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Jaundice AND gallbladder cancer

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https://read.qxmd.com/read/30725292/primary-sclerosing-cholangitis-a-concise-review-of-diagnosis-and-management
#1
REVIEW
Zachary P Fricker, David R Lichtenstein
Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. The diagnosis can be confirmed via cholangiography, either magnetic resonance cholangiography (MRCP) or endoscopic retrograde cholangiography if the former is inconclusive...
February 6, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30711243/incidental-versus-non-incidental-gallbladder-cancer-index-cholecystectomy-before-oncologic-re-resection-negatively-impacts-survival-in-t2b-tumors
#2
Eduardo A Vega, Eduardo Vinuela, Masayuki Okuno, Katharina Joechle, Marcel Sanhueza, Cristian Diaz, Nicolas Jarufe, Jorge Martinez, Andres Troncoso, Alfonso Diaz, Yun S Chun, Ching-Wei D Tzeng, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Conflicting data exists whether non-oncologic index cholecystectomy (IC) leading to discovery of incidental gallbladder cancer (IGBC) negatively impacts survival. This study aimed to determine whether a subgroup of patients derives a disadvantage from IC. METHODS: Patients with IGBC and non-IGBC treated at an academic USA and Chilean center during 1999-2016 were compared. Patients with T1, T4 tumor or preoperative jaundice were excluded. T2 disease was classified into T2a (peritoneal-side tumor) and T2b (hepatic-side tumor)...
January 30, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30632340/management-and-outcome-of-jaundice-secondary-to-malignancies-of-the-gall-bladder-biliary-tree-and-pancreas-a-single-centre-experience
#3
Adnan Salim, Sadia Jabbar, Farhan Ul Amin, Kashif Malik
BACKGROUND: Obstructive jaundice due to malignancies of the biliary tree, gall bladder and pancreas account for a significant number of patients managed by tertiary centres. Management options are curative or palliative, depending on disease stage. This study was performed to see the effectiveness of treatment modalities for these patients and eventual outcome. METHODS: This cross-sectional analytical study was conducted at the Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital Lahore, from January 2015 to June 2016...
October 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://read.qxmd.com/read/30568393/nomogram-to-predict-overall-survival-after-gallbladder-cancer-resection-in-china
#4
Yi Bai, Zhi-Song Liu, Jian-Ping Xiong, Wei-Yu Xu, Jian-Zhen Lin, Jun-Yu Long, Fei Miao, Han-Chun Huang, Xue-Shuai Wan, Hai-Tao Zhao
AIM: To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma (GBC) into a predictive nomogram. METHODS: One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital (PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) in China from January 1, 2003 to January 1, 2018...
December 7, 2018: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/30538384/safety-and-efficacy-of-low-dose-single-agent-capecitabine-in-inoperable-gallbladder-cancer-with-jaundice-post-single-system-single-catheter-external-biliary-drainage-a-pilot-study-from-a-highly-endemic-area
#5
Ravi Gupta, Akshay Anand, Manoj Kumar, Mlb Bhatt, Sudhir Singh, Abhinav Arun Sonkar
Gallbladder cancer (CaGB) in the subcontinent belongs to low socioeconomic status, and at the time of diagnosis, a large number is unresectable or inoperable so the palliative treatment remains the only option. In the present study, attempt was made to see the effect and safety profile of single-agent oral capecitabine in inoperable CaGB in presence of low levels of jaundice post-single-catheter transhepatic external biliary drainage. In N  = 35 of inoperable jaundiced CaGB, post-biliary drainage capecitabine in low dose was started when their total bilirubin levels fell to 10 mg% or below...
December 2018: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/30453917/use-of-retrieval-bag-in-the-prevention-of-wound-infection-in-elective-laparoscopic-cholecystectomy-is-it-evidence-based-a-meta-analysis
#6
REVIEW
Davide La Regina, Francesco Mongelli, Stefano Cafarotti, Andrea Saporito, Marcello Ceppi, Matteo Di Giuseppe, Antonjacopo Ferrario di Tor Vajana
BACKGROUND: Surgical site infections complicate elective laparoscopic cholecystectomies in 2,4-3,2% of cases. During the operation the gallbladder is commonly extracted with a retrieval bag. We conducted a meta-analysis to clarify whether its use plays a role in preventing infections. METHODS: Inclusion criteria: elective cholecystectomy, details about the gallbladder extraction and data about local or systemic infection rate. EXCLUSION CRITERIA: cholecystitis, jaundice, concurrent antibiotic therapy, immunosuppression, cancer...
