keyword
https://read.qxmd.com/read/38457007/learning-ratio-performance-on-a-brief-visual-learning-and-memory-test-moderates-cognitive-training-gains-in-double-decision-task-in-healthy-older-adults
#1
JOURNAL ARTICLE
Cheshire Hardcastle, Jessica N Kraft, Hanna K Hausman, Andrew O'Shea, Alejandro Albizu, Nicole D Evangelista, Emanuel M Boutzoukas, Emily J Van Etten, Pradyumna K Bharadwaj, Hyun Song, Samantha G Smith, Eric Porges, Steven T DeKosky, Georg A Hishaw, Samuel S Wu, Michael Marsiske, Ronald Cohen, Gene E Alexander, Adam J Woods
Cognitive training using a visual speed-of-processing task, called the Useful Field of View (UFOV) task, reduced dementia risk and reduced decline in activities of daily living at a 10-year follow-up in older adults. However, there was variability in the achievement of cognitive gains after cognitive training across studies, suggesting moderating factors. Learning trials of visual and verbal learning tasks recruit similar cognitive abilities and have overlapping neural correlates with speed-of-processing/working memory tasks and therefore could serve as potential moderators of cognitive training gains...
March 8, 2024: GeroScience
https://read.qxmd.com/read/38426007/investigating-amplitude-of-low-frequency-fluctuation-and-possible-links-with-cognitive-impairment-in-childhood-and-adolescence-onset-schizophrenia-a-correlation-study
#2
JOURNAL ARTICLE
Yinghui Liang, Rongrong Shao, Yanhong Xia, Yadi Li, Suqin Guo
BACKGROUND: Cognitive impairment (CI) is a distinctive characteristic of schizophrenia, with evidence suggesting that childhood and adolescence onset schizophrenia (CAOS), representing severe but rare forms of schizophrenia, share continuity with adult-onset conditions. While relationships between altered brain function and CI have been identified in adults with schizophrenia, the extent of brain function abnormalities in CAOS remains largely unknown. In this study, we employed resting-state functional magnetic resonance imaging (rs-fMRI) to investigate functional alterations in brain areas among patients with CAOS...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38424122/visual-processing-speed-and-its-association-with-future-dementia-development-in-a-population-based-prospective-cohort-epic-norfolk
#3
JOURNAL ARTICLE
Ahmet Begde, Thomas Wilcockson, Carol Brayne, Eef Hogervorst
Visual processing deficits have frequently been reported when studied in individuals with dementia, which suggests their potential utility in supporting dementia screening. The study uses EPIC-Norfolk Prospective Population Cohort Study data (n = 8623) to investigate the role of visual processing speed assessed by the Visual Sensitivity Test (VST) in identifying the risk of future dementia using Cox regression analyses. Individuals with lower scores on the simple and complex VST had a higher probability of a future dementia diagnosis HR1...
February 29, 2024: Scientific Reports
https://read.qxmd.com/read/38254919/association-study-of-a-comprehensive-panel-of-neuropeptide-related-polymorphisms-suggest-potential-roles-in-verbal-learning-and-memory
#4
JOURNAL ARTICLE
Nesli Avgan, Heidi G Sutherland, Rod A Lea, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Neuropeptides are mostly expressed in regions of the brain responsible for learning and memory and are centrally involved in cognitive pathways. The majority of neuropeptide research has been performed in animal models; with acknowledged differences between species, more research into the role of neuropeptides in humans is necessary to understand their contribution to higher cognitive function. In this study, we investigated the influence of genetic polymorphisms in neuropeptide genes on verbal learning and memory...
December 24, 2023: Genes
https://read.qxmd.com/read/38183890/the-association-of-csf-biomarkers-and-cognitive-decline-with-choroid-plexus-volume-in-early-parkinson-s-disease
#5
JOURNAL ARTICLE
Peikun He, Yuyuan Gao, Lin Shi, Yanyi Li, Yihui Qiu, Shujun Feng, Zihui Tie, Liangxu Gong, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
OBJECTIVE: This study aims to determine the link between choroid plexus (CP) volume and cognitive decline in patients with early-stage Parkinson's disease (PD) and to test whether pathological proteins in the cerebrospinal fluid (CSF) are involved in the modulation of any detrimental effects from CP volume. METHODS: Data on 95 early-stage PD patients with 5 years of follow-up were collected from the Parkinson's Progression Marker Initiative cohort. The patients were separated into three groups based on tertiles of baseline CP volume...
