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Rong Cai, Chunying Chen
Engineering nanomaterials are increasingly considered promising and powerful biomedical tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials have been tested in clinical trials. This wide gap between bench discoveries and clinical application is mainly due to the limited understanding of the biological identity of nanomaterials. When they are exposed to the human body, nanoparticles inevitably interact with bodily fluids and thereby adsorb hundreds of biomolecules. A "biomolecular corona" forms on the surface of nanomaterials and confers a new biological identity for NPs, which determines the following biological events: cellular uptake, immune response, biodistribution, clearance, and toxicity...
December 27, 2018: Advanced Materials
Bharathi D Jagadeesan, Andrew W Grande, Ramachandra P Tummala
Background/Objective: Compliant dual-lumen balloon microcatheters have been used to perform balloon-assisted embolization (BAE) of brain arteriovenous malformations (AVMs) with ethylene vinyl alcohol copolymer (Onyx). However, vessel rupture and microcatheter retention have been reported from BAE using these microcatheters. Using an extra-compliant balloon microcatheter (Scepter XC; Microvention, Tustin, CA, USA) could help avoid pial vessel rupture during BAE. We herein report our experience using this balloon microcatheter for BAE...
October 2018: Interventional Neurology
Adam N Wallace, Yasha Kayan, Josser E Delgado Almandoz, Jennifer L Fease, Anna A Milner, Jill M Scholz
BACKGROUND: The Scepter XC balloon catheter can be used for balloon-assisted coiling (BAC) of cerebral aneurysms but also accommodates delivery of a low-profile visible intraluminal stent (LVIS Jr.). We assessed the safety and effectiveness of BAC using the Scepter XC, with LVIS Jr. stent-assisted coiling (SAC) as a bailout option. METHODS: A single-institution prospectively maintained neurointerventional database was reviewed for wide-necked (neck width ≥4 mm or dome/neck ratio <2) saccular aneurysms treated using the Scepter XC...
January 2019: World Neurosurgery
Bharathi D Jagadeesan, Kenneth K Liao, Ganesh Raveendran
Complex Coronary artery to Pulmonary artery fistulas (CPFs) can be difficult to manage with embolization or ligation. An 88-year-old woman with exertional angina was found to have a complex precordial CPF, severe Mitral regurgitation, and Pulmonary Hypertension. CPF treatment was recommended prior to minimally invasive mitral valve replacement (to avoid postoperative myocardial ischemia from worsened steal). The CPF was supplied by multiple branches from the LAD and RCA, and formed a complex common varicosity with multiple drainage channels to the pulmonary artery...
July 18, 2018: Catheterization and Cardiovascular Interventions
Andrew S Griffin, Nicholas Befera, Erik Hauck
Background and importance Pial arteriovenous fistulas (AVFs) of the brain are treacherous lesions that can be challenging to treat because of high risk of hemorrhage. We report on a rare case of a pial AVF with a giant venous varix as a draining vein treated successfully with flow-directed balloon-assisted Onyx embolization. Clinical presentation A 56-year-old female with headaches underwent brain magnetic resonance imaging, which demonstrated a 4 cm aneurysmal malformation in the right temporal lobe. A diagnostic cerebral angiogram demonstrated a right temporal pial AVF fed by an enlarged right posterior cerebral artery with drainage into a giant venous varix...
January 1, 2018: Interventional Neuroradiology
Bradley A Gross, Daniel A Tonetti, Gregory M Weiner, David M Panczykowski, William J Ares, Cynthia L Kenmuir, Ashutosh P Jadhav, Tudor G Jovin, Brian T Jankowitz
Introduction: Balloon angioplasty can be a requisite approach for the treatment of symptomatic and/or severe vasospasm. Dual-lumen microcatheter balloons have multiple potential advantages for this indication including accommodating a 0.014-inch wire and the potential to deliver superselective vasodilators directly via the microcatheter prior to angioplasty. Methods: The authors reviewed a 3-year institutional experience with the Scepter XC balloon (Microvention, Tustin, CA, USA) in the treatment of postaneurysmal subarachnoid hemorrhage vasospasm, focusing on treatment methods, angiographic, and clinical results...
