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Adult Growth Hormone Deficiency

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https://read.qxmd.com/read/30772372/auxological-characteristics-of-pediatric-patients-with-permanent-or-transient-isolated-growth-hormone-deficiency-response-to-treatment-and-final-height
#1
Beatriz Villafuerte, Raquel Barrio, María Martín-Frías, Milagros Alonso, Belén Roldán
INTRODUCTION: Treatment with recombinant human growth hormone (rhGH) has been shown to improve adult height in pediatric patients with GH deficiency (GHD). However, reassessment of patients after they reach their final height shows some of them have permanent GH deficiency (PGHD), while others had a transient deficiency (TGHD). The study objective was to assess, in a cohort of pediatric patients with GHD, potential differences in response to treatment with rhGH depending on whether deficiency is permanent or transient...
February 13, 2019: Endocrinología, Diabetes y Nutrición
https://read.qxmd.com/read/30717585/a-novel-homozygous-mutation-of-the-acid-labile-subunit-igfals-gene-in-a-male-adolescent
#2
Sukran Poyrazoglu, Vivian Hwa, Firdevs Bas, Andrew Dauber, Ron Rosenfeld, Feyza Darendeliler
Acid-labile subunit (ALS) forms ternary complexes with insulin like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and is essential for normal circulating IGF-1 levels. The IGFALS gene encodes the ALS, and mutations in IGFALS cause ALS deficiency. We describe a patient with ALS deficiency with a novel homozygous frameshift mutation in IGFALS presenting with short stature and delayed puberty but ultimately achieving an adult height (AH) comparable to his target height (TH). A 15 3/12 year old boy presented with short stature (149...
February 5, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30712287/short-and-long-term-responsiveness-to-low-dose-gh-in-adult-growth-hormone-deficiency-ghd-role-of-gh-receptor-ghr-polymorphism
#3
Antonio Bianchi, Antonella Giampietro, Linda Tartaglione, Sabrina Chiloiro, Raffaella Gentilella, Chiara Bima, Carmelo Anile, Alessandro Olivi, Alfredo Pontecorvi, Laura De Marinis
PURPOSE: in patients with Growth Hormone Deficiency (GHD), low doses of recombinant human Growth Hormone (rhGH) have a similar or better long-term clinical effect than higher doses. Pharmacogenetic studies suggest that GH receptor (GHR) polymorphism influences only some metabolic parameters. Nonetheless there is no clear scientific evidence proving the effects of lower rhGH dose regimens on metabolic parameters. The aim of our prospective study is to evaluate the effects of GHR polymorphism in adult GHD patients treated with low rhGH dose during short (6 and 12 months) and long-term (5 years) follow-up...
February 3, 2019: Journal of Neuroendocrinology
https://read.qxmd.com/read/30690723/growth-hormone-deficiency-and-neurocognitive-function-in-adult-survivors-of-childhood-acute-lymphoblastic-leukemia
#4
Kevin R Krull, Chenghong Li, Nicholas S Phillips, Yin Ting Cheung, Tara M Brinkman, Carmen L Wilson, Gregory T Armstrong, Raja B Khan, Thomas E Merchant, Noah D Sabin, DeoKumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Charles A Sklar, Wassim Chemaitilly
BACKGROUND: The impact of growth hormone deficiency (GHD) on neurocognitive function is poorly understood in survivors of childhood acute lymphoblastic leukemia (ALL). This study examined the contribution of GHD to functional outcomes while adjusting for cranial radiation therapy (CRT). METHODS: Adult survivors of ALL (N = 571; 49% female; mean age, 37.4 years; age range, 19.4-62.2 years) completed neurocognitive tests and self-reported neurocognitive symptoms, emotional distress, and quality of life...
January 28, 2019: Cancer
https://read.qxmd.com/read/30684167/pituitary-incidentalomas-in-paediatric-age-are-different-from-those-described-in-adulthood
#5
Pedro Souteiro, Rúben Maia, Rita Santos-Silva, Rita Figueiredo, Carla Costa, Sandra Belo, Cíntia Castro-Correia, Davide Carvalho, Manuel Fontoura
PURPOSE: Guidelines on pituitary incidentalomas evaluation and management are limited to adults since there are no data on this matter in the paediatric population. We aim to analyse the morphologic characteristics, hormonal profile and follow-up of these lesions in children. METHODS: We have searched for pituitary incidentalomas in the neuroimaging reports and electronic medical records of the Paediatric Endocrinology Clinic of our centre. Patients with 18 years-old or less were included...
