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Nigel Rollins, Tanya Doherty
No abstract text is available yet for this article.
March 2019: Lancet Global Health
Aaron Doherty, Sinead McNicholas, Helena Burger, Paolo Boldrini, Mark Delargy
BACKGROUND: Rehabilitation facilities have among the highest prevalence of Multidrug resistant organism (MDRO) colonisation of any inpatient population.1 There is no formal consensus on how patients with MDROs should be managed in the rehabilitation setting. AIM: To assess how rehabilitation hospitals throughout Europe manage patients with MDROs, and the impact of MDRO carriage on outcomes. DESIGN: Cross-sectional study. SETTING: Online questionnaire distributed to European rehabilitation facilities POPULATION: European rehabilitation facilities METHODS: A Survey Monkey® questionnaire was designed and circulated to rehabilitation hospitals via the European Union of Medical Specialists - Physical and Rehabilitation Medicine Section...
February 15, 2019: European Journal of Physical and Rehabilitation Medicine
James J Burston, Ana M Valdes, Stephen G Woodhams, Paul I Mapp, Joanne Stocks, David J G Watson, Peter R W Gowler, Luting Xu, Devi R Sagar, Gwen Fernandes, Nadia Frowd, Laura Marshall, Weiya Zhang, Michael Doherty, David A Walsh, Victoria Chapman
Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic treatment strategies. Here, the effect of existing anxiety on future osteoarthritis (OA) pain was investigated, and potential mechanisms were studied in an animal model. Pressure pain detection thresholds, anxiety, and depression were assessed in people with (n = 130) or without (n = 100) painful knee OA...
March 2019: Pain
Jessica Pflipsen, Cian McDermott, Eva Mary Doherty, Niamh Humphries
BACKGROUND: In recent years, attrition from Emergency Medicine (EM) training in Ireland has increased. Australian data illustrates that increasing numbers of Irish-trained doctors are embarking on EM training in Australia. This has implications for EM in Ireland, particularly for Emergency Departments already under strain. An adequate supply of qualified specialist EM doctors is essential to provide high-quality patient care. AIMS: The aim of this study is to gain insights into the reasons for attrition from EM training in Ireland...
February 18, 2019: Irish Journal of Medical Science
Wesley Doherty, Pete Bridge
INTRODUCTION/BACKGROUND: Treatment-induced erectile dysfunction (ED) is a common side effect of radiotherapy and androgen deprivation therapy (ADT) that impacts on patient quality of life. Penile rehabilitation interventions including pharmacologic and physical therapies aim to reduce the impact of ED. Despite The National Institute for Health and Care Excellence guidelines recommending access to ED services, penile rehabilitation is not widely discussed or implemented. This systematic review aimed to appraise the evidence base for penile rehabilitation and identify evidence-based recommendations for practice...
March 2019: Journal of Medical Imaging and Radiation Sciences
Lauren K Macreadie, Emily J Mensforth, Ravichandar Babarao, Kristina Konstas, Shane G Telfer, Cara M Doherty, John Tsanaktsidis, Stuart R Batten, Matthew R Hill
One prominent aspect of metal organic frameworks (MOFs) is the ability to tune the size, shape and chemical characteristics of their pores. MOF-5, with its open cubic connectivity of Zn4O clusters joined by two dimensional, terephthalate linkers, is the archetypal example: both functionalized and elongated linkers produce isoreticular frameworks that define pores with new shapes and chemical environments. The recent discovery of scalable methods to produce cubane-1,4-dicarboxylic acid (1,4-H2cdc) allows the first such opportunity to explore new applications for the most prospective reticular architectures...
February 18, 2019: Journal of the American Chemical Society
S C Ring, D C Purfield, M Good, P Breslin, E Ryan, A Blom, R D Evans, M L Doherty, D G Bradley, D P Berry
Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in Republic of Ireland was the biological extinction of bTB; that purpose has yet to be achieved. Objectives of the present study were to develop the statistical methodology and variance components to undertake routine genetic evaluations for resistance to bTB; also of interest was the detection of regions of the bovine genome putatively associated with bTB infection in dairy and beef breeds...