March 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38101486/impact-of-apolipoprotein-e-apoe-genotype-on-neurocognitive-function-ncf-in-patients-with-brain-metastasis-bm-an-analysis-of-nrg-oncology-s-rtog-0614
#6
JOURNAL ARTICLE
Jeffrey S Wefel, Snehal Deshmukh, Paul D Brown, David R Grosshans, Erik P Sulman, Jane H Cerhan, Minesh P Mehta, Deepak Khuntia, Wenyin Shi, Mark V Mishra, John H Suh, Nadia N Laack, Yuhchyau Chen, Amarinthia Amy Curtis, Joanna M Laba, Ahmed Elsayed, Anu Thakrar, Stephanie L Pugh, Deborah W Bruner
PURPOSE: Whole brain radiotherapy (WBRT) is a common treatment for brain metastases (BM) and is frequently associated with decline in neurocognitive functioning (NCF). The e4 allele of the apolipoprotein E (APOE) gene is associated with increased risk of Alzheimer's disease, and NCF decline associated with a variety of neurologic diseases and insults. APOE carrier status has not been evaluated as a risk factor for onset-time or extent of NCF impairment in patients with BM treated with WBRT...
December 13, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37949447/impact-of-integrase-strand-transfer-inhibitors-on-cognition-in-the-hailo-cohort
#7
JOURNAL ARTICLE
Jane A O'Halloran, Luis Parra-Rodriguez, Charles W Goss, Mansi Agarwal, Sarah Cooley, Kunling Wu, Elizabeth Westerhaus, Rachel Presti, Beau M Ances, Katherine Tassiopoulos, Kristine M Erlandson
BACKGROUND: Integrase inhibitors (INSTIs) have been associated with poorer cognition in people with HIV (PWH). We examined the impact of switching to INSTIs on neuropsychological (NP) outcomes in PWH 40 years of age and older. METHODS: From the AIDS Clinical Trials Group observational cohort study, HAILO, we identified PWH who switched to INSTIs, had ≥2 NP assessments before and at least 1 after switch, and maintained viral suppression while on INSTIs. NP performance was assessed with a composite score (NPZ4) including Hopkins Verbal Learning Test (HVLT-R), Digit Symbol test (DSY), Trail Making A, and Trail Making B, while adjusting for covariates and learning effects...
December 15, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/37865967/semantic-clustering-fon-common-list-learning-tasks-a-systematic-review-of-the-state-of-the-literature-and-recommendations-for-future-directions
#8
REVIEW
Jessica L Bair, Sarah D Patrick, Emily T Noyes, Andrew C Hale, Elizabeth B Campbell, Addie M Wilson, Michael T Ransom, Robert J Spencer
INTRODUCTION: On some list-learning tasks, such as the California Verbal Learning Test (CVLT) or Hopkins Verbal Learning Test (HVLT), examinees have the opportunity to group words based on semantically related categories (i.e., semantic clustering). Semantic clustering (SC) is often considered the most efficient organizational strategy and adopting SC is presumed to improve learning and memory. In addition, SC is conceptualized as reflecting higher-order executive functioning skills. Although SC measures have intuitive appeal, to date, there are no comprehensive reviews of the SC literature base that summarize its psychometric utility...
October 22, 2023: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/37814198/connecting-memory-and-functional-brain-networks-in-older-adults-a-resting-state-fmri-study
#9
JOURNAL ARTICLE
Jori L Waner, Hanna K Hausman, Jessica N Kraft, Cheshire Hardcastle, Nicole D Evangelista, Andrew O'Shea, Alejandro Albizu, Emanuel M Boutzoukas, Emily J Van Etten, Pradyumna K Bharadwaj, Hyun Song, Samantha G Smith, Steven T DeKosky, Georg A Hishaw, Samuel S Wu, Michael Marsiske, Ronald Cohen, Gene E Alexander, Eric C Porges, Adam J Woods
Limited research exists on the association between resting-state functional network connectivity in the brain and learning and memory processes in advanced age. This study examined within-network connectivity of cingulo-opercular (CON), frontoparietal control (FPCN), and default mode (DMN) networks, and verbal and visuospatial learning and memory in older adults. Across domains, we hypothesized that greater CON and FPCN connectivity would associate with better learning, and greater DMN connectivity would associate with better memory...
