Jonathan E Elliott, Brittany R Ligman, Mohini D Bryant-Ekstrand, Allison T Keil, Katherine Powers, Cosette Olivo, Lee Neilson, Ronald B Postuma, Amélie Pelletier, Jean-François Gagnon, Ziv Gan-Or, Eric Yu, Lang Liu, Erik K St Louis, Leah K Forsberg, Julie A Fields, Owen A Ross, Daniel E Huddleston, Donald L Bliwise, Alon Y Avidan, Michael J Howell, Carlos H Schenck, Jennifer McLeland, Susan R Criswell, Aleksandar Videnovic, Emmanuel H During, Mitchell G Miglis, David R Shprecher, Joyce K Lee-Iannotti, Bradley F Boeve, Yo-El S Ju, Miranda M Lim
STUDY OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is strongly associated with phenoconversion to an overt synucleinopathy, e.g., Parkinson's disease (PD), Lewy Body Dementia (LBD), and related disorders. Comorbid traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) - henceforth "neurotrauma" (NT) - increase the odds of RBD by ~2.5-fold and is associated with an increased rate of service-connected PD in Veterans. Thus, RBD and NT are both independently associated with PD; however, it is unclear how NT influences neurological function in patients with RBD...
January 5, 2024: Sleep