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https://read.qxmd.com/read/30758760/demographic-and-clinical-characteristics-of-5294-jaw-cysts-a-retrospective-study-of-38-years
#1
Paris Tamiolakis, Grigorios Thermos, Konstantinos I Tosios, Alexandra Sklavounou-Andrikopoulou
The aim of the present study is to report the demographic and clinical characteristics of all jaw cysts diagnosed in a single Oral Pathology Department. 5294 cases of jaw cysts diagnosed during a 38-year period were retrospectively collected and classified according to the latest classification of Head and Neck Tumors of the World Health Organization. The patients' gender and age, as well as the main clinical features of the cysts were retrieved from biopsy report forms. Jaw cysts were more common in male patients, with a male to female ratio of 1...
February 13, 2019: Head and Neck Pathology
https://read.qxmd.com/read/30746377/ghost-cell-odontogenic-carcinoma-of-the-jaws-report-of-two-cases-and-a-literature-review
#2
Meng-Qi Jia, Jun Jia, Li Wang, Hai-Xiao Zou
BACKGROUND: Ghost cell odontogenic carcinoma (GCOC) is a rare malignant odontogenic epithelial tumor with features of benign calcifying odontogenic cysts. Herein, we report two new cases of GCOC and systematically review the previous literature. CASE SUMMARY: In case 1, a 46-year-old man complained of painless swelling of the right maxilla for 3 years, with a 1-mo history of hemorrhinia in the right nasal cavity. In case 2, a 72-year-old man was referred to our hospital with a chief complaint of painful swelling of the right mandible...
February 6, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30736811/multidisciplinary-oral-rehabilitation-of-an-adolescent-suffering-from-juvenile-gorlin-goltz-syndrome-a-case-report
#3
Manfred Nilius, Jürgen Kohlhase, Johann Lorenzen, Günter Lauer, Matthias C Schulz
BACKGROUND: The Gorlin-Goltz syndrome is an autosomal dominant disorder characterized by keratocystic odontogenic tumors in the jaws, multiple basal cell carcinomas and skeletal abnormities. Frequently, the manifestation of the syndrome occurs in the adolescent years. CASE PRESENTATION: An 11-year-old boy was referred to our clinic due to the persistence of the lower deciduous molars. The further diagnosis revealed bilateral keratocystic odontogenic tumors in the region of teeth 33 and 45 representing a symptom of a Gorlin-Goltz syndrome...
February 8, 2019: Head & Face Medicine
https://read.qxmd.com/read/30701020/tnf%C3%AE-mediated-ceramide-generation-triggers-cisplatin-induced-apoptosis-in-b16f10-melanoma-in-a-pkc%C3%AE-independent-manner
#4
Sweta Ghosh, Junaid Jibran Jawed, Kuntal Halder, Sayantan Banerjee, Bidisha Paul Chowdhury, Akata Saha, Subir Kumar Juin, Suchandra Bhattacharyya Majumdar, Anamika Bose, Rathindranath Baral, Subrata Majumdar
Ceramide is one of the important cellular components involved in cancer regulation and exerts its pleiotropic role in the protective immune response without exhibiting any adverse effects during malignant neoplasm. Although, the PKCδ-ceramide axis in cancer cells has been an effective target in reduction of cancer, involvement of PKCδ in inducing nephrotoxicity have become a major questionnaire. In the present study, we have elucidated the mechanism by which cisplatin exploits the ceramide to render cancer cell apoptosis leading to the abrogation of malignancy in a PKCδ independent pathway with lesser toxicity...
December 28, 2018: Oncotarget
https://read.qxmd.com/read/30693256/chondroid-tenosynovial-giant-cell-tumor-of-temporomandibular-joint
#5
Sujeeth Kumar Shetty, Usha Hegde, Garima Agarwal, H S Sreeshyla
Tenosynovial giant cell tumor (TGCT), a benign proliferative lesion arising from the synovial membrane of the joints, is rarely seen in the temporomandibular joint. It frequently presents as a painful, preauricular swelling and affects the jaw functions. Two types of TGCT seen are diffuse TGCT (TGCT-D) and localized TGCT. A case of TGCT-D is described here, the highlight of the case being extensive areas of chondroid metaplasia which mimicked chondroid lesions, but was ruled out based on negative immunohistochemical findings within the tumor cells...
