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https://read.qxmd.com/read/30762911/secreted-frizzled-related-protein-5-serum-levels-in-human-periodontitis-a-nested-case-control-study
#1
Juliane Schulz, Carina Knappe, Christian Graetz, Louisa Mewes, Kathrin Türk, Anna K Black, Wolfgang Lieb, Arne S Schäfer, Karim M Fawzy El-Sayed, Christof E Dörfer, Stefan Schreiber, Matthias Laudes, Dominik M Schulte
AIM: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach. MATERIALS AND METHODS: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design...
February 14, 2019: Journal of Clinical Periodontology
https://read.qxmd.com/read/30762267/the-effect-of-cumin-supplementation-on-metabolic-profiles-in-patients-with-metabolic-syndrome-a-randomized-triple-blind-placebo-controlled-clinical-trial
#2
Ashti Morovati, Bahram Pourghassem Gargari, Parvin Sarbakhsh, Hushyar Azari, Lida Lotfi-Dizaji
Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks...
February 14, 2019: Phytotherapy Research: PTR
https://read.qxmd.com/read/30762138/antidepressive-effects-of-kaempferol-mediated-by-reduction-of-oxidative-stress-proinflammatory-cytokines-and-up-regulation-of-akt-%C3%AE-catenin-cascade
#3
Wenqi Gao, Wei Wang, Yan Peng, Zhifang Deng
Kaempferol (KFL), the major constituent of various fruits and vegetables, could attenuate oxidaitve stress and inflammation. The aims of the present study were to explore the ameliorative abilities of KFL on the depressive-like behaviors in a chronic social defeat stress (CSDS) mouse model, and to determine the potential mechanisms on oxidative stress, neuroinflammation, and AKT/β-catenin signaling pathway. Three behavioral tests, sucrose preference test (SPT), social interaction test (SIT), and tail suspension test (TST), were used to evaluate