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Ellen Backman, Mats Granlund, Ann-Kristin Karlsson
BACKGROUND: Everyday routines play a vital role in child functioning and development. This study explored health professionals' documentation of everyday life and health care during the first year following gastrostomy tube placement in children and the content of intervention goals. METHODS: The medical records of 39 children (median age 38 months, min-max: 15-192) in one region of Sweden were analysed. A content analysis approach was used with an inductive qualitative analysis supplemented by a deductive, quantitative analysis of documented intervention goals following the ICF-CY...
February 14, 2019: Disability and Rehabilitation
Sang-Min Lee, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Chang-Rack Lee, Dong-Wook Son, Jun-Gu Park
BACKGROUND: Meniscal allograft transplantation (MAT) is a widely performed surgical technique used to reconstruct meniscal deficiencies after meniscectomy. However, the long-term effects of extrusion on clinical and radiologic outcomes are unclear. HYPOTHESIS: In long-term follow-up, extrusion after MAT would show poorer outcomes than nonextrusion and would lead to faster progression of arthritic changes. STUDY DESIGN: Cohort study; Level of evidence, 3...
February 14, 2019: American Journal of Sports Medicine
Christian Reichardt, Susan Monro, Fabian H Sobotta, Katsuya L Colón, Tariq Sainuddin, Mat Stephenson, Eric Sampson, John Roque, Huimin Yin, Johannes C Brendel, Colin G Cameron, Sherri McFarland, Benjamin Dietzek
This study investigates the correlation between photocytotoxicity and the prolonged excited-state lifetimes exhibited by certain Ru(II) polypyridyl photosensitizers comprised of π-expansive ligands. The eight metal complexes selected for this study differ markedly in their triplet state configurations and lifetimes. Human melanoma SKMEL28 and human leukemia HL60 cells were used as in vitro models to test photocytotoxicity induced by the compounds when activated by either broadband visible or monochromatic red light...
February 14, 2019: Inorganic Chemistry
Mats Fredriksen, Jens Egeland, Jan Haavik, Ole Bernt Fasmer
OBJECTIVE: The aim of this study was to examine whether reaction time parameters in adult patients with ADHD could predict their response to methylphenidate (MPH). METHOD: Previously unmedicated patients ( N = 123) were administered the Conners' Continuous Performance Test II (CPT II) at baseline and after 6 weeks of treatment with immediate-release MPH. In addition to traditional CPT measures, we extracted intraindividual raw data and analyzed time series using linear and nonlinear mathematical models...
February 14, 2019: Journal of Attention Disorders
Susan Reutman, Renee Lewis
Motivating employees to increase their physical activity is a health promotion challenge. A Move-A-Thon (MAT) event approach was implemented as an alternative incentive to help workers to optimize their physical activity levels. We implemented a demonstration project in which workers were incentivized for their participation through monetized donations to charity. Their steps were monitored over the 2-week demonstration period. The MAT goal was for participants to achieve a minimum of 3,000 daily steps for 2 weeks, for which they could earn a total donation of up to US$20...
February 14, 2019: Workplace Health & Safety
Felipe J Núñez, Flor M Mendez, Padma Kadiyala, Mahmoud S Alghamri, Masha G Savelieff, Maria B Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Meghna Saxena, Rohin Patel, Stephen Carney, Marissa Z Guo, Marta Edwards, Mats Ljungman, Tingting Qin, Maureen A Sartor, Rebecca Tagett, Sriram Venneti, Jacqueline Brosnan-Cashman, Alan Meeker, Vera Gorbunova, Lili Zhao, Daniel M Kremer, Li Zhang, Costas A Lyssiotis, Lindsey Jones, Cameron J Herting, James L Ross, Dolores Hambardzumyan, Shawn Hervey-Jumper, Maria E Figueroa, Pedro R Lowenstein, Maria G Castro
Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1R132H ) are younger at diagnosis and live longer. IDH1 mutations co-occur with other molecular lesions, such as 1p/19q codeletion, inactivating mutations in the tumor suppressor protein 53 (TP53 ) gene, and loss-of-function mutations in alpha thalassemia/mental retardation syndrome X-linked gene ( ATRX ). All adult low-grade gliomas (LGGs) harboring ATRX loss also express the IDH1R132H mutation. The current molecular classification of LGGs is based, partly, on the distribution of these mutations...
