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Vancomycin powder

Sebastian P Boelch, Martin C Jordan, Joerg Arnholdt, Andre F Steinert, Maximilian Rudert, Martin Luedemann
The effect of doubling the immersion fluid (eluate) volume on antibiotic concentrations and on mechanical stability from vancomycin and gentamicin loaded bone cements was investigated in vitro. Antibiotic loaded bone cements containing premixed 1.34% gentamicin antibiotic concentration in the cement powder (wt), premixed 1.19% gentamicin wt and 4.76% vancomycin wt and premixed 1.17% wt gentamicin additionally manually blended with 4.68% wt vancomycin were tested. Six specimens per group were immersed in 4 ml and 8 ml for 6 weeks while the eluate was exchanged every 24 h...
February 14, 2019: Journal of Materials Science. Materials in Medicine
Andrei Fernandes Joaquim, Jerônimo Buzetti Milano, Jefferson Walter Daniel, Fernando Luiz Rolemberg Dantas, Franz Jooji Onishi, Eduardo de Freitas Bertolini, Marcelo Luiz Mudo, Ricardo Vieira Botelho
No abstract text is available yet for this article.
August 2018: Revista da Associação Médica Brasileira
Benjamin Clippinger, Mark Ayzenberg, Michael Narvaez, Dillon Arango, Corrado Minimo, Joshua Pahys, John Handal
Placement of vancomycin powder into the surgical wound prior to closure has been shown to reduce postoperative infections in spine surgery. This study examines the effect of vancomycin powder on formation of epidural fibrosis (EF). Twenty-two rats underwent a two-level lumbar laminectomy. A control group, a low-dose and a high dose vancomycin powder (applied prior to closure) group was formed. Rats were sacrificed at 30 days and a blinded fellowshiptrained pathologist evaluated the laminectomy segments for EF...
December 6, 2018: Orthopedic Reviews
Abhiram Gande, Alex Rosinski, Torin Cunningham, Nitin Bhatia, Yu-Po Lee
BACKGROUND CONTEXT: Surgical site infection (SSI) is a serious and costly complication of spine surgery. Many surgeons apply vancomycin powder to the surgical wound to prevent SSIs. While multiple studies have reported reduced rates of SSI, others have suggested that widespread use of intra-wound vancomycin may increase the incidence of vancomycin-resistant, gram-negative, or polymicrobial spinal infections. PURPOSE: To systematically review the current literature on vancomycin powder in spine surgery and its impact on SSI culture profiles...
January 17, 2019: Spine Journal: Official Journal of the North American Spine Society
Nick N Patel, George N Guild, Arun R Kumar
Background: Periprosthetic joint infection (PJI) is a devastating complication after hip and knee arthroplasty. Intrawound vancomycin has been described extensively in the spine literature; however, information regarding use in arthroplasty is limited. We investigate the efficacy and safety of intrawound vancomycin in arthroplasty surgery. Methods: All primary total hip and knee arthroplasty cases (n = 460) performed by a single surgeon from April 2016 to October 2017 were reviewed...
December 2018: Arthroplasty Today
Yu-Po Lee, Saifal-Deen Farhan, Arif Pendi, Torin J Cunningham, P Douglas Kiester, Peter Hahn, Charles D Rosen, Nitin Bhatia
Study Design: Retrospective chart review. Objectives: To evaluate the efficacy of tobramycin and vancomycin powder in reducing surgical site infections in posterior lumbar instrumented fusion. Methods: A multicenter, electronic database search was conducted for all patients who underwent posterior instrumented lumbar fusions. Results: The addition of vancomycin powder decreased postoperative infections from an incidence of 5...
December 2018: Global Spine Journal
Anubhav Jamwal, Kavita Sharma, Rajni Chauhan, Saurabh Bansal, Gunjan Goel
Background/Aims: Cronobacter sakazakii, an emergent pathogen is considered as a major concern to infants and neonates fed on reconstituted powdered infant milk formula. In conjunction with many other factors, biofilm forming capacity adds to its pathogenic potential. In view of the facts that infants are at highest risk to C. sakazakii infections, and emerging antibiotic resistance among pathogens, it is imperative to evaluate probiotic cultures for their efficacy against C. sakazakii...
