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Side effect management

August Kuwawenaruwa, Kate Ramsey, Peter Binyaruka, Jitihada Baraka, Fatuma Manzi, Josephine Borghi
Demand side financing strategies have been a popular means of increasing coverage and availability of effective maternal and child health services in low and middle income countries (LMIC). However, most research to date has focused on the effects of demand side financing on the use and costs of care with less attention being paid to how they work to achieve outcomes. This study used a mixed methods evaluation to determine the effect of a targeted health insurance scheme on access to affordable quality maternal and child care, and assess implementation fidelity and how this affected programme outcomes...
February 10, 2019: Social Science & Medicine
Stefanie J Schmidt, René Hurlemann, Johannes Schultz, Sven Wasserthal, Christian Kloss, Wolfgang Maier, Andreas Meyer-Lindenberg, Martin Hellmich, Ana Muthesius-Digón, Tanja Pantel, Pia-Sophie Wiesner, Joachim Klosterkötter, Stephan Ruhrmann
AIM: Meta-analyses indicate positive effects of both antipsychotic and cognitive-behavioural interventions in subjects clinically at high risk (CHR) for psychosis in terms of a delay or prevention of psychotic disorders. However, these effects have been limited regarding social functioning and the relative efficacy of both types of interventions remains unclear. Furthermore, neuroprotective substances seem to be a promising alternative agent in psychosis-prevention as they are associated with few and weak side-effects...
February 19, 2019: Early Intervention in Psychiatry
Christine C Davis, Sarah Caulfield
No abstract text is available yet for this article.
February 15, 2019: Oncology (Williston Park, NY)
Xi-Ding Yang, Ping-Fei Fang, Da-Xiong Xiang, Yong-Yu Yang
Diabetic neuropathic pain (DNP) has a huge impact on quality of life and can be difficult to treat. Oral treatment is the most frequently used method for DNP, but its use is often limited by systemic side effects. Topical use of drugs as an alternative option for DNP treatment is currently gaining interest. In the present review, a summary is provided of the available agents for topical use in patients with DNP, including lidocaine plasters or patches, capsaicin cream, gel or patches, amitriptyline cream, clonidine gel, ketamine cream, extracts from medicinal plants including nutmeg extracts and Citrullus colocynthis extract oil, and certain compounded topical analgesics...
March 2019: Experimental and Therapeutic Medicine
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
The post-Finasteride syndrome (PFS) has been claimed to occur in men who have taken oral finasteride to treat hair loss or benign prostatic hyperplasia. While the incidence of persistent sexual, mental, and physical side effects despite quitting finasteride is unknown, and the condition is not recognized by the scientific community, individuals who suffer from PFS do present with very distinctive and homogenous symptoms. The concept has emerged from reports of nondermatologists, neuroendocrinological research, case reports, and uncontrolled studies...
November 2018: International Journal of Trichology
Massimo Sabbatini, L Ferreri, A Pisani, I Capuano, M Morgillo, A Memoli, E Riccio, B Guida
AIMS: The nutritional management of renal transplant recipients (RTR) represents a complex problem either because the recovery of renal function is not complete and for the appearance of "unavoidable" metabolic side effects of immunosuppressive drugs. Nevertheless, it remains a neglected problem, whereas an appropriate dietary intervention could favorably affect graft survival. DATA SYNTHESIS: Renal transplantation is associated with steroids and calcineurin inhibitors administration, liberalization of diet after dialysis restrictions, and patients' better quality of life...
January 12, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Tsu-Hsiang Kuo, Yueh-Hsiung Kuo, Chun-Yu Cho, Chih-Jung Yao, Gi-Ming Lai, Shuang-En Chuang
Radiotherapy for treatment of hepatocellular carcinoma causes severe side effects, including acute hepatitis and chronic fibrosis. Complementary and alternative medicine (CAM) has emerged as an important part of integrative medicine in the management of diseases. Antrodia cinnamomea (AC), a valuable medicinal fungus originally found only in Taiwan, has been shown to possess anti-oxidation, vaso-relaxtation, anti-inflammation, anti-hepatitis, and anti-cancer effects. In this paper we evaluate the protective effects of ethanol extract of Antrodia cinnamomea (ACE) against radiotoxicity both in normal liver cell line CL48 and in tumor-bearing mice...
