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(Bladder Cancer) AND Screening

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https://read.qxmd.com/read/30779109/the-identification-of-new-biomarkers-for-bladder-cancer-a-study-based-on-tcga-and-geo-datasets
#1
Junyi Hu, Lijie Zhou, Zhengshuai Song, Ming Xiong, Youpeng Zhang, Yu Yang, Ke Chen, Zhaohui Chen
Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years. Available biomarkers are not sensitive enough for the diagnosis of BC, whereas the standard diagnostic method, cystoscopy, is an invasive test and expensive. Hence, seeking new biomarkers of BC is urgent and challenging. With that order, we screened the overlapped differentially expressed genes (DEGs) of GSE13507 and TCGA BLCA datasets...
February 18, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30756323/perceptions-of-cancer-causes-prevention-and-treatment-among-navajo-cancer-survivors
#2
Jennifer W Bea, Hendrik 'Dirk' de Heer, Brian Kinslow, Luis Valdez, Etta Yazzie, Pearl Curley, Shelby Dalgai, Anna L Schwartz
Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. An experienced, bilingual facilitator led the discussions using a standardized guide...
February 12, 2019: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://read.qxmd.com/read/30742384/-a-prognostic-value-of-level-of-antiviral-antibodies-in-the-development-of-recurrence-of-bladder-cancer
#3
I V Kosova, O B Loran, L A Sinyakova, L V Gundorova, V A Kosov, I E Pogodina, D N Kolbasov
INTRODUCTION: Serological diagnosis of virus-associated tumors attracts the attention of many specialists. The changes in the level of antiviral antibodies in tumors of different localizations are proved. In some cases, the authors suggest using these data either for screening of tumors or for controlling the cure. AIM: to evaluate the predictive value of antiviral antibodies for the recurrence of bladder cancer. MATERIALS AND METHODS: a level of antiviral antibodies (IgG, M) against Epstein-Barr virus (EBV), herpes simplex virus (HSV) 1 and 2 types, cytomegalovirus (CMV) of 100 patients with bladder cancer (72 men and 28 women) aged from 38 to 90 years (mean age 65+/-10) was studied...
December 2018: Urologii︠a︡
https://read.qxmd.com/read/30717562/-effective-components-and-signaling-pathways-of-epimedium-brevicornumbased-on-network-pharmacology
#4
Run-Tong Zhang, Hai-Ning Wu, Gui-Hong Yu, Yuan-Li Zhou, Xiao-Bin Jia, Liang Feng
The aim of this paper was to find out the active components of Epimedium brevicornum using network pharmacology, and find the potential targets and mechanisms. The TCMSP database was used to screen the active ingredients, and TTD and DrugBank databases were used to predict the potential targets with the literature mining. The pathway annotation was used to enrich and analyze the active ingredients and potential targets of E. brevicornum. The results showed that E. brevicornum had34 potential target active ingredients, including 21 flavones components, such as icariin, epimedin A, epimedin B, epimedin C, Yinyanghuo A, Yinyanghuo C and so on, 2 lignans involved in (+)-cycloolivil and olivil, 3 sterols consisting of sitosterol, 24-epicampesterol and poriferast-5-en-3beta-ol...
December 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/30713670/further-application-of-hyperbaric-oxygen-in-prostate-cancer
#5
REVIEW
Qi-Zhong Lu, Xiang Li, Jun Ouyang, Jin-Quan Li, Gang Chen
Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for multiple pathological states, which involves hypoxic conditions. Over the past 50 years, HBOT has been recommended and used in a wide variety of medical conditions, clinically in the treatment of ischemic or nonhealing wounds and radiation-injured tissue, and in the treatment of malignancy. The mechanism of this treatment is providing oxygen under pressure which is higher than the atmosphere thus increasing tissue oxygen concentration...
