Ingrid Fricke-Galindo, Salvador García-Carmona, Jesús Alanis-Ponce, Gloria Pérez-Rubio, Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson Robles-Hernández, Rafael de Jesús Hernández-Zenteno, Daniela Valencia-Pérez Rea, Brandon Bautista-Becerril, María Elena Ramírez-Díaz, Filiberto Cruz-Vicente, María de Lourdes Martínez-Gómez, Raúl Sansores, Ramcés Falfán-Valencia
The receptor for advanced glycation end products (RAGE) and its gene ( AGER ) have been related to lung injury and inflammatory diseases, including chronic obstructive pulmonary disease (COPD). We aimed to evaluate the association of rs2071288, rs3134940, rs184003, and rs2070600 AGER single-nucleotide variants and the soluble-RAGE plasma and sputum levels with COPD secondary to biomass-burning smoke (BBS) and tobacco smoking. Four groups, including 2189 subjects, were analyzed: COPD secondary to BBS exposure (COPD-BBS, n = 342), BBS-exposed subjects without COPD (BBES, n = 774), tobacco smoking-induced COPD (COPD-TS, n = 434), and smokers without COPD (SWOC, n = 639)...
April 15, 2024: Heliyon