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ACL AND Nervous system OR Neuroplastic OR Neuroplasticity

Todd Furman, Holly Silvers-Granelli
Soccer players recovering from anterior cruciate ligament (ACL) injuries have better options for treatment today than they did 25 years ago. Surgical techniques have improved, and rehabilitation protocols have evolved considerably. Although the rehabilitation community is doing a better job of treating this patient population, the evidence does demonstrate that both re-injury and return- to-play (RTP) rates are still suboptimal. Most protocols focus on normalizing strength and range of motion (ROM) and achieving limb symmetry with soccer-specific movements...
December 2018: American Journal of Orthopedics
Elina Cv Brinck, Elina Tiippana, Michael Heesen, Rae Frances Bell, Sebastian Straube, R Andrew Moore, Vesa Kontinen
BACKGROUND: Inadequate pain management after surgery increases the risk of postoperative complications and may predispose for chronic postsurgical pain. Perioperative ketamine may enhance conventional analgesics in the acute postoperative setting. OBJECTIVES: To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia. SEARCH METHODS: We searched CENTRAL, MEDLINE and Embase to July 2018 and three trials registers (metaRegister of controlled trials, ClinicalTrials...
December 20, 2018: Cochrane Database of Systematic Reviews
Magdalena Szmyrka, Anna Pokryszko-Dragan, Krzysztof Słotwiński, Ewa Gruszka, Lucyna Korman, Ryszard Podemski, Piotr Wiland
BACKGROUND: Cognitive impairment (CI) is a frequent problem in lupus patients, regardless of their overt neuropsychiatric (NP) involvement. OBJECTIVES: The aim of our study was to test cognitive abilities in systemic lupus erythematosus (SLE) patients by means of neuropsychological testing and event-related potentials (ERPs), and to search for their cognitive abilities correlations with a wide range of auto-antibodies. MATERIAL AND METHODS: A total of 37 SLE patients were subjected to a battery of neuropsychological tests, recommended by the American College of Rheumatology (ACR), and to ERPs...
July 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Xin Miao, Hongshi Huang, Xiaoqing Hu, Dai Li, Yuanyuan Yu, Yingfang Ao
BACKGROUND: Reestablishing knee stability is the core of the treatment of ACL (Anterior Cruciate Ligament) injury. Some patients still have a feeling of instability of the knee after ACL injury treatment. This unstable feeling may be caused by central nervous system changes after ACL rupture. METHODS: To identify the central changes after ACL rupture, EEG spectra were recorded to compare ACL patients and healthy controls when they were walking, jogging, and landing...
2017: PloS One
Ellen Casey, Maria Reese, Ezi Okafor, Danielle Chun, Christine Gagnon, Franz Nigl, Yasin Y Dhaher
BACKGROUND: Rates of musculoskeletal injury differ substantially between the genders, with females more likely to experience conditions such as anterior cruciate ligament (ACL) injuries than males in the same sports. Emerging evidence suggests a significant hormonal contribution. Most research has focused solely on how hormonal fluctuations affect connective tissue, but a direct link between hormonal shifts, ligamentous laxity, and ACL injury has not been borne out. There is also evidence to suggest that sex hormones can modulate the central nervous system, but how this affects neuromuscular control is not well understood...
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Nicholas Bhojwani, Peter Szpakowski, Sasan Partovi, Martin H Maurer, Ulrich Grosse, Hendrik von Tengg-Kobligk, Lisa Zipp-Partovi, Nathan Fergus, Christos Kosmas, Konstantin Nikolaou, Mark R Robbin
Diffusion-weighted imaging (DWI) is an established diagnostic tool with regards to the central nervous system (CNS) and research into its application in the musculoskeletal system has been growing. It has been shown that DWI has utility in differentiating vertebral compression fractures from malignant ones, assessing partial and complete tears of the anterior cruciate ligament (ACL), monitoring tumor response to therapy, and characterization of soft-tissue and bone tumors. DWI is however less useful in differentiating malignant vs...
October 2015: Quantitative Imaging in Medicine and Surgery
Dustin R Grooms, Stephen J Page, James A Onate
BACKGROUND: Anterior cruciate ligament (ACL) injury has multifactorial causes encompassing mechanical, hormonal, exposure, and anatomical factors. Alterations in the central nervous system also play a role, but their influence after injury, recovery, and recurrent injury remain unknown. Modern neuroimaging techniques can be used to elucidate the underlying functional and structural alterations of the brain that predicate the neuromuscular control adaptations associated with ACL injury...
