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Ting Li, Zhao-Hui Liu, Kui Li, Hui-Hui Bai
OBJECTIVE: The Vaginal Microecology Evaluation System (VMES) is a technical and economically feasible tool to assess the vaginal microbiomes of gynecological outpatients. The aim of this review was to introduce knowledge on the potential changes that can occur in the vaginal microbiome and how to use the Evaluation System to diagnose and manage a broad range of vaginal infections. DATA SOURCES: This review was based on data in articles published in PubMed up to December 10, 2018, with the following keywords: "Vaginal microecosystem", "vaginal microbiome", "vaginal microbiota", and "vaginal flora"...
March 19, 2019: Chinese Medical Journal
Lei Gu, Yidong Xu, Wangyan Xu, Meng Li, Hui Su, Cong Li, Zhongchen Liu
Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC. We aimed to investigate the effect of IDB on exosome secretion in a CRC xenograft mouse model. An IDB mouse model was established and was inoculated with the CRC cell line SW480 as a xenograft tumor. Tumor growth was monitored for 15 days in sham and IDB mice, after which blood was collected to assess serum exosome secretion...
March 19, 2019: Investigational New Drugs
Sha Zhao, Guanghui Gao, Wei Li, Xuefei Li, Chao Zhao, Tao Jiang, Yijun Jia, Yayi He, Aiwu Li, Chunxia Su, Shengxiang Ren, Xiaoxia Chen, Caicun Zhou
OBJECTIVES: Gut microbiome plays a dominant role in modulating therapeutic efficacy of immune checkpoint inhibitors (ICIs) targeting the programmed cell death receptor/ligand-1 (PD-1/PD-L1) pathway, suggesting that co-administration of antibiotics (Abx), which might result in dysbacteriosis, can attenuate the clinical outcomes of ICIs. The current study aimed to investigate the predictive role of Abx on ICIs treatment in patients with advanced non-small cell lung cancer (NSCLC). The impact of proton pump inhibitors (PPIs), another medication that can induce dysbacteriosis, was also investigated...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Haoran Lu, Luxuan Zhang, Junfang Xiao, Che Wu, Huanmin Zhang, Yihu Chen, Zhengyong Hu, Wencheng Lin, Qingmei Xie, Hongxin Li
BACKGROUND: As a low pathogenic influenza virus, avian influenza virus subtype H9N2 (H9N2 AIV) often induces high morbidity in association with secondary bacterial infections in chickens or mammals. To explore this phenomenon, the relationship between intestinal microflora changes and bacterial translocations was studied post H9N2 AIV challenge and post AIV infection plus Ageratum-liquid treatment. METHODS: Illumina sequencing, histological examination and Neongreen-tagged bacteria were used in this study to research the microbiota composition, intestinal barrier, and bacterial translocation in six weeks of BALB/c mice...
February 21, 2019: Virology Journal
Dongwen Ma, Yidan Chen, Tingtao Chen
Bacterial vaginosis (BV), caused by the vaginal dysbacteriosis as well as the excessive growth of pathogenic bacteria, is a pathological condition of the vagina; its treatment using the antibiotics metronidazole or clindamycin often causes high recurrence rates. Considering the similar physiological environments of the intestinal tract and vaginal tract, as well as the pathological mechanism of intestinal infection and vaginal infection, we first propose the conception of vaginal microbiota transplantation (VMT) and discuss its potential use in BV...
January 31, 2019: FEMS Microbiology Letters
Qiujin Jia, Yingyu Xie, Chunmiao Lu, Ao Zhang, Yanmin Lu, Shichao Lv, Junping Zhang
Gut microbiota (GM) is a collection of bacteria, fungi, archaea, viruses and protozoa, etc. They inhabit human intestines and play an essential role in human health and disease. Close information exchange between the intestinal microbes and the host performs a vital role in digestion, immune defence, nervous system regulation, especially metabolism, maintaining a delicate balance between itself and the human host. Studies have shown that the composition of GM and its metabolites are firmly related to the occurrence of various diseases...