October 10, 2023: GeroScience
https://read.qxmd.com/read/37807489/b-79-response-time-to-derived-relations-is-related-to-episodic-memory-performance
#10
JOURNAL ARTICLE
Kylie R Kadey, Bradley J Dixon, Marci DeBrito, John L Woodard
OBJECTIVE: After two stimulus pairs with a common stimulus are presented, healthy adults readily derive multiple indirect associations between each stimulus without explicit training. Factors related to this ability to derive new associations are relatively unstudied. We investigated the effects of sex and episodic memory performance on response times (RT) for different stimulus types (letters versus symbols) during trained and derived relational responding. METHOD: Ninety-four cognitively healthy young adults were administered a relational responding (RR) task and the Hopkins Verbal Learning Test-Revised (HVLT-R) remotely via videoconferencing...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37807355/a-184-validity-of-the-infrequent-patterns-of-performance-embedded-performance-validity-indicators-in-a-mixed-clinical-sample
#11
JOURNAL ARTICLE
Adam Parks, Clare Reinhart, Eric Ecklund-Johnson, Amanda Brunette, Carrie Spresser, Ioan Stroescu
OBJECTIVE: Novel performance validity tests (PVTs) for the Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R), derived from infrequent patterns of performance (IPOP), were developed to examine invalid memory performance while reducing false positive misclassification. To examine their classification accuracy, these indicators were compared to several existing embedded PVTs in a mixed clinical sample. METHOD: A chart review was completed for 75 adult outpatients (Mean Age = 52, Range = 19-85) referred to an academic medical center outpatient clinic for neuropsychological evaluation...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37807346/a-183-novel-performance-validity-indicators-for-frequently-used-memory-tests-using-infrequent-patterns-of-memory-performance
#12
JOURNAL ARTICLE
Adam Parks, Clare Reinhart, Eric Ecklund-Johnson, Amanda Brunette, Carrie Spresser, Ioan Stroescu
OBJECTIVE: Determining performance validity is an imperative part of neuropsychological assessment in concussion management. Several existing embedded performance validity tests (PVTs) have been developed for popular measures of memory, Hopkins Verbal Learning Test Revised (HVLT-R) and Brief Visuospatial Memory Test Revised (BVMT-R). However, many PVTs utilize cognitive performance measures to classify performance invalidity, which increases the likelihood of false positives, especially in clinical populations...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37807228/a-83-associations-between-subjective-and-objective-cognition-depression-and-quality-of-life-in-men-living-with-hiv
#13
JOURNAL ARTICLE
Christopher Collette, Victor A Del Bene, Vidyulata Kamath, Alexandra Jacob, Pariya Fazeli, David E Vance
OBJECTIVE: In people living with HIV, subjective cognitive dysfunction is widely reported; however, few studies have examined the relationship between subjective cognitive functioning and performance-based measures of cognitive functioning, mood, and quality of life (QoL). METHODS: Men living with HIV (MLWH) (n = 51, mean age = 54 years, 67% Black) completed measures of subjective cognitive functioning (Cognitive Failures Questionnaire; CFQ), objective cognitive performance (HVLT-R, TMT, UFOV, WRAT-3 Reading), health-related QoL (Medical Outcomes Short-Form; SF-36), mood (CES-D), and overall QoL (Control, Autonomy, Self-Realization, and Pleasure Quality of Life Scale; CASP-19)...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37807210/a-97-anticholinergic-burden-scales-are-not-created-equal-differential-relationships-to-cognition-in-parkinson-s-disease
#14
JOURNAL ARTICLE
Lauren E Kenney, Lauren G Santos, Alyssa Ray, Alfredo A Paredes, Adrianna M Ratajska, Kara Eversole, Dawn Bowers
OBJECTIVE: Cognitive changes are common in Parkinson's disease (PD). While previous research suggests greater anticholinergic medication use relates to worse broad cognition in PD, its domain-specific relationships remain unknown. This study compared three anticholinergic scales to examine their relationship to worse memory and executive function in individuals with PD. METHOD: Participants included 493 non-demented individuals with PD (mean age = 65...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37785504/integration-of-an-app-based-cognitive-evaluation-program-into-radiosurgery-practice-outcomes-and-patient-survey-analysis-from-a-prospective-observational-study
#15
JOURNAL ARTICLE
T Kutuk, V Perez-Marrero, Y Lee, Y Odia, A La Rosa, M D Hall, H Appel, S Ramos, M Ramirez, M W McDermott, M Ahluwalia, M P Mehta, R Kotecha
