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Anna Rose Johnson, Andres F Doval, Melisa D Granoff, Sabine A Egeler, Miguel G Bravo, A Samandar Dowlatshahi, Samuel J Lin, Bernard T Lee
BACKGROUND: Spanish-speaking Hispanics living in the United States utilize the internet as a primary means to obtain health information. Accurate, accessible information is important for English speakers; however, it could have even greater utility for Spanish speakers who have lower health literacy levels. The aim of this study was to evaluate and compare online English and Spanish carpal tunnel surgery materials provided by using a multimetric approach. MATERIALS AND METHODS: A web search using the English term "carpal tunnel surgery" was performed...
February 7, 2019: Journal of Surgical Research
Liudmila Liutsko, Tania Iglesias, Josep Maria Tous Ral, Alexander Veraksa
Researchers have suggested that the link between personality traits and Attention-Deficit/Hyperactivity Disorder (ADHD) could be a crucial factor in understanding the disorder's diatheses. The aim of our study was to contribute to research on personality differences (based on fine motor precision - a novel approach) in children with and without ADHD symptoms. The Children Sustained Attention Task (CSAT) and Proprioceptive Diagnostics of Temperament and Character (DP-TC) were administered to children with an ADHD diagnosis and age-matched controls...
2018: Frontiers in Psychology
Jesina Chigavazira, Ritin Fernandez, Maria Mackay, Samuel Lapkin
BACKGROUND: Clinical supervision of pre-registration nursing students has become an integral role of the registered nurse. The Clinical Supervision Self-assessment Tool relating to knowledge (CSAT-Knowledge) and the individual's skills (CSAT-Skills) of clinical supervision and comprising of 30 items each originally is widely used for nurses in Australia. However, the psychometric properties of this tool have not been previously reported. OBJECTIVE: To adapt the Clinical Supervision Self-Assessment Tool for nurses and to investigate the psychometric properties of the modified tool to measure registered nurses' knowledge and skills regarding supervising pre-registration nursing students...
November 2018: Nurse Education Today
C V Guthier, A V D'Amico, M T King, P L Nguyen, P F Orio, S Sridhar, G M Makrigiorgos, R A Cormack
PURPOSE: In situ drug release concurrent with radiation therapy has been proposed to enhance the therapeutic ratio of permanent prostate brachytherapy. Both brachytherapy sources and brachytherapy spacers have been proposed as potential eluters to release compounds, such as nanoparticles or chemotherapeutic agents. The relative effectiveness of the approaches has not been compared yet. This work models the physical dose enhancement of implantable eluters in conjunction with brachytherapy to determine which delivery mechanism provides greatest opportunity to enhance the therapeutic ratio...
June 15, 2018: Medical Physics
Gabriel Altit, Shazia Bhombal, Theresa A Tacy, Valerie Y Chock
BACKGROUND: For neonates with congenital heart disease (CHD), left-sided (LL) and right-sided (RL) single ventricular physiologies (LL, hypoplastic left heart syndrome; RL, tricuspid atresia or pulmonary atresia with intact ventricular septum) may demonstrate distinct changes in tissue saturation in the first 72 h of life. Near-infrared spectroscopy (NIRS) can measure regional cerebral saturation (Csat) and renal saturation (Rsat) to clarify differences between LL and RL over time. OBJECTIVES: Our primary objective was to measure changes in Csat and Rsat in the first 72 h of life using NIRS between CHD infants with LL compared to RL...
2018: Neonatology
Kamaljot S Kaler, Zachary A Valley, Kheira C Bettir, Shoaib M Safiullah, Daniel Lama, Renai Yoon, Jaime Landman, Ralph V Clayman
INTRODUCTION AND OBJECTIVES: We hypothesized that crowdsourcing assessments could be applied to the Postureteroscopic Lesion Scale (PULS) for ureteral injury. METHODS: At a single institution, we prospectively digitally recorded 14 ureters at the terminal portion of standard ureteroscopic procedures. Each recording was reviewed by 10 global experts to determine a mean PULS score. Following training, the Crowd-Sourced Assessment of Technical Skills, C-SATS® (C-SATS, Inc...