January 27, 2019: Journal of Cellular and Molecular Medicine
Ziwei Song, Yuanyuan Cai, Xingzhen Lao, Xue Wang, Xiaoxuan Lin, Yingyun Cui, Praveen Kumar Kalavagunta, Jun Liao, Liang Jin, Jing Shang, Jing Li
BACKGROUND: Bile salt hydrolase plays an important role in bile acid-mediated signaling pathways, which regulate lipid absorption, glucose metabolism, and energy homeostasis. Several reports suggest that changes in the composition of bile acids are found in many diseases caused by dysbacteriosis. RESULTS: Here, we present the taxonomic identification of bile salt hydrolase (BSH) in human microbiota and elucidate the abundance and activity differences of various bacterial BSH among 11 different populations from six continents...
January 23, 2019: Microbiome
Franco Frati, Cristina Salvatori, Cristoforo Incorvaia, Alessandro Bellucci, Giuseppe Di Cara, Francesco Marcucci, Susanna Esposito
Asthma is one of the most common chronic respiratory diseases worldwide. It affects all ages but frequently begins in childhood. Initiation and exacerbations may depend on individual susceptibility, viral infections, allergen exposure, tobacco smoke exposure, and outdoor air pollution. The aim of this review was to analyze the role of the gut⁻lung axis in asthma development, considering all asthma phenotypes, and to evaluate whether microbe-based therapies may be used for asthma prevention. Several studies have confirmed the role of microbiota in the regulation of immune function and the development of atopy and asthma...
December 30, 2018: International Journal of Molecular Sciences
Xiaomei Wang, Qin Qi, Yuanyuan Wang, Huangan Wu, Xiaoming Jin, Huan Yao, Duiyin Jin, Yanan Liu, Cun Wang
Background: The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of moxibustion in IBS treatment remains unknown. Methods: An IBS rat model was established by colorectal distention (CRD) stimulus and mustard oil clyster. Sixty-five male rats were randomly divided into six groups: normal, IBS model, moxibustion, electroacupuncture (EA), Bifid-triple Viable Capsule (BTVC) and Pinaverium Bromide (PB) groups...
2018: Chinese Medicine
Rong Bohan, Xia Tianyu, Zhang Tiantian, Feng Ruonan, Huang Hongtao, Wu Qiong, Sun Chao
Normally, the gut microbiota has a mutually beneficial association with host health and maintains its commensal status in mammals. Conversely, it can also negatively influence host physiology under some certain circumstances, including obesity and other disease states. Although numerous gut microbial functions directly affect the gastrointestinal tract, in this paper, we focus on the influences of the gut microbiota on host adipose tissue and energy metabolism, particularly lipometabolism. We thoroughly discuss two important microbial products, short-chain fat acids and lipopolysaccharides, which are linked to several mechanisms involved in obesity and adipose, including differentiation, energy metabolism and immunity...
February 2019: Journal of Nutritional Biochemistry
Jiangyan Li, Meng Tang, Yuying Xue
Gut bacteria are involved in regulating several important physiological functions in the host, and intestinal dysbacteriosis plays an important role in several human diseases, including intestinal, metabolic and autoimmune disorders. Although silver nanoparticles (AgNPs) are increasingly being incorporated into medical and consumer products due to their unique physicochemical properties, studies have indicated their potential to affect adversely the gut bacteria. In this review, we focus on the biotoxicological effects of AgNPs entering the gastrointestinal tract and the relationship of these effects with important nanoscale properties...
January 2019: Journal of Applied Toxicology: JAT
Guangsheng Wan, Manli Xie, Hongjie Yu, Hongyu Chen
In this study we investigated the association between intestinal dysbacteriosis with colorectal cancer progress and the underlying molecular mechanisms. Tumor progression was evaluated using xenograft mice model. The epithelial-mesenchymal transition (EMT) markers were quantified by both real-time PCR and immunoblotting. The serum content of IL-6 and TNF-α were measured with ELISA kits. Cell proliferation was determined by the Cell Counting Kit-8. Intestinal dysbacteriosis was successfully simulated by the administration of a large dose of antibiotics and was demonstrated to promote xenograft tumor growth and induce EMT...
