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REVIEW
Khanh Quang Huynh, Anh Tuan Le, Thang Thanh Phan, Toan Trong Ho, Suong Phuoc Pho, Hang Thuy Nguyen, Binh Thanh Le, Thuc Tri Nguyen, Son Truong Nguyen
BACKGROUND: MicroRNA-1246 (miR-1246), an oncomiR that regulates the expression of multiple cancer-related genes, has been attracted and studied as a promising indicator of various tumors. However, diverse conclusions on diagnostic accuracy have been shown due to the small sample size and limited studies included. This meta-analysis is aimed at systematically assessing the performance of extracellular circulating miR-1246 in screening common cancers. METHODS: We searched the PubMed/MEDLINE, Web of Science, Cochrane Library, and Google Scholar databases for relevant studies until November 28, 2022...
2023: Oxidative Medicine and Cellular Longevity
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JOURNAL ARTICLE
Kranti V Peddada, Connor M Delman, Christopher T Holland, John P Meehan, Zachary C Lum
INTRODUCTION: Controversy exists on the ideal type of fixation in total knee arthroplasty (TKA). Noncemented fixation has been theorized to improve patient outcomes and longevity of implantation without increased risk of aseptic loosening or radiolucent lines. We sought to compare (1) patient-reported outcomes, (2) survivorship, and (3) revision rates for all-cause and aseptic loosening in a noncemented tantalum total knee with its cemented counterpart. METHODS: Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were searched using a combination of keywords "trabecular metal," "tantalum knee," "total knee arthroplasty," and "cementless trabecular...
April 1, 2023: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
#23
JOURNAL ARTICLE
Anastasia Leshchyk, Qingyan Xiang, Stacy L Andersen, Anastasia Gurinovich, Zeyuan Song, Joseph H Lee, Kaare Christensen, Anatoliy Yashin, Mary Wojczynski, Karen Schwander, Thomas T Perls, Stefano Monti, Paola Sebastiani
Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging, cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs in centenarians and individuals with familial longevity is poorly understood. We used MOsaic CHromosomal Alteration (MoChA) to discover mCAs in 2050 centenarians, offspring, and 248 controls from the New England Centenarian Study (NECS) and in 3642 subjects with familial longevity and 920 spousal controls from the Long-Life Family Study (LLFS)...
March 29, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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JOURNAL ARTICLE
Gerben J Westerhof, Abigail M Nehrkorn-Bailey, Han-Yun Tseng, Allyson Brothers, Jelena Sophie Siebert, Susanne Wurm, Hans-Werner Wahl, Manfred Diehl
This article updates and extends an earlier meta-analysis (Westerhof et al., 2014) on the longitudinal effects of subjective aging (SA) on health outcomes. A systematic search in different databases (APA PsycInfo, PubMed, Web of Science, and Scopus) resulted in 99 articles, reporting on 107 studies. Participants: Studies had a median sample size of 1,863 adults with a median age of 66 years. A randomized effect meta-analysis showed a significant, small effect (likelihood ratio = 1.347; 95% confidence interval [1...
March 27, 2023: Psychology and Aging
#25
JOURNAL ARTICLE
Shanquan Chen, Yuqi Wang
BACKGROUND: In China, improving mental health has been far behind its accomplishments for other diseases. With depression as one of the most prevalent mental disorders, the aim of this study was to evaluate temporal trends in the prevalence and treatment of those who screen positive for depression in China, by age, gender, and province. METHODS: We used data from three nationally representative sample surveys: the China Health and Retirement Longitudinal Study (CHARLS), the China Family Panel Studies (CFPS), and the Chinese Longitudinal Healthy Longevity Survey (CLHLS)...
2023: Frontiers in Psychiatry
#26
JOURNAL ARTICLE
Lingxuan Li, Shin Murakami
Current research on the angiotensin-converting-enzyme ( ACE ) gene has yielded controversial results on whether different ACE polymorphisms are linked with human longevity. ACE polymorphisms are a risk factor for Alzheimer's disease and age-onset diseases that may contribute to the mortality of older people. Our goal is to consolidate existing studies, using artificial intelligence-assisted software to come to a more precise understanding of the role of the ACE gene in human longevity. The I (insertion) and D (deletion) polymorphisms in the intron are correlated with the levels of circulating ACE; homozygous D (DD) is high, and homozygous I (II) is low...
February 8, 2023: International Journal of Molecular Sciences
#27
JOURNAL ARTICLE
Justin R Eastwood, Andréaz Dupoué, Kaspar Delhey, Simon Verhulst, Andrew Cockburn, Anne Peters
Suboptimal conditions during development can shorten telomeres, the protective DNA caps on the end of chromosomes. Shorter early-life telomere length (TL) can indicate reduced somatic maintenance, leading to lower survival and shorter lifespan. However, despite some clear evidence, not all studies show a relationship between early-life TL and survival or lifespan, which may be due to differences in biology or study design (e.g., survival period measured). In superb fairy-wrens (Malurus cyaneus), we assessed whether early-life TL predicts mortality across different life-history stages (fledgling, juvenile, adult)...
