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Paulina Bierwagen, Kamil Szpotkowski, Mariusz Jaskolski, Anna Urbanowicz
Outer surface protein C (OspC) is one of the most abundant surface lipoproteins produced during early infection by the Borrelia spirochete, the causative agent of Lyme disease. The high sequence variability of the ospC gene results in the production of several and strongly divergent OspC types. One of the known roles of OspC is the recruitment of blood components, including complement regulators, to facilitate the bloodstream survival of Borrelia at an essential stage of host infection. Here, we identify and describe a new interaction between OspC and human fibrinogen...
March 15, 2019: FEBS Journal
Osamu Ichikawa, Benjamin S Glicksberg, Nicholas Genes, Brian A Kidd, Li Li, Joel T Dudley
Lyme disease (LD) is the most common tick-borne illness in the United States. Although appropriate antibiotic treatment is effective for most cases, up to 20% of patients develop post-treatment Lyme disease syndrome (PTLDS). There is an urgent need to improve clinical management of LD using precise understanding of disease and patient stratification. We applied machine-learning to electronic medical records to better characterize the heterogeneity of LD and developed predictive models for identifying medications that are associated with risks of subsequent comorbidities...
March 14, 2019: Scientific Reports
Yves Hansmann
No abstract text is available yet for this article.
November 2018: La Revue du Praticien
Richard I Horowitz, Phyllis R Freeman
Purpose: We collected data from an online survey of 200 of our patients, which evaluated the efficacy of dapsone (diaminodiphenyl sulfone, ie, DDS) combined with other antibiotics and agents that disrupt biofilms for the treatment of chronic Lyme disease/post-treatment Lyme disease syndrome (PTLDS). We also collected aggregate data from direct retrospective chart review, including laboratory testing for Lyme, other infections, and associated tick-borne coinfections. This helped us to determine the frequency of exposure to other infections/coinfections among a cohort of chronically ill Lyme patients, evaluate the efficacy of newer "persister" drug regimens like DDS, and determine how other infections and tick-borne coinfections may be contributing to the burden of chronic illness leading to resistant symptomatology...
2019: International Journal of General Medicine
Svitlana Smiyan, Igor Galaychuk, Igor Zhulkevych, Volodymyr Nykolyuk, Roman Komorovsky, Sofiya Gusak, Ivan Bilozetsky
Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren's syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder...
2019: Reumatologia
Peter Reinink, Michael N T Souter, Tan-Yun Cheng, Tamara van Gorkom, Stefanie Lenz, Joanna Kubler-Kielb, Klemen Strle, Kristin Kremer, Steven F T Thijsen, Allen C Steere, Dale I Godfrey, Daniel G Pellicci, D Branch Moody, Ildiko Van Rhijn
Lyme disease is a common multi-system disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and related Borrelia species. The monoglycosylated diacylglycerol known as B. burgdorferi glycolipid II (BbGL-II) is a major target of antibodies in sera from infected individuals. Here we show that CD1b presents BbGL-II to human T cells and that the T cell receptor (TCR) mediates the recognition. However, we did not detect increased frequency of CD1b-BbGL-II binding T cells in the peripheral blood of Lyme disease patients compared to controls...
March 10, 2019: European Journal of Immunology
Lise E Nigrovic, Desiree N Neville, Fran Balamuth, Jonathan E Bennett, Michael N Levas, Aris C Garro
Of 1770 children undergoing emergency department evaluation for Lyme disease, 362 (20.5%) children had Lyme disease. Of those with an available tick bite history, only a minority of those with Lyme disease had a recognized tick bite (60/325; 18.5%, 95% confidence interval 14.6-23.0%). Lack of a tick bite history does not reliably exclude Lyme disease.
