keyword
https://read.qxmd.com/read/38486205/role-of-beta-1%C3%A2-3-1%C3%A2-6-d-glucan-derived-from-yeast-on-natural-killer-nk-cells-and-breast-cancer-cell-lines-in-2d-and-3d-cultures
#1
JOURNAL ARTICLE
Abdelhadi Boulifa, Martin J Raftery, Alexander Sebastian Franzén, Clarissa Radecke, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
BACKGROUND: Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we investigated the effect of beta-(1,3)(1,6)-D-glucan derived from yeast on the proliferation of primary NK cells and breast cancer cell lines in 2D and 3D models, and on the cytotoxicity of primary NK cells against breast cancer cell lines in 2D and 3D models...
March 14, 2024: BMC Cancer
https://read.qxmd.com/read/38341907/adherence-and-impact-of-an-oral-nutritional-supplement-enriched-in-leucine-evoo-epa-and-dha-and-beta-glucans-on-the-coverage-of-energy-and-protein-requirements-in-patients-with-cancer-and-malnutrition-alisenoc-study
#2
JOURNAL ARTICLE
Samara Palma Milla, Pedro P García Luna, Alfonso Vidal Casariego, Francisco Villazón González, Tomás Martín Folgueras, Olatz Izaola Jáuregui, Silvia García Rey, Alicia Calleja Fernández, Bricia López Plaza, Tamara Casañas Quintana, Daniel A de Luis Román
OBJECTIVE: The aim of this study was to evaluate the impact of an enhanced ONS (enriched in EPA, DHA, leucine, and beta-glucans) on the dietary intake of cancer patients. METHODS: A randomized, double-blind, parallel, controlled, and multicenter clinical trial was conducted in patients with cancer and malnutrition. The trial compared prescribed dietary advice and two packs per day, for 8 weeks, of a hypercaloric (400 kcal/pack) and hyperproteic ONS (20 g/pack) with fiber and specific ingredients (leucine, EPA and DHA, and beta-glucans) (enhanced-ONS) versus an isocaloric and isoproteic formula (standard-ONS) without specific ingredients...
January 10, 2024: Nutrition
https://read.qxmd.com/read/38251046/current-views-about-the-inflammatory-damage-triggered-by-bacterial-superantigens-and-experimental-attempts-to-neutralize-superantigen-mediated-toxic-effects-with-natural-and-biological-products
#3
REVIEW
Luigi Santacroce, Skender Topi, Ioannis Alexandros Charitos, Roberto Lovero, Paolo Luperto, Raffaele Palmirotta, Emilio Jirillo
Superantigens, i.e., staphylococcal enterotoxins and toxic shock syndrome toxin-1, interact with T cells in a different manner in comparison to conventional antigens. In fact, they activate a larger contingent of T lymphocytes, binding outside the peptide-binding groove of the major histocompatibility complex class II. Involvement of many T cells by superantigens leads to a massive release of pro-inflammatory cytokines, such as interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor-alpha and interferon-gamma...
January 9, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/37986091/negative-serum-1-3-%C3%AE-d-glucan-has-a-low-power-to-exclude-pneumocystis-jirovecii-pneumonia-pjp-in-hiv-uninfected-patients-with-positive-qpcr
#4
JOURNAL ARTICLE
Yuan Huang, Jie Yi, Jing-Jing Song, Li-Jun Du, Xiao-Meng Li, Lin-Lin Cheng, Song-Xin Yan, Hao-Long Li, Yong-Mei Liu, Hao-Ting Zhan, Ya-Ling Dou, Yong-Zhe Li
OBJECTIVE: The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results. METHODS: This was a single-center retrospective study between 2019 and 2021. The diagnosis of PJP was based on the following criteria: detection of P. jirovecii in sputum or BAL specimen by qPCR or microscopy; Meet at least two of the three criteria: (1) have respiratory symptoms of cough and/or dyspnea, hypoxia; (2) typical radiological picture findings; (3) receiving a complete PJP treatment...