October 2017: Interventional Neurology
Denham S Ward, Mark R Williams, Dennis C Turk, Robert H Dworkin, Daniel I Sessler, Franklin Dexter
No abstract text is available yet for this article.
August 2017: Anesthesia and Analgesia
Di Wu, Feng Xie, Ling Xiao, Fen Feng, Shifang Huang, Lu He, Meiqing Liu, Qun Zhou, Lanfang Li, Linxi Chen
Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Western blots were used for protein expression in LVH rats and cultured H9c2 cardiomyocytes. Transmission electron microscopy (TEM) was used to monitor morphological features of cells. In addition, the diameter and volume of H9c2 cells were detected by Scepter™ Handheld Automated Cell Counter...
August 2017: DNA and Cell Biology
Ata Firuzi, Mohammad Javad Alemzadeh-Ansari, Hamid Reza Pouraliakbar
Acquired causes of coronary fistulas are rare disorders and may develop following coronary atherosclerosis, infection, or trauma (iatrogenic). Iatrogenic coronary fistulas may be acquired secondary to surgical or nonsurgical interventions. We describe a case of an iatrogenic coronary artery-left ventricle fistula following mitral valve replacement surgery, presented with ventricular arrhythmia and heart failure. In a unique technique, we implanted three coils with the aid of a Scepter C balloon with inflation at the ostial portion of the left circumflex artery...
April 2017: Journal of the Saudi Heart Association
Xianli Lv, Xiheng Chen, Huijian Ge, Hongwei He, Chuhan Jiang, Youxiang Li
OBJECTIVE: The purpose of this study is to report our initial experience of Onyx embolization of the high-flow fistula part of arteriovenous malformation (AVM) using a double-lumen balloon catheter. METHODS: A Scepter C balloon catheter was used in 2 patients with AVMs associated with high-flow fistulas. The fistulas were located in the anterior cerebral artery and the middle cerebral artery. RESULTS: Onyx embolization was successful in 2 cases, resulting in elimination of the high-flow fistula part of the AVM...
December 2016: World Neurosurgery
Kazuki Takahira, Taketo Kataoka, Tatsuya Ogino, Hideki Endo, Hirohiko Nakamura
OBJECTIVE The authors describe a method by which they easily and atraumatically navigate a large-bore reperfusion catheter of the Penumbra system to an embolus by using a coaxial system with a compliant balloon catheter in patients with tortuous arteries. METHODS A retrospective review of the prospective endovascular database was performed to identify cases in which a coaxial system with a compliant balloon catheter (Scepter C, MicroVention/Terumo; or TransForm C, Stryker Neurovascular) and a large-bore reperfusion catheter of the Penumbra system (Penumbra, Inc...
April 2017: Journal of Neurosurgery
Jeremy Heit, Ian Connolly, Omar Choudhri
No abstract text is available yet for this article.
December 2016: Clinical Neuroradiology
Yihao Tao, Yin Niu, Gang Zhu, Zhi Chen
Dural arteriovenous fistula (DAVFs) induced by trauma in the superior sagittal sinus (SSS) are rare and difficult to treat because of their unique midline location, multiplicity of arterial feeders, and critical venous drainage. We report a case of an endovascular treatment using dual lumen balloon microcatheter on a patient with post-traumatic SSS DAVF. By the use of dual lumen Scepter balloon microcatheter, proximal Onyx reflux was prevented. In this case, complete embolization of the DAVFs was achieved and the outcome of the patient was fairly good...
April 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Travis R Ladner, Lucy He, Brandon J Davis, George L Yang, George B Wanna, J Mocco
OBJECT Paragangliomas are highly vascular head and neck tumors for which preoperative embolization is often considered to facilitate resection. The authors evaluated their initial experience using a dual-lumen balloon to facilitate preoperative embolization in 5 consecutive patients who underwent preoperative transarterial Onyx embolization assisted by the Scepter dual-lumen balloon catheter between 2012 and 2014. OBJECT The authors reviewed the demographic and clinical records of 5 patients who underwent Scepter-assisted Onyx embolization of a paraganglioma followed by resection between 2012 and 2014...
