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https://read.qxmd.com/read/30771786/neurological-recovery-following-traumatic-spinal-cord-injury-a-systematic-review-and-meta-analysis
#1
REVIEW
MirHojjat Khorasanizadeh, Mahmoud Yousefifard, Mahsa Eskian, Yi Lu, Maryam Chalangari, James S Harrop, Seyed Behnam Jazayeri, Simin Seyedpour, Behzad Khodaei, Mostafa Hosseini, Vafa Rahimi-Movaghar
OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis...
February 15, 2019: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/30771756/validation-of-a-methodology-for-neuro-urological-and-lumbosacral-stimulation-studies-in-domestic-pigs-a-humanlike-animal-model
#2
Thomas Guiho, Christine Azevedo-Coste, David Guiraud, Claire Delleci, Grégoire Capon, Natalia Delgado-Piccoli, Luc Bauchet, Jean-Rodolphe Vignes
OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes...
February 15, 2019: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/30771682/seldi-tof-ms-analysis-of-hepatocellular-carcinoma-in-an-australian-cohort
#3
Steven M Schlichtemeier, Christopher B Nahm, Aiqun Xue, Anthony J Gill, Ross C Smith, Thomas J Hugh
BACKGROUND: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT)...
February 13, 2019: Journal of Surgical Research
https://read.qxmd.com/read/30771657/chronic-exposure-to-microcystin-lr-reduces-thyroid-hormone-levels-by-activating-p38-mapk-and-mek-erk-signal-pathway
#4
Jihai Chen, Rongwen Bian, Jiang Li, Liang Qiu, Bing Lu, Xiaojun Ouyang
Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. MC-LR was orally administered to mice at 0, 1, 10, 20 and 40 μg/L for 6 consecutive months for histopathological and immunoblot analysis...
February 13, 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30771414/two-dimensional-cancer-theranostic-nanomaterials-synthesis-surface-functionalization-and-applications-in-photothermal-therapy
#5
REVIEW
Chandran Murugan, Varsha Sharma, Rajesh Kumar Murugan, Gnanasekar Malaimegu, Anandhakumar Sundaramurthy
In recent years, novel two-dimensional (2D) nanomaterials are of great interest for diverse potential applications such as device fabrication, energy storage, sensing and theranostics because of their superlative physical features namely, large surface area, minimal thickness, tunable composition and easier surface modification methods. Rapid exploration in design and fabrication of 2D nano-structures have opened new avenue for cancer theranostics as it can encapsulate group of cancer cells and inflict major damage with great specificity in a non-invasive manner...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30771412/long-term-correction-of-hemophilia-b-using-adenoviral-delivery-of-crispr-cas9
#6
Calvin J Stephens, Elvin J Lauron, Elena Kashentseva, Zhi Hong Lu, Wayne M Yokoyama, David T Curiel
Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting. Due to its monogenic nature, HB is one of the primary targets for gene therapy. Indeed, successful correction of HB has been shown in clinical trials using gene therapy approaches. However, application of these strategies to non-adult patients is limited due to high cell turnover as young patients develop, resulting in vector dilution and subsequent loss of therapeutic expression...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30771366/effects-of-nicotinamide-on-spatial-memory-and-inflammation-after-juvenile-traumatic-brain-injury
#7
Aidan C Smith, Ryan C Holden, Sherry M Rasmussen, Michael R Hoane, Michael J Hylin
Age is a consistent predictor of outcome following traumatic brain injury (TBI). Although children and adolescents have the highest rate of hospitalizations and long-term disabilities, few preclinical studies have attempted to model and treat TBI in this population. Studies using nicotinamide (NAM), a soluble B-group vitamin, in older animals (3-6 months) have shown improved functional recovery in experimental models of TBI. The purpose of this study was two-fold: to examine the preclinical efficacy of NAM at different doses on behavioral outcomes in juvenile rats and examine the microglial response over time...
February 13, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30771269/zika-transmission-patterns-a-meta-review
#8
REVIEW
S Runge-Ranzinger, A C Morrison, P Manrique-Saide, O Horstick
OBJECTIVE: To assesses what is known and identify knowledge gaps for Zika virus (ZIKV) transmission patterns. METHODS: Meta-review searching the databases BioSys; Cochrane Infectious Diseases Group Specialised Register and Cochrane Central Register of Controlled Trials; EMBASE; Google Scholar; LILACS; MEDLINE (PubMed); Web of Science; and WHOLIS with the term "ZIKA". Systematic reviews and reviews specifying the search methods and describing potential modes of transmission were eligible for analysis...