2019: PloS One
Wesley E Barry, Erica N Barin, Lori C Marshall, Majella Doherty, Eugene Nguyen, Cory McLaughlin, Lucas Kaplan, James E Stein, Aaron R Jensen
Apprehension in taking independent care of children with medical devices may lead to unnecessary visits to the ED and/or acute clinic (AC). To address these concerns, our institution implemented a gastrostomy tube (GT) class in 2011 for caretakers. We hypothesized that inappropriate GT-related ED/AC visits would be lower in preoperatively educated caregivers. We performed a retrospective cohort study of all patients aged 0 to 18 who received GT (surgical or percutaneous) at our institution between 2006 and 2015 (n = 1340)...
October 1, 2018: American Surgeon
John U Doherty, Smadar Kort, Roxana Mehran, Paul Schoenhagen, Prem Soman, Gregory J Dehmer, John U Doherty, Paul Schoenhagen, Thomas M Bashore, Nicole M Bhave, Dennis A Calnon, Blase Carabello, John Conte, Timm Dickfeld, Daniel Edmundowicz, Victor A Ferrari, Michael E Hall, Brian Ghoshhajra, Praveen Mehrotra, Tasneem Z Naqvi, T Brett Reece, Randall C Starling, Molly Szerlip, Wendy S Tzou, John B Wong, John U Doherty, Gregory J Dehmer, Steven R Bailey, Nicole M Bhave, Alan S Brown, Stacie L Daugherty, Larry S Dean, Milind Y Desai, Claire S Duvernoy, Linda D Gillam, Robert C Hendel, Christopher M Kramer, Bruce D Lindsay, Warren J Manning, Manesh R Patel, Ritu Sachdeva, L Samuel Wann, David E Winchester, Michael J Wolk
This document is the second of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. The first document1 addresses the evaluation and use of multimodality imaging in the diagnosis and management of valvular heart disease, whereas this document addresses this topic with regard to structural (nonvalvular) heart disease...
February 7, 2019: Journal of the American Society of Echocardiography
Panagiotis Kirmizakis, Rory Doherty, Carlos A Mendonça, Ricardo Costeira, Chris C R Allen, Ulrich S Ofterdinger, Leonid Kulakov
Here, we show the electrical response, bacterial community, and remediation of hydrocarbon-contaminated groundwater from a gasworks site using a graphite-chambered bio-electrochemical system (BES) that utilizes granular activated carbon (GAC) as both sorption agent and high surface area anode. Our innovative concept is the design of a graphite electrode chamber system rather than a classic non-conductive BES chamber coupled with GAC as part of the BES. The GAC BES is a good candidate as a sustainable remediation technology that provides improved degradation over GAC, and near real-time observation of associated electrical output...
February 9, 2019: Environmental Science and Pollution Research International
Birthe Dorgau, Majed Felemban, Gerrit Hilgen, Martin Kiening, Darin Zerti, Nicola Claire Hunt, Mary Doherty, Phil Whitfield, Dean Hallam, Kathryn White, Yuchun Ding, Natalio Krasnogor, Jumana Al-Aama, Hani Z Asfour, Evelyne Sernagor, Majlinda Lako
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation. To mimic this phenomenon in vitro, tissue decellularisation approaches have been developed, resulting in the generation of natural ECM scaffolds that have comparable physical and biochemical properties of the natural tissues and are currently gaining traction in tissue engineering and regenerative therapies due to the ease of standardised production, and constant availability...
January 22, 2019: Biomaterials
Ruth Doherty
No abstract text is available yet for this article.
February 8, 2019: British Dental Journal
Joseph Barker, Karl Smith Byrne, Aiden Doherty, Charlie Foster, Kazem Rahimi, Rema Ramakrishnan, Mark Woodward, Terence Dwyer
Background: Physical inactivity is associated with an increased risk of major chronic diseases, although uncertainty exists about which chronic diseases, themselves, might contribute to physical inactivity. The objective of this study was to compare the physical activity of those with chronic diseases to healthy individuals using an objective measure of physical activity. Methods: We conducted a cross-sectional analysis of data from 96 706 participants aged 40 years or older from the UK Biobank prospective cohort study (2006-10)...
