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Mani daneshmand

Yaron D Barac, Adam Nevo, Oliver Jawitz, Nazish K Hashmi, Peter Henkel, Laura J Blue, Joseph Kelly, Chetan B Patel, Mani A Daneshmand, Jacob N Schroder, Carmelo A Milano, Ian Welsby
No abstract text is available yet for this article.
January 24, 2019: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Yaron D Barac, Jacob N Schroder, Muath Bishawi, Chetan B Patel, Carmelo A Milano, Mani A Daneshmand
Intra-aortic balloon pump (IABP) is often used to support patients in decompensated heart failure. Placement of the IABP via the axillary artery facilitates long term support with the device and may allow for the conversion of an acute heart failure (HF) patient into a chronic HF patient by using a modified weaning protocol; allowing for medical symptom management and removal of mechanical support. We will discuss strategies for supporting these complicated patients. This article is protected by copyright. All rights reserved...
January 23, 2019: Artificial Organs
Desiree Bonadonna, Yaron D Barac, David N Ranney, Craig R Rackley, Kevin Mumma, Jacob N Schroder, Carmelo A Milano, Mani A Daneshmand
Utilization of extracorporeal membrane oxygenation (ECMO) has increased dramatically over the last decade. Despite this trend, many medical centers have limited, if any, access to this technology or the resources necessary to manage these complex patients. In an effort to improve the current infrastructure of regional ECMO care, ECMO centers of excellence have an obligation to partner with facilities within their communities and regions to increase access to this potentially life-saving technology. While the need for this infrastructure is widely acknowledged in the ECMO community, few reports describe the actual mechanisms by which a successful interfacility transport program can operate...
January 4, 2019: Seminars in Thoracic and Cardiovascular Surgery
Yaron D Barac, Adam Nevo, Jacob N Schroder, Carmelo A Milano, Mani A Daneshmand
Left ventricular assist devices are (LVAD) used for circulatory support in patients with end-stage heart failure. Hemolysis/pump dysfunction is a well-known complication of this therapy with various etiologic causes. A small proportion of these complications are caused by outflow graft obstructions; this complication has received little attention in the scientific literature. Herein, we provide a comprehensive overview of the role of the LVAD outflow graft obstruction and its treatment options.
December 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Maziar Khorsandi, Jacob Schroder, Mani Daneshmand, Muath Bishawi, Omar Bouamra, Patrick Winterton, Ashley Y Choi, Chetan Patel, Joseph Rogers, J Mauricio Del Rio, Carmelo Milano
BACKGROUND: Right heart failure occurs in 9-44% of left ventricular assist device (LVAD) implants of which less than 10% require a right ventricular assist device (RVAD) support either concurrently with the LVAD or staged, as a delayed procedure. We have reported our outcomes based on whether the RVAD was placed concurrently or staged. METHODS: Clinical data were obtained from the Duke University Medical Center database. The study focused on all consecutive adult patients who received continuous flow LVAD - with either "concurrent" or "staged" (within 7 days) extracorporeal, temporary RVAD, between October 2007 and October 2017...
December 21, 2018: Annals of Thoracic Surgery
David N Ranney, Judson B Williams, Hillary Mulder, Daniel Wojdyla, Morgan L Cox, C Michael Gibson, Michael J Mack, Mani A Daneshmand, John H Alexander, Renato D Lopes
Although in situ internal mammary artery (is-IMA) grafting remains the most frequent conduit in coronary artery bypass grafting (CABG), circumstances may necessitate free grafting of the IMA (f-IMA), though differences in outcomes have not been fully characterized. The purpose of this study was to compare clinical and angiographic outcomes of is-IMA versus f-IMA coronary bypass grafts in patients who underwent elective CABG surgery. In 1,829 patients in the angiographic cohort of PREVENT IV, 1,572 (85.9%) had at least 1 IMA graft; of these, 34 (2...
November 24, 2018: American Journal of Cardiology
David Ranney, Sarah Hatch, Desiree Bonadonna, Mani Daneshmand
Although life-saving, cardiopulmonary resuscitation (CPR) has been associated with traumatic injuries in adult patients surviving cardiac arrest. In addition to rib and sternal fractures, intraabdominal injuries have also been shown to occur, particularly after prolonged external cardiac massage. Early detection of these injuries remains difficult and is often masked by concomitant hemodynamic instability and the higher likelihood of other injuries such as retroperitoneal hemorrhage. Accurate diagnosis is further complicated when venoarterial (VA) extracorporeal membrane oxygenation (ECMO) is instituted...
November 28, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Yaron D Barac, Mike S Mulvihill, Morgan L Cox, Muath Bishawi, Jacob Klapper, John Haney, Mani Daneshmand, Matthew G Hartwig
BACKGROUND: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudices against the allocation of allografts to type O candidates, given that the pool of potential donors is smaller. METHODS: We performed a retrospective cohort review of the Organ Procurement and Transplantation Network/United Network of Organ Sharing registry from May 2005 to March 2017 for adult candidates on the waiting list for first-time isolated lung transplantation...
September 25, 2018: Journal of Heart and Lung Transplantation
Yaron D Barac, Dominick J Megna, Anthony W Castleberry, Jacob N Schroder, Mani A Daneshmand, Joseph G Rogers, Chetan B Patel, Mihai Podgoreanu, Carmelo A Milano
No abstract text is available yet for this article.
