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Acute Myocardial Infarctation

Alessandra V L Quidim, Tatiana Bruno, Paola Caroline Lacerda Leocádio, Itamar S Santos, Jacqueline Isaura Alvarez-Leite, Penélope Lacrísio Dos Reis Menta, Paulo A Lotufo, Isabela M Benseñor, Alessandra C Goulart
INTRODUCTION: We aimed to analyze the association of nitrotyrosine (N-TYR) levels and long-term survival in an ongoing coronary heart disease (CHD) prospective cohort, the Acute Coronary Syndrome Registry Strategy (ERICO study). METHODS: N-TYR levels collected during acute and subacute phase from onset of acute coronary syndrome (ACS) symptoms (myocardial infarction and unstable angina) were evaluated in 342 patients. We calculated case-fatality rates (180-days, 1 year, 2 years and 4 years) and survival analyses up to 4 years using Kaplan-Meier curves and Cox regression with respective cumulative hazard ratios (95% confidence interval; 95%CI), according to N-TYR tertiles up to 4 years of follow-up...
February 15, 2019: Clinical Biochemistry
Nienke M Nota, Chantal M Wiepjes, Christel J M de Blok, Louis J G Gooren, Baudewijntje P C Kreukels, Martin den Heijer
In hypogonadal/postmenopausal individuals, hormone therapy has been associated with an increased risk for cardiovascular events (CVEs). A steeply growing population that often receives exogenous hormones are transgender individuals. While transgender individuals hypothetically have an increased risk of CVEs, there is little known about the occurrence of CVEs in this population(1). Therefore, we determined the incidences of acute/spontaneous strokes (ischemic/haemorrhagic, transient ischemic attack, or subarachnoid haemorrhage), myocardial infarctions (MIs), and venous thromboembolic events (VTEs) in transwomen and transmen receiving transgender hormone therapy (THT)...
February 18, 2019: Circulation
Deliang Shen, Zhenhua Li, Shiqi Hu, Ke Huang, Teng Su, Hongxia Liang, Feiran Liu, Ke Cheng
Stem cell therapies have shown promise in treating acute and chronic ischemic heart disease. However, current therapies are limited by the low retention and poor integration of injected cells in the injured tissue. Taking advantage of the natural infarct-homing ability of platelets, we engineered CD34 antibody-linked platelets (P-CD34) to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart. In vitro, P-CD34 could bind to damaged aortas and capture endogenous stem cells in whole blood...
February 18, 2019: Nano Letters
Mehdi Rahnavard, Mehdi Hassanpour, Mahdi Ahmadi, Morteza Heidarzadeh, Hassan Amini, Masoumeh Zirak Javanmard, Mohammad Nouri, Reza Rahbarghazi, Nasser Safaie
Cardiovascular diseases are the main cause of death globally. Many attempts have been done to ameliorate the pathological changes after the occurrence of myocardial infarction. Curcumin is touted as a polyphenol phytocompound with appropriate cardioprotective properties. In this study, the therapeutic effect of curcumin was investigated on acute myocardial infarction in the model of rats. Rats were classified into four groups; control, isoproterenol hydrochloride (ISO) (100 mg/kbw), curcumin (50 mg/kbw), and curcumin plus ISO treatment groups...
February 18, 2019: Journal of Cellular Biochemistry
Kevin P Liou, Sze-Yuan M Ooi, Stephen P Hoole, Nick E J West
Background: The utility of fractional flow reserve (FFR) to guide revascularisation in the management of acute coronary syndrome (ACS) remains unclear. Objective: This study aims to compare the clinical outcomes of patients following FFR-guided revascularisation for either ACS or stable angina (SA) and in particular focuses on the outcome of those with deferred revascularisation after FFR. Methods: A meta-analysis of existing literature was performed...
2019: Open Heart
Yu Du, Yingxin Zhao, Yong Zhu, Chenping Hu, Jianwei Zhang, Qingwei Ji, Wei Liu, Hongya Han, Lixia Yang, Dai Zhang, Shan Tong, Zhijian Wang, Yonghe Guo, Xiaoli Liu, Yujie Zhou
AIM: Several members of secreted frizzled-related protein (SFRP) are involved in the process of myocardial ischemia-reperfusion injury. However, little is known about the role of SFRP5 in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: In this cross-sectional study, 85 patients with first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 patients without coronary artery disease (CAD) were enrolled...
