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Naofumi Miyahara, Kazuhito Nii, Alberto Benazzo, Mir Alireza Hoda, Akinori Iwasaki, Walter Klepetko, Thomas Klikovits, Konrad Hoetzenecker
BACKGROUND: Recent studies have indicated that solid predominant (SP) subtype of lung adenocarcinoma (LADC) may be associated with early recurrence and worse prognosis. Hence, a systematic review and meta-analysis were performed to evaluate the association between LADC subtype and survival. METHODS: The MEDLINE, SCOPUS, Web of Science and Cochrane Libraries were reviewed for eligible studies in December 2017. Studies were included if they compared outcomes of patients with and without SP subtype in resection specimens of LADC patients after surgical treatment by using multivariate Cox regression analysis...
February 4, 2019: European Journal of Surgical Oncology
Herman T den Dekker, Kimberley Burrows, Janine F Felix, Lucas A Salas, Ivana Nedeljkovic, Jin Yao, Sheryl L Rifas-Shiman, Carlos Ruiz-Arenas, N Amin, Mariona Bustamante, Dawn L DeMeo, A John Henderson, Caitlin G Howe, Marie-France Hivert, M Arfan Ikram, Johan C de Jongste, Lies Lahousse, Pooja R Mandaviya, Joyce B van Meurs, Mariona Pinart, Gemma C Sharp, Lisette Stolk, André G Uitterlinden, Josep M Anto, Augusto A Litonjua, Carrie V Breton, Guy G Brusselle, Jordi Sunyer, George Davey Smith, Caroline L Relton, Vincent W V Jaddoe, Liesbeth Duijts
RATIONALE: We aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course. METHODS: We meta-analyzed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to Forced Expiratory Volume in 1 s (FEV1), FEV1/Forced Vital Capacity (FVC), and Forced Expiratory Flow at 75% of FVC (FEF75) at ages 7-13 years...
February 14, 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Angelo Silverio, Maria Vincenza Polito, Leonardo Pace, Federica D'Auria, Gennaro Vitulano, Massimo Scarano, Rodolfo Citro, Gennaro Galasso, Federico Piscione
BACKGROUND: The predictors of outcome in patients with de novo diagnosis of heart failure (HF) with reduced ejection fraction (HFrEF) are poorly known. METHODS AND RESULTS: All consecutive HFrEF patients admitted between October 2012 and November 2017 with their first episode of HF were scheduled for an outpatient follow-up. After 3 months, patients with confirmed HFrEF underwent Iodine-123 Meta-Iodobenzylguanidine imaging. We defined three study endpoints: HF rehospitalization, cardiac death and all-cause death...
February 13, 2019: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Yishan Wang, Huijuan Wang, Chunfang Zhang, Chao Zhang, Huqin Yang, Ruiyue Gao, Zhaohui Tong
BACKGROUND: With the development of new techniques to easily obtain lower respiratory tract specimens, bronchoalveolar lavage fluid and other lung fluids are gaining importance in pulmonary disease diagnosis. We aimed to review and summarize lung fluid biomarkers associated with acute respiratory distress syndrome diagnosis and mortality. METHODS: After searching PubMed, Embase, Web of Science, and the Cochrane Library for articles published prior to January 11, 2018, we performed a meta-analysis on biomarkers for acute respiratory distress syndrome diagnosis in at-risk patients and those related to disease mortality...
February 12, 2019: Critical Care: the Official Journal of the Critical Care Forum
Utkarsha Pathak, Naresh Chandra Gupta, Jagdish Chandra Suri
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality in developing nations. In this meta-analysis, we aimed to determine the association between indoor air pollution and risk of COPD. Database searches were conducted using indoor air pollution, biomass and COPD related terms to identify relevant articles. The eligible studies were case-control, retrospective cohort, cross-sectional studies and conducted in adults that assessed COPD using any diagnostic criteria. A total of 35 studies with 73,122 participants were included...
February 13, 2019: International Journal of Environmental Health Research
Bin Tang, Jun Wang, Lin-Lin Luo, Qiu-Gen Li, Dan Huang
BACKGROUND The 2018 Global Initiative for Chronic Obstructive Lung Disease publication suggested that the combination of bronchodilator therapy of inhaled glucocorticoid/long-acting β₂ adrenoceptor agonist is more effective in improving pulmonary function and health status in the treatment of patients with acute exacerbations than the individual components; however, it is not known whether this also the case for stable chronic obstructive pulmonary disease (COPD). The purpose of this meta-analysis was to evaluate the effectiveness of budesonide/formoterol in the maintenance and relief therapy of patients with stable COPD...