November 20, 2023: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/37859870/pneumocystis-jirovecii-pneumonia-pcp-in-a-non-hiv-lung-cancer-patient-in-the-absence-of-common-risk-factors
#5
Shahnawaz Hashmi, Dawood Yousuf, Prasad Kumar
Pneumocystis jirovecii pneumonia (PCP) has been described mainly in AIDs and in immunocompromised patients with hematological malignancies, organ transplant recipients, collagen vascular disease, and primary immune deficiencies or those under treatment with steroids or chemotherapy. The incidence of PCP pneumonia is increasing in solid organ tumors and hematological malignancies receiving chemotherapy. Pneumocystis pneumonia has been rarely reported in patients with non-small cell lung cancer (NSCLC). We describe a 68-year-old woman with a recent diagnosis of squamous cell lung cancer, who received radiotherapy two weeks prior to the current hospital admission with shortness of breath and dry cough...
September 2023: Curēus
https://read.qxmd.com/read/37643037/unusual-case-of-cladosporium-sphaerospermum-endogenous-endophthalmitis-during-golimumab-therapy-case-report-and-literature-review
#6
JOURNAL ARTICLE
Michele Cavalleri, Alessandro Marchese, Vincenzo Starace, Francesco Bandello, Giulio Modorati, Elisabetta Miserocchi
PURPOSE: To report a case of fungal endogenous endophthalmitis from Cladosporium sphaerospermum in a patient with juvenile idiopathic arthritis receiving chronic immunosuppressive therapy with golimumab (tumor necrosis factor-α blocker). METHODS: Case report and review of the literature. RESULTS: A 34-year-old woman receiving chronic immunosuppressive therapy with golimumab for juvenile idiopathic arthritis was referred for unilateral visual loss and ocular pain...
September 1, 2023: Retinal Cases & Brief Reports
https://read.qxmd.com/read/37570749/in-vivo-zymosan-treatment-induces-il15-secreting-macrophages-and-klrg1-expressing-nk-cells-in-mice
#7
JOURNAL ARTICLE
Hyun Jung Park, Sung Won Lee, Yun Hoo Park, Tae-Cheol Kim, Sujin Lee, Seyeong Lee, Luc Van Kaer, Seokmann Hong
Beta-glucan (β-glucan) is a natural polysaccharide produced by fungi, bacteria, and plants. Although it has been reported that β-glucan enhances innate immune memory responses, it is unclear whether different types of β-glucans display similar immune effects. To address this issue, we employed zymosan (β-1,3-glycosidic linkage) and pustulan (β-1,6-glycosidic linkage) to investigate their in vivo effects on innate memory immune responses. We examined the changes of innate memory-related markers in macrophages and natural killer (NK) cells, two immune cell types that display innate memory characteristics, at two different time points (16 h and 7 days) after β-glucan stimulation...
July 31, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37441529/oat-beta-glucan-reduces-colitis-by-promoting-autophagy-flux-in-intestinal-epithelial-cells-via-ephb6-tfeb-axis
#8
JOURNAL ARTICLE
Mingyang Xu, Fangmei Ling, Junrong Li, Yidong Chen, Shuang Li, Yiyu Cheng, Liangru Zhu
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the gastrointestinal tract, mainly including Crohn's disease and ulcerative colitis. Epidemiological findings suggest that inadequate dietary fibers intake may be a risk factor for IBD. Oat beta-glucan is a type of fermentable dietary fiber and has been proved to reduce experimental colitis. However, the mechanism remains unclear. The aim of this study was to explore the role and possible mechanism of oat beta-glucan in reducing experimental colitis...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36804157/oral-intake-of-combined-natural-immunostimulants-suppresses-the-7-12-dmba-croton-oil-induced-two-step-skin-carcinogenesis-in-swiss-albino-mice
#9
JOURNAL ARTICLE
Mohammed Abdellaoui, Assia Kadi, Yamina Abrazi, Yacine Kadi, Adnane Gary, Hind Kherfi, Zinelaabidine Cheraiet, Mahfoud Messarah
BACKGROUND: The immune system is critical in fighting cancer, so is it possible that the natural stimulation of this system can slow down or stop the evolution of cancer? Our in vivo study aimed to evaluate the protective effect of the combination of five types of immunostimulants, which are Beta-glucan and Arabinogalactan as polysaccharides and three mushroom extracts (Reishi, Maitake, and Shiitake), on 7,12-Dimethyl Benz[a]anthracene (DMBA)/ Croton oil-induced papilloma in Swiss albino mice...