February 16, 2019: Tropical Medicine & International Health: TM & IH
https://read.qxmd.com/read/30770964/reductive-soil-disinfestation-effectively-alleviates-the-replant-failure-of-sanqi-ginseng-through-allelochemical-degradation-and-pathogen-suppression
#9
Yunlong Li, Baoying Wang, Yafeng Chang, Yuting Yang, Chunzhi Yao, Xinqi Huang, Jinbo Zhang, Zucong Cai, Jun Zhao
Replant failure has threatened the production of Sanqi ginseng (Panax notoginseng) mainly due to the accumulation of soil-borne pathogens and allelochemicals. Reductive soil disinfestation (RSD) is an effective practice used to eliminate soil-borne pathogens; however, the potential impact of RSD on the degradation of allelochemicals and the growth of replant Sanqi ginseng seedlings remain poorly understood. In this study, RSD was conducted on a Sanqi ginseng monoculture system (SGMS) and a maize-Sanqi ginseng system (MSGS), defined as SGMS_RSD and MSGS_RSD, respectively...
February 15, 2019: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/30770594/structural-assessments-in-decellularized-extracellular-matrix-of-porcine-semilunar-heart-valves-evaluation-of-cell-niches
#10
João Gabriel Roderjan, Lúcia de Noronha, Marco Augusto Stimamiglio, Alejandro Correa, Amanda Leitolis, Ronaldo Rocha Loures Bueno, Francisco Diniz Affonso da Costa
Tissue-engineered heart valves aim to reproduce the biological properties of natural valves with anatomically correct structure and physiological performance. The closest alternative to creating an ideal heart valve substitute is to use decellularized porcine heart valves, due to their anatomy and availability. However, the immunological barrier and the structural maintenance limit the long-term physiological performance of decellularized porcine heart valves. This study investigated the extracellular matrix (ECM) structure of aortic and pulmonary porcine valves decellularized by a low concentration sodium dodecyl sulfate (SDS)-based method in order to determine the ECM scaffold (ECMS) conditions related to remodeling potential...
February 16, 2019: Xenotransplantation
https://read.qxmd.com/read/30770464/spatial-memory-formation-requires-netrin-1-expression-by-neurons-in-the-adult-mammalian-brain
#11
Edwin W Wong, Stephen D Glasgow, Lianne J Trigiani, Daryan Chitsaz, Vladimir Rymar, Abbas Sadikot, Edward S Ruthazer, Edith Hamel, Timothy E Kennedy
Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory...
March 2019: Learning & Memory
https://read.qxmd.com/read/30770073/potential-for-long-term-benefit-of-cognitive-behavioral-therapy-as-an-adjunct-treatment-for-men-with-erectile-dysfunction
#12
Sikandar Khan, Amira Amjad, David Rowland
INTRODUCTION: Psychosexual counseling may enhance sexual performance outcomes in men with erectile dysfunction (ED) treated with a phosphodiesterase type 5 (PDE5) inhibitor. AIM: To determine the potential long-term effects of cognitive behavioral therapy (CBT) on Pakistani men with ED who had undergone treatment with a PDE5 inhibitor (PDE5i). METHODS: In a 15-18-month follow-up, we reassessed a subsample of 20 men who had been treated with either PDE5is (monotherapy group) or CBT + PDE5i (combined group) on 2 dimensions: sexual functioning and mental health functioning...
February 2019: Journal of Sexual Medicine
https://read.qxmd.com/read/30769877/current-therapeutic-results-and-treatment-options-for-older-patients-with-relapsed-acute-myeloid-leukemia
#13
REVIEW
Felicetto Ferrara, Federica Lessi, Orsola Vitagliano, Erika Birkenghi, Giuseppe Rossi
Considerable progress has been made in the treatment of acute myeloid leukemia (AML). However, current therapeutic results are still unsatisfactory in untreated high-risk patients and poorer in those with primary refractory or relapsed disease. In older patients, reluctance by clinicians to treat unfit patients, higher AML cell resistance related to more frequent adverse karyotype and/or precedent myelodysplastic syndrome, and preferential involvement of chemorefractory early hemopoietic precursors in the pathogenesis of the disease further account for poor prognosis, with median survival lower than six months...
February 14, 2019: Cancers
https://read.qxmd.com/read/30769853/stem-cell-derived-extracellular-vesicles-for-treating-joint-injury-and-osteoarthritis
#14
REVIEW
Jiao Jiao Li, Elham Hosseini-Beheshti, Georges E Grau, Hala Zreiqat, Christopher B Little
Extracellular vesicles (EVs) are nanoscale particles secreted by almost all cell types to facilitate intercellular communication. Stem cell-derived EVs theoretically have the same biological functions as stem cells, but offer the advantages of small size, low immunogenicity, and removal of issues such as low cell survival and unpredictable long-term behaviour associated with direct cell transplantation. They have been an area of intense interest in regenerative medicine, due to the potential to harness their anti-inflammatory and pro-regenerative effects to induce healing in a wide variety of tissues...