January 25, 2019: Pituitary
https://read.qxmd.com/read/30678118/growth-hormone-gh-therapy-during-the-transition-period-should-we-think-about-early-retesting-in-patients-with-idiopathic-and-isolated-gh-deficiency
#6
Laura Penta, Marta Cofini, Laura Lucchetti, Letizia Zenzeri, Alberto Leonardi, Lucia Lanciotti, Daniela Galeazzi, Alberto Verrotti, Susanna Esposito
To investigate growth hormone (GH) secretion at the transition age, retesting of all subjects who have undergone GH replacement therapy is recommended when linear growth and pubertal development are complete to distinguish between transitional and persistent GH deficiency (GHD). Early retesting of children with idiopathic and isolated GHD (i.e., before the achievement of final height and/or the adult pubertal stage) can avoid possible over-treatment. Here, we report data from our population with idiopathic and isolated GHD to encourage changes in the management and timing of retesting...
January 23, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30657741/risk-of-hypertension-following-perinatal-adversity-iugr-and-prematurity
#7
REVIEW
Trassanee Chatmethakul, Robert D Roghair
Consistent with the paradigm shifting observations of David Barker and colleagues that revealed a powerful relationship between decreased weight through 2 years of age and adult disease, intrauterine growth restriction (IUGR) and preterm birth are independent risk factors for the development of subsequent hypertension. Animal models have been indispensable in defining the mechanisms responsible for these associations and the potential targets for therapeutic intervention. Among the modifiable risk factors, micronutrient deficiency, physical immobility, exaggerated stress hormone exposure and deficient trophic hormone production are leading candidates for targeted therapies...
January 1, 2019: Journal of Endocrinology
https://read.qxmd.com/read/30657359/correlation-of-increased-serum-adipsin-with-increased-cardiovascular-risks-in-adult-patients-with-growth-hormone-deficiency
#8
Yunting Wang, Xiaoya Zheng, Xin Xie, Wenjie Qian, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) patients have an increased cardiovascular morbidity and mortality. Adipsin as an adipokine that is significantly correlated with metabolism disease, especially in people with obesity. The objective of our study was to compare AGHD patients with healthy subjects to evaluate whether adipsin levels are closely related to glycolipid metabolism and cardiovascular risks in AGHD patients. METHODS: Our study included 88 AGHD patients and 88 age-, weight- and BMI-matched healthy subjects...
January 18, 2019: Endocrine Practice
https://read.qxmd.com/read/30657116/an-icet-a-survey-on-occult-and-emerging-endocrine-complications-in-patients-with-%C3%AE-thalassemia-major-conclusions-and-recommendations
#9
Vincenzo De Sanctis, Ashraf T Soliman, Duran Canatan, Ploutarchos Tzoulis, Shahina Daar, Salvatore Di Maio, Heba Elsedfy, Mohamed A Yassin, Aldo Filosa, Nada Soliman, Karimi Mehran, Forough Saki, Praveen Sobti, Shruti Kakkar, Soteroula Christou, Alice Albu, Constantinos Christodoulides, Yurdanur Kilinc, Soad Al Jaouni, Doaa Khater, Saif A Alyaarubi, Su Han Lum, Saveria Campisi, Salvatore Anastasi, Maria Concetta Galati, Giuseppe Raiola, Yasser Wali, Ihab Z Elhakim, Demetris Mariannis, Vassilis Ladis, Christos Kattamis
In adult thalassemia major (TM) patients, a number of occult and emerging endocrine complications, such as: central hypothyroidism (CH), thyroid cancer, latent hypocortisolism, and growth hormone deficiency (GHD) have emerged and been reported. As the early detection of these complications is essential for appropriate treatment and follow-up, the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescent Medicine (ICET-A) promoted a survey on these complications in adult TM patients, among physicians (pediatricians, hematologists and endocrinologists) caring for TM patients in different countries...