November 19, 2018: BMC Surgery
https://read.qxmd.com/read/30259519/outcomes-of-surgical-resection-of-gallbladder-cancer-in-patients-presenting-with-jaundice-a-systematic-review-and-meta-analysis
#7
REVIEW
Bobby V M Dasari, Mihnea I Ionescu, Timothy M Pawlik, James Hodson, Robert P Sutcliffe, Keith J Roberts, Paolo Muiesan, John Isaac, Ravi Marudanayagam, Darius F Mirza
INTRODUCTION: Preoperative jaundice is considered a relative contraindication to radical gallbladder cancer (GBC) resection due to poor prognosis and high postoperative morbidity. Recent reports have indicated that aggressive surgery may improve long-term survival for patients with advanced GBC who present with obstructive jaundice. The current systematic review and meta-analysis aimed to compare postoperative outcomes among jaundiced and non-jaundiced patients with resectable GBC. METHODS: An electronic search was performed using several Medical Subject Headings terms: cholecyst, gallbladder, tumor, cancer, carcinoma, adenocarcinoma, neoplasia, neoplasm, jaundice, and icterus...
September 2018: Journal of Surgical Oncology
https://read.qxmd.com/read/30159303/mirizzi-syndrome-diagnosis-and-management-of-a-challenging-biliary-disease
#8
Gennaro Clemente, Andrea Tringali, Agostino M De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante
Background: Mirizzi syndrome is a condition difficult to diagnose and treat, representing a particular "challenge" for the biliary surgeon. The disease can mimic cancer of the gallbladder, causing considerable diagnostic difficulties. Furthermore, it increases the risk of intraoperative biliary injury during cholecystectomy. The aim of this study is to point out some particular aspects of diagnosis and treatment of this condition. Methods: The clinical records of patients with Mirizzi syndrome, treated in the last five years, were reviewed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30090008/prognostic-significance-of-the-fibrinogen-to-albumin-ratio-in-gallbladder-cancer-patients
#9
Wei-Yu Xu, Hao-Hai Zhang, Jian-Ping Xiong, Xiao-Bo Yang, Yi Bai, Jian-Zhen Lin, Jun-Yu Long, Yong-Chang Zheng, Hai-Tao Zhao, Xin-Ting Sang
AIM: To investigate the prognostic role of fibrinogen-to-albumin ratio (FAR) on patients with gallbladder cancer (GBC) in this study. METHODS: One hundred and fifty-four GBC patients were retrospectively analyzed, who received potentially curative cholecystectomy in our institute from March 2005 to December 2017. Receiver operating characteristic curve (ROC curve) was used to determine the optimal cut-offs for these biomarkers. In addition, Kaplan-Meier survival analysis as well as multivariate analysis were applied for prognostic analyses...
August 7, 2018: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/29779309/-the-survival-prediction-model-of-advanced-gallbladder-cancer-based-on-bayesian-network-a-multi-institutional-study
#10
Z H Tang, Z M Geng, C Chen, S B Si, Z Q Cai, T Q Song, P Gong, L Jiang, Y H Qiu, Y He, W L Zhai, S P Li, Y C Zhang, Y Yang
Objective: To investigate the clinical value of Bayesian network in predicting survival of patients with advanced gallbladder cancer(GBC)who underwent curative intent surgery. Methods: The clinical data of patients with advanced GBC who underwent curative intent surgery in 9 institutions from January 2010 to December 2015 were analyzed retrospectively.A median survival time model based on a tree augmented naïve Bayes algorithm was established by Bayesia Lab software.The survival time, number of metastatic lymph nodes(NMLN), T stage, pathological grade, margin, jaundice, liver invasion, age, sex and tumor morphology were included in this model...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/29761515/association-of-perioperative-transfusion-with-survival-and-recurrence-after-resection-of-gallbladder-cancer-a-10-institution-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#11
MULTICENTER STUDY
Alexandra G Lopez-Aguiar, Cecilia G Ethun, Mia R McInnis, Timothy M Pawlik, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza W Beal, Ioannis Hatzaras, Rivfka Shenoy, Kenneth Cardona, Shishir K Maithel
BACKGROUND AND OBJECTIVES: Perioperative blood transfusion is associated with poor outcomes in several malignancies. Its effect in gallbladder cancer (GBC) is unknown. METHODS: All patients with GBC who underwent curative-intent resection at 10-institutions from 2000 to 2015 were included. The effect of blood transfusion on overall survival (OS) and recurrence-free (RFS) was evaluated. RESULTS: Of 262 patients with curative-intent resection for GBC, 61 patients (23%) received blood transfusions...