February 15, 2019: International Journal of Molecular Sciences
Gregory Kaltsas, Dionysia Kolomodi, Harpal Randeva, Ashley Grossman
CONTEXT: Although the majority of sellar lesions are related to pituitary adenomas, the region gives rise to a variety of neoplasms that can be associated with substantial morbidity and/or mortality. EVIDENCE ACQUISITION: Information from reviews and guidelines of relevant societies dealing with such neoplasms, and articles that have provided new developments which made important contributions in their pathogenesis and treatment up to 2018, were obtained: public indexes such as PubMed/MEDLINE were used with the search items...
February 19, 2019: Journal of Clinical Endocrinology and Metabolism
Carina Feuz, Karen Tse, Maisie Kwan, Christine Hill, Peter Rakaric, Kieng Tan, Tara Rosewall
OBJECTIVES: Although it is widely acknowledged that radiotherapy treatments can have a negative impact on a patient's sexual health, this aspect of side effect management is not commonly addressed by radiation therapists or by other cancer specialists. It is important for radiation therapists to recognize and address possible sexual health issues to provide a holistic approach to care. This quality-improvement project was designed to help radiation therapists discuss the sexual health needs of patients undergoing radiotherapy by improving their clinical knowledge, skills, and comfort level about the topic...
March 2019: Journal of Medical Imaging and Radiation Sciences
Anvesh R Kompelli, Jonathan S Ni, Shaun A Nguyen, Eric J Lentsch, David M Neskey, Ted A Meyer
Objectives: Obstructive sleep apnea (OSA) is a prevalent disease with significant health impacts. While first line therapy is CPAP, long-term compliance is low and device misuse is common, highlighting the need for alternative therapies. Upper airway surgery is one alternative, but substantial side effects hamper efficacy. A new alternative is an implantable hypoglossal nerve stimulator (HNS). These devices utilize neuromodulation to dilate/reinforce the airway and reduce side effects associated with traditional surgery...
March 2019: World Journal of Otorhinolaryngology—Head and Neck Surgery
Federica Dall'Oglio, Francesco Lacarrubba, Maria Luca, Simona Boscaglia, Corinne Granger, Giuseppe Micali
Purpose: Topical agents play a key role in the management of facial seborrheic dermatitis (SD) by reducing inflammation and scale production. The aim of this open-label trial was to assess the efficacy and tolerability of a new non-corticosteroid, antifungal/anti-inflammatory/antiseborrheic cream containing piroctone olamine, stearyl glycyrrhetinate, and zinc PCA in the treatment of facial SD using clinical and instrumental evaluation. Patients and methods: Twenty adult subjects affected by mild-to-moderate inflamed facial SD were enrolled and instructed to apply the study cream twice daily for 60 days...
2019: Clinical, Cosmetic and Investigational Dermatology
James Weiquan Li, Tiing Leong Ang, Lai Mun Wong, Andrew Boon Eu Kuek, Malcolm Teck Kiang Tan, Kwong Ming Fock, Eng Kiong Teo
INTRODUCTION: Endoscopic submucosal dissection (ESD) provides a higher en bloc and R0 resection rate than endoscopic mucosal resection (EMR). Colorectal ESD is not widely used because of its technical difficulty and risk of complications, especially for right-sided colonic lesions. We audited the clinical outcomes of our initial experience with colorectal ESD. METHODS: We reviewed data collected from a prospective registry of patients who underwent colorectal ESD from December 2014 to March 2018...
February 18, 2019: Singapore Medical Journal
Yina Lan, Jinhao Lyu, Xiaoxiao Ma, Lin Ma, Xin Lou
BACKGROUND: Carotid artery stenting (CAS) and endarterectomy (CEA) are major treatment strategies for patients with internal carotid artery (ICA) stenosis; however, the dynamic cerebral blood flow (CBF) changes after CAS and CEA remain unclear. PURPOSE: This study aimed to monitor consecutive CBF changes at 24-h intervals in patients who underwent CAS and CEA to explore the potential pattern of CBF alternation and compare the effect on CBF changes of different surgical methods...
