Vinai Gondi, Snehal Deshmukh, Paul D Brown, Jeffrey S Wefel, Terri S Armstrong, Wolfgang A Tome, Mark R Gilbert, Andre Konski, Clifford G Robinson, Joseph A Bovi, Tammie L S Benzinger, David Roberge, Vijayananda Kundapur, Isaac Kaufman, Sunjay Shah, Kenneth Y Usuki, Andrew M Baschnagel, Minesh P Mehta, Lisa A Kachnic
PURPOSE: Initial report of NRG Oncology CC001, a phase 3 trial of whole-brain radiation therapy plus memantine (WBRT + memantine) with or without hippocampal avoidance (HA), demonstrated neuroprotective effects of HA with a median follow-up of fewer than 8 months. Herein, we report the final results with complete cognition, patient-reported outcomes, and longer-term follow-up exceeding 1 year. METHODS AND MATERIALS: Adult patients with brain metastases were randomized to HA-WBRT + memantine or WBRT + memantine...
May 6, 2023: International Journal of Radiation Oncology, Biology, Physics