June 2018: Journal of Surgical Oncology
https://read.qxmd.com/read/29685046/a-retrospective-analysis-of-patients-with-gallbladder-cancer-surgical-treatment-and-survival-according-to-tumor-stage
#12
Iago Justo, Alberto Marcacuzco, Oana-Anisa Nutu, Alejandro Manrique, Jorge Calvo, Óscar Caso, Félix Cambra, Álvaro García-Sesma, Luis Carlos Jiménez-Romero
INTRODUCTION: gallbladder cancer is the most common biliary neoplasm and the sixth most common tumor of the digestive system. The disease has an ominous prognosis, with a 5-year survival rate of approximately 5%. It is usually diagnosed late and surgical resection is the only potential cure. METHODS: a retrospective study was carried out in 92 patients with a pathological diagnosis of gallbladder cancer from January 2000 to January 2016. RESULTS: the mean age of cases was 72 ± 11 years; 64 subjects were females and 28 were males...
August 2018: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/28536803/prospective-multicenter-phase-ii-study-of-gemcitabine-plus-cisplatin-in-patients-with-unresectable-gallbladder-cancer
#13
MULTICENTER STUDY
Yoshiki Hirooka, Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Koji Nonogaki, Akira Kanamori, Takanori Hirai, Hiroki Uchida, Osamu Shirai, Hideki Ishikawa, Hidemi Goto
PURPOSE: To evaluate the efficacy and safety of gemcitabine plus cisplatin in Japanese patients with unresectable gallbladder cancer (GBC). METHODS: Chemo-naïve patients with histologically proven unresectable GBC were enrolled in this study. The patients received gemcitabine (1000 mg/m2 ) and cisplatin (25 mg/m2 ) on days 1 and 8, every 21 days. A response assessment was done by CT scan every 4 weeks. The primary end points were to determine the response rates [RR; complete response (CR) + partial response (PR)] and the disease control rate [DCR; CR + PR + stable disease (SD)]...
July 2017: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/28497252/gallbladder-cancer-presenting-with-jaundice-uniformly-fatal-or-still-potentially-curable
#14
Thuy B Tran, Jeffrey A Norton, Cecilia G Ethun, Timothy M Pawlik, Stefan Buettner, Carl Schmidt, Eliza W Beal, William G Hawkins, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Kamran Idrees, Chelsea A Isom, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, George A Poultsides
BACKGROUND: Jaundice as a presenting symptom of gallbladder cancer has traditionally been considered to be a sign of advanced disease, inoperability, and poor outcome. However, recent studies have demonstrated that a small subset of these patients can undergo resection with curative intent. METHODS: Patients with gallbladder cancer managed surgically from 2000 to 2014 in 10 US academic institutions were stratified based on the presence of jaundice at presentation (defined as bilirubin ≥4 mg/ml or requiring preoperative biliary drainage)...
August 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://read.qxmd.com/read/28233537/predictors-of-curative-resection-and-long-term-survival-of-gallbladder-cancer-a-retrospective-analysis
#15
Pramod Kumar Mishra, Sundeep Singh Saluja, Nabi Prithiviraj, Vaibhav Varshney, Neeraj Goel, Nilesh Patil
BACKGROUND: Gallbladder cancer (GBC) is an aggressive malignancy. We analysed factors predicting resectability and survival of patients with GBC and the impact of surgical obstructive jaundice (SOJ). METHODS: Four hundred and thirty-seven patients with suspected GBC were analysed (52 excluded: benign pathology n = 35, missed GBC n = 17). The remaining 385 patients were divided into non-SOJ (n = 234) and SOJ (n = 151) groups. Predictors of resectability and long term survival were analysed and compared with their subgroups...