PURPOSE/OBJECTIVE(S): Cognitive decline is a significant consequence of stereotactic radiosurgery (SRS) in patients with brain metastases. This is often underrecognized and understudied outside of a formal clinical trial setting as traditional methods are often logistically difficult and need specialized personnel and additional time. To address these challenges, we implemented a prospective study (NCT05504681), incorporating an innovative app-based solution to monitor patient assessments over time, collect patient data easily, and be suitable for cross-cultural use in multiple languages for monitoring post-SRS cognitive decline...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784751/predicting-neurocognitive-decline-in-multiple-brain-metastases-patients-undergoing-distributed-stereotactic-radiosurgery
#16
JOURNAL ARTICLE
Z Yang, M Chen, M Kazemimoghadam, Z Wardak, C Chukwuma, S Stojadinovic, R D Timmerman, T Dan, W Lu, X Gu
PURPOSE/OBJECTIVE(S): Stereotactic radiosurgery (SRS) is the standard of care for treating a limited number (<3) of brain metastasis (BMs), which offers reduced neurotoxicity compared to whole brain radiotherapy (WBRT). Contemporary advancements in SRS made it possible to also commonly treat multiple (>4) BMs (mBMs). Emphasizing the value of preserving quality of life (QoL) after SRS, there is an urgent need for a systematic study of potential neurocognitive decline in patients receiving SRS treatment for mBMs...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784718/quantitative-analysis-of-brainage-using-neuroimaging-data-to-estimate-radiation-induced-brain-aging-and-associations-with-cognitive-changes-in-brain-metastases-patients
#17
JOURNAL ARTICLE
M E Orr, A B Hopper, M A Salans, A Reyes, A Stasenko, P Sanghvi, C McDonald, J A Hattangadi-Gluth, R Karunamuni
PURPOSE/OBJECTIVE(S): Radiotherapy is critical in brain tumor management yet causes accelerated aging via irreparable damage to white matter, cortex, and subcortical areas. BrainAGE is an open-source machine learning tool that analyses morphology from raw quantitative structural MRI to generate a predictive 'BrainAge' value, enabling analyses of patients with neurodegenerative diseases. We assessed the utility of this algorithm in measuring brain age morphology in brain metastases patients on a clinical trial, analyzed differences in BrainAge and chronological age, and explored associations with cognitive performance...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37660439/social-cognition-and-psychosocial-functioning-in-schizophrenia-and-bipolar-disorder-theory-of-mind-as-a-key-to-understand-schizophrenia-dysfunction
#18
JOURNAL ARTICLE
Sarah Corrêa de Sales, Marieli Philippsen, Letícia Stephane de Jesus, Marcelo Alves Carriello, Pedro Henrique Pereira Alvim, Diogo Fernando Bornancin Costa, Laura Canani da Rosa, Mathias Hasse-Sousa, Letícia Sanguinetti Czepielewski, Raffael Massuda
Functional impairment is a common symptom in schizophrenia (SZ) and bipolar disorder (BD). Pharmacological treatments have limited functional recovery in both disorders. Social cognition, a cognitive process, has been associated with functioning in mental disorders. Theory of mind (ToM) is considered a key factor in understanding the social cognitive deficits in SZ and BD. Our study aimed to investigate the relationship between ToM and functioning in SZ, BD, and healthy controls (HC) and compare ToM and functioning impairments between groups...
September 1, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37530515/an-exploratory-pilot-study-of-neuropsychological-performance-in-two-huntington-disease-centers-of-excellence-clinics
#19
JOURNAL ARTICLE
M Agustina Rossetti, Kendra M Anderson, Kaitlyn R Hay, Victor A Del Bene, Andrea S Celka, Adam Piccolino, Amelia L Nelson Sheese, Melissa Huynh, Liang Zhu, Daniel O Claassen, Erin Furr Stimming, Ciaran M Considine
OBJECTIVES: To describe the characteristics of patients receiving a clinical referral for neuropsychological evaluation in two Huntington's Disease Society of America Centers of Excellence (HDSA COE). In this exploratory pilot study, we used an empirically supported clinical neuropsychological battery to assess differences in cognitive performance between premanifest and manifest HD patient groups (compared with each other and normative expectations). METHOD: Clinical data from 76 adult genetically confirmed patients referred for neuropsychological evaluations was retrospectively collected from two HDSA COEs...
August 1, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37441142/effect-of-shi-zhen-an-shen-herbal-formula-granule-in-the-treatment-of-young-people-at-ultra-high-risk-for-psychosis-a-pilot-study
#20
JOURNAL ARTICLE
Hong Zhu, Yanzhe Ning, Sisi Zheng, Sitong Feng, Linrui Dong, Hongxiao Jia
INTRODUCTION: To date, there is no conclusive evidence for early interventions on ultra-high risk (UHR) for psychosis. The Chinese herbal medicine is confirmed to be beneficial in improving psychiatric symptoms and cognitive impairments for schizophrenia patients. However, the effect of Chinese herbal medicine on treating UHR patients remains unknown. METHODS: Eighty UHR patients were recruited from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule (SZAS-HFG) combined with aripiprazole placebo or aripiprazole combined with SZAS-HFG placebo for a 12-week treatment...
2023: Frontiers in Psychiatry
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