February 15, 2019: La Radiologia Medica
Terry Kit Selfe, Sijin Wen, Karen Sherman, Maryanna Klatt, Kim E Innes
BACKGROUND: Restless legs syndrome (RLS) is a common and burdensome sleep disorder associated with profound impairment of health, well-being, and quality of life. Unfortunately, the medications used for RLS management carry risk of serious side effects, including augmentation of symptoms. Yoga, an ancient mind-body discipline designed to promote physical, emotional, and mental well-being, may offer a viable, low-risk new treatment. The primary objectives of this pilot, parallel-arm, randomized controlled trial (RCT) are to assess the acceptability and feasibility of a 12-week yoga vs...
February 15, 2019: Trials
Nazish Sayed, Mohamed Ameen, Joseph C Wu
Treatment of cancer has evolved in the last decade with the introduction of new therapies. Despite these successes, the lingering cardiotoxic side-effects from chemotherapy remain a major cause of morbidity and mortality in cancer survivors. These effects can develop acutely during treatment, or even years later. Although many risk factors can be identified prior to beginning therapy, unexpected toxicity still occurs, often with lasting consequences. Specifically, cardiotoxicity results in cardiac cell death, eventually leading to cardiomyopathy and heart failure...
February 15, 2019: Cardiovascular Research
Sarah Barnard, Jacqueline French
Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist...
February 15, 2019: Journal of Women's Health
Jed Lusthaus, Ivan Goldberg
Glaucoma is an irreversible progressive optic neuropathy, for which the major proven treatment is to lower the intraocular pressure (IOP). Five groups of IOP-lowering eye drops have varying mechanisms of action. Some drops, such as β-blockers and α-2 agonists, have potentially serious systemic side effects. Acetazolamide is the only available oral agent; it is effective at lowering IOP, but significant side effects relegate its use usually to refractory glaucoma. Two new eye drops, netarsudil and latanoprostene bunod, have recently been approved by the United States Food and Drug Administration...
February 14, 2019: Medical Journal of Australia
Abdulaziz Alhossan, Ziyad Alrabiah, Sultan Alghadeer, Salmeen Bablghaith, Syed Wajid, Mohammed Al-Arifi
Introduction: Proton pump inhibitors (PPIs) effectively suppress acid secretion and play an important role in peptic ulcer disease and gastroesophageal reflux disease . There is a real concern about the overutilization of PPIs, which will lead to significant high cost and undesirable outcomes . Despite that most of PPIs are classified as prescribed medications, yet most of their users take them without prescription in Saudi Arabia. Therefore, it was important to understand community pharmacists practice in dealing with PPIs and to evaluate their despising pattern of these medications...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Lino Del Pup, P Villa, I D Amar, C Bottoni, G Scambia
Sexual dysfunction in female cancer patients remains under-diagnosed and under-treated. As sexual dysfunction is becoming an increasingly common side effect of cancer treatments, it is imperative for healthcare providers and especially gynecologic oncologists to include a comprehensive evaluation of sexual health as a routine part of the workup of such patients. Although most oncologists are not experienced in treating sexual dysfunctions, simple tools can be incorporated into clinical practice to improve the management of these conditions...
February 13, 2019: International Journal of Gynecological Cancer
Véronique Bourcy, Emmanuelle Boubouloux, Virginie Moiteaux, Fabienne Empereur, David Guillet, Martine Jouin-Bernier, Laure de Decker
Anticancer medicines evolve in terms of their mode of action as well as their galenics. The advent of oral therapies has multiple benefits such as the possibility of taking the treatments at home. However, what are the implications with regard to compliance, the management of side effects and the community-hospital relationship? Elderly patients, often isolated, taking several medicines and frail, are disorientated faced with all these medications and their side effects. A study was undertaken to evaluate the benefit of visits by private practice nurses to support patients taking oral cancer drugs...
January 2019: Soins. Gérontologie
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