June 2016: Journal of Neurosurgery
Edgar A Samaniego, Mario Martínez-Galdámez, German Abdo
OBJECTIVE: To describe the treatment of direct high flow carotid-cavernous sinus fistulas (dCCFs) with the double lumen balloon Scepter C. MATERIALS AND METHODS: 7 patients with dCCFs were identified and treated with a double lumen balloon Scepter C. 5 patients had post-traumatic dCCFs and two patients had spontaneous dCCFs due to a ruptured cavernous-carotid aneurysm. The double lumen balloon was used in characterizing the angioarchitecture of the fistula in all patients...
May 2016: Journal of Neurointerventional Surgery
Ana Zaragoza Martí, Rosario Ferrer Cascales, María José Cabañero Martínez, Jose Antonio Hurtado Sánchez, Ana Laguna Pérez
INTRODUCTION: the Mediterranean diet (MD) and model quality diet is associated with a reduction in mortality and an improvement in quality of life in elderly. OBJECTIVE: To evaluate the relationship between nutritional status and lifestyles with the degree of adherence to the DM in elderly Methods: Sample consists of 60 subjects who attended the nursing consultation of a scepter health of Alicante with an index greater than 24.9 body mass. The frequency questionnaire food consumption MEDIS-FFQ questionnaire PREDIMED adherence to the Mediterranean diet and anthropometric assessment was used...
April 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Travis R Ladner, Lucy He, Nikita Lakomkin, Brandon J Davis, Joseph S Cheng, Clinton J Devin, J Mocco
BACKGROUND: Intraoperative bleeding is a significant risk in surgery for highly vascular spinal tumors, but preoperative embolization can safely decrease intraoperative blood loss in extrinsic spine tumors. Onyx, widely used for cerebrovascular embolization, has been increasingly used as an embolic agent for preoperative spinal tumor embolization. The Scepter catheter, a dual-lumen balloon catheter, may improve tumor parenchymal penetration without the danger and limitations of significant embolic reflux...
February 2016: Journal of Neurointerventional Surgery
Raoul Pop, Monica Manisor, Valérie Wolff, Pierre Kehrli, Christian Marescaux, Rémy Beaujeux
PURPOSE: We present a technical development of the endovascular treatment technique for vein of Galen aneurysmal malformation, using Onyx™ (ethylene vinyl alcohol copolymer) delivered under flow control through double-lumen balloon microcatheters. MATERIALS AND METHODS: An 11-month-old patient that initially presented with increasing head circumference was diagnosed with mural type vein of Galen aneurysmal malformation. Complete cure was obtained in a single endovascular treatment session...
January 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Sasisekhar Bennuru, Sébastien D S Pion, Joseph Kamgno, Samuel Wanji, Thomas B Nutman
INTRODUCTION: Administration of ivermectin (IVM) as part of mass drug administration (MDA) campaigns for onchocerciasis and/or lymphatic filariasis (LF) has been suspended in areas co-endemic for Loa loa due to severe post-treatment adverse events (SAEs) associated with high-burden of infection (>30,000 mf/ml). One simple approach for preventing SAEs is to identify and exclude individuals at risk from MDA. Here, we describe a repurposed hand-held automated cell counter (Scepter 2.0; HHAC) as a rapid, point-of-care method for quantifying microfilariae (mf) in the blood of infected individuals...
September 2014: PLoS Neglected Tropical Diseases
Ajit S Puri, Anna L Kühn, Samuel Y Hou, Ajay K Wakhloo
Onyx is a non-adhesive polymer used for embolization of arteriovenous malformations and dural arteriovenous fistulas (DAVFs). The limiting factor for Onyx embolization is usually the amount of microcatheter reflux, which can be safely tolerated. The dual microcatheter technique, compliant balloon use proximally and the use of the dual lumen Scepter balloon have been described to prevent and limit proximal Onyx reflux. We describe the use the Navien 058 intermediate guide catheter to accept the Onyx reflux in its lumen and possibly also serve as a mechanical barrier to avoid reflux into the anastomotic channel connecting the occipital artery to the vertebral artery during DAVF embolization via the occipital artery...
July 2014: Interventional Neuroradiology
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