keyword
https://read.qxmd.com/read/38364957/an-account-on-the-history-of-pharmacology-in-spain
#1
EDITORIAL
Ana María Aldea-Perona, Jesús Flórez Beledo, Jesús Frías Iniesta, Antonio G García, Juan Tamargo, Francisco Zaragozá
Here we present an account on the history of pharmacology in Spain. Pharmacology as an independent science in Europe began with the creation of university chairs. Of particular relevance was the appointment in 1872 of Osswald Shmiedeberg as chairman of an Institute of Pharmacology at the University of Strassbourg, Germany. Teófilo Hernando pioneered in Spain the new emerging pharmacology at the beginning of the XX Century. He made a posdoctoral stay in the laboratory of Schmiedeberg, working on digitalis...
February 14, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38146758/a-suicide-attempt-by-ingestion-of-oleander-leaves-and-treatment-with-digoxin-specific-fab-antibody-fragments
#2
Tanja Kovačević, Branka Polić, Tatjana Ćatipović Ardalić, Davor Petrović, Luka Stričević, Maja Rogulj, Joško Markić
Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander leaves, which contain natural cardiac glycosides, and her treatment with a specific antidote. The girl presented with an oedema of the uvula indicating local toxicity, severe bradycardia, first-degree atrioventricular block, drowsiness, and vomiting. Having taken her medical history, we started treatment with atropine, intravenous infusion of dextrose-saline solution and gastroprotection, but it was not successful...
December 1, 2023: Arhiv za Higijenu Rada i Toksikologiju
https://read.qxmd.com/read/38133175/deliberate-self-poisoning-with-plants-in-southeastern-france-a-poison-center-20-year-report
#3
REVIEW
Romain Torrents, Julien Reynoard, Mathieu Glaizal, Corinne Schmitt, Katharina Von Fabeck, Audrey Boulamery, Luc de Haro, Nicolas Simon
INTRODUCTION: In a few regions of the globe, deliberate botanical intoxication may induce significant rates of toxicity and fatality. The objective of this report was to describe plant self-intoxication using the experiences of the southeastern France poison control center (PCC) between 2002 and 2021. RESULTS: During those 20 years, 262 deliberate plants poisonings were reported involving 35 various plants. In most of the cases, poisoning was caused by Nerium oleander (n = 186, 71%), followed by the Datura genus (4...
November 24, 2023: Toxins
https://read.qxmd.com/read/37558139/development-and-validation-of-a-risk-prediction-nomogram-for-serious-arrhythmias-in-acute-digoxin-toxicity-among-pediatrics-a-multicenter-study
#4
JOURNAL ARTICLE
Dina El Gameel, Asmaa Fady Sharif, Osama Shoeib, Elsayed Ibrahim Elgebally, Manar Maher Fayed
Digoxin is a cardiac glycoside obtained from the leaves of the foxglove plant, Digitalis lanata. Several studies have described the safety of digoxin in various life-threatening events, notably cardiac arrhythmias. Early identification of high-risk patients and subsequent initiation of the utmost medical care are associated with a better prognosis. The assessment of serum digoxin levels, which is not always convenient, is the only tool used to evaluate the severity of digoxin exposure. However, the feasibility of this tool, particularly in resource-restricted countries, remains unclear...
August 7, 2023: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/37465135/a-novel-module-based-method-of-teaching-electrocardiogram-interpretation-for-emergency-medicine-residents
#5
JOURNAL ARTICLE
Alexandra S Koutsoubis, Emily Fishbein, Megan Stobart-Gallagher, Behzad B Pavri, Jennifer White
AUDIENCE: This online learning module is designed for PGY 1-3 emergency medicine (EM) residents. INTRODUCTION: Interpretation of the 12-lead electrocardiogram (ECG) is an essential skill for EM residents. The traditional approach to ECG interpretation in medical school is primarily didactic, teaching: "rate, rhythm, axis," etc. Throughout residency, EM residents continue to receive lectures and practical ECG teaching to independently interpret ECGs with accuracy and efficiency...