February 22, 2023: Molecular Ecology
#28
JOURNAL ARTICLE
Mohamad D Bairakdar, Ambuj Tewari, Matthias C Truttmann
Aging is a ubiquitous biological process that limits the maximal lifespan of most organisms. Significant efforts by many groups have identified mechanisms that, when triggered by natural or artificial stimuli, are sufficient to either enhance or decrease maximal lifespan. Previous aging studies using the nematode Caenorhabditis elegans (C. elegans) generated a wealth of publicly available transcriptomics datasets linking changes in gene expression to lifespan regulation. However, a comprehensive comparison of these datasets across studies in the context of aging biology is missing...
March 2023: Experimental Gerontology
#29
JOURNAL ARTICLE
Fabian Hellbach, Lucy Sinke, Ricardo Costeira, Sebastian-Edgar Baumeister, Marian Beekman, Panayiotis Louca, Emily R Leeming, Olatz Mompeo, Sarah Berry, Rory Wilson, Nina Wawro, Dennis Freuer, Hans Hauner, Annette Peters, Juliane Winkelmann, Wolfgang Koenig, Christa Meisinger, Melanie Waldenberger, Bastiaan T Heijmans, P Eline Slagboom, Jordana T Bell, Jakob Linseisen
PURPOSE: Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation. METHODS: Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated...
December 26, 2022: European Journal of Nutrition
#30
JOURNAL ARTICLE
Ruttana Phetsitong, Patama Vapattanawong, Rosie Mayston, Martin Prince, Kia-Chong Chua
Caregivers have become older as longevity increases. Caregiving for older people can cause burdens and psychological morbidity, which are the chronic stresses perceived by informal caregivers. This study aimed to compare the levels of care burden and psychological morbidity between older and younger caregivers in low- and middle-income countries. A cross-sectional survey was conducted in Cuba, the Dominican Republic, Peru, Venezuela, Mexico, Puerto Rico, and China. Data were collected by the 10/66 Dementia Research Group...
December 7, 2022: International Journal of Environmental Research and Public Health
#31
JOURNAL ARTICLE
Yvonne Leung, Nir Barzilai, Agnieszka Batko-Szwaczka, Nina Beker, Kathrin Boerner, Carol Brayne, Henry Brodaty, Karen Siu-Lan Cheung, María M Corrada, John D Crawford, Alessia A Galbussera, Yasuyuki Gondo, Henne Holstege, Marc Hulsman, Yoshiko Lily Ishioka, Daniela Jopp, Claudia H Kawas, Jeff Kaye, Nicole A Kochan, Bobo Hi-Po Lau, Darren M Lipnicki, Jessica W Lo, Ugo Lucca, Steve R Makkar, Gabriella Marcon, Peter Martin, Kenichi Meguro, Sofiya Milman, Leonard W Poon, Angela Recchia, Oscar Ribeiro, Emma Riva, Christoph Rott, Sietske Am Sikkes, Ingmar Skoog, Blossom Stephan, Jan Szewieczek, Laetitia Teixeira, Mauro Tettamanti, Krzysztof Wilczyński, Perminder Sachdev
INTRODUCTION: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. METHODS: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. RESULTS: The mean age was 98...
December 1, 2022: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#32
REVIEW
Xiaoyong Han, Rangyin Zhao, Yongfeng Wang, Haizhong Ma, Miao Yu, Xiaohong Chen, Dongzhi Zhang, Shixun Ma, Bin Liu, Hui Cai
BACKGROUND: According to relevant clinical research, dietary and circulating antioxidants vitamin A are connected with the risk of breast, cervical, and ovarian cancer in women. However, there was inconsistency between the findings. We completed this meta-analysis at the right moment to address this contradiction of the problem. METHODS: Web of Science, Embase, and PubMed databases were searched using the proposed search strategy and filtered using the inclusion and exclusion criteria as well as the NOS quality score...
2022: Oxidative Medicine and Cellular Longevity
#33
REVIEW
Rubén López-Bueno, Lars Louis Andersen, Ai Koyanagi, Rodrigo Núñez-Cortés, Joaquín Calatayud, José Casaña, Borja Del Pozo Cruz
BACKGROUND: While handgrip strength is associated with all-cause and cause-specific mortality, whether such associations are dose-dependent is largely unknown. Therefore, we conducted a systematic review on the dose-response relationship of handgrip strength with all-cause mortality, cancer, and cardiovascular mortality. METHODS: The data source included three electronic databases (PubMed/MEDLINE, Web of Science and Scopus) from inception to 8 February 2022. Prospective cohort studies of healthy adults with objective measures of handgrip strength were included...
