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Haifeng Zhang, Zhijiang Wang, Jing Wang, Xiaozhen Lyu, Xiao Wang, Ying Liu, Xiangzhu Zeng, Huishu Yuan, Huali Wang, Xin Yu
The present study aimed to explore the effect of computerized multi-domain cognitive training (MDCT) on brain gray matter volume and neuropsychological performance in patients with amnestic mild cognitive impairment (amnestic MCI). Twenty-one patients with amnestic MCI participated in a computerized MDCT program. The program targeted a broad set of cognitive domains via programs focused on reasoning, memory, visuospatial, language, calculation, and attention. Seventeen Participants completed the intervention and all completed a battery of neuropsychological tests to evaluate cognitive function while 12 out of 17 underwent 3 T MRI scanning before and after the intervention to measure gray matter (GM) volume...
January 31, 2019: Translational Psychiatry
Hannah E Brunet, Jessica Z K Caldwell, Jason Brandt, Justin B Miller
Sex is an important factor to consider when evaluating memory with older adults. This present study aimed to examine sex differences in memory within a clinical sample of older adults (N = 1084). Raw learning and recall scores on the Hopkins Verbal Learning Test, Revised (HVLT-R) and Brief Visuospatial Memory Test, Revised (BVMT-R) were compared between sexes within the entire sample and cohorts stratified by age. Within the entire sample, women outperformed men in HVLT-R learning and recall, and there were no sex differences in BVMT-R performance...
January 20, 2019: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Erin Trifilio, Jared J Tanner, London Butterfield, Paul Mangal, Jacqueline E Maye, Michael Marsiske, Catherine C Price, Dawn Bowers
OBJECTIVE: Many patients require repeat neuropsychological evaluations to determine change over time. Repeat evaluations lead to practice effects, which can impact the validity of the assessment. The current study assessed, in older adults, the validity of an alternative set of verbal memory stories created by Newcomer and colleagues. METHOD: A total 154 of non-demented adults, ages 60-92, completed the WMS-III logical memory (LM) stories and two Newcomer stories (Carson-Jones) as part of a larger battery of neurocognitive tests...
January 12, 2019: Clinical Neuropsychologist
Amal A Wanigatunga, Todd M Manini, Delilah R Cook, Jeffrey Katula, Roger A Fielding, Arthur F Kramer, Joe Verghese, Stephen R Rapp, Kaycee M Sink, Abby C King, Thomas W Buford, Steve Anton, Neelesh Nadkarni, Janine M Jennings, Kieran Reid, Mark A Espeland, Thomas M Gill, Marco Pahor, Joe R Nocera
Over the last few decades, considerable evidence shows that greater levels of aerobic exercise and cardiovascular fitness benefit cognitive performance. However, the degree to which free-living activity in community settings is related to cognitive performance remains unclear, particularly in older adults vulnerable to disability. Also, it is unknown whether the manner in which daily physical activity (PA) and sedentary time are accumulated throughout the day is associated with cognition. Cross-sectional associations between accelerometer-characterized PA and sedentary patterns and cognitive performance were examined in 1,274 mobility-limited older adults...
2018: Frontiers in Aging Neuroscience
Travis M Scott, Hetta Gouse, John Joska, Kevin G F Thomas, Michelle Henry, Anna Dreyer, Reuben N Robbins
The Hopkins Verbal Learning Test-Revised (HVLT-R) has been adapted for use in many different languages and in low- and middle-income countries. However, few adaptations have evaluated performance differences between home- and acquired-language administrations. The present study examined performance on an adapted HVLT-R between multilingual South Africans who chose to be tested in a home or acquired language. The HVLT-R was administered to 112 multilingual, isiXhosa as home language, Black South African adults (49% men) with no major medical, neurological, or psychiatric problems...
September 28, 2018: Applied Neuropsychology. Adult
Diego B Rebouças, Francisco Diego Rabelo-da-Ponte, Rafael Massuda, Leticia S Czepielewski, Clarissa S Gama
BACKGROUND: Verbal memory impairment may be considered an endophenotype in schizophrenia (SZ), also affecting the siblings of SZ subjects. Furthermore, the immune-inflammatory system response has an important modulatory effect on brain processes, especially on memory circuits. OBJECTIVE: Investigating the relationship between TNF-α and IL-6 and memory performance in patients with SZ, their unaffected siblings (SB) and healthy controls (HC). METHODS: 35 subjects with SZ, 36 SB, and 47 HC underwent a neurocognitive assessment for verbal memory by means of the revised Hopkins Verbal Learning Test (HVLT-R) in addition to serum cytokines analyses...