October 2018: Medical Gas Research
https://read.qxmd.com/read/30711015/detection-of-pagetoid-urothelial-intraepithelial-neoplasia-extending-to-the-vagina-by-cervical-screening-cytology-a-case-report-with-renewed-immunochemical-summary
#6
Yuki Koyanagi, Chiaki Kubo, Shigenori Nagata, Ayumi Ryu, Koji Hatano, Rieko Kano, Satoshi Tanada, Jun-Ichi Ashimura, Atsushi Idota, Shoji Kamiura, Tomoyuki Yamasaki, Shin-Ichi Nakatsuka
BACKGROUND: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. CASE PRESENTATION: A 68-year-old Japanese postmenopausal woman developed brown vaginal discharge after radical cystectomy for bladder cancer (high-grade UC, pT2a pN0 cM0 [Union for International Cancer Control, 8th edition]) concomitant with focal in-situ UC in the urethra...
February 2, 2019: Diagnostic Pathology
https://read.qxmd.com/read/30694688/synthesis-and-aggregation-of-a-porphyrin-cored-hyperbranched-polyglycidol-and-its-application-as-a-macromolecular-photosensitizer-for-photodynamic-therapy
#7
Alaa Kadhim, Luke K McKenzie, Helen E Bryant, Lance James Twyman
Macromolecules are potentially useful delivery systems for cancer drugs as their size allows them to utilize the enhanced permeability and retention effect (EPR), which facilitates selective delivery to (and retention within) tumors. In addition, macromolecular delivery systems can prolong circulation times as well as protecting and solubilizing toxic and hydrophobic drug moieties. Overall these properties and abilities can result in an enhanced therapeutic effect. Photodynamic therapy (PDT) combines the use of oxygen and a photosensitizer (PS), that become toxic upon light-irradiation...
January 29, 2019: Molecular Pharmaceutics
https://read.qxmd.com/read/30657341/comparison-of-different-prognostic-models-for-predicting-cancer-specific-survival-in-bladder-transitional-cell-carcinoma
#8
ChuiGuo Huang, WeiWen Zhou, Pan Song, NaiJun Yuan
OBJECTIVE: To construct the newly valuable nomogram which can compare the predictive performance with American Joint Committee on Cancer (AJCC) staging system in bladder transitional cell carcinoma (BTCC). METHODS: BTCC patients were screened (2004-2015) from the SEER database. The nomogram incorporating lymph node ratio was constructed to evaluate individualized cancer-specific survival. RESULTS: The C-index of the nomogram for predicting cancer-specific survival was 0...
January 18, 2019: Future Oncology
https://read.qxmd.com/read/30636892/incidences-and-oncological-outcomes-of-urothelial-carcinoma-in-kidney-transplant-recipients
#9
Jiwoong Yu, Chung Un Lee, Minyong Kang, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hyun Hwan Sung
Purpose: We investigated to determine if there is an increased rate of urothelial carcinoma (UC) in kidney transplant (KT) recipients and to compare oncological outcomes of UC in KT recipients with non-KT patients. Patients and methods: Among 2,186 patients who underwent KT in our institute, nine patients developed UC after KT in our center. Age-standardized rates (ASRs) were calculated to compare incidence rates of UC between KT patients and the general population...
2019: Cancer Management and Research
https://read.qxmd.com/read/30618079/identification-of-several-cell-cycle-relevant-genes-highly-correlated-with-the-progression-and-prognosis-of-human-bladder-urothelial-tumor
#10
Lu Wang, Song Chen, Yongwen Luo, Lushun Yuan, Tianchen Peng, Kaiyu Qian, Xuefeng Liu, Yu Xiao, Xinghuan Wang
The incidence of bladder cancer (BCa) in China is the highest among genitourinary system tumors, and its progression is affected by multitudinous pathways, of which cell cycle progress plays an important role. This study screened and enriched differentially expressed genes (DEGs) from four gene expression profiles using bioinformatics analysis methods. The enrichment and analysis of gene function showed that these genes were highly correlated with cell cycle regulation. Identification of candidate small molecules was conducted to evaluate the application of clinical transformation in these DEGs...