October 2022: Journal of education & teaching in emergency medicine
https://read.qxmd.com/read/36415069/toxicological-emergencies
#6
JOURNAL ARTICLE
Syed Azharuddin, Osakpolor Ogbebor, Mareena Shuster, Bridget Smith, Hammad Arshad, Tariq Cheema
Poisoning, drug overdose, and adverse drug effects continue to be a common encounter, especially in the intensive care unit (ICU). Patients are often critically ill or have a potential to rapidly deteriorate and warrant ICU admission. Adults suffering from overdoses rarely give a complete and accurate description of the quantity or type of medications ingested. In most adult cases, multiple substances are involved. A tentative diagnosis in most overdose and poisoning cases can be made by physical examination and simple laboratory tests (electrolyte panel, creatinine, serum osmolarity, urinalysis, etc)...
January 2023: Critical Care Nursing Quarterly
https://read.qxmd.com/read/34646651/a-case-of-digoxin-toxicity-due-to-acute-renal-failure
#7
Stephanie Digiovanni-Kinsley, Brandon Duke, Richard Giovane, Cameron Paisley
Since the publication of the Digitalis Investigation Group trial in 1997, digoxin use has declined significantly. Medications such as angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) and beta-blockers that have been demonstrated to have a decrease in morbidity and mortality are prescribed in favor of digoxin. Despite the reduction in digoxin use and improved therapeutic monitoring, digoxin toxicity remains a significant cause of morbidity and mortality. When digoxin toxicity is suspected, patients should be managed with supportive care, including discontinuation of the medication, and consideration for administration of digoxin-specific antibody fragment...
August 2021: Curēus
https://read.qxmd.com/read/34441571/utilizing-big-data-to-identify-tiny-toxic-components-digitalis
#8
JOURNAL ARTICLE
Elizabeth Sage Hunter, Robert Literman, Sara M Handy
The botanical genus Digitalis is equal parts colorful, toxic, and medicinal, and its bioactive compounds have a long history of therapeutic use. However, with an extremely narrow therapeutic range, even trace amounts of Digitalis can cause adverse effects. Using chemical methods, the United States Food and Drug Administration traced a 1997 case of Digitalis toxicity to a shipment of Plantago (a common ingredient in dietary supplements marketed to improve digestion) contaminated with Digitalis lanata . With increased accessibility to next generation sequencing technology, here we ask whether this case could have been cracked rapidly using shallow genome sequencing strategies (e...
August 3, 2021: Foods (Basel, Switzerland)
https://read.qxmd.com/read/34097451/a-young-woman-with-palpitations-a-poison-or-a-remedy
#9
JOURNAL ARTICLE
Dinkar Bhasin, Rahul Kumar, Anunay Gupta
No abstract text is available yet for this article.
June 8, 2021: Circulation
https://read.qxmd.com/read/33965642/oct-findings-in-presumed-digoxin-retinal-toxicity
#10
JOURNAL ARTICLE
Pamela Capellan, M Abdallah Mahrous, Kyle D Kovacs
No abstract text is available yet for this article.
November 2021: Ophthalmology Retina
https://read.qxmd.com/read/33851916/in-vitro-and-in-vivo-antileishmanial-activity-of-%C3%AE-acetyl-digitoxin-a-cardenolide-of-digitalis-lanata-potentially-useful-to-treat-visceral-leishmaniasis
#11
JOURNAL ARTICLE
Camila S Freitas, Daniela P Lage, João A Oliveira-da-Silva, Rafaella R Costa, Débora V C Mendonça, Vívian T Martins, Thiago A R Reis, Luciana M R Antinarelli, Amanda S Machado, Grasiele S V Tavares, Fernanda F Ramos, Rory C F Brito, Fernanda Ludolf, Miguel A Chávez-Fumagalli, Bruno M Roatt, Gabriela S Ramos, Jennifer Munkert, Flaviano M Ottoni, Priscilla R V Campana, Mariana C Duarte, Denise U Gonçalves, Elaine S Coimbra, Fernão C Braga, Rodrigo M Pádua, Eduardo A F Coelho
Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileishmanial activity of β-acetyl-digitoxin (b-AD), a cardenolide isolated from Digitalis lanata leaves, assayed in vitro and in vivo against Leishmania infantum. Results showed direct action of b-AD against parasites, as well as efficacy for the treatment of Leishmania-infected macrophages...