April 2018: Journal of Endourology
Theodore V Parran, Joseph Z Muller, Elina Chernyak, Chris Adelman, Christina M Delos Reyes, Douglas Rowland, Mykola Kolganov
IMPORTANCE: Office-based opiate agonist therapy has dramatically expanded access to medication-assisted treatment over the past decade but has also led to increased buprenorphine diversion. OBJECTIVE: Our study sought to characterize physicians who participate in office-based therapy (OBT) to assess patient access to OBT in Ohio 10 years after its introduction. DESIGN/SETTING/PARTICIPANTS: Cross-sectional telephone survey of Drug Addiction Treatment Act-waivered physicians in Ohio listed by the Center for Substance Abuse Treatment (CSAT)...
2017: Substance Abuse: Research and Treatment
Paola Lambelet, Carlo Tascini, Simona Fortunato, Alessandro Stefanelli, Federico Simonetti, Chiara Vettori, Alessandro Leonildi, Francesco Menichetti
The mortality for carbapenem-resistant Klebsiella pneumoniae (KPC-Kp) infection ranges from 18 to 48% depending on the type of therapy. Mortality rates in hematologic patients are even higher, up to 85%. Gut decontamination with oral gentamicin might be an option to avoid a subsequent KPC-Kp infection in colonized patients. We treated 14 hematologic patients with oral gentamicin, 80 mg four times daily, for 7 to 25 days in order to eradicate KPC-Kp from the gut, starting oral gentamicin therapy when possible after the discontinuation of systemic antibiotic therapy...
July 2017: New Microbiologica
Sarah B Hunter, Christina Y Huang
Substance use disorders are common among juvenile justice populations, and few resources exist to address this problem as young offenders transition into the community upon release. To address this need, in October 2010, the Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Substance Abuse Treatment (CSAT), awarded three-year grants to community-based organizations to expand and/or enhance substance abuse treatment and recovery and reentry services to sentenced offenders returning to the community...
2014: Rand Health Quarterly
Jeremy W Bray, Frances K Del Boca, Bonnie G McRee, Susan W Hayashi, Thomas F Babor
AIMS: Since 2003, the US Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment (SAMHSA, CSAT) has awarded 32 Screening, Brief Intervention and Referral to Treatment (SBIRT) grants to states, territories and tribal organizations to enhance services for persons with, or at risk for, substance use disorders. The grants supported an expansion of the continuum of care to include screening, brief intervention, brief treatment and referral to treatment in general medical and community settings...
February 2017: Addiction
Wanghui Xu, Qing Zhao, Lei Xing, Zhanglin Lin
The increasing demand for antigenic peptides in the development of novel serologic diagnostics and epitope-based vaccines requires rapid and reliable peptide synthesis techniques. Here we investigated a method for efficient recombinant expression and purification of medium- to large-sized antigenic peptides in E. coli. Previously we devised a streamlined protein expression and purification scheme based on a cleavable self-aggregating tag (cSAT), which comprised an intein molecule and a self-aggregating peptide ELK16...
November 3, 2016: Scientific Reports
Salin Gupta Patel, Paul M Bummer
This report examines the energetics of aggregate formation between hydroxypropyl methylcellulose (HPMC) and model ionic surfactants including sodium dodecyl sulfate (SDS) at pharmaceutically relevant concentrations using the isothermal titration calorimetry (ITC) technique and a novel treatment of calorimetric data that accounts for the various species formed. The influence of molecular weight of HPMC, temperature and ionic strength of solution on the aggregate formation process was explored. The interaction between SDS and HPMC was determined to be an endothermic process and initiated at a critical aggregation concentration (CAC)...
January 10, 2017: International Journal of Pharmaceutics
Valerie Y Chock, Laura A Rose, Jeanet V Mante, Rajesh Punn
BACKGROUND: Near-infrared spectroscopy (NIRS) may assist with characterization of a hemodynamically significant patent ductus arteriosus (hsPDA) by measuring cerebral and renal saturation (Csat and Rsat) levels. We hypothesized that Csat and Rsat in preterm infants with an hsPDA would be decreased compared to those with no PDA or nonsignificant PDA. METHODS: This non a-priori designed study retrospectively investigated clinical and ECHO characteristics of preterm infants <29 wk gestation who underwent routine NIRS monitoring...
November 2016: Pediatric Research
Elżbieta Jabłonowska, Ewa Nazaruk, Dorota Matyszewska, Chiara Speziale, Raffaele Mezzenga, Ehud M Landau, Renata Bilewicz
The interactions of liquid-crystalline monoolein (GMO) cubic phase nanoparticles with various model lipid membranes spread at the air-solution interface by the Langmuir technique were investigated. Cubosomes have attracted attention as potential biocompatible drug delivery systems, and thus understanding their mode of interaction with membranes is of special interest. Cubosomes spreading at the air-water interface as well as interactions with a monolayer of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) compressed to different surface pressures were studied by monitoring surface pressure-time dependencies at constant area...