October 2015: Journal of Athletic Training
Roger C Ho, C Thiaghu, Huiyi Ong, Yanxia Lu, Cyrus S Ho, Wilson W Tam, Melvyn W Zhang
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most devastating presentations of SLE and comprises of psychiatric, central and peripheral neurological signs and symptoms. Previous studies suggest the possible associations between various autoantibodies (Abs) and NPSLE. The magnitudes of such association varied between studies. We performed a meta-analysis to pool data on serum and cerebrospinal fluid (CSF) levels and positivity of Abs in blood and cerebrospinal fluid in patients with NPSLE and SLE...
February 2016: Autoimmunity Reviews
Dustin R Grooms, Stephen Page, James A Onate
BACKGROUND:   Anterior cruciate ligament (ACL) injury has multifactorial causes encompassing mechanical, hormonal, exposure, and anatomical factors. Alterations in the central nervous system also play a role, but their influence after injury, recovery, and recurrent injury remain unknown. Modern neuroimaging techniques can be used to elucidate the underlying functional and structural alterations of the brain that predicate the neuromuscular control adaptations associated with ACL injury...
September 29, 2015: Journal of Athletic Training
Bart Dingenen, Luc Janssens, Thomas Luyckx, Steven Claes, Johan Bellemans, Filip F Staes
The goal of this study was to evaluate muscle activation onset times (MAOT) of both legs during a transition task from double-leg stance (DLS) to single-leg stance (SLS) in anterior cruciate ligament injured (ACLI) (n=15) and non-injured control subjects (n=15) with eyes open and eyes closed. Significantly delayed MAOT were found in the ACLI group compared to the control group for vastus lateralis, vastus medialis obliquus, hamstrings medial, hamstrings lateral, tibialis anterior, peroneus longus and gastrocnemius in both vision conditions, for gluteus maximus and gluteus medius with eyes open and for tensor fascia latae with eyes closed...
December 2015: Human Movement Science
Mohammad Shawkat Ali, Pritesh Ranjan Dash, Mahmuda Nasrin
BACKGROUND: Kaempferia galanga is an important medicinal plant and has been traditionally used to help restlessness, stress, anxiety, depression etc. in tropics and subtropics of Asia including Bangladesh, India, China, Japan and Indochina. Literature survey revealed that there are very less reports on neuropharmacological activity of this plant. Therefore, the present study investigated the sedative activity of different extracts of rhizome and leaf of Kaempferia galanga. METHODS: The sedative activity was evaluated by using thiopental sodium induced sleeping time, hole cross and open field tests in Swiss albino mice at the doses of 100 and 200 mg/kg body weight per oral (p...
2015: BMC Complementary and Alternative Medicine
Tomasz Hawro, Andrzej Bogucki, Maria Krupińska-Kun, Marcus Maurer, Anna Woźniacka
BACKGROUND: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a common and potentially fatal manifestation of SLE. Antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA), anticardiolipin (aCL) and antibodies to β2glycoprotein I (anti-β2GPI), the most important aPL antigen, are thought to play a role in some forms of NPSLE. As of yet, their specific roles in NPSLE manifestations remain to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS: 57 SLE patients (53 women) were assessed for LA, aCL and anti-β2GPI twice, to determine persistent positivity...
2015: PloS One
Ravish Singhal, Sadbhavna Pandit, Ashok Saini, Paramjit Singh, Neeraj Dhawan
The presentation of the typical characteristics of the acrocallosal syndrome (ACLS) are hypoplasia/agenesis of corpus callosum, moderate to severe mental retardation, characteristic craniofacial abnormalities, distinctive digital malformation, and growth retardation in a neonate. An Indian neonate presented on day 1 of life (youngest in the literature to be reported) with combination of abnormalities consistent with the acrocallosal syndrome and some additional findings. The baby, born to non-consanguineous, healthy parents, presented with macrocephaly, prominent forehead, hypertelorism, polydactyly of the hands and feet, duplication of hallux, hypotonia, recurrent cyanotic episodes, rib anomalies, dextro-positioning of heart, and delayed fall of umbilical cord...
2014: Iranian Journal of Child Neurology
Mohammad Adawi, Bishara Bisharat, Abdalla Bowirrat
Neuromyelitis optica (NMO) is usually a relapsing demyelinating disease of the central nervous system associated with optic neuritis, transverse myelitis involving three or more contiguous spinal cord segments, and seropositivity for NMO-IgG antibody. NMO is often mistaken for multiple sclerosis and there are relatively sporadic publications about NMO and overlapping systemic or organ-specific autoimmune diseases, such as systemic lupus erythematosus (SLE). We described a unique case of a 25-year-old Arab young woman who was diagnosed with SLE, depending on clinical, laboratory investigations and after she had fulfilled the diagnostic criteria for SLE and had presented the following findings: constitutional findings (fatigue, fever, and arthralgia); dermatologic finding (photosensitivity and butterfly rash); chronic renal failure (proteinuria up to 400 mg in 24 hours); hematologic and antinuclear antibodies (positivity for antinuclear factor (ANF), anti-double-stranded DNA antibodies, direct Coombs, ANA and anti-DNA, low C4 and C3, aCL by IgG and IgM)...