February 13, 2019: Science Translational Medicine
Xiao Wang, Kristina Sundquist, Peter J Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A Memon, Jan Sundquist, Bengt Zöller
BACKGROUND: Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to examine whether circulating miRNAs are associated with the risk of VTE recurrence. RESULTS: A nested case-control study design was used where plasma samples were obtained from 78 patients with unprovoked VTE from the Malmö Thrombophilia Study (MATS)...
February 13, 2019: Clinical Epigenetics
Suhui Yang, Andrea Shergalis, Dan Lu, Anahita Kyani, Ziwei Lu, Mats Ljungman, Nouri Neamati
Protein disulfide isomerase (PDI) is responsible for nascent protein folding in the endoplasmic reticulum (ER) and is critical for glioblastoma survival. To improve the potency of lead PDI inhibitor BAP2 ((E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)benzonitrile), we designed and synthesized 67 novel analogues. We determined that PDI inhibition relied on the A ring hydroxyl group of the chalcone scaffold and cLogP increase in the sulfonamide chain improved potency. Docking studies revealed that BAP2 and analogues bind to His256 in the b' domain of PDI, and mutation of His256 to Ala abolishes BAP2 analogue activity...
February 13, 2019: Journal of Medicinal Chemistry
Sungwoo Chun, Wonkyeong Son, Gwangyeob Lee, Shi Hyeong Kim, Jong Woo Park, Seon Jeong Kim, Changhyun Pang, Changsoon Choi
Applications in the field of portable and wearable electronics are becoming multifunctional, and the achievement of transparent electronics extensively expands the applications into devices such as wearable flexible displays or skin-attachable mobile computers. Moreover, the self-charging power system (SCPS) is the core technique for realizing portable and wearable electronics. Here, we propose a transparent and flexible multifunctional electronic system in which both an all-in-one SCPS and a touch sensor are combined...
February 13, 2019: ACS Applied Materials & Interfaces
Omar Bari, Phillip R Cohen
Pityriasis amiantacea (PA) is a hair disorder characterized by matting of multiple hair shafts, typically occurring as an idiopathic condition. A 67-year-old woman with multiple myeloma who developed PA following a bone marrow transplant with melphalan conditioning is described.She noted initial changes in scalp hair regrowth 4 weeks posttransplant. During the next 4 months she developed multiple lesions of PA that rapidly responded to management, including mineral oil under occlusion in the evening followed by daily shampooing with alternating coal tar, salicylic acid, and ketoconazole shampoos...
January 2019: Cutis; Cutaneous Medicine for the Practitioner
Sven Le Moine Bauer, Andreas Gilje Sjøberg, Stéphane L'Haridon, Runar Stokke, Irene Roalkvam, Ida Helene Steen, Håkon Dahle
A bacterial strain, designated BAR1T , was isolated from a microbial mat growing on the surface of a barite chimney at the Loki's Castle Vent Field, at a depth of 2216 m. Cells of strain BAR1T were rod-shaped, Gram-reaction-negative and grew on marine broth 2216 at 10-37 °C (optimum 27-35 °C), pH 5.5-8.0 (optimum pH 6.5-7.5) and 0.5-5.0 % NaCl (optimum 2 %). The DNA G+C content was 57.38 mol%. The membrane-associated major ubiquinone was Q-10, the fatty acid profile was dominated by C18 : 1ω7c (91 %), and the polar lipids detected were phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, one unidentified aminolipid, one unidentified lipid and one unidentified phospholipid...
February 13, 2019: International Journal of Systematic and Evolutionary Microbiology
Saman Salim, Moncef Zarrouk, Johan Elf, Anders Gottsäter, Signy Sveinsdottir, Peter Svensson, Stefan Acosta
It is unknown whether the risk factor profile for mesenteric venous thrombosis (MVT) is different from systemic venous thromboembolism (VTE). The aim of the present population-based study was to compare acquired and inherited risk factors in MVT versus VTE. Identification of all MVT patients at Skåne University Hospital between 2000 and 2015 was performed in patient records and AuriculA (Swedish anticoagulation registry). VTE patients were retrieved from the Malmö Thrombophilia Study (MATS), including 1465 consecutive unselected VTE patients between 1998 and 2008...
February 12, 2019: Journal of Thrombosis and Thrombolysis
Christina E Rodriguez, Kaylin A Klie
Pharmacotherapy, or medication-assisted treatment (MAT), is a critical component of a comprehensive treatment plan for the pregnant woman with opioid use disorder (OUD). Methadone and buprenorphine are two types of opioid-agonist therapy which prevent withdrawal symptoms and control opioid cravings. Methadone is a long-acting mu-opioid receptor agonist that has been shown to increase retention in treatment programs and attendance at prenatal care while decreasing pregnancy complications. However methadone can only be administered by treatment facilities when used for OUD...
