Oana M Dumitrascu, Jonah Doustar, Dieu-Trang Fuchs, Yosef Koronyo, Dale S Sherman, Michelle Shizu Miller, Kenneth O Johnson, Roxana O Carare, Steven R Verdooner, Patrick D Lyden, Julie A Schneider, Keith L Black, Maya Koronyo-Hamaoui
INTRODUCTION: The vascular contribution to Alzheimer's disease (AD) is tightly connected to cognitive performance across the AD continuum. We topographically describe retinal perivascular amyloid plaque (AP) burden in subjects with normal or impaired cognition. METHODS: Using scanning laser ophthalmoscopy, we quantified retinal peri-arteriolar and peri-venular curcumin-positive APs in the first, secondary and tertiary branches in twenty-eight subjects. Perivascular AP burden among cognitive states was correlated with neuroimaging and cognitive measures...
February 29, 2024: bioRxiv