January 2023: Gulf Journal of Oncology
https://read.qxmd.com/read/36758755/beta-glucan-as-an-immune-stimulant-in-tumor-microenvironment-insight-into-lessons-and-promises-from-past-decade
#10
REVIEW
VartikaMishra, Vachaspati Tripathi, Priyanka Yadav, M P Singh
Cancer is characterized by a perturbed immune landscape. Inside tumor microenvironment, immune system is reprogrammed to facilitate tumor growth and survival rather than eliminating it. This immune evasive mechanism needs to be reversed to normal for effective anticancer therapeutic strategy. Immunotherapy has emerged as a novel strategy for redeployment of immune cells against cancer. However, they suffer in their efficacy, response rate and side effects. This necessitated us to turn toward natural repertoires which can act as a substitute to conventional immunotherapeutics...
February 7, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/36604547/inducing-trained-immunity-in-pro-metastatic-macrophages-to-control-tumor-metastasis
#11
JOURNAL ARTICLE
Chuanlin Ding, Rejeena Shrestha, Xiaojuan Zhu, Anne E Geller, Shouzhen Wu, Matthew R Woeste, Wenqian Li, Haomin Wang, Fang Yuan, Raobo Xu, Julia H Chariker, Xiaoling Hu, Hong Li, David Tieri, Huang-Ge Zhang, Eric C Rouchka, Robert Mitchell, Leah J Siskind, Xiang Zhang, Xiaoji G Xu, Kelly M McMasters, Yan Yu, Jun Yan
Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the metastatic microenvironment. Here, we explore the implications of reprogramming pre-metastatic niche myeloid cells by inducing trained immunity with whole beta-glucan particle (WGP). WGP-trained macrophages had increased responsiveness not only to lipopolysaccharide but also to tumor-derived factors. WGP in vivo treatment led to a trained immunity phenotype in lung interstitial macrophages, resulting in inhibition of tumor metastasis and survival prolongation in multiple mouse models of metastasis...
February 2023: Nature Immunology
https://read.qxmd.com/read/36377664/human-dectin-1-deficiency-impairs-macrophage-mediated-defense-against-phaeohyphomycosis
#12
JOURNAL ARTICLE
Rebecca A Drummond, Jigar V Desai, Amy P Hsu, Vasileios Oikonomou, Donald C Vinh, Joshua A Acklin, Michael S Abers, Magdalena A Walkiewicz, Sarah L Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J Oler, Daisuke Yamanaka, Katrin D Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas Sp Viall, Christa S Zerbe, Elise Mn Ferré, Monica M Schmitt, Tom DiMaggio, Stefania Pittaluga, John A Butman, Adrian M Zelazny, Yvonne R Shea, Cesar A Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C Bloch, Sean G Kelly, M Suzanne Whitworth, Ganesh Rao, Cindy J Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C Kenyon, William R Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F Freeman, John E Bennett, Rodrigo Hasbun, Constantinos M Mikelis, Kyung J Kwon-Chung, Yasmine Belkaid, Gordon D Brown, Jean K Lim, Douglas B Kuhns, Steven M Holland, Michail S Lionakis
Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis remain unclear. We evaluated a patient with progressive, refractory Corynespora cassiicola phaeohyphomycosis and found that he carried biallelic deleterious mutations in CLEC7A encoding the CARD9-coupled, β-glucan-binding receptor, Dectin-1. The patient's PBMCs failed to produce TNF-α and IL-1β in response to β-glucan and/or C...