September 25, 2018: Journal of Thoracic and Cardiovascular Surgery
Stephen Gaeta, Jacob N Schroder, Mani A Daneshmand, Kevin L Thomas, Donald D Hegland, Jonathan P Piccini, James P Daubert, Jason I Koontz, Albert Y Sun
No abstract text is available yet for this article.
September 2018: JACC. Clinical Electrophysiology
Brandi A Bottiger, Alina Nicoara, Laurie D Snyder, Paul E Wischmeyer, Jacob N Schroder, Chetan B Patel, Mani A Daneshmand, Robert N Sladen, Kamrouz Ghadimi
The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary failure may be under consideration for heart or lung transplantation along with bridging therapies such as ventricular assist device implantation or venovenous extracorporeal membrane oxygenation, respectively. Early identification of frail patients in an attempt to modify the risk of postoperative morbidity and mortality has become an important area of study over the last decade...
August 9, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Katherine V Clark-Knowles, Danielle Dewar-Darch, Karen E Jardine, Josée Coulombe, Manijeh Daneshmand, Xiaohong He, Michael W McBurney
SIRT1 is a protein deacetylase with a broad range of biological functions, many of which are known to be important in carcinogenesis, however much of the literature regarding the role of SIRT1 in cancer remains conflicting. In this study we assessed the effect of SIRT1 on the initiation and progression of thymic T cell lymphomas. We employed mouse strains in which SIRT1 activity was absent or could be reversibly modulated in conjunction with thymic lymphoma induction using either the N-nitroso-N-methylurea (NMU) carcinogenesis or the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) transgene...
October 1, 2018: Experimental Cell Research
Muath Bishawi, Jun-Neng Roan, Jordan Richards, Zachary Brown, Laura Blue, Mani A Daneshmand, Jacob N Schroder, Dawn E Bowles, Carmelo A Milano
Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices...
May 11, 2018: Journal of Visualized Experiments: JoVE
Jamie R Privratsky, Sebastian Diaz, Alina Nicoara, Mani A Daneshmand
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly utilized life-saving measure. However, left-ventricular distention from inadequate left-ventricular off-loading can lead to unwanted pulmonary and cardiac complications. We are writing to indicate our agreement with a recent article by Brechot et al. published in the June 2017 issue where the authors demonstrated that intra-aortic balloon pump provides mechanical support to off-load the left ventricle during VA-ECMO, which prevents pulmonary edema...
May 1, 2018: European Heart Journal. Acute Cardiovascular Care
Muath Bishawi, Jeremy Joseph, Chetan Patel, Jacob Schroder, Mani Daneshmand, Dawn Bowles, Joseph Rogers, Carmelo Milano
BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-center retrospective review of all patients from 2009 to 2014 in whom a rotary flow LVAD was implanted. All patients with symptoms of a cerebrovascular event underwent a non-contrast head computed tomography scan...
June 2018: Journal of Cardiac Surgery
Haider J Warraich, Di Lu, Stacy Cobb, Lauren B Cooper, Adam DeVore, Chetan B Patel, Paul B Rosenberg, Jacob N Schroder, Mani A Daneshmand, Carmelo A Milano, Adrian F Hernandez, Joseph G Rogers, Robert J Mentz
BACKGROUND: Deaths from drug intoxication have increased in the United States but outcomes of recipients of orthotopic heart transplantation (OHT) from these donors are not well characterized. METHODS: We performed a retrospective analysis of the United Network for Organ Sharing's STAR database between January 2000 and March 2014 and assessed mortality and retransplantation using adjusted Cox models by mechanism of donor death. RESULTS: Of the 31,660 OHTs from 2000 to 2014, 1233 (3...
May 2018: American Heart Journal
Morgan L Cox, Brian C Gulack, Dylan P Thibault, Xia He, Matthew L Williams, Vinod H Thourani, Jeffery P Jacobs, J Matthew Brennan, Mani A Daneshmand, Deepak Acharya
OBJECTIVES: Previous studies have demonstrated a 20% mortality rate among patients undergoing isolated coronary artery bypass grafting (CABG) for cardiogenic shock. However, outcomes following CABG for cardiogenic shock in patients who are neurologically unresponsive preoperatively are unknown. METHODS: Utilizing the Society of Thoracic Surgeons Adult Cardiac Surgery Database between July 2011 and December 2013, patients undergoing urgent or emergent CABG within 7 days of an acute myocardial infarction complicated by cardiogenic shock were identified...
October 1, 2018: European Journal of Cardio-thoracic Surgery
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
Jessica L Seidelman, Sarah S Lewis, Kirk Huslage, Nancy Strittholt, Sheila Vereen, Chris Sova, Bonnie Taylor, Desiree Bonadonna, David Ranney, Utlara Nag, Mani Daneshmand, Deverick J Anderson, Daniel J Sexton, Becky A Smith
No abstract text is available yet for this article.
March 2018: Infection Control and Hospital Epidemiology
Yaron D Barac, Hazim Alwair, David F Kong, Chetan B Patel, Mani A Daneshmand, Carmelo A Milano, Jacob N Schroder
Axillary artery intraaortic balloon pump (IABP) placement enables those awaiting transplant to ambulate and get stronger, but motion increases risk of IABP migration. The management of a migrated pump in a 44-year-old man with heart failure is described.
January 2018: Journal of Invasive Cardiology
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