Pedro Alves Soares Vaz de Castro, Letícia Bitencourt, Juliana Lacerda de Oliveira Campos, Bruna Luisa Fischer, Stephanie Bruna Camilo Soares de Brito, Beatriz Santana Soares, Juliana Beaudette Drummond, Ana Cristina Simões E Silva
Nephrogenic diabetes insipidus (NDI) is characterized by the inability to concentrate urine that results in polyuria and polydipsia, despite having normal or elevated plasma concentrations of arginine vasopressin (AVP). In this study, we review the clinical aspects and diagnosis of NDI, the various etiologies, current treatment options and potential future developments. NDI has different clinical manifestations and approaches according to the etiology. Hereditary forms of NDI are mainly caused by mutations in the genes that encode key proteins in the AVP signaling pathway, while acquired causes are normally associated with specific drug exposure, especially lithium, and hydroelectrolytic disorders...
April 26, 2022: Journal of Pediatric Endocrinology & Metabolism: JPEM