January 7, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30611645/urologic-conditions-associated-with-malignancy
#11
REVIEW
Eric M Lo, James M Hotaling, Alexander W Pastuszak
INTRODUCTION: Recent advances in cancer research have highlighted the role of genetics in malignancy. Genetic dysregulation of core cellular functions similarly influences benign conditions. These common genetic factors have led researchers to identify an association between certain urologic conditions and malignancy. The objective of this review is to evaluate the literature linking benign urologic conditions including male infertility, Peyronie's disease, cryptorchidism, and hypospadias, to malignancy...
January 2, 2019: Urologic Oncology
https://read.qxmd.com/read/30609030/microarray-expression-profiles-analysis-revealed-lncrna-oxct1-as1-promoted-bladder-cancer-cell-aggressiveness-via-mir-455-5p-jak1-signaling
#12
Jin-Bo Chen, Ye-Wen Zhu, Xi Guo, Cui Yu, Pei-Hua Liu, Chao Li, Jiao Hu, Hui-Huang Li, Long-Fei Liu, Min-Feng Chen, He-Qun Chen, Zu Xiong-Bing
Bladder cancer (BCa) is one of the most prevalent cancers of the urinary system worldwide. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) perform a vital function in the pathogenesis and progression of BCa. In the current study, we identified a novel lncRNA OXCT1-AS1 and investigated its role and potential mechanisms in BCa. The microarray results showed the expression of lncRNAs, microRNAs, and messenger RNAs between BCa primary tumor tissues and metastatic lymph nodes were significantly different...
January 4, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30608133/plasmoelectronic-based-ultrasensitive-assay-of-tumor-suppressor-micrornas-directly-in-patient-plasma-design-of-highly-specific-early-cancer-diagnostic-technology
#13
Thakshila Liyanage, Adrianna N Masterson, Hector H Oyem, Hristos Kaimakliotis, Hang Nguyen, Rajesh Sardar
It is becoming understood that microRNAs hold great promise for non-invasive liquid biopsies for screening for different types of cancer, but current state-of-the-art RT-PCR and microarray techniques have sensitivity limitations that currently restrict their use. Herein, we report a new transduction mechanism involving delocalization of photoexcited conduction electrons wavefunction of gold triangular nanoprism (Au TNP) in the presence of -ssDNA/microRNA duplexes. This plasmoelectronic effect reduces the electron density of Au TNPs and substantially affects their localized surface plasmon resonance (LSPR) properties that together allow us to achieve a sensitivity for microRNA assay as low as 140 zeptomolar concentrations for our nanoplasmonic sensors...
January 4, 2019: Analytical Chemistry
https://read.qxmd.com/read/30589832/risk-of-primary-neuroendocrine-pancreatic-tumor-after-a-first-primary-cancer-a-us-population-based-study
#14
Geetanjali R Kamath, Michelle K Kim, Emanuela Taioli
OBJECTIVE: This study aimed to describe the relative and excess risk of pancreatic neuroendocrine tumor (NET) at least 6 months after the first primary cancer (FPC) among the US population. METHODS: Surveillance, Epidemiology, and End-Results Program data were analyzed for patients diagnosed as having FPC from 2000 to 2015 (n = 4,008,092). Standardized incidence ratios, excess risk, and average time to diagnosis of a second primary pancreatic NET were reported by FPC site, stratified by sex and receipt of radiotherapy and chemotherapy...
December 26, 2018: Pancreas
https://read.qxmd.com/read/30587457/de-novo-malignancy-in-heart-transplant-recipients-a-single-center-experience-in-japan
#15
Yuki Kimura, Masanobu Yanase, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Sachi Matsuda, Hiromi Takenaka, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Takuya Watanabe, Megumi Morii Ikura, Kyoichi Wada, Yorihiko Matsumoto, Osamu Seguchi, Satsuki Fukushima, Tomoyuki Fujita, Junjiro Kobayashi, Norihide Fukushima
BACKGROUND: Because of aggressive immunosuppression, heart transplant recipients have a high risk of de novo malignancy, which is a major cause of death and worse prognosis, regardless of the type. However, the impact of de novo malignancy on Japanese heart transplant recipients is unknown. METHODS: We analyzed 103 Japanese heart transplant recipients over 18-years-old at the time of transplantation between April 1999 and April 2017. Patient characteristics and prognosis were compared between heart transplant recipients with or without de novo malignancy after heart transplantation (HTx)...