February 5, 2019: International Journal of Epidemiology
Padma Kadiyala, Dan Li, Fernando M Nuñez, David Altshuler, Robert Doherty, Rui Kuai, Minzhi Yu, Neha Kamran, Marta Edwards, James J Moon, Pedro R Lowenstein, Maria G Castro, Anna Schwendeman
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an immunosuppressive tumor microenvironment (TME), and the presence of the blood-brain barrier, which hampers the transport of chemotherapeutic compounds to the central nervous system (CNS). High-density lipoprotein (HDL)-mimicking nanodiscs hold considerable promise to achieve delivery of bioactive compounds into tumors. Herein, we tested the ability of synthetic HDL nanodiscs to deliver chemotherapeutic agents to the GBM microenvironment and elicit tumor regression...
February 11, 2019: ACS Nano
Steven Gary Noyce, James L Doherty, Zhihui Cheng, Hui Han, Shane Bowen, Aaron D Franklin
Thousands of reports have demonstrated the exceptional performance of sensors based on carbon nanotube (CNT) transistors, with promises of transformative impact. Yet, the effect of long-term bias stress on individual CNTs, critical for most sensing applications, has remained uncertain. Here we report bias ranges under which CNT transistors can operate continuously for months or more without degradation. Using a custom characterization system, the impacts of defect formation and charge traps on the stability of CNT-based sensors under extended bias are determined...
February 5, 2019: Nano Letters
Ruairi P McDonnell, John V O' Doherty, Bernadette Earley, Anne Marie Clarke, David A Kenny
Background: Previous research in both calves and other species has suggested n -3 polyunsaturated fatty acids (PUFA) and β-glucans may have positive effects on immune function. This experiment measured performance, behaviour, metabolite and immunological responses to pre-weaning supplementation of dairy bull calves with n -3 PUFA in the form of fish oil and β-glucans derived from seaweed extract. 44 Holstein Friesian bull calves, aged 13.7 ± 2.5 d and weighing 48.0 ± 5.8 kg were artificially reared using an electronic feeding system...
2019: Journal of Animal Science and Biotechnology
Laura J Bailey, Julie Bianchi, Aidan J Doherty
Eukaryotic Primase-Polymerase (PrimPol) is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures. To elucidate the cellular requirements for PrimPol in human cells, we generated PrimPol-deleted cell lines and show that it plays key roles in maintaining active replication in both the nucleus and mitochondrion, even in the absence of exogenous damage. Human cells lacking PrimPol exhibit delayed recovery after UV-C damage and increased mutation frequency, micronuclei and sister chromatin exchanges but are not sensitive to genotoxins...
January 31, 2019: Nucleic Acids Research
Clare White, Simon I R Noble, Max Watson, Flavia Swan, Victoria L Allgar, Eoin Napier, Annmarie Nelson, Jayne McAuley, Jennifer Doherty, Bernadette Lee, Miriam J Johnson
BACKGROUND: The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current international thromboprophylaxis guidance is applicable to this population. We aimed to determine prevalence and predictors of femoral deep vein thrombosis in patients admitted to specialist palliative care units (SPCUs). METHODS: We did this prospective longitudinal observational study in five SPCUs in England, Wales, and Northern Ireland (four hospices and one palliative care unit)...
February 2019: Lancet Haematology
K Ismail, K Stewart, K Ridge, E Britneff, R Freudenthal, D Stahl, P McCrone, C Gayle, A M Doherty
AIMS: We examined the effectiveness of a service innovation, Three Dimensions for Diabetes (3DFD), that consisted of a referral to an integrated mental health, social care and diabetes treatment model, compared with usual care in improving biomedical and health economic outcomes. METHODS: Using a non-randomized control design, the 3DFD model was offered in two inner-city boroughs in London, UK, where diabetes health professionals could refer adult residents with diabetes, suboptimal glycaemic control [HbA1c ≥ 75 mmol/mol (≥ 9...
February 1, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
Devon M Kollmyer, Kyla E Wright, Nicole M Warner, Michael J Doherty
Mortality associated with cannabis used for treatment of epilepsy is not well documented. We discuss two fatalities in the setting of epilepsy and self-determined therapy with cannabis (SDTC). One patient had probable sudden unexpected death in epilepsy, the second death was due to seizure-associated drowning. Both directed SDTC over conventional anti-seizure medications. Where recreational cannabis is legal, decisions to use cannabis are often self-directed and independent of physician advice of cannabis risks, in part because physicians may not be aware of the risk of SDTC...
2019: Epilepsy & Behavior Case Reports
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