February 15, 2019: Journal of Atherosclerosis and Thrombosis
Ryusuke Miki, Masato Takeuchi, Takumi Imai, Tomotsugu Seki, Shiro Tanaka, Masaki Nakamura, Koji Kawakami
BACKGROUND: An admission to the intensive care unit (ICU) after developing acute myocardial infarction (AMI) has been the standard of care and is recommended by professional societies. However, evidence that justifies its use, such as a reduction in mortality, has never been shown despite the associated financial burden. This study aimed to investigate the association between ICU admission and a reduction in 30-day mortality in patients who developed AMI. METHODS: The multicenter retrospective cohort study was conducted using data from an administrative database between 2014 and 2016 in Japan...
February 14, 2019: Journal of Cardiology
Julio O Cabrera-Rego, Raúl A Escobar-Torres, Juan D Parra-Jiménez, Juan Valiente-Mustelier
OBJECTIVE: To determine the relation between epicardial fat thickness and coronary in-stent restenosis in patients with acute myocardial infarction and percutaneous coronary intervention. METHODS: A prospective study was conducted, which included 129 patients (67.3% male, mean age 62.9±10 years) with ST segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention with bare metal stent. Patients were divided in two groups according to the presence (n=21) or not (n=108) of in-stent restenosis during one year follow-up...
February 14, 2019: Clínica e Investigación en Arteriosclerosis
Mahek Shah, Shantanu Patil, Soumya Patnaik, Manyoo Agrawal, Brijesh Patel, Byomesh Tripathi, Ulrich Jorde, Carl Lavie
We reviewed 54,044 adult cases of cardiogenic shock (CS) accompanying acute coronary syndrome from the 2005 to 2014 Nationwide Inpatient Sample. We evaluated outcomes among patients who were nonobese, obese (body mass index 30.0 to 39.9 kg/m2 ) and extremely-obese (body mass index ≥40 kg/m2 ). A multivariate analysis was performed to assess their impact on in-hospital mortality. There were 3,602 (6.6%) and 1,610 (2.9%) admissions among patients who were obese and extremely-obese. Those obese and extremely-obese were younger compared with the nonobese (62...
January 24, 2019: American Journal of Cardiology
Sophie Z Gu, Benjamin Beska, Danny Chan, Dermot Neely, Jonathan A Batty, Jennifer Adams-Hall, Helen Mossop, Weiliang Qiu, Vijay Kunadian
Background Dementia is a growing health burden of an aging population. This study aims to evaluate the prevalence of cognitive impairment and the predictors of cognitive decline at 1 year in older patients with non-ST-elevation acute coronary syndrome undergoing invasive care. Methods and Results Older patients with non-ST-elevation acute coronary syndrome were recruited into the ICON1 study. Cognition was evaluated using Montreal Cognitive Assessment. The composite major adverse cardiovascular events comprised death, myocardial infarction, unplanned revascularization, stroke, and significant bleeding at 1 year...
February 19, 2019: Journal of the American Heart Association
Zhonglin Liu, Christy Barber, Akash Gupta, Li Wan, Young-Wook Won, Lars R Furenlid, Qin Chen, Ankit A Desai, Ming Zhao, David A Bull, Evan C Unger, Diego R Martin
INTRODUCTION: The objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using 99m Tc-duramycin SPECT imaging. METHODS: Rat hearts with Ischemia-reperfusion (I/R) was prepared by coronary ligation for 45-min followed by reperfusion. The feasibility of 99m Tc-duramycin in detecting myocardial I/R injury and its kinetic profile were first verified in the ischemic hearts with 2-h reperfusion (n = 6)...
January 17, 2019: Nuclear Medicine and Biology
Sumayya Shahzad, Somaiya Mateen, Asif Hasan, Shagufta Moin
BACKGROUND: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. OBJECTIVE: The present study was designed to assess the degree of oxidative stress and inflammation in correlation with GRACE (Global Registry of Acute Coronary Events) risk score in patients of MI...