September 23, 2018: Innate Immunity
Dana K Dittoe, Steven C Ricke, Aaron S Kiess
Recently, antibiotics have been withdrawn from some poultry diets; leaving the birds at risk for increased incidence of dysbacteriosis and disease. Furthermore, mortalities occurring from disease contribute between 10 to 20% of production cost in developed countries. Currently, numerous feed supplements are being proposed as effective antibiotic alternatives in poultry diets, such as prebiotics, probiotics, acidic compounds, competitive exclusion products, herbs, essential oils, and bacteriophages. However, acidic compounds consisting of organic acids show promise as antibiotic alternatives...
2018: Frontiers in Veterinary Science
Lígia A B M Mendonça, Rosângela Dos Santos Ferreira, Rita de Cássia Avellaneda Guimarães, Alinne P de Castro, Octávio L Franco, Rosemary Matias, Cristiano M E Carvalho
Colorectal cancer exerts a strong influence on the epidemiological panorama worldwide, and it is directly correlated to etiologic factors that are substantiated by genetic and environmental elements. This complex mixture of factors also has a relationship involving the structural dependence and composition of the gut microbiome, leading to a dysbacteriosis process that may evolve to serious modifications in the intestinal lining, eventually causing the development of a neoplasm. The gastrointestinal tract presents defense strategies and immunological properties that interfere in intestinal permeability, inhibiting the bacterial translocation, thus maintaining the integrity of intestinal homeostasis...
2018: Frontiers in Oncology
Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang, Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count...
2018: Cell Cycle
Ziad Nabee, Rajesh Jeewon, Prity Pugo-Gunsam
Background: Salivary changes and proliferation of specific bacterial communities are known to result in oral disease which may adversely impact on systemic conditions like diabetes and cardiovascular diseases. Objectives: This study reports on the changes in oral ecology of healthy and diseased adults and the possible role in disease causation. Methods: The study comprised 150 participants divided into control (healthy), diabetic and cardiac groups...
December 2017: African Health Sciences
Anna Fábián, Mariann Rutka, Tamás Ferenci, Renáta Bor, Anita Bálint, Klaudia Farkas, Ágnes Milassin, Kata Szántó, Zsuzsanna Lénárt, Ferenc Nagy, Zoltán Szepes, Tamás Molnár
Background and Aims: Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases. Materials and Methods: The use of herbs and botanicals, lifestyle modifications and mind/body therapies, patient satisfaction, and continuous use of conventional medicine were assessed with an anonymous questionnaire at a tertiary IBD unit in Hungary...
2018: Gastroenterology Research and Practice
Thanit Chalermwatanachai, Ramiro Vilchez-Vargas, Gabriele Holtappels, Tim Lacoere, Ruy Jáuregui, Frederiek-Maarten Kerckhof, Dietmar H Pieper, Tom Van de Wiele, Mario Vaneechoutte, Thibaut Van Zele, Claus Bachert
Chronic rhinosinusitis with nasal polyp (CRSwNP) patients are often characterized by asthma comorbidity and a type-2 inflammation of the sinonasal mucosa. The mucosal microbiota has been suggested to be implicated in the persistence of inflammation, but associations have not been well defined. To compare the bacterial communities of healthy subjects with CRSwNP patients, we collected nasal swabs from 17 healthy subjects, 21 CRSwNP patients without asthma (CRSwNP-A), and 20 CRSwNP patients with co-morbid asthma (CRSwNP+A)...
May 21, 2018: Scientific Reports
Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice...
July 2018: International Immunopharmacology
Lei Zhang, Fei Li, Wang-Jun Qin, Chao Fu, Xiang-Lin Zhang
Ginsenoside Re, an active ingredient in Panax ginseng, is widely used as a therapeutic and nutriment. The intestinal microbiota plays crucial roles in modulating the pharmacokinetics and pharmacological actions of ginsenoside Re. The aim of this study was to explore the relationship between bacterial community variety and the metabolic profiles of ginsenoside Re. We developed two models with intestinal dysbacteriosis: a pseudo-germ-free model induced by a nonabsorbable antimicrobial mixture (ATM), and Qi-deficiency model established via over-fatigue and acute cold stress (OACS)...
October 2018: Biomedical Chromatography: BMC
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