2014: Clinical Medicine Insights. Case Reports
Consuelo García-Gea, Joan Martínez, Maria Rosa Ballester, Ignasi Gich, Román Valiente, Rosa Maria Antonijoan
OBJECTIVE: The aim of this study was to compare the effects of concomitant administration of alcohol and bilastine versus alcohol alone on the central nervous system. METHODS: Twenty-four healthy young volunteers of both sexes participated in a randomized, double-blind, double-dummy, crossover, and positive-controlled and placebo-controlled clinical trials. At 1-week intervals, subjects received six different treatments: (i) placebo; (ii) alcohol 0.8 g/kg alone (ALC); (iii) ALC in combination with: bilastine 20 mg (B20 + A); (iv) bilastine 80 mg (B80 + A); (v) cetirizine 10 mg (CET + A); and (vi) hydroxyzine 25 mg (HYD + A)...
March 2014: Human Psychopharmacology
Amal Bakry Abdul-Sattar, Tarek Goda, Mohamed G Negm
OBJECTIVES: To identify the prevalence and the possible risk factors of occurrence and severity of neuropsychiatric (NP) manifestations in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: This is a cross-sectional study. The assessment of SLE patients is based on rheumatologic, neurologic and psychiatric evaluation, immunoserologic testing, and cerebral magnetic resonance imaging (MRI). Factors associated with NP manifestations were explored using regression models...
December 2013: International Journal of Rheumatic Diseases
Carmelo Morales-Angulo, Sandra Vergara Pastrana, Sergio Obeso-Agüera, Leticia Acle, Miguel Ángel González-Gay
INTRODUCTION AND OBJECTIVES: Behçet disease (BD) is a systemic immune-mediated vasculitis of unknown origin characterised by recurrent orogenital ulceration, ocular inflammation and skin lesions. The aim of our study was to identify ear, nose and throat (ENT) manifestations associated with BD. PATIENTS AND METHODS: Retrospective review of the medical records of all patients diagnosed with BD who attended a tertiary public hospital in Cantabria (Spain) over a period of 22 years...
January 2014: Acta Otorrinolaringológica Española
Rui Wu
To investigate role of eye's sign in the patients with neuropsychiatric systemic lupus erythematosus (NPSLE). The scores of eye's sign in bulbar conjunctival microvascular changes were assessed in all patients according to our criteria. The disease activity was measured with SLE Disease Activity Index (SLEDAI) score. Anticardiolipin antibody (aCL) and hemorheology were performed in patients. The eye's sign and whole-blood viscosity were significantly higher in NPSLE patients than those in non-NPSLE patients...
April 2014: Rheumatology International
Zahra Basiri, Mahmoud Gholyaf, Mansureh Faridnia, Ebrahim Nadi, Mandana Bairanvand
The central immunological disturbance in systemic lupus erythematosus (SLE) is autoantibody production. Some of these antibodies affecting components of the cell nucleus are the major characteristics of SLE. The present study was aimed to assess importance of anticardiolipin (ACL) antibody and its association with clinical state in SLE patients. A cross sectional study was performed on 100 patients with SLE referred to rheumatology outpatient clinic in Ekbatan hospital in Hamadan (Iran) between 2007 and 2008...
2013: Acta Medica Iranica
Alan M Borowoy, Janet E Pope, Earl Silverman, Paul R Fortin, Christian Pineau, C Douglas Smith, Hector Arbillaga, Dafna Gladman, Murray Urowitz, Michel Zummer, Marie Hudson, Lori Tucker, Christine Peschken
OBJECTIVES: The (ever) prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) can vary widely depending on the definition used. We determined the prevalence of NPSLE in 1000 Faces of Lupus, a large multicenter Canadian cohort. METHODS: Adults enrolled at 10 sites who satisfied the American College of Rheumatology (ACR) classification for systemic lupus erythematosus (SLE) were included. NPSLE was defined as (i) NPSLE by ACR classification criteria (seizures or psychosis), (ii) ACR, SLEDAI (seizure, psychosis, organic brain syndrome, cranial nerve disorder, headache, and cerebrovascular accident (CVA)), SLAM (CVA, seizure, cortical dysfunction, and headache), and SLICC (cognitive impairment, psychosis, seizures, CVA, cranial or peripheral neuropathy, and transverse myelitis) with and (iii) without minor nonspecific NPSLE manifestations (including mild depression, mild cognitive impairment, and electromyogram-negative neuropathies), and (iv) by ACR and SLEDAI neuropsychiatric (NP) indexes alone...
October 2012: Seminars in Arthritis and Rheumatism
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