2021: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/33605413/bidirectional-ventricular-tachycardia-in-a-young-female-a-case-of-andersen-tawil-syndrome
#12
JOURNAL ARTICLE
Jacob L Ransom, Ka C Wong, Jacqueline Kircher, Courtney Usry, Christopher Larson
Bidirectional ventricular tachycardia (VT) is a rare ventricular dysrhythmia with a limited differential diagnosis that includes digitalis toxicity, catecholaminergic polymorphic VT, aconite poisoning, and genetic channelopathy syndromes, specifically, Andersen-Tawil syndrome (ATS). We present a case of a young female with palpitations found to have bidirectional VT on cardiac event monitor and strong family history of cardiac dysrhythmias. Her physical examination findings included minor dysmorphic features of mandibular hypoplasia, hypertelorism, and clinodactyly...
February 19, 2021: Military Medicine
https://read.qxmd.com/read/33569535/transient-bilateral-chorea-secondary-to-digoxin-toxicity-in-a-female-with-acute-kidney-injury-a-case-report
#13
James Mannion, Samreen Tariq, Patrick Owens
BACKGROUND: Chorea secondary to digoxin toxicity is rare, with only three published cases describing the phenomenon. We report the case of a 78-year-old female presenting with intermittent vomiting and diarrhoea for 4 weeks. She had a history of chronic kidney disease and digoxin use for atrial fibrillation. CASE SUMMARY: A 78-year-old lady presented to the emergency department with a 4-week history of intermittent vomiting and diarrhoea. These symptoms commenced after a course of antibiotics prescribed by her general practitioner for a urinary tract infection...
February 2021: European Heart Journal. Case Reports
https://read.qxmd.com/read/33331728/-a-poisonous-spring-smoothie-with-wild-herbs-accidental-intoxication-with-foxglove-digitalis-purpurea
#14
JOURNAL ARTICLE
Jurjen S Kingma, Irene M Frenay, Arend Jan Meinders, Vincent F van Dijk, Ankie M Harmsze
BACKGROUND: At a time when self-sufficiency and health are becoming increasingly important in society, the chances of intoxications with wild plants are increasing. Foxglove contains poisonous cardiac glycosides such as digoxin, digitoxin and gitoxin. The levels vary greatly and depend on the season and the location of the plants. The "non-digoxin" cardiac glycosides show a limited cross-reaction with the digoxin assay. This means that a low or therapeutic digoxin level does not rule out a severe foxglove intoxication...
November 12, 2020: Nederlands Tijdschrift Voor Geneeskunde
https://read.qxmd.com/read/33292750/use-of-sacubitril-valsartan-in-patients-with-cardio-toxicity-and-heart-failure-due-to-chemotherapy
#15
JOURNAL ARTICLE
Vanesa Gregorietti, Teresa Lopez Fernandez, Diego Costa, Elías Ortega Chahla, Andrés J Daniele
BACKGROUND: Cancer therapy-related cardiac dysfunction (CTRCD) is a critical problem with an impact on both oncological and cardiovascular prognosis, especially when it prevents patients from receiving cancer treatment. Standard therapy for heart failure (HF) is recommended for CTRCD, but there is no well-established evidence on how sacubitril/valsartan may help cancer patients with cardiotoxicity. OBJECTIVES: The aim of this trial was to study the effectiveness of sacubitril-valsartan in patients with CTRCD treated in cardio-oncology units...
November 5, 2020: Cardio-Oncology
https://read.qxmd.com/read/33191446/digitoxigenin-presents-an-effective-and-selective-antileishmanial-action-against-leishmania-infantum-and-is-a-potential-therapeutic-agent-for-visceral-leishmaniasis
#16
JOURNAL ARTICLE
Camila S Freitas, João A Oliveira-da-Silva, Daniela P Lage, Rafaella R Costa, Débora V C Mendonça, Vívian T Martins, Thiago A R Reis, Luciana M R Antinarelli, Amanda S Machado, Grasiele S V Tavares, Fernanda F Ramos, Vinicio T S Coelho, Rory C F Brito, Fernanda Ludolf, Miguel A Chávez-Fumagalli, Bruno M Roatt, Gabriela S Ramos, Jennifer Munkert, Flaviano M Ottoni, Priscilla R V Campana, Maria V Humbert, Elaine S Coimbra, Fernão C Braga, Rodrigo M Pádua, Eduardo A F Coelho
Treatment for visceral leishmaniasis (VL) is hampered mainly by drug toxicity, their high cost, and parasite resistance. Drug development is a long and pricey process, and therefore, drug repositioning may be an alternative worth pursuing. Cardenolides are used to treat cardiac diseases, especially those obtained from Digitalis species. In the present study, cardenolide digitoxigenin (DIGI) obtained from a methanolic extract of Digitalis lanata leaves was tested for its antileishmanial activity against Leishmania infantum species...