February 12, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Eun Yeong Cho, Se Yong Kim, Min-Ji Kim, Seonwoo Kim, Dong Ah Park, Kwang Ha Yoo, Yong Bum Park, Yong Il Hwang, Chin Kook Rhee, Ji Ye Jung, Hyun Lee, Hye Yun Park
Background: A single long-acting bronchodilator, ultra-long acting muscarinic antagonist (ultra-LAMA) or ultra-long acting β2 -agonist (ultra-LABA) is preferred for the initial treatment of patients with chronic obstructive pulmonary disease (COPD); however, there are few head-to-head comparative studies between the two. Here, a meta-analysis of randomized controlled trials was performed to compare the clinical efficacy between ultra-LABA and ultra-LAMA in patients with moderate-to-severe COPD...
December 2018: Journal of Thoracic Disease
Cristin Conrad, Desi Newberry
BACKGROUND: Patent ductus arteriosus (PDA) is the persistence of a fetal shunt between the pulmonary artery and the aorta. This structure normally closes in the first 3 days after birth; however, closure is delayed in up to 80% of infants born at 25 to 28 weeks of gestation. Persistent PDA results in pulmonary overcirculation and systemic hypoperfusion. PURPOSE: The purpose of this article is to review pathophysiology and treatment options for PDA. METHODS: A literature review was conducted using PubMed, CINAHL, and Google Scholar (2013-2018)...
January 31, 2019: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Hayley Barnes, Zoe Brown, Andrew Burns, Trevor Williams
BACKGROUND: Pulmonary hypertension (PH) comprises a group of complex and heterogenous conditions, characterised by elevated pulmonary artery pressure, and which left untreated leads to right-heart failure and death. PH includes World Health Organisation (WHO) Group 1 pulmonary arterial hypertension (PAH); Group 2 consists of PH due to left-heart disease (PH-LHD); Group 3 comprises PH as a result of lung diseases or hypoxia, or both; Group 4 includes PH due to chronic thromboembolic occlusion of pulmonary vasculature (CTEPH), and Group 5 consists of cases of PH due to unclear and/or multifactorial mechanisms including haematological, systemic, or metabolic disorders...
January 31, 2019: Cochrane Database of Systematic Reviews
Karoline Stentoft Larsen, Birgit Skoffer, Lisa Gregersen Oestergaard, Maurits Van Tulder, Annemette Krintel Petersen
PURPOSE: The purpose of this review was to investigate the effect of respiratory physiotherapy after lung resection on mortality, postoperative pulmonary complications (PPC), length of stay, lung volumes, and adverse events. MATERIAL AND METHODS: Randomized or quasi-randomized controlled trials were searched in CENTRAL, PubMed, EMBASE, Cinahl, PEDro, and hand searching of related studies. Various respiratory physiotherapy interventions were compared to standard care, sham treatment, or no treatment...
January 24, 2019: Physiotherapy Theory and Practice
Yongbin Lu, Ruixia Chang, Jia Yao, Xinni Xu, Yongjun Teng, Ning Cheng
OBJECTIVES: To evaluate the effectiveness of long-term treatment of statins for chronic obstructive pulmonary disease (COPD), and to answer which one is better. METHODS: General meta-analysis was performed to produce polled estimates of the effect of mortality, inflammatory factors, and lung function index in COPD patients by the search of PubMed, Web of Science, Embase, and China National Knowledge Infrastructure for eligible studies. A network meta-analysis was performed to synthetically compare the effectiveness of using different statins in COPD patients...
January 23, 2019: Respiratory Research
Neeti Rustagi, Surjit Singh, Naveen Dutt, Ashok Kuwal, Kirti Chaudhry, Shashank Shekhar, Richard Kirubakaran
Bronchoscopic lung volume reduction (BLVR) methods have emerged as a new treatment option for patients with severe emphysema. Endobronchial valves and coils have been extensively studied. This review assesses efficacy, safety, and cost effectiveness of the BLVR procedures (stent, valves, vapor ablation, endobronchial coils, lung sealant) in patients with severe emphysema. Databases were searched until October 2016, and randomized controlled trials (RCTs) comparing available BLVR procedures to standard medical care or sham bronchoscopy were included...
January 1, 2019: Turkish Thoracic Journal
Zhuhui Yuan, Yang Wang, Jim Zhang, Jiasheng Zheng, Wei Li
PURPOSE: We conducted a meta-analysis assessing clinical outcomes of radiofrequency ablation (RFA) and microwave ablation (MWA) for treating lung cancer. METHODS: Databases were searched up to 2017 to identify high-quality studies. The results were presented as pooled estimates with 95% confidence intervals (CIs). RESULTS: Fifty-three studies were included, and up to 3,432 patients were pooled. The estimated 1-, 2-, 3-, 4-, and 5-year overall survival (OS) rates were higher for RFA-treated patients compared with those treated by MWA...
