Dmitry Mitin, Friedemann Bullinger, Sergey Dobrynin, Jörn Engelmann, Klaus Scheffler, Mikhail Kolokolov, Olesya Krumkacheva, Kai Buckenmaier, Igor Kirilyuk, Alexey Chubarov
In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between the target tissue and background. Several promising approaches have been developed to increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced MRI (OMRI). In this study, a macromolecular construct based on human serum albumin and nitroxyl radicals (HSA-NIT) was developed using a new synthesis method that significantly increased the modification to 21 nitroxide residues per protein...
April 5, 2024: International Journal of Molecular Sciences