November 1, 2022: Ageing Research Reviews
#34
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Benign prostatic hyperplasia is a common urological disease affecting older men worldwide, but comprehensive data about the global, regional, and national burden of benign prostatic hyperplasia and its trends over time are scarce. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated global trends in, and prevalence of, benign prostatic hyperplasia and disability-adjusted life-years (DALYs) due to benign prostatic hyperplasia, in 21 regions and 204 countries and territories from 2000 to 2019...
November 2022: The Lancet. Healthy longevity
#35
JOURNAL ARTICLE
Suraj Samtani, Gowsaly Mahalingam, Ben Chun Pan Lam, Darren M Lipnicki, Maria Fernanda Lima-Costa, Sergio Luís Blay, Erico Castro-Costa, Xiao Shifu, Maëlenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Röhr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary Ganguli, Erin Jacobsen, Tiffany F Hughes, Michael Crowe, Tze Pin Ng, Jane Maddock, Anna Marseglia, René Mélis, Dorota Szcześniak, Henrik Wiegelmann, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S Sachdev, Henry Brodaty
BACKGROUND: Poor social connections (eg, small networks, infrequent interactions, and loneliness) are modifiable risk factors for cognitive decline. Existing meta-analyses are limited by reporting aggregate responses, a focus on global cognition, and combining social measures into single constructs. We aimed to investigate the association between social connection markers and the rate of annual change in cognition (ie, global and domain-specific), as well as sex differences, using an individual participant data meta-analysis...
October 20, 2022: The Lancet. Healthy longevity
#36
REVIEW
Fei Xie, Shichao Li, Yao Fan, Wusheng Li, Qijun Lv, Xin Sun, Yingshuang Chen, Xiangdong Yang
Objective: To systematically assess effectiveness and safety of Bifidobacterium quadruple viable bacteria combined with mesalamine against ulcerative colitis (UC) in the Asian population. Methods: An electronic search was conducted in PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases for a random collection of controlled trials of Bifidobacterium quadruple viable bacteria combined with mesalamine against UC. Following data screening and extraction, a Cochrane risk assessment tool was adopted to evaluate the quality of the included studies, and RevMan 5...
2022: Oxidative Medicine and Cellular Longevity
#37
JOURNAL ARTICLE
James F Mbinta, Binh P Nguyen, Prosper Mandela A Awuni, Janine Paynter, Colin R Simpson
BACKGROUND: Given the substantial impact of herpes zoster on health and quality of life, and its considerable economic burden, prevention through vaccination is a priority. We aimed to evaluate the effectiveness of the herpes zoster vaccines (recombinant zoster vaccine [RZV] and zoster vaccine live [ZVL]) against incident herpes zoster and postherpetic neuralgia in older adults. METHODS: We did a systematic review and meta-analysis of studies assessing the effectiveness of herpes zoster vaccines in adults aged 50 years or older, compared with no vaccination or another vaccine...
April 2022: The Lancet. Healthy longevity
#38
JOURNAL ARTICLE
Jinyuan Wang, Biyun Liao, Changsheng Wang, Ou Zhong, Xiaocan Lei, Yuli Yang
Purpose: This systematic review and meta-analysis aim at elucidating the heterogeneity in beneficial effects of antioxidant supplementation in obese adults by exploring the differential effects of antioxidant supplementation on basic indicators of obesity, lipid metabolism, systemic antioxidant capacity, inflammatory biomarkers, and liver function. Methods: The inclusion criteria specified randomized controlled trials with antioxidant intervention for adults (mean body mass index (BMI) > 30), from inception to Aug...
2022: Oxidative Medicine and Cellular Longevity
#39
REVIEW
Ai-Fang Zhou, Ke Zhu, Pei-Min Pu, Zhuo-Yao Li, Ya-Yun Zhang, Bing Shu, Xue-Jun Cui, Min Yao, Yong-Jun Wang
Ischemic stroke, the most common type of stroke, can lead to a long-term disability with the limitation of effective therapeutic approaches. Ginsenoside-Rd (G-Rd) has been found as a neuroprotective agent. In order to investigate and discuss the neuroprotective function and underlying mechanism of G-Rd in experimental animal models following cerebral ischemic/reperfusion (I/R) injury, PubMed, Embase, SinoMed, and China National Knowledge Infrastructure were searched from their inception dates to May 2022, with no language restriction...
2022: Oxidative Medicine and Cellular Longevity
#40
JOURNAL ARTICLE
Rui Zhao, Sixin Liu, Yiming Liu, Shuxia Cui
Background: Peri-implant mucositis (PiM) is characterized as a reversible inflammatory change of the peri-implant soft tissues without alveolar bone loss or continuing marginal bone loss. Without proper control of PiM, the reversible inflammation may advance to peri-implantitis (PI). Mechanical debridement (MD) by the implant surface is the most common and conventional nonsurgical approach to treat PiM but with limitations in complete resolution of diseases. For more than a decade, chlorhexidine (CHX) and active compounds has been investigated in the treatment of PiM...
2022: Oxidative Medicine and Cellular Longevity
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