November 15, 2022: Journal of Clinical Investigation
https://read.qxmd.com/read/36340302/hepatoprotective-effects-of-aureobasidium-pullulans-derived-%C3%AE-1-3-1-6-glucans-in-a-murine-model-of-non-alcoholic-steatohepatitis
#13
JOURNAL ARTICLE
Nobunao Ikewaki, Gary A Levy, Gene Kurosawa, Masaru Iwasaki, Vidyasagar D Dedeepiya, Suryaprakash Vaddi, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J K Abraham
Background: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent conditions characterized by inflammation and fibrosis of the liver, which can progress to cirrhosis and hepatocellular carcinoma if left untreated. Conventional modalities are mainly symptomatic, with no definite solution. Beta-glucan-based biological response modifiers are a potential strategy in lieu of their beneficial metabolic effects. Aureobasidium pullulans strains AFO-202 and N-163 beta-glucans were evaluated for anti-fibrotic and anti-inflammatory hepatoprotective potentials in a NASH animal model in this study...
November 2022: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/36183755/prompting-immunostimulatory-activity-of-curdlan-with-grafting-methoxypolyethylene-glycol
#14
JOURNAL ARTICLE
Lei Luo, Qing Zhou, Yingkui Hu, Qiang Ding, Zongbao Zhou, Chuang Wang, Xiaoying Wang, Hang Li, Shunqing Tang
The immunostimulatory activity of polysaccharides can improve human immunity, but their activity is low and prompting the activity is a great challenge. Curdlan, is a linear beta-1,3-glucan and has the potential to induce immune responses. However, owing to its tight triple helix structure and insolubility in water, its immunostimulatory activity is weakened. The keyway to promote its immunostimulatory activity is to relax its tight triple helix structure. In this work, methoxypolyethylene glycol (mPEG) was grafted onto curdlan (curdlan-g-mPEG) to unwind its triple helix structure...
September 29, 2022: International Journal of Biological Macromolecules
https://read.qxmd.com/read/36142859/beta-glucan-from-s-cerevisiae-protected-aom-induced-colon-cancer-in-cgas-deficient-mice-partly-through-dectin-1-manipulated-macrophage-cell-energy
#15
JOURNAL ARTICLE
Sulaiman Binmama, Cong Phi Dang, Peerapat Visitchanakun, Pratsanee Hiengrach, Naraporn Somboonna, Thanya Cheibchalard, Prapaporn Pisitkun, Ariya Chindamporn, Asada Leelahavanichkul
Although the impacts of Saccharomyces cerevisiae on cancers are mentioned, data on its use in mice with cyclic GMP-AMP synthase deficiency (cGAS-/-) are even rarer. Here, 12 weeks of oral administration of S. cerevisiae protected cGAS-/- mice from azoxymethane (AOM)-induced colon cancers, partly through dysbiosis attenuation (fecal microbiome analysis). In parallel, a daily intralesional injection of a whole glucan particle (WGP; the beta-glucan extracted from S. cerevisiae ) attenuated the growth of subcutaneous tumor using MC38 (murine colon cancer cell line) in cGAS-/- mice...