February 10, 2019: Immunobiology
Taciana Pereira Sant'Ana Santos, Mariana de Menezes Pereira, Maria Isabel Schinoni, Geraldo Pedral Sampaio, Roque Aras, Maria Luiza Sousa Atta, Ajax M Atta
There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Twenty-six CHC patients, 35 individuals with atherosclerosis (Athero) and 27 healthy individuals were examined for risk factors for CVD, lipid profile, atherogenic risk indexes, and insulin resistance (IR)...
February 13, 2019: Cytokine
Hans-Josef Feistritzer, Ingo Eitel, Alexander Jobs, Suzanne de Waha-Thiele, Thomas Stiermaier, Mohamed Abdel-Wahab, Philipp Lurz, Sebastian J Reinstadler, Martin Reindl, Gert Klug, Bernhard Metzler, Steffen Desch, Holger Thiele
Data derived from several studies suggest a better survival in smokers with acute myocardial infarction, a phenomenon referred to as the 'smoker's paradox'. We aimed to investigate the association of smoking with cardiac magnetic resonance (CMR) imaging determined infarct severity and major adverse cardiac events (MACE) defined as the occurrence of death, reinfarction, and congestive heart failure at 12 months in patients with non-ST-elevation myocardial infarction (NSTEMI) reperfused by early percutaneous coronary intervention (PCI)...
February 15, 2019: International Journal of Cardiovascular Imaging
Laura J Davidson, Charles J Davidson
The optimal revascularization strategy for CAD in the TAVR population is not well-defined and decisions about which patients require PCI have been largely operator dependent or based on SYNTAX score. In a TAVR population, complete revascularization does not improve short or long term mortality, but is associated with decreased acute myocardial infarction and revascularization, when compared with incomplete revascularization. Future prospective studies should evaluate revascularization strategies in TAVR patients, including considering functional lesion assessment with fractional flow reserve, especially as TAVR indications are likely to soon expand to a younger and healthier cohort...
February 15, 2019: Catheterization and Cardiovascular Interventions
Allison B Hall, Emmanouil S Brilakis
Saphenous vein graft (SVG) percutaneous coronary intervention carries high rates of acute (no reflow and periprocedural myocardial infarction) and long-term (restenosis and re-occlusion) complications. Long-term follow-up from the two largest trials of drug-eluting vs. bare metal stents in SVG lesions (The Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein graft Angioplasty and Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts? Trial) definitely show no difference between the two stent types, suggesting that bare metal stents should be preferred given lower cost...
February 15, 2019: Catheterization and Cardiovascular Interventions
Choongki Kim, Dong-Ho Shin, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Juhee Park, Hyeyeong Lee, Dong-Sook Kim, Sang-Kwon Oh, Yangsoo Jang
BACKGROUND: Ticagrelor has been widely accepted in clinical practice for treatment of acute myocardial infarction (AMI), however its clinical safety and efficacy have not been revealed sufficiently in Asian populations. METHODS AND RESULTS: Among a total 20,270 patients (age <75 years) with AMI undergoing percutaneous coronary intervention who received dual antiplatelet therapy for at least 30 days, clinical outcomes at 1 year were assessed from the database of Health Insurance Review and Assessment Service in Korea between 2013 and 2014...
March 2019: Journal of Cardiology
Anna Lisowska, Przemysław Święcki, Małgorzata Knapp, Monika Gil, Włodzimierz J Musiał, Karol Kamiński, Tomasz Hirnle, Agnieszka Tycińska
PURPOSE: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI)...
February 12, 2019: Advances in Medical Sciences
Arthelma C Tyson, Shailraj Parikh, Kuldeep Singh, Saqib Zia, Jonathan S Deitch, Jonathan A Schor
BACKGROUND: Routine laboratory testing to rule out myocardial infarction (MI) after carotid endarterectomy (CEA) is common in many centers. Its utility in this patient population has not been thoroughly investigated. We hypothesize that routine testing for MI in post-CEA patients is of low-yield and not cost-effective. METHODS: A retrospective review of 291 consecutive CEAs from February, 2011 to July, 2015 was performed. Two patients were excluded: one for postoperative non-cardiac death and one for preoperative MI...
February 12, 2019: Annals of Vascular Surgery
Brittanny M Polanka, Suman Kundu, Kaku A So-Armah, Matthew S Freiberg, Samir K Gupta, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Chung-Chou H Chang, Stephen S Gottlieb, Vincent C Marconi, Julie A Womack, Jesse C Stewart
BACKGROUND: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. METHODS: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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