January 21, 2019: Seminars in Perinatology
Juste Baranauskaite, Erika Adomavičiūtė, Virginija Jankauskaitė, Mindaugas Marksa, Zita Barsteigienė, Jurga Bernatoniene
An electrospun mat of Eudragit E100 (EE100) (a cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate) was used as a delivery system for oregano ethanolic extract (OEE). Oregano is a biologically active material which is widely used because of the antibacterial and antifungal activity. The oregano herb consists of phenolic compounds, the main of which are rosmarinic acid and from essential oil-carvacrol. Such a material could be an ideal candidate for oral drug systems...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Robert J Macielak, Jameson K Mattingly, Ursula M Findlen, Aaron C Moberly, Prashant S Malhotra, Oliver F Adunka
OBJECTIVE: To evaluate the prevalence of bilateral hearing loss in children with unilateral enlarged vestibular aqueduct (EVA) at a single institution. METHODS: A retrospective case review was performed at a tertiary care pediatric referral center involving children with radiologic findings of unilateral EVA and normal labyrinthine anatomy of the contralateral ear diagnosed via CT and/or MRI. The main outcome measure of interest is the number of patients with unilateral EVA who were diagnosed with bilateral hearing loss...
January 25, 2019: International Journal of Pediatric Otorhinolaryngology
Philippe Tummers, Menekse Göker, Pernilla Dahm-Kahler, Mats Brännström, Stefan G Tullius, Xavier Rogiers, Steven Van Laecke, Steven Weyers
No abstract text is available yet for this article.
February 4, 2019: Transplantation
Chaofeng Hao, Jinrong Yin, Manli Sun, Qinhu Wang, Jie Liang, Zhuyun Bian, Huiquan Liu, Jin-Rong Xu
Ascospores are the primary inoculum in Fusarium graminearum. Interestingly, 70 of its genes have premature stop codons (PSC) and require A-to-I editing during sexual reproduction to encode full-length proteins, including the ortholog of yeast Ama1, a meiosis-specific activator of APC/C. In this study, we characterized the function of FgAMA1 and its PSC editing. FgAMA1 was specifically expressed during sexual reproduction. The Fgama1 mutant was normal in growth and perithecium formation but defective in ascospogenesis...
February 11, 2019: Molecular Microbiology
Tao Wang, Jiao Zhang, Min Hu, Yuehui Zhang, Peng Cui, Xin Li, Juan Li, Edvin Vestin, Mats Brännström, Linus R Shao, Håkan Billig
The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial dysfunction are not fully understood, and although accumulating evidence shows that the use of metformin has beneficial effects in PCOS patients, the precise regulatory mechanisms of metformin on endometrial function under PCOS conditions have only been partially explored. To address these clinical challenges, this study aimed to assess the protein expression patterns of glycolytic enzymes, estrogen receptor (ER), and androgen receptor (AR) along with differences in mitochondria-dependent apoptosis in PCOS patients with and without endometrial hyperplasia in vivo and to investigate the effects of metformin in PCOS patients with endometrial hyperplasia in vitro ...
2019: International Journal of Biological Sciences
Mira Park, Hyeon Ku Park, Hye Kyoung Shin, Dawon Kang, Bishweshwar Pant, Hang Kim, Jin-Kyu Song, Hak Yong Kim
In recent years, noise has become a serious hazard and can have permanent biological and psychological effects on humans and other organisms in nature. Textile materials are commonly used as absorbent acoustic materials for noise reduction. This work examines the use of electrospun nylon-6 and polyurethane nanofibres (PU NFs) to improve the sound absorption and sound insulation properties of polyurethane foam. In this work, nylon-6 and polyurethane nanofibres were prepared by an electrospinning technique and were glued to a polyurethane foam...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu, Amirrudin Muhammad, Tiffiny Chau Dee Ho, Bazilah Jusoh, Nor Azlina Zolkifli, Ravindran Thayan, Adiratna Mat Ripen, Murizal Zainol, Ami Fazlin Syed Mohamed
BACKGROUND: Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with DEN-2 dengue virus. METHODS: The AG129 mice were fed orally with FCPLJ for 3 consecutive days after 24 h of dengue virus inoculation...
February 11, 2019: BMC Complementary and Alternative Medicine
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