September 19, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36004705/in-vitro-cytotoxic-activity-of-an-aqueous-alkali-extract-of-the-tinder-conk-mushroom-fomes-fomentarius-agaricomycetes-on-murine-fibroblasts-human-colorectal-adenocarcinoma-and-cutaneous-melanoma-cells
#16
JOURNAL ARTICLE
Joachim Storsberg, Anne Krüger-Genge, Liudmila Kalitukha
Bioactive complexes of medicinal mushrooms have become attractive as complementary anticancer remedies. Our in vitro study focused on the cytotoxicity of the polyphenol-reach and beta-glucan-containing aqueous alkali extract from Fomes fomentarius fruiting bodies (FFE) using murine fibroblasts (L929), human colon adenocarcinoma cells (Caco-2), and cutaneous melanoma cells (COLO-818). Dose-dependent FFE cytotoxicity with an half maximal inhibitory concentration of 0.44 mg/mL was observed for L929 cells upon analysis of the total number of adherent cells, degree of cell viability, cell morphology, and mitochondrial metabolic activity...
2022: International Journal of Medicinal Mushrooms
https://read.qxmd.com/read/35368741/immune-enhancing-effect-of-water-soluble-beta-glucan-derived-from-enzymatic-hydrolysis-of-yeast-glucan
#17
JOURNAL ARTICLE
Yingji Xin, Hyanggi Ji, Eunae Cho, Kyung-Baeg Roh, Jiyoung You, Deokhoon Park, Eunsun Jung
Immunostimulants play an important role in the treatment of immunodeficiency. Macrophages are the first line in our immune defense system and play a critical role in the immune response. Therefore, finding new and better substances to induce an immune response by activating macrophages is an attractive research topic, especially in the fields of immunopharmacology and cancer prevention. Keratinocytes actively crosstalk with immune cells during wound repair, so enhancing the function of keratinocytes is also an important part of improving immunity...
July 2022: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/35001040/impact-of-heroin-and-hiv-on-gut-integrity-and-immune-activation
#18
JOURNAL ARTICLE
Corrilynn O Hileman, Emily R Bowman, Janelle Gabriel, Aaren Kettelhut, Danielle Labbato, Cheryl Smith, Ann Avery, Theodore Parran, Nicholas Funderburg, Grace A McComsey
BACKGROUND: Altered gut integrity is central to HIV-related immune activation. Opioids may promote similar changes in gut permeability and/or increase systemic inflammation potentially augmenting processes already occurring in people with HIV (PWH). SETTING: Urban hospital systems in Cleveland, Ohio and surrounding communities. METHODS: This is prospectively-enrolled, cross-sectional study including people with and without HIV using heroin, and people with and without HIV who have never used heroin matched by age, sex and CD4+ count (PWH only) to compare markers of gut integrity, microbial translocation, systemic inflammation, and immune activation...
January 7, 2022: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/34973723/corrigendum-to-beta-d-glucan-based-drug-delivery-system-and-its-potential-application-in-targeting-tumor-associated-macrophages-carbohydrate-polymers-253-2021-117258
#19
Yuting Su, Lei Chen, Fan Yang, Peter C K Cheung
No abstract text is available yet for this article.
February 15, 2022: Carbohydrate Polymers
https://read.qxmd.com/read/34944886/phase-i-trial-of-oral-yeast-derived-%C3%AE-glucan-to-enhance-anti-gd2-immunotherapy-of-resistant-high-risk-neuroblastoma
#20
JOURNAL ARTICLE
Fiorella Iglesias Cardenas, Audrey Mauguen, Irene Y Cheung, Kim Kramer, Brian H Kushner, Govind Ragupathi, Nai-Kong V Cheung, Shakeel Modak
Beta glucans, complex polysaccharides, prime leukocyte dectin-1 and CR3-receptors and enhance anti-tumor cytotoxicity of complement-activating monoclonal antibodies. We conducted a phase I study (clinicaltrials.gov NCT00492167) to determine the safety of the combination of yeast-derived beta glucan (BG) and anti-GD2 murine monoclonal antibody 3F8 in patients with relapsed or refractory high-risk neuroblastoma. Patients received intravenous 3F8 (fixed dose of 10 mg/m2 /day × 10 days) and oral BG (dose-escalated from 10-200 mg/kg/day × 17 days in cohorts of 3-6 patients each)...
December 14, 2021: Cancers
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