Valerie Y Chock, Emily Smith, Sylvia Tan, M Bethany Ball, Abhik Das, Susan R Hintz, Haresh Kirpalani, Edward F Bell, Lina F Chalak, Waldemar A Carlo, C Michael Cotten, John A Widness, Kathleen A Kennedy, Robin K Ohls, Ruth B Seabrook, Ravi M Patel, Abbot R Laptook, Toni Mancini, Gregory M Sokol, Michele C Walsh, Bradley A Yoder, Brenda B Poindexter, Sanjay Chawla, Carl T D'Angio, Rosemary D Higgins, Krisa P Van Meurs
BACKGROUND: Extremely low birth weight (ELBW) infants are at risk for end-organ hypoxia and ischemia. Regional tissue oxygenation of the brain and gut as monitored with near-infrared spectroscopy (NIRS) may change with postnatal age, but normal ranges are not well defined. METHODS: A prospective study of ELBW preterm infants utilized NIRS monitoring to assess changes in cerebral and mesenteric saturation (Csat and Msat) over the first week after birth. This secondary study of a multicenter trial comparing hemoglobin transfusion thresholds assessed cerebral and mesenteric fractional tissue oxygen extraction (cFTOE and mFTOE) and relationships with perinatal variables...
October 2022: Pediatric Research