December 3, 2018: Intestinal Research
Hossein Elgafy, Craig J Raberding, Megan L Mooney, Kyle A Andrews, Joan M Duggan
AIM: To define a ten-step protocol that reduced the incidence of surgical site infection in the spine surgery practice of the senior author and evaluate the support for each step based on current literature. METHODS: In response to unexplained increased infection rates at our institution following spine surgery, a ten-step protocol was implemented: (1) preoperative glycemic management based on hemoglobin A1c (HbA1c); (2) skin site preoperative preparation with 2% chlorhexidine gluconate disposable cloths; (3) limit operating room traffic; (4) cut the number of personnel in the room to the minimum required; (5) absolutely no flash sterilization of equipment; (6) double-gloving with frequent changing of outer gloves; (7) local application of vancomycin powder; (8) re-dosing antibiotic every 4 h for prolonged procedures and extending postoperative coverage to 72 h for high-risk patients; (9) irrigation of subcutaneous tissue with diluted povidone-iodine solution after deep fascial closure; and (10) use of DuraPrep skin preparation at the end of a case before skin closure...
November 18, 2018: World Journal of Orthopedics
Abuduwufuer Tailaiti, Jun Shang, Shuo Shan, Aikeremujiang Muheremu
Background: Despite great advances in aseptic surgical techniques, surgical site infection (SSI) is still one of the main complications after spine surgery. SSI can bring tremendous physical, psychological, and economic challenges to patients. Intrawound vancomycin application is a much disputed method for the prevention of SSI after spine surgery. Objective: The aim of this study is to review the current literature for studies on the intra-wound application of vancomycin powder and to analyze its effectiveness in the prevention of postoperative SSI...
2018: Therapeutics and Clinical Risk Management
Sebastian P Boelch, Kilian Rueckl, Clara Fuchs, Martin Jordan, Markus Knauer, Andre Steinert, Maximilian Rudert, Martin Luedemann
Purpose: Copal® spacem is a new PMMA bone cement for fabricating spacers. This study compares elution of gentamicin, elution of vancomycin, and compressive strength of Copal® spacem and of Palacos® R+G at different vancomycin loadings in the powder of the cements. We hypothesized that antibiotic elution of Copal® spacem is superior at comparable compressive strength. Methods: Compression test specimens were fabricated using Copal® spacem manually loaded with 0...
2018: BioMed Research International
Hudson Polonini, Sharlene Loures da Silva, Marcos Antônio Fernandes Brandão, Tiene Bauters, Barbara De Moerloose, Anderson de Oliveira Ferreira
Compounded liquid medication is frequently required in children to allow easy dose adjustment and overcome swallowing difficulties. The objective of this study was to evaluate the stability of oral suspensions compounded with SyrSpend SF PH4 and the commonly used active pharmaceutical ingredients baclofen 2.0 mg/mL, carvedilol 5.0 mg/mL, hydrochlorothiazide 2.0 mg/mL, mercaptopurine 10.0 mg/mL, methadone hydrochloride 10.0 mg/mL, oseltamivir phosphate 6.0 mg/mL, phenobarbital 9.0 mg/mL and 15.0 mg/mL, propranolol hydrochloride 0...
November 2018: International Journal of Pharmaceutical Compounding
Jessica Bear, Natalie Rollick, David Helfet
PURPOSE OF REVIEW: Tibial plafond, or pilon, fractures can be some of the most difficult fractures to manage. As they are often associated with high-energy trauma, both the soft tissue involvement and the comminuted fracture pattern pose challenges to fixation. Furthermore, the complex anatomy and trauma to the cartilage at the time of injury predispose pilon fractures to poor functional outcomes and high rates of posttraumatic arthritis. This review will discuss the recent developments in the treatment of tibial pilon fractures...
December 2018: Current Reviews in Musculoskeletal Medicine
Stefanie M Shiels, David J Tennent, Alicia L Lofgren, Joseph C Wenke
Infectious complications can reduce fracture healing rate. Broad spectrum antibiotics are commonly administered to prevent and treat musculoskeletal infections. Local antibiotics are applied to the wound site to increase therapeutic concentrations without increasing systemic toxicity however may hinder local tissue recovery. Rifampin has been shown to eradicate mature Staphylococcal biofilms and its use proven for treating musculoskeletal infections. In this study, a spontaneously healing defect model in a rat was used to investigate the impact rifampin powder has on endogenous bone healing in both a sterile and contaminated wound...