July 2018: Annals of Maxillofacial Surgery
https://read.qxmd.com/read/30684212/benign-osteoblastoma-of-the-palate-a-rare-clinical-presentation
#6
Dhanya Mary Sam, Sreeja P Kumar, Beena Varma, Anju P David, Rakesh Suresh
Osteoblastoma is a rare, benign type of osteoblastic tumor. It constitutes approximately 1% of all primary bone tumors. Osteoblastoma most commonly affects the long bones; it very rarely affects the jaw bones. Because of its clinical and histological similarity with other bony tumors, such as osteoid osteoma and fibro-osseous lesions, osteoblastoma is a diagnostic challenge. Very few cases of osteoblastoma involving the maxillofacial region have been reported to date. We herein describe a 15-year-old female patient with osteoblastoma that presented as a palatal swelling of 6 months' duration...
January 25, 2019: Oral Radiology
https://read.qxmd.com/read/30651707/an-insight-into-the-cannibalistic-behavior-of-giant-cell-granulomas-of-the-jaws
#7
Aadithya B Urs, Punyo Yaming, Rewa Malhotra
Background: Cellular cannibalism is defined as a large cell engulfing a smaller one within its cytoplasm. It is predominantly a feature of aggressive malignancies but has recently been demonstrated in giant cell (GC) lesions such as GC tumor of tendon sheath, central GC granuloma (CGCG) and peripheral GC granuloma (PGCG). Aim: The aim of the study is to assess the cannibalistic GCs in CGCG and PGCG and correlate with aggressiveness of the lesion. Settings and Design: Archival data of histopathologically confirmed cases of CGCG ( n = 40) and PGCG ( n = 25) were studied in the Department of Oral Pathology, Maulana Azad Institute of Dental Sciences...
September 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://read.qxmd.com/read/30641523/parathyroid-carcinoma
#8
Filomena Cetani, Elena Pardi, Claudio Marcocci
Parathyroid carcinoma (PC) is a rare endocrine malignancy, accounting for <1% of all cases of sporadic primary hyperparathyroidism (PHPT) and up to 15% in the hereditary hyperparathyroidism-jaw tumor syndrome. Genomic alterations identified in PC are mostly represented by CDC73 gene mutations, codifying for a loss-of-function protein termed parafibromin. Whole exome sequencing identified mutations in other genes, such as mTOR, KMT2D, CDKN2C, THRAP3, PIK3CA, and EZH2 genes, CCND1 gene amplification. The diagnosis of PC is quite difficult due to the lack of reliable clinical diagnostic criteria, and in the majority of cases is made postoperatively at histological examination...
2019: Frontiers of Hormone Research
https://read.qxmd.com/read/30641519/familial-and-hereditary-forms-of-primary-hyperparathyroidism
#9
F Cetani, F Saponaro, S Borsari, C Marcocci
Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT...
2019: Frontiers of Hormone Research
https://read.qxmd.com/read/30641515/primary-hyperparathyroidism
#10
Laura Masi
The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. The most common disorders include primary hyperparathyroidism (PHPT), malignancy, granulomatous diseases, and medications. PHPT is a disease characterized by excessive secretion of PTH...
2019: Frontiers of Hormone Research
https://read.qxmd.com/read/30634582/efficacy-of-azatyrosine-phenylbutyric-hydroxamides-a-histone-deacetylase-inhibitor-on-chemotherapy-induced-gastrointestinal-mucositis
#11
Po-Lin Liao, Shih-Hsuan Huang, Chien-Hung Hung, Wei-Kuang Huang, Chi-Hao Tsai, Jaw-Jou Kang, Hui-Po Wang, Yu-Wen Cheng
Gastrointestinal mucositis is a serious side effect of chemotherapy. Currently, no effective treatment exists for chemotherapy-induced mucositis, prompting the need to develop an anti-mucositis agent for use in clinics. The present study investigated whether azatyrosine-PBHA (AzP), a histone deacetylase inhibitor, has a therapeutic effect on intestinal mucosa. The results indicated that AzP did not affect the proliferation and viability of cancer cells, outcomes that are achieved by suberoylanilide hydroxamic acid (SAHA)...