January 15, 2019: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/30654108/spot-the-silent-sufferers-a-call-for-clinical-diagnostic-criteria-for-solar-and-nutritional-osteomalacia
#10
REVIEW
Suma Uday, Wolfgang Högler
Osteomalacia and rickets result from defective mineralization when the body is deprived of calcium. Globally, the main cause of osteomalacia is a lack of mineral supply for bone modeling and remodeling due to solar vitamin D and/or dietary calcium deficiency. Osteomalacia occurs when existing bone is replaced by unmineralized bone matrix (osteoid) during remodeling in children and adults, or when newly formed bone is not mineralized in time during modeling in children. Rickets occurs when hypomineralization affects the epiphyseal growth plate chondrocytes and adjacent bone metaphysis in growing children...
January 14, 2019: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/30583130/stent-assisted-coil-embolization-for-a-ruptured-posterior-communicating-artery-pseudoaneurysm-after-endoscopic-trans-sphenoidal-surgery-for-pituitary-adenoma
#11
Yusuke Morinaga, Kouhei Nii, Kimiya Sakamoto, Ritsurou Inoue, Takafumi Mitsutake, Hayatsura Hanada
BACKGROUND: Intracranial pseudoaneurysm is a rare complication of endoscopic endonasal surgery. Herein, we describe two-staged stent-assisted coil embolization for posterior communicating artery pseudoaneurysm after endoscopic endonasal surgery for pituitary adenoma. CASE DESCRIPTION: A 68-year-old man had a history of severe adult growth hormone secretion deficiency, requiring growth hormone replacement therapy; secondary adrenocortical hypofunction; hyperthyroidism; hypertension; constipation; glaucoma; and hyperuricemia...
December 21, 2018: World Neurosurgery
https://read.qxmd.com/read/30538484/childhood-onset-growth-hormone-deficiency-and-the-transition-to-adulthood-current-perspective
#12
REVIEW
M Ahmid, S F Ahmed, M G Shaikh
Childhood-onset growth hormone deficiency (CO-GHD) is an endocrine condition associated with a broad range of health issues from childhood through to adulthood, which requires particular attention during the transition period from adolescence to young adulthood. There is uncertainty in the clinical practice of the management of CO-GHD during transition regarding the clinical assessment and management of individual patients during and after transition to obtain optimal follow-up and improved health outcomes...
2018: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/30522126/identifying-potentially-modifiable-factors-associated-with-treatment-non-adherence-in-paediatric-growth-hormone-deficiency-a-systematic-review
#13
REVIEW
Selina Graham, John Weinman, Vivian Auyeung
BACKGROUND: Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence. METHODS: A search of 11 electronic databases was undertaken to identify relevant articles, published in English, between 1985 and 2018...
December 6, 2018: Hormone Research in Pædiatrics
https://read.qxmd.com/read/30500870/growth-hormone-s-links-to-cancer
#14
Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski
Several components of the GH axis are involved in tumor progression and GH-induced intracellular signaling has been strongly associated with breast cancer susceptibility in genome-wide association studies. In the general population, high IGF-I levels and low IGFBP-3 levels within the normal range are associated with the development of common malignancies, and components of the GH-IGF signaling system exhibit correlations with clinical, histopathological and therapeutic parameters in cancer patients. Despite promising findings in preclinical studies, anti-cancer therapies targeting the GH-IGF signaling system have led to disappointing results in clinical trials...
November 30, 2018: Endocrine Reviews
https://read.qxmd.com/read/30481154/bone-microarchitecture-and-volumetric-bone-density-impairment-in-young-male-adults-with-childhood-onset-growth-hormone-deficiency
#15
Hongbo Yang, Kemin Yan, Xu Yuping, Qi Zhang, Linjie Wang, Fengying Gong, Huijuan Zhu, Weibo Xia, Hui Pan
Context Adult growth hormone deficiency (AGHD) is characterized by low bone density and increased risk of fracture. Bone microarchitecture is insufficiently evaluated in patients with childhood-onset AGHD (CO AGHD). Objective To assess volumetric bone density (vBMD) and bone microarchitecture in CO AGHD in early adulthood after cessation of recombinant growth hormone (rhGH) treatment. Design and subjects Case-control study in a major academic medical center in Beijing, including 20 young male adults with CO AGHD and 30 age- and weight-matched non-athletic healthy men...