February 26, 2019: Ticks and Tick-borne Diseases
Seungeun Han, Charles Lubelczyk, Graham J Hickling, Alexia A Belperron, Linda K Bockenstedt, Jean I Tsao
Borrelia miyamotoi is a relapsing fever spirochete transmitted by ticks in the Ixodes ricinus complex. In the eastern United States, B. miyamotoi is transmitted by I. scapularis, which also vectors several other pathogens including B. burgdorferi sensu stricto. In contrast to Lyme borreliae, B. miyamotoi can be transmitted vertically from infected female ticks to their progeny. Therefore, in addition to nymphs and adults, larvae can vector B. miyamotoi to wildlife and human hosts. Two widely varying filial infection prevalence (FIP) estimates - 6% and 73% - have been reported previously from two vertically infected larval clutches; to our knowledge, no other estimates of FIP or transovarial transmission (TOT) rates for B...
February 26, 2019: Ticks and Tick-borne Diseases
Sam F Armstrong, Peter J Green
No abstract text is available yet for this article.
March 2019: Journal of Cutaneous Medicine and Surgery
Thomas Weiss, Peter Zhu, Hannah White, Matthew Posner, J Kenneth Wickiser, Michael A Washington, Jason Barnhill
Lyme disease is a continuing threat to military personnel operating in arboriferous and mountainous environments. Here we present the case of a 24-year-old Second Lieutenant, a recent graduate from the United States Military Academy, with a history of Lyme disease who developed recurrent knee effusions following surgery to correct a hip impingement. Although gonococcal arthritis was initially suspected from preliminary laboratory results, a comprehensive evaluation contradicted this diagnosis. Despite antibiotic therapy, aspiration of the effusions, and steroid treatment to control inflammation, the condition of the patient deteriorated to the point where he was found to be unfit for duty and subsequently discharged from active military service...
March 6, 2019: Military Medicine
Michael E von Fricken, Lkhunrev Rolomjav, Madeline Illar, Doniddemberel Altantogtokh, Kathryn M Hogan, Baasandagva Uyanga, Dalantai Ganbold, Nyamdorj Tsogbadrakh
INTRODUCTION: In Asia, Borrelia garinii, B. afzelii, and B. bavariensis are transmitted by Ixodes persulcatus ticks and clinically present with a wide range of neurological and arthritic symptoms. This report aims to provide details on the geographic distribution of suspected cases of Lyme borreliosis (LB), reported to local Mongolian hospitals between 2007 and 2017. METHODS: This report examines 150 reported cases of suspected LB from 13 aimags (provinces) in Mongolia from April 2007 to August 2017, including date and location of infection, method of diagnosis (indirect immunofluorescent assay and/or enzyme-linked immunosorbent assay test), frequency of specific symptoms, and case demographics...
March 5, 2019: Vector Borne and Zoonotic Diseases
Daniel L Robertson, Leah M Babin, Jenna R Krall, Michael E von Fricken, Heibatollah Baghi, Kathryn H Jacobsen
Years when the deer population is robust during the autumn hunting season may point toward an elevated risk of Lyme disease (LD) in the human population two summers later. We applied overdispersed Poisson regression models to county-specific data from New Jersey for each year from 2000 to 2014. The average relative risk of LD for each additional hunter-killed deer per square mile was 1.12 (1.10, 1.14) for 2000-2007 and 1.11 (1.09, 1.13) for 2008-2014. The hunting data already collected for conservation and wildlife management purposes may be a relevant component of LD surveillance activities...
March 1, 2019: EcoHealth
Daniel B Horton, Alysha J Taxter, Amy L Davidow, Brandt Groh, David D Sherry, Carlos D Rose
OBJECTIVE: Few factors have consistently been linked to antibiotic-refractory Lyme arthritis (ARLA). We sought to identify clinical and treatment factors associated with pediatric ARLA. METHODS: We performed a case-control study in 3 pediatric rheumatology clinics in a Lyme-endemic region (2000-2013). Eligible children were aged ≤ 18 years with arthritis and had positive testing for Lyme disease by Western blot. Cases were 49 children with persistently active arthritis despite ≥ 8 weeks of oral antibiotics or ≥ 2 weeks of parenteral antibiotics; controls were 188 children whose arthritis resolved within 3 months of starting antibiotics...
