M Hong, K R Ryan, P D Arkwright, A R Gennery, C Costigan, M Dominguez, D W Denning, V McConnell, A J Cant, M Abinun, G P Spickett, D C Swan, C S Gillespie, D A Young, D Lilic
Patients with chronic mucocutaneous candidiasis (CMC) have an unknown primary immune defect and are unable to clear infections with the yeast Candida. CMC includes patients with AIRE gene mutations who have autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), and patients without known mutations. CMC patients have dysregulated cytokine production, suggesting that defective expression of pattern recognition receptors (PRRs) may underlie disease pathogenesis. In 29 patients with CMC (13 with APECED) and controls, we assessed dendritic cell (DC) subsets and monocyte Toll-like receptor (TLR) expression in blood...
April 2009: Clinical and Experimental Immunology