February 1, 2019: European Journal of Endocrinology
https://read.qxmd.com/read/30411985/targeted-literature-review-of-the-humanistic-and-economic-burden-of-adult-growth-hormone-deficiency
#16
Jane Loftus, Cecilia Camacho-Hubner, Judith Hey-Hadavi, Kelly Goodrich
BACKGROUND: Quality of life (QoL) and health economic data are becoming increasingly important factors in healthcare decision-making. While there is a wealth of information establishing the benefit of growth hormone (GH) replacement therapy on adults with growth hormone deficiency (aGHD), recent reviews on the QoL and health economic impact of aGHD and the effect of treatment on these factors is limited. OBJECTIVE: The aim of this article is to summarise the impact of early and sustained treatment on the QoL and economic burden of aGHD by conducting a targeted literature review...
November 9, 2018: Current Medical Research and Opinion
https://read.qxmd.com/read/30389240/are-hypothyroidism-and-hypogonadism-clinically-relevant-in-patients-with-malignant-gliomas-a-longitudinal-trial-in-patients-with-glioma
#17
Ammon Handisurya, Tamara Rumpold, Carola Caucig-Lütgendorf, Birgit Flechl, Matthias Preusser, Aysegül Ilhan-Mutlu, Karin Dieckmann, Georg Widhalm, Anna Grisold, Adelheid Wöhrer, Johannes Hainfellner, Robin Ristl, Christine Kurz, Christine Marosi, Alois Gessl, Marco Hassler
BACKGROUND: So far, the development and course of therapy-induced deficiencies in hypothalamic-pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient's quality of life substantially. METHODS: In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion...
October 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://read.qxmd.com/read/30367939/effect-of-16-weeks-vitamin-d-replacement-on-calcium-phosphate-homeostasis-in-overweight-and-obese-adults
#18
Jakub Mesinovic, Aya Mousa, Kirsty Wilson, Robert Scragg, Magdalena Plebanski, Maximilian de Courten, David Scott, Negar Naderpoor, Barbora de Courten
This randomised placebo-controlled trial aimed to determine the effect of 16-weeks cholecalciferol supplementation on calcium-phosphate homeostasis and bone mineral density (BMD) in overweight and obese adults. Fifty-four vitamin D-deficient (25OHD<50 nmol/L), overweight and obese adults (mean age 32 ± 8.5 years) were included in the trial. Participants were randomly assigned to receive either a bolus oral dose of 100,000 IU cholecalciferol followed by 4000 IU cholecalciferol/d or a matching placebo for 16 weeks...
October 24, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/30346875/growth-hormone-deficiency-and-nonalcoholic-fatty-liver-disease-with-insights-from-humans-and-animals-pediatric-implications
#19
Rohan K Henry
In addition to its growth promoting role, growth hormone (GH) has a significant effect on intermediary metabolism in the well state. Despite the latter fact, pediatric practitioners are usually focused on the growth promoting aspects of GH as opposed to those metabolic. In recent years various animal and human studies (in adults mainly) and clinical reports in children have repeatedly shown the association of GH deficiency (GHD) and fatty liver disease. Based on this well-identified association, despite a lack of studies involving children, it behooves the pediatric clinician to ensure that not only patients with GHD are appropriately treated but also that adolescents even beyond the period of linear growth should be appropriately transitioned to adult GH therapy should this be appropriate...
October 20, 2018: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/30338487/gender-dependent-growth-and-insulin-like-growth-factor-1-responses-to-growth-hormone-therapy-in-prepubertal-growth-hormone-deficient-children
#20
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Majcher, Beata Pyrżak
Gender seems to be an important factor influencing the response to recombinant human growth hormone (rhGH) therapy in GH-deficient adolescents and adults. The results of studies evaluating gender-specific response to rhGH therapy in prepubertal GH-deficient children are divergent. The aim of this study was to determine the effect of gender on the growth and insulin-like growth factor-1 (IGF-1) responses in 75 prepubertal GH-deficient children during the first 2 years of rhGH therapy. There were no baseline gender differences in age, bone age, anthropometrical parameters, and IGF-1 SDS for bone age...
October 19, 2018: Advances in Experimental Medicine and Biology
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