February 14, 2019: Nanomaterials
https://read.qxmd.com/read/30769788/multi-organs-on-chips-towards-long-term-biomedical-investigations
#15
REVIEW
Yi Zhao, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxicity over conventional two-dimensional (2D) and three-dimensional (3D) cell cultures, as well as animal models. Recent advancements of OOC systems have evidenced the fabrication of 'multi-organ-on-chip' (MOC) models, which connect separated organ chambers together to resemble an ideal pharmacokinetic and pharmacodynamic (PK-PD) model for monitoring the complex interactions between multiple organs and the resultant dynamic responses of multiple organs to pharmaceutical compounds...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30769278/lestaurtinib-cep-701-modulates-the-effects-of-early-life-hypoxic-seizures-on-cognitive-and-emotional-behaviors-in-immature-rats
#16
Yasser Medlej, Houssein Salah, Lara Wadi, Sarah Saad, Bashir Bashir, Jad Allam, Zahraa Atoui, Nora Darwish, Nabil Karnib, Hala Darwish, Firas Kobeissy, Kevin K W Wang, Eva Hamade, Makram Obeid
Hypoxic encephalopathy of the newborn is a major cause of long-term neurological sequelae. We have previously shown that CEP-701 (lestaurtinib), a drug with an established safety profile in children, attenuates short-term hyperexcitability and tropomyosin-related kinase B (TrkB) receptor activation in a well-established rat model of early life hypoxic seizures (HS). Here, we investigated the potential long-term neuroprotective effects of a post-HS transient CEP-701 treatment. Following exposure to global hypoxia, 10 day old male Sprague-Dawley pups received CEP-701 or its vehicle and were sequentially subjected to the light-dark box test (LDT), forced swim test (FST), open field test (OFT), Morris water maze (MWM), and the modified active avoidance (MAAV) test between postnatal days 24 and 44 (P24-44)...
February 12, 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30769029/forsythiaside-prevents-%C3%AE-amyloid-induced-hippocampal-slice-injury-by-upregulating-2-arachidonoylglycerol-via-cannabinoid-receptor-1-dependent-nf-%C3%AE%C2%BAb-pathway
#17
Liqing Chen, Yan Yan, Tinggui Chen, Liwei Zhang, Xiaoxia Gao, Chenhui Du, Huizhi Du
In the study, the neuroprotectivities of forsythiaside, a main constituent of Forsythia suspensa (Thunb.) Vahl (F. suspensa, Lianqiao in Chinese), were investigated in the hippocampal slices. Forsythiaside suppressed the overexpression of cyclooxygenase-2 (COX-2) and monoacylglycerol lipase (MAGL) proteins induced by β-amyloid (Aβ25-35 ) to upregulate the levels of 2-arachidonoylglycerol (2-AG), an endogenous endocannabinoids. Then the inhibition of forsythiaside on COX-2 was deeply studied by the molecular docking...
February 12, 2019: Neurochemistry International
https://read.qxmd.com/read/30768897/chitosan-acetylation-degree-influences-the-physical-properties-of-polysaccharide-nanoparticles-implication-for-the-innate-immune-cells-response
#18
Franco Furlani, Pasquale Sacco, Eva Decleva, Renzo Menegazzi, Ivan Donati, Sergio Paoletti, Eleonora Marsich
The aim of the present contribution is twofold, as it reports: i) on the role played by chitosan acetylation degree for the stability of nanoparticles formed with hyaluronan (NPs); ii) on the effect of the interaction of such NPs with immune cells. Chitosans with similar viscosity-average molecular weight, (M_v ) ̅, (i.e. 200 000) and different fraction of acetylated units (FA), together with a low molecular weight hyaluronan were chosen for developing a selected library of formulations via electrostatic complex coacervation...
February 15, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30768418/a-randomized-controlled-trial-attachment-based-family-and-non-directive-supportive-treatments-for-suicidal-youth
#19
Guy S Diamond, R Rogers Kobak, E Stephanie Krauthamer Ewing, Suzanne A Levy, Joanna L Herres, Jody M Russon, Robert J Gallop
OBJECTIVE: To evaluate the efficacy of Attachment-based Family Therapy (ABFT) compared to a Family Enhanced Non-Directive Supportive Therapy (FE-NST) for reducing adolescents' suicide ideation and depressive symptoms. METHOD: A randomized controlled trial of 129 suicidal adolescents, between the ages of 12 to 18 (49% were African-American) were randomized to ABFT (n = 66) or FE-NST (n = 63) for 16 weeks of treatment. Assessments occurred at baseline, 4, 8, 12, and 16 weeks...
October 30, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30768406/deficient-functioning-of-fronto-striatal-circuits-during-the-resolution-of-cognitive-conflict-in-cannabis-using-youth
#20
Marilyn Cyr, Gregory Z Tau, Martine Fontaine, Frances R Levin, Rachel Marsh
OBJECTIVE: Disturbances in self-regulatory control are involved in the initiation and maintenance of addiction, including cannabis use disorder (CUD). In adults, chronic cannabis use is associated with disturbances in fronto-striatal circuits during tasks that require the engagement of self-regulatory control, including the resolution of cognitive conflict. Understudied are the behavioral and neural correlates of these processes earlier in the course of cannabis use, disentangled from effects of long-term use...
October 30, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
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