October 1, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Cyrus Caroom, Dustin Moore, Nithya Mudaliar, Craig Winkler, Jefferson Murphree, Ian Ratheal, Michael Fry, Mark Jenkins, Jessica Tullar, Abdul Hamood
OBJECTIVES: To compare the effectiveness of both vancomycin powder and antibiotic bead placement to irrigation and debridement alone in prevention of infection in a contaminated open fracture model in rats. METHODS: In a previously described model of contaminated open fractures, 45 rats had simulated open fractures created, stabilized, and contaminated with Staphylococcus aureus. They were then treated 6 hours later with 3 interventions: irrigation and debridement alone (control group) or in combination with placement of polymethyl methacrylate beads containing vancomycin and tobramycin powders (antibiotic bead group) or placement of 10 mg of intrawound vancomycin powder (powder group)...
October 2018: Journal of Orthopaedic Trauma
Fred A Sweet, Craig W Forsthoefel, Andrea R Sweet, Ryan K Dahlberg
BACKGROUND: The purpose of this study was to compare the local application of a variety of antimicrobial agents with intravenous (IV) antibiotics for infection prophylaxis in a rat model. METHODS: A total of 120 adult male Sprague-Dawley rats were implanted with an expanded polytetrafluoroethylene (ePTFE) vascular graft in a submuscular position and challenged with 2 × 10 colony-forming units of methicillin-sensitive Staphylococcus aureus (MSSA). Twenty rats received pretreatment with IV cefazolin and 20 rats were pretreated with IV vancomycin...
September 19, 2018: Journal of Bone and Joint Surgery. American Volume
Mikinobu Takeuchi, Norimitsu Wakao, Mitsuhiro Kamiya, Atsuhiko Hirasawa, Kenta Murotani, Masakazu Takayasu
OBJECTIVE Retrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion. METHODS In this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field...
August 10, 2018: Journal of Neurosurgery. Spine
Ena Nielsen, Lindsay M Andras, Liam R Harris, David L Skaggs
INTRODUCTION: The aim of this study was to investigate whether preoperative methicillin-resistant Staphylococcus aureus (MRSA) swab results were predictive of surgical site infections (SSIs) in pediatric patients who have undergone spinal fusion. METHODS: We conducted a retrospective chart review of patients who underwent posterior spinal fusion between 2004 and 2014 to determine preoperative MRSA colonization status and SSI rates and organisms. Before October 1, 2012, we administered vancomycin to the patients for infection prophylaxis; beginning October 1, 2012, patients received ceftazidime and Ancef (cefazolin for injection; GlaxoSmithKline)...
September 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
A Sharipova, S K Swain, I Gotman, D Starosvetsky, S G Psakhie, R Unger, E Y Gutmanas
An original fabrication route of high-strength bulk Fe-5Ag and Fe-10Ag nanocomposites with enhanced degradation rate is reported. Near fully dense materials with fine nanostructures and uniform distribution of Ag nanoparticles were obtained employing high energy attrition milling of Fe-Ag2 O powder blends followed by cold sintering - high pressure consolidation at ambient temperature that allowed the retention of the nanoscale structure. Annealing in hydrogen flow at 550 °C resulted in enhanced ductility without coarsening the nanostructure...
October 2018: Journal of the Mechanical Behavior of Biomedical Materials
Pavlos Texakalidis, Victor M Lu, Yagiz Yolcu, Panagiotis Kerezoudis, Mohammed Ali Alvi, Ian F Parney, Jeremy L Fogelson, Mohamad Bydon
BACKGROUND: Surgical site infections (SSIs) after spine and brain surgery present a major burden to patients and hospitals by increasing morbidity, mortality, and healthcare costs. OBJECTIVE: To review available literature investigating the role of intrawound powdered vancomycin against SSIs after neurosurgical operations. METHODS: All randomized and observational English language studies of intrawound powdered vancomycin use in spinal and cranial surgery were included and analyzed using random-effects modeling...
July 3, 2018: Neurosurgery
Marko Tomov, Nathan Wanderman, Elie Berbari, Bradford Currier, Michael Yaszemski, Ahmad Nassr, Paul Huddleston, Mohamad Bydon, Brett Freedman
BACKGROUND CONTEXT: Surgical site infections (SSI) following spine surgery are debilitating complications to patients and costly to the healthcare system. PURPOSE: Review the impact and cost effectiveness of 5 SSI prevention interventions on SSI rates in an orthopedic spine surgery practice at a major quaternary healthcare system over a 10-year period. STUDY DESIGN: Retrospective observational study. PATIENT SAMPLE: All of the surgical patients of the 5 spine surgeons in our department over a 10-year period were included in this study...
June 2, 2018: Spine Journal: Official Journal of the North American Spine Society
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