August 2017: American Journal of Surgery
https://read.qxmd.com/read/28062877/-right-hepatectomy-in-block-with-hiliar-extra-hepatic-bile-duct-for-gallbladder-cancer-clinical-case
#16
Claudio Mengoa Quintanilla, Giovanni De la Cruz Robles, Sergio Puma Condori, Carol Durand Mendoza
Gallbladder cancer is the most common malignancy of the biliary tract. Usually seen in advanced stages. There are still many controversies about the type of curative surgical treatment for each stage of the disease. The only chance of long term survival for patients with advanced tumors is aggressive, large surgeries that implies multiorgan resection.We report the case of a patient with gallbladder cancer with jaundice at diagnosis, who underwent extended hepatectomy (segment IV B, segment I and extra hepatic hilar bile duct included)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://read.qxmd.com/read/27959300/cholestatic-liver-injury-care-of-patients-with-primary-biliary-cholangitis-or-primary-sclerosing-cholangitis
#17
COMPARATIVE STUDY
Laurie Larson, Michelle James, Andrea Gossard
The most common causes of chronic cholestatic liver disease are primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Both disease processes are characterized by a destruction of intrahepatic and/or extrahepatic biliary ducts. The etiology is not entirely clear; however, there is an underlying autoimmune component contributing to both disease processes. Although PBC and PSC are often diagnosed and managed in the outpatient setting, in some instances, a patient may have jaundice, fatigue, and pruritus requiring evaluation and determination of the cholestatic cause...
October 2016: AACN Advanced Critical Care
https://read.qxmd.com/read/27916350/murine-model-of-long-term-obstructive-jaundice
#18
COMPARATIVE STUDY
Hiroaki Aoki, Masayo Aoki, Jing Yang, Eriko Katsuta, Partha Mukhopadhyay, Rajesh Ramanathan, Ingrid A Woelfel, Xuan Wang, Sarah Spiegel, Huiping Zhou, Kazuaki Takabe
BACKGROUND: With the recent emergence of conjugated bile acids as signaling molecules in cancer, a murine model of obstructive jaundice by cholestasis with long-term survival is in need. Here, we investigated the characteristics of three murine models of obstructive jaundice. METHODS: C57BL/6J mice were used for total ligation of the common bile duct (tCL), partial common bile duct ligation (pCL), and ligation of left and median hepatic bile duct with gallbladder removal (LMHL) models...
November 2016: Journal of Surgical Research
https://read.qxmd.com/read/27585469/complicated-gallstone-disease-diagnosis-and-management-of-mirizzi-syndrome
#19
Sujit S Kulkarni, Mayo Hotta, Linda Sher, Robert R Selby, Dilipkumar Parekh, James Buxbaum, Maria Stapfer
BACKGROUND: Mirizzi syndrome (MS) is characterized by an obstruction of the proximal bile duct due to extrinsic compression by either an impacted stone in the gallbladder neck or local inflammatory changes. Although this is a rare syndrome in developed countries (0.7-1.4 %), preoperative diagnosis and careful surgical management are essential to avoid bilio-vascular injuries and misdiagnosed malignancy. METHODS: The purpose of this study was to review our experience in the diagnosis and management of MS, assess the role of laparoscopy and the risk of concomitant gallbladder carcinoma...
May 2017: Surgical Endoscopy
https://read.qxmd.com/read/27431375/metal-versus-plastic-stents-for-unresectable-gallbladder-cancer-with-hilar-duct-obstruction
#20
Dao-Jian Gao, Bing Hu, Xin Ye, Tian-Tian Wang, Jun Wu
BACKGROUND AND AIM: Metal stents usually have a longer stent patency than plastic stents for malignant biliary obstruction. However, stent patency and patient survival may differ depending on the causative disease and stent type. There are no data regarding the selection of stents for unresectable gallbladder cancer (GC) with hilar duct obstruction. The aim of the present study was to evaluate the efficacy of metal versus plastic stents for unresectable GC with hilar duct obstruction...
January 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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