Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, Takahiro Yamada, Keisuke Yamazaki, Takefusa Tarusawa, Taiyo Tanba, Tatsuya Mikami, Atsushi Matsubara, Yasuyuki Ishibashi, Kenichi Hakamada, Shigeyuki Nakaji
Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small fibre neuropathy. These findings suggest that various metabolic changes may be involved in small fibre neuropathy. Herein, we explored the correlation between pain sensation and changes in plasma metabolites in healthy Japanese subjects. The pain threshold evaluated from the intraepidermal electrical stimulation was used to quantify pain sensation in a total of 1021 individuals in the 2017 Iwaki Health Promotion Project...
2024: Brain communications