September 24, 2018: Neuroimmunomodulation
María Gómez-Gallego, Juan Gómez-García
OBJECTIVES: Chronic stress has shown to have marked effects on learning and memory. A broader understanding of these effects has special interest in the context of Alzheimer's disease (AD). This study aims to analyze the moderating effect of cognitive impairment in the relationships between stress and verbal memory performance by considering biological and psychological measures of stress. METHOD: The sample consisted of 80 AD patients and 104 healthy controls. Salivary cortisol and state anxiety was measured as stress markers...
September 24, 2018: Aging & Mental Health
Christina G Wong, Lisa J Rapport, Brooke A Billings, Virginia Ramachandran, Brad A Stach
OBJECTIVE: Research has found that adults with hearing loss perform worse on cognitive testing than adults without hearing loss; however, heavy emphasis on tests involving auditory stimuli may overdiagnose cognitive impairment among individuals with hearing loss. This study compared visual- and auditory-verbal memory tests among adults with and without hearing loss. METHOD: Forty-one adults with hearing loss (HL) and 41 age-matched adults with normal hearing (NH) completed a neuropsychological battery that included auditory and visual versions of the Hopkins Verbal Learning Testing-Revised (HVLT-R)...
September 13, 2018: Neuropsychology
Li Zhou, Ruoyun Ouyang, Hong Luo, Yating Peng, Ping Chen, Siying Ren, Guiqian Liu
The present study investigated the nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response element (ARE) signaling pathway in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome (OSAHS). Their correlation with neurocognitive impairment metrics was investigated to explore potential pathogenesis in OSAHS. Forty-eight patients with OSAHS and 28 controls underwent testing with the Epworth Sleep Scale (ESS), MATRICS Consensus Cognitive Battery (MCCB), Stroop Color and Word Test, polysomnography (PSG), and measurements of the concentration of plasma superoxide dismutase (SOD) and thioredoxin (Trx)...
2018: Oxidative Medicine and Cellular Longevity
Kathleen E Wilson, Haley Demyanovich, Leah H Rubin, Heidi J Wehring, Catherine Kilday, Deanna L Kelly
Recent literature suggests that schizophrenia is linked to an abnormal response of the immune system. Interferon-γ is a cytokine that acts as a mediator between immune stimulation and the kynurenine pathway and may be related to cognitive abilities. The objectives of the present study are to determine if serum cytokines are correlated with cognitive function differently in patients with schizophrenia compared to controls. Fourteen midlife (30-70 year-old) females with DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 13 midlife control females were analyzed...
December 2018: Psychiatric Quarterly
Fabrício Stewan Feltrin, Ana Luiza Zaninotto, Vinícius M P Guirado, Fabiola Macruz, Daniel Sakuno, Mariana Dalaqua, Luiz Gustavo Antunes Magalhães, Wellingson Silva Paiva, Almir Ferreira de Andrade, Maria C G Otaduy, Claudia C Leite
BACKGROUND AND OBJECTIVE: Diffuse axonal injury (DAI) induces a long-term process of brain atrophy and cognitive deficits. The goal of this study was to determine whether there are correlations between brain volume loss, microhaemorrhage load (MHL) and neuropsychological performance during the first year after DAI. METHODS: Twenty-four patients with moderate or severe DAI were evaluated at 2, 6 and 12 months post-injury. MHL was evaluated at 3 months, and brain volumetry was evaluated at 3, 6 and 12 months...
2018: Brain Injury: [BI]
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, David S Reynolds, Richard P Butt
The effect of PF-06372865, a subtype-selective positive allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, on chronic low back pain was investigated in a randomised, placebo- and active-controlled phase 2 clinical trial. The parallel treatment group trial consisted of a 1-week single-blind placebo run in the phase, followed by 4-week double-blind treatment. Patients were randomised to receive either PF-06372865, naproxen, or placebo twice a day for 4 weeks. The primary end point was the numerical rating score of low back pain intensity after 4 weeks of active treatment...
September 2018: Pain
Hongyan Wang, Bin Zhang, Botao Zeng, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Chunbo Li, Jijun Wang, Donald C Goff
Dopamine in the prefrontal cortex (PFC) plays an important role in cognitive performance and regulates by catechol-O-methyltransferase (COMT) expression. To clarify the effect of COMT genotype on cognitive function in patients with schizophrenia, we performed DNA genotyping, cognitive evaluations, and functional magnetic resonance imaging (fMRI) in antipsychotic-naïve patients with first-episode schizophrenia (FES) and matched healthy control subjects. We found that all cognitive domains were impaired in patients with FES compared with healthy subjects...
