferation essential genes (PEGs) are crucial to the survival of cancer cells. This study aimed to build a PEG signature to predict BLCA prognosis and treatment efficacy. Methods: BLCA PEGs and differentially expressed PEGs were identified using DepMap and TCGA-BLCA datasets, respectively. Based on the prognostic analysis of the differentially expressed PEGs, a PEG model was constructed. Subsequently, we analyzed the relationship between the PEG signature and prognosis of BLCA patients as well as their response to chemotherapy...
2024: Journal of Cancer
https://read.qxmd.com/read/38369583/feasibility-analysis-of-arterial-ct-radiomics-model-to-predict-the-risk-of-local-and-metastatic-recurrence-after-radical-cystectomy-for-bladder-cancer
#40
JOURNAL ARTICLE
Huawang Lv, Xiaozhou Zhou, Yuan Liu, Yuting Liu, Zhiwen Chen
PURPOSE: To construct a radiomics-clinical nomogram model for predicting the risk of local and metastatic recurrence within 3 years after radical cystectomy (RC) of bladder cancer (BCa) based on the radiomics features and important clinical risk factors for arterial computed tomography (CT) images and to evaluate its efficacy. METHODS: Preoperative CT datasets of 134 BCa patients (24 recurrent) who underwent RC were collected and divided into training (n = 93) and validation sets (n = 41)...
February 19, 2024: Discover. Oncology
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