January 2021: Parasitology Research
https://read.qxmd.com/read/32852924/acute-hyperkalemia-in-the-emergency-department-a-summary-from-a-kidney-disease-improving-global-outcomes-conference
#17
REVIEW
Gregor Lindner, Emmanuel A Burdmann, Catherine M Clase, Brenda R Hemmelgarn, Charles A Herzog, Jolanta Małyszko, Masahiko Nagahama, Roberto Pecoits-Filho, Zubaid Rafique, Patrick Rossignol, Adam J Singer
Hyperkalemia is a common electrolyte disorder observed in the emergency department. It is often associated with underlying predisposing conditions, such as moderate or severe kidney disease, heart failure, diabetes mellitus, or significant tissue trauma. Additionally, medications, such as inhibitors of the renin-angiotensin-aldosterone system, potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs, succinylcholine, and digitalis, are associated with hyperkalemia. To this end, Kidney Disease: Improving Global Outcomes (KDIGO) convened a conference in 2018 to identify evidence and address controversies on potassium management in kidney disease...
October 2020: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://read.qxmd.com/read/32300626/high-resolution-tandem-mass-spectrometry-dataset-reveals-fragmentation-patterns-of-cardiac-glycosides-in-leaves-of-the-foxglove-plants
#18
JOURNAL ARTICLE
Baradwaj Gopal Ravi, Mary Grace E Guardian, Rebecca Dickman, Zhen Q Wang
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ) has been developed to characterize and quantify cardiac glycosides in fresh-leaf extracts of the foxglove ( Digitalis sp. ) plants [1]. In this report, the fragmentation spectra of additional authentic standards of cardiac glycoside (digitoxigenin, digoxigenin, β -acetyldigoxin) and cardenolides identified in the leaves of Digitalis lanata ( D...
June 2020: Data in Brief
https://read.qxmd.com/read/32015920/ocular-hypotonia-and-transient-decrease-of-vision-as-a-consequence-of-exposure-to-a-common-toad-poison
#19
Renato Pejic, Marija Simic Prskalo, Josip Simic
The common toad produces venom (bufotoxin) that is produced in the parotid gland of the toad as well as in the skin. This toxic compound is a potent inhibitor of Na+ /K+ -ATPase activity. Physiological effects of bufotoxin are similar to those of digitalis and cause increased heart rate and muscle contractions. Ocular toxicity was described. A 67-year-old female patient was admitted to the emergency service because of sudden vision loss and a burning sensation in both eyes after she had been exposed to the poison of a toad...
2020: Case Reports in Ophthalmological Medicine
https://read.qxmd.com/read/31871798/a-case-report-of-accidental-intoxication-following-ingestion-of-foxglove-confused-with-borage-high-digoxinemia-without-major-complications
#20
Maria Silvia Negroni, Arianna Marengo, Donatella Caruso, Alessandro Tayar, Patrizia Rubiolo, Flavio Giavarini, Simone Persampieri, Enrico Sangiovanni, Franca Davanzo, Stefano Carugo, Maria Laura Colombo, Mario Dell'Agli
Foxglove ( Digitalis purpurea L.) leaves are frequently confused with borage ( Borago officinalis L.), which is traditionally used as a food ingredient. Due to the presence of the cardiac glycosides, mostly digitoxin, foxglove leaves are poisonous to human and may be fatal if ingested. A 55-year-old Caucasian woman complaining weakness, fatigue, nausea, and vomiting was admitted to the Emergency Department. Her symptoms started following consumption of a home-made savory pie with 5 leaves from a plant bought in a garden nursery as borage...
2019: Case Reports in Cardiology
keyword
keyword
167771
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.