March 1, 2019: Journal of Rheumatology
Daniel B Horton, Alysha J Taxter, Amy L Davidow, Brandt Groh, David D Sherry, Carlos D Rose
OBJECTIVE: To determine whether second-line intra-articular glucocorticoid (IAGC) injection improves outcomes in children with persistently active Lyme arthritis after initial antibiotics. METHODS: We conducted an observational comparative effectiveness study through chart review within three pediatric rheumatology centers with distinct clinical approaches to second-line treatment of Lyme arthritis. We primarily compared children receiving second-line IAGCs to children receiving a second course of antibiotics alone...
March 1, 2019: Journal of Rheumatology
Andrea Bušová, Erik Dorko, Kvetoslava Rimárová, Jana Diabelková, Tímea Rovenská, Eva Feketeová, Matúš Bereš, Róbert Čellár, Zuzana Baranová, Tomáš Kampe, Karim Benhatchi
OBJECTIVE: Lyme disease (LD) is chronic, multi-system zoonosis transmitted by ticks, and LD aetiological agents are spirochetes of the Borrelia burgdorferi sensu lato complex. The aim of the cross-sectional study was to analyze the LD incidence on the basis of the presence of specific antibodies in the serum of patients in Eastern Slovakia, and to compare the results of serological ELISA and immunoblot assays. METHODS: Venous blood with questionnaires was obtained by field sampling of respondents from Eastern Slovakia...
December 2018: Central European Journal of Public Health
Andrea Bušová, Erik Dorko, Eva Feketeová, Kvetoslava Rimárová, Jana Diabelková, Tímea Rovenská, Tomáš Csank
OBJECTIVE: The aim of the presented cross-sectional seroepidemiological study was to determine the current presence of antibodies against B. burgdorferi s.l. in the groups of Slovak population, and to identify potential risk factors to Lyme borreliosis. METHODS: A group of 261 adults (patients from the Neurological Clinic with possible symptoms of LB and healthy persons with possible working exposure to tick bite: gardeners and soldiers working in afforested areas) were examined in order to assess the seroprevalence of anti-Borrelia antibodies...
December 2018: Central European Journal of Public Health
Petr Kodym, Zuzana Kurzová, Dagmar Berenová, Dušan Pícha, Dita Smíšková, Lenka Moravcová, Marek Malý
No abstract text is available yet for this article.
March 2019: Journal of Clinical Microbiology
Katie M Clow, Patrick A Leighton, David L Pearl, Claire M Jardine
Significant global ecological changes continue to drive emergence of tick-borne zoonoses around the world. This poses an important threat to both human and animal health, and highlights the need for surveillance systems that are capable of monitoring these complex diseases effectively across different stages of the emergence process. Our objective was to develop an evidence-based framework for surveillance of emerging tick-borne zoonoses. We conducted a realist review to understand the available approaches and major challenges associated with surveillance of emerging tick-borne zoonoses...
June 2019: One Health
Per Bjark
No abstract text is available yet for this article.
February 26, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Bryant J Webber, Rachael P Burganowski, Leah Colton, James D Escobar, Sonal R Pathak, Kelly J Gambino-Shirley
OBJECTIVES: To evaluate the impact of false positive IgM immunoblots on Lyme disease treatment and case reporting in a large healthcare system. METHODS: We obtained results of all Lyme disease serologic tests ordered at U.S. Air Force healthcare facilities in the United States between January 2013 and December 2017. We conducted chart reviews to adjudicate positive IgM immunoblots (from two-tier and independent testing) as true positives or false positives using established criteria, and we assessed whether these cases were reported to the U...
February 22, 2019: Clinical Microbiology and Infection
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