December 22, 2018: Journal of Cardiology
https://read.qxmd.com/read/30554493/quality-of-bowel-preparation-for-colonoscopy-in-patients-with-a-history-of-abdomino-pelvic-surgery-retrospective-cohort-study
#16
Bun Kim, Byung Chang Kim, Jeongseon Kim, Hyun Jin Oh, Kum Hei Ryu, Bum Joon Park, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han
PURPOSE: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. MATERIALS AND METHODS: In the health screening cohort of the National Cancer Center, 12881 participants who underwent screening or surveillance colonoscopy between June 2007 and December 2014 were included...
January 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30533316/identification-of-key-candidate-genes-and-biological-pathways-in-bladder-cancer
#17
Xin Gao, Yinyi Chen, Mei Chen, Shunlan Wang, Xiaohong Wen, Shufang Zhang
Background: Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for key genes associated with the development of bladder cancer and reveal their potential molecular mechanisms. Methods: The GSE7476, GSE13507, GSE37815 and GSE65635 expression profiles were downloaded from the Gene Expression Omnibus database, and these datasets contain 304 tissue samples, including 81 normal bladder tissue samples and 223 bladder cancer samples...
2018: PeerJ
https://read.qxmd.com/read/30503795/placement-of-inflatable-penile-implants-in-patients-with-prior-radical-pelvic-surgery-a-literature-review
#18
REVIEW
SriGita K Madiraju, Tariq S Hakky, Paul E Perito, Jared J Wallen
BACKGROUND: Penile prosthesis for erectile restoration remains the only surgical option for medical refractory erectile dysfunction. Many expert prosthetic surgeons recommend special care when placing a reservoir in a patient who has undergone prior radical pelvic surgery (PRPS) due to distortion of anatomy and obliteration of the dead space in the traditionally used space of Retzius. AIM: Review all the current literature on penile prosthesis implantation in patients with prior pelvic surgery, with an emphasis on tips and tricks for reservoir placement in this unique population...
November 29, 2018: Sexual Medicine Reviews
https://read.qxmd.com/read/30476975/evaluation-of-second-solid-cancers-after-hematopoietic-stem-cell-transplantation-in-european-patients
#19
André Tichelli, Eric Beohou, Myriam Labopin, Gérard Socié, Alicia Rovó, Manuela Badoglio, Anja van Biezen, Peter Bader, Rafael F Duarte, Grzegorz Basak, Nina Salooja
Importance: Incidence and risk factors of second solid cancers (SSCs) that occur after hematopoietic stem cell transplantation (HSCT) are well documented. However, clinical outcome data of patients who developed an SSC after HSCT are limited. Objective: To assess the outcome of patients with an SSC occurring after HSCT from the time of SSC diagnosis. Design, Setting, and Participants: This cohort study used data of 4065 patients from 26 countries registered with the European Society for Blood and Marrow Transplantation, which has maintained clinical data since 1977 of patients who received a transplant...
November 21, 2018: JAMA Oncology
https://read.qxmd.com/read/30475602/a-novel-near-infrared-fluorescent-probe-tmtp1-peg4-icg-for-in-vivo-tumor-imaging
#20
Ying Zhou, Jiang Guiying, Wei Wang, Rui Wei, Xi Chen, Xueqian Wang, Juncheng Wei, Ding Ma, Fei Li, Ling Xi
Molecular imaging agents are considered to be promising tracers for tumor imaging and guided therapy. TMTP1 was screened through the FliTrx bacterial peptide display system in our laboratory previously and shown to specifically target to primary tumors and metastatic foci. In this study, Small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. It was successfully synthesized and certificated. CCK-8 assay showed it was nontoxic to normal cells and cancerous cells...
November 26, 2018: Bioconjugate Chemistry
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