September 2018: Schizophrenia Research
Aistė Pranckevičienė, Vytautas Jurkuvėnas, Vytenis Pranas Deltuva, Arimantas Tamašauskas, Adomas Bunevičius
This study aimed to evaluate clinical utility of The Hopkins Verbal Learning Test-Revised (HVLT-R) for assessment of preoperative memory function in meningioma patients and to investigate prognostic value of memory assessment in predicting outcomes after meningioma excision surgery. A total of 93 meningioma patients were assessed 2-3 days preoperatively using HVLT-R, and EORTC QLQ-30 and QLQ-BN20. Functional outcome at discharge was evaluated using The Glasgow Outcome Scale. A sample of 95 healthy controls was matched to patients according to age, gender, and education...
April 4, 2018: Applied Neuropsychology. Adult
Hanan Al Rayes, Chiara Tani, Andrew Kwan, Sherief Marzouk, Kenneth Colosimo, Jorge Medina-Rosas, Ahmed Mustafa, Jiandong Su, Panos Lambiris, Marta Mosca, Zahi Touma
OBJECTIVES: To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. METHODS: This review was prepared with a protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Protocols statement. Literature search in Ovid Medline, Embase, and Psyc INFO for articles on CD in adult SLE patients was conducted. Included studies were critically appraised (Newcastle-Ottawa Evaluation Scale) and the Pooled Prevalence (PP) of CD was studied for all instruments...
October 2018: Seminars in Arthritis and Rheumatism
Jung Goo Lee, Min Kyung Park, Yeong Hoon Kim, Yang-Wook Kim, Kyubok Jin, Sung Woo Park, Mi Kyoung Seo, Young Hoon Kim
OBJECTIVE: In the current study, we investigated whether there are relations among depressive symptoms, cognitive performance and serum BDNF levels in the patients with chronic kidney disease (CKD). METHODS: Sixty patients with CKD and 65 healthy controls participated. Depressive symptoms were evaluated with Beck depression inventory (BDI) and Hamilton Depression Rating Scale (HDRS). Mini-Mental State Examination included in the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (MMSE-KC) assessment packet was used for the evaluation of overall cognitive function...
February 2018: Psychiatry Investigation
Vishnu P Murty, Rachel A McKinney, Sarah DuBrow, Maria Jalbrzikowski, Gretchen L Haas, Beatriz Luna
Contextual information is used to support and organize episodic memory. Prior research has reliably shown memory deficits in psychosis; however, little research has characterized how this population uses contextual information during memory recall. We employed an approach founded in a computational framework of free recall to quantify how individuals with first episode of psychosis (FEP, N = 97) and controls (CON, N = 55) use temporal and semantic context to organize memory recall. Free recall was characterized using the Hopkins Verbal Learning Test-Revised (HVLT-R)...
February 15, 2018: NPJ Schizophrenia
Ronald A Cohen, S Siegel, J M Gullett, E Porges, A J Woods, H Huang, Y Zhu, K Tashima, M-Z Ding
Human immunodeficiency virus (HIV) continues to have adverse effects on cognition and the brain in many infected people, despite a reduced incidence of HIV-associated dementia with combined antiretroviral therapy (cART). Working memory is often affected, along with attention, executive control, and cognitive processing speed. Verbal working memory (VWM) requires the interaction of each of the cognitive component processes along with a phonological loop for verbal repetition and rehearsal. HIV-related functional brain response abnormalities during VWM are evident in functional MRI (fMRI), though the neural substrate underlying these neurocognitive deficits is not well understood...
June 2018: Journal of Neurovirology
Erin Cassidy-Eagle, Allison Siebern, Lisa Unti, Jill Glassman, Ruth O'Hara
OBJECTIVES: Improving the sleep of older adults with mild cognitive impairment (MCI) represents a first step in discovering whether interventions directed at modifying this risk factor also have the potential to alter the cognitive decline trajectory. METHODS: A six-session, adapted version of a cognitive behavioral therapy for insomnia (CBT-I) was administered to older adults (N = 28; 14 per group) with MCI across two residential facilities. Participants were randomly assigned to either the sleep intervention or an active control group and completed a neuropsychological battery at three time points (e...
March 2018: Clinical Gerontologist
K Chase Bailey, Jason R Soble, Kathleen M Bain, Chrystal Fullen
Objective: Embedded performance validity tests (PVTs) within the Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R) were recently identified. This study aimed to further validate/replicate these embedded PVTs. Method: Eighty clinically referred veterans who underwent neuropsychological evaluation were included. Validity groups were established by passing/failing 2-3 well-validated PVTs, with 75% (n = 60) classified as valid and 25% (n = 20) noncredible...
November 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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