January 10, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30595406/the-long-noncoding-rna-kiaa0125-is-upregulated-in-ameloblastomas
#12
Marina Gonçalves Diniz, Josiane Alves França, Fabrício A S Vilas-Boas, Fabrício Tinôco Alvim de Souza, George Adrian Calin, Ricardo Santiago Gomez, Sílvia Ferreira de Sousa, Carolina Cavalieri Gomes
Ameloblastoma and adenomatoid odontogenic tumor (AOT) are jaw tumors derived from the teeth forming apparatus. While ameloblastoma is a destructive, debilitating lesion, with conventional surgical treatment leading to facial deformity and morbodities, AOT shows indolent clinical behavior. The underlying molecular mechanisms associated with their biological behavior are unknown. The use of high-density whole-genome microarray analysis in ameloblastomas and AOT revealed high frequency of genomic gain at 14q32...
December 26, 2018: Pathology, Research and Practice
https://read.qxmd.com/read/30594039/oncologic-outcomes-in-metastatic-colorectal-cancer-with-regorafenib-with-folfiri-as-a-third-or-fourth-line-setting
#13
Cheng-Jen Ma, Ching-Wen Huang, Tsung-Kun Chang, Hsiang-Lin Tsai, Wei-Chih Su, Yung-Sung Yeh, Po-Jung Chen, Jaw-Yuan Wang
BACKGROUND: To evaluate the efficacy and toxicities of regorafenib plus irinotecan, dose-escalated on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping, in previously heavily treated metastatic colorectal cancer (mCRC) and the prognostic values of EGFR expression, KRAS mutations, and tumor sidedness. METHODS: Forty-one patients with mCRC with disease progression after treatment with fluoropyrimidines, oxaliplatin, irinotecan, anti-VEGF, and anti-EGFR MoAbs were subjected to UGT1A1 genotyping and received regorafenib combined with FOLFIRI with dose-escalated irinotecan...
December 26, 2018: Translational Oncology
https://read.qxmd.com/read/30591866/benefits-and-risks-of-adjuvant-treatment-with-zoledronic-acid-in-stage-ii-iii-breast-cancer-10-years-follow-up-of-the-azure-randomized-clinical-trial-big-01-04
#14
R E Coleman, M Collinson, W Gregory, H Marshall, R Bell, D Dodwell, M Keane, M Gil, P Barrett-Lee, D Ritchie, A Bowman, V Liversedge, R H De Boer, J L Passos-Coelho, S O'Reilly, G Bertelli, J Joffe, J E Brown, C Wilson, J C Tercero, J Jean-Mairet, R Gomis, D Cameron
Adjuvant bisphosphonates improve disease outcomes in postmenopausal early breast cancer (EBC) but the long-term effects are poorly described. The AZURE trial (ISRCTN79831382) was designed to determine whether adjuvant zoledronic acid (ZOL) improves disease outcomes in EBC. Previous analyses showed no effect on overall outcomes but identified benefits in postmenopausal women. Here we present the long-term risks and benefits of adjuvant ZOL with 10-years follow-up. Patients and methods: 3360 patients with stage II/III breast cancer were included in an academic, international, phase III, randomized, open label trial...
November 2018: Journal of Bone Oncology
https://read.qxmd.com/read/30578079/a-new-osteoclastogenesis-pathway-induced-by-cancer-cells-targeting-osteoclast-precursor-cells
#15
Akane Wada, Maiko Tsuchiya, Yuu Ozaki-Honda, Kou Kayamori, Kei Sakamoto, Akira Yamaguchi, Tohru Ikeda
The precise mechanism of osteolysis induced by tumors infiltrating into the bone remains unclear. The main hypothesis is that tumor cells generate receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor-alpha (TNF-α), or other molecules that activate the expression of RANKL in osteoblasts, osteocytes, or bone marrow stromal cells. Administration of bisphosphonates or anti-RANKL antibody drugs, which suppress systemic bone resorption, prevents osteolysis induced by tumors infiltrating into the bone...