September 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Qing Zhao, Wanghui Xu, Lei Xing, Zhanglin Lin
BACKGROUND: Peptides have recently become attractive for therapeutic applications. However, efficient production of medium- to large-sized peptides (30-100 amino acids [aa]) remains challenging both by recombinant and chemical synthesis. We previously reported the formation of active enzyme aggregates in Escherichia coli cells induced by the short β-structured peptide ELK16 (LELELKLKLELELKLK) and developed a streamlined protein expression and purification approach. In this approach, a cleavable self-aggregating tag (cSAT) consisting of an intein molecule and ELK16 was used to release the recombinant peptides with reasonable purity from active aggregates...
August 5, 2016: Microbial Cell Factories
Ming F Tam, Tsuey Chyi S Tam, Virgil Simplaceanu, Nancy T Ho, Ming Zou, Chien Ho
The unliganded tetrameric Hb S has axial and lateral contacts with neighbors and can polymerize in solution. Novel recombinants of Hb S with single amino acid substitutions at the putative axial (recombinant Hb (rHb) (βE6V/αH20R) and rHb (βE6V/αH20Q)) or lateral (rHb (βE6V/αH50Q)) or double amino acid substitutions at both the putative axial and lateral (rHb (βE6V/αH20R/αH50Q) and rHb (βE6V/αH20Q/αH50Q)) contact sites were expressed in Escherichia coli and purified for structural and functional studies...
August 28, 2015: Journal of Biological Chemistry
Adeel Ahmed Khan, Zafar Fatmi, Muhammad Masood Kadir
The study assessed the diagnostic accuracy of the Hemoglobin Color Scale (HCS), comparing clinical signs assessment technique (CSAT) of health care providers against the gold standard of laboratory hemoglobinometry. A cross-sectional validation study was conducted among 194 pregnant women located in 2 towns of periurban settings in Karachi, from June 2012 to February 2013. Anemia was assessed by HCS and CSAT by health care providers and compared with laboratory hemoglobinometry. The sensitivity and specificity of HCS were 70...
September 2015: Asia-Pacific Journal of Public Health
M H C Vieira, R J Oliveira, L P M Eça, I S O Pereira, L C Hermeto, R Matuo, W S Fernandes, R A Silva, A C M B Antoniolli
Rupture of the Achilles tendon diminishes quality of life. The gold-standard therapy is a surgical suture, but this presents complications, including wound formation and inflammation. These complications spurred evaluation of the therapeutic potential of mesenchymal stem cells (MSCs) from adipose tissue. New Zealand rabbits were divided into 6 groups (three treatments with two time points each) evaluated at either 14 or 28 days after surgery: cross section of the Achilles tendon (CSAT); CSAT + Suture; and CSAT + MSC...
December 12, 2014: Genetics and Molecular Research: GMR
Zhanglin Lin, Qing Zhao, Bihong Zhou, Lei Xing, Wanghui Xu
Rapid protein expression and purification remains a critical technological need, in particular as the number of proteins being identified is exploding. In this chapter, we describe a simple and rapid scheme for expression and purification of recombinant proteins using Escherichia coli, by taking advantage of two self-aggregating peptide fusion tags 18A (EWLKAFYEKVLEKLKELF) and ELK16 (LELELKLKLELELKLK) that can drive target proteins into active protein aggregates in vivo. In practice, a target protein is fused at the N-terminus of the self-cleavable Mxe GyrA intein, which is followed by the 18A or ELK16 tag...
2015: Methods in Molecular Biology
Daniel Holst, Timothy M Kowalewski, Lee W White, Timothy C Brand, Jonathan D Harper, Mathew D Sorenson, Sarah Kirsch, Thomas S Lendvay
BACKGROUND: Crowdsourcing is the practice of obtaining services from a large group of people, typically an online community. Validated methods of evaluating surgical video are time-intensive, expensive, and involve participation of multiple expert surgeons. We sought to obtain valid performance scores of urologic trainees and faculty on a dry-laboratory robotic surgery task module by using crowdsourcing through a web-based grading tool called Crowd Sourced Assessment of Technical Skill (CSATS)...
May 2015: Journal of Endourology
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