January 12, 2019: Journal of the American College of Radiology: JACR
Conal Hayton, Dayle Terrington, Andrew M Wilson, Nazia Chaudhuri, Colm Leonard, Stephen J Fowler
BACKGROUND: Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We also assessed correlation with lung function, ability to distinguish diagnostic subgroups and change in response to treatment. METHODS: MEDLINE, EMBASE and Web of Science databases were searched...
January 11, 2019: Respiratory Research
Rosa Faner, Jarrett D Morrow, Sandra Casas-Recasens, Suzanne M Cloonan, Guillaume Noell, Alejandra López-Giraldo, Ruth Tal-Singer, Bruce E Miller, Edwin K Silverman, Alvar Agustí, Craig P Hersh
BACKGROUND: Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by these surrogate tissues. The aim of this study was to explore this question. METHODS: We used Weighted Gene Co-expression Network Analysis (WGCNA) to identify shared pathological mechanisms across four COPD gene-expression datasets: two sets of lung tissues (L1 n = 70; L2 n = 124), and one each of induced sputum (S; n = 121) and peripheral blood (B; n = 121)...
January 8, 2019: Respiratory Research
Gao Zhen, Liu Yingying, Dong Jingcheng
BACKGROUND: Traditional Chinese medicine (TCM) is commonly used to combine with pharmacotherapy for stable chronic obstructive pulmonary disease (COPD) in China and other Asian countries such as South Korea and Japan. The objective of this systematic review is to evaluate the efficacy and safety of tonifying kidney therapy (Bushen, TK) for stable COPD. METHODS: Randomized controlled trials (RCTs) of TK for stable COPD were searched from 4 databases including Pubmed, the Cochrane library, CBM (China Biology Medicine disc, CBMdisc), CNKI (China National Knowledge Infrastructure) from inception to December 2017...
December 2018: Medicine (Baltimore)
K H C Li, J C S Ho, B Recaldin, M Gong, J Ho, G Li, T Liu, W K K Wu, M C S Wong, Y Xia, M Dong, G Tse
BACKGROUND AND OBJECTIVES: Heart and lung transplantation is a high-risk procedure, requiring intensive immunosuppressive therapy for preventing organ rejection. Alemtuzumab, a CD52-specific monoclonal antibody, is increasingly used for induction therapy compared with conventional agents. However, there has been no systematic review comparing its efficacy with traditional therapeutic drugs. METHODS: PubMed and EMBASE were searched to October 1, 2017, for articles on alemtuzumab in cardiothoracic transplant surgery...
December 2018: Transplantation Proceedings
K H C Li, J C S Ho, B Recaldin, M Gong, J Ho, G Li, T Liu, W K K Wu, M C S Wong, Y Xia, M Dong, G Tse
BACKGROUND AND OBJECTIVES: Heart and lung transplantation is a high-risk procedure requiring intensive immunosuppressive therapy for preventing organ rejection. Alemtuzumab, a CD52-specific monoclonal antibody, is increasingly used for induction therapy compared with conventional agents. However, there has been no systematic review comparing its efficacy with traditional therapeutic drugs. METHODS: PubMed and EMBASE were searched to October 1, 2017, for articles on alemtuzumab in cardiothoracic transplant surgery...
December 2018: Transplantation Proceedings
Rahul Verma, Jackie Chiang, Hong Qian, Reshma Amin
RATIONALE: Respiratory muscle strength in children can be assessed by maximal inspiratory (MIP), expiratory (MEP), and sniff nasal inspiratory pressures (SNIP). However, previous studies involved small cohorts of healthy children and reported wide reference ranges. OBJECTIVES: To perform a systematic review to summarize existing reference ranges for MIP, MEP, and SNIP tests in healthy children and to conduct a meta-analysis to develop comprehensive prediction equations...
December 18, 2018: Annals of the American Thoracic Society
Qiukui Hao, Bi Rong Dong, Jirong Yue, Taixiang Wu, Guan J Liu
BACKGROUND: Thrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk of adverse effects of thrombolytic therapy, such as major or minor haemorrhage. This is the third update of the Cochrane review first published in 2006. OBJECTIVES: To assess the effects of thrombolytic therapy for acute pulmonary embolism...
December 18, 2018: Cochrane Database of Systematic Reviews
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