December 18, 2018: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30567450/paediatric-oral-surgery-endoscopic-approach-in-ameloblastic-fibroma-management-a-preliminary-report
#16
G F Ferrazzano, M Coda, A Romano, G Dell'Aversana Orabona, L Califano, A Ingenito, T Cantile
AIM: Ameloblastic fibroma (AF) is a rare benign odontogenic tumor of slow-growing behaviour characterised by proliferation of both epithelial and mesenchymal odontogenic tissues. Treatment of AF is usually conservative by means of enucleation, curettage and long term follow-up. CASE REPORT: This report describes a case of AF in a 12-year-old boy. Examination of the oral cavity revealed absence of tooth 3.7 and mild swelling in the same mandibular area. Orthopantomography and Cone Beam Computed Tomography (CBCT) showed a wide multilocular radiolucent lesion at the left mandibular angle, extending from the first molar to the lower part of the mandibular branch; agenesis of tooth 3...
December 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://read.qxmd.com/read/30551989/parathyroid-carcinoma
#17
REVIEW
Antonio Stefano Salcuni, Filomena Cetani, Vito Guarnieri, Vincenzo Nicastro, Elisabetta Romagnoli, Danilo de Martino, Alfredo Scillitani, David E C Cole
Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline. Therefore, in patients who carry germline CDC73 gene mutations, its finding permits to identify the carriers among relatives and sometimes to early detect a parathyroid lesion in such subjects...
December 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/30546242/a-case-of-dental-hamartoma-associated-with-unerupted-primary-canine-in-maxillary-region
#18
Ashish Katiyar, Kirtija Gupta, Swati Solanki, Sukriti Gupta
Odontomas are usually one of the most common odontogenic tumors of the jaw and are perhaps more accurately defined as a hamartoma than a true neoplasm. It is asymptomatic, nonaggressive, slow growing, and benign nature. They are considered to be the malformations of the dental tissue and can sometimes interfere with the eruption of the associated tooth leading to its impaction or delayed eruption. Complex odontomas in primary teeth are rare and unusually diagnosed before the second decade of life. This article aims to present the case of a child with complex odontoma and its effective treatment planning...
July 2018: National Journal of Maxillofacial Surgery
https://read.qxmd.com/read/30536424/evolution-of-our-understanding-of-the-hyperparathyroid-syndromes-a-historical-perspective
#19
REVIEW
Stephen J Marx, David Goltzman
We review advancing and overlapping stages for our understanding of the expressions of six hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903 to 1967), the introduction of robust measurement of serum calcium was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects, and inheritability was reported in each syndrome...
December 10, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30526545/multicenter-phase-ii-study-on-cisplatin-pemetrexed-and-bevacizumab-followed-by-maintenance-with-pemetrexed-and-bevacizumab-for-patients-with-advanced-or-recurrent-nonsquamous-non-small-cell-lung-cancer-map-study
#20
Yasuhiro Tsutani, Yoshihiro Miyata, Takeshi Masuda, Kazunori Fujitaka, Mihoko Doi, Yoshikazu Awaya, Shoichi Kuyama, Soichi Kitaguchi, Kazuhiro Ueda, Noboru Hattori, Morihito Okada
BACKGROUND: We evaluated the safety and efficacy of induction chemotherapy with bevacizumab followed by maintenance chemotherapy with bevacizumab for advanced non-small cell lung cancer (NSCLC) in this multicenter phase II study. METHODS: Chemotherapy-naïve patient with stage IIIB-IV or recurrent nonsquamous NSCLC were eligible. We planned approximately four cycles of induction cisplatin (75 mg/m2 ), pemetrexed (500 mg/m2 ), and bevacizumab (15 mg/kg) followed by maintenance with pemetrexed (500 mg/m2 ) and bevacizumab (15 mg/kg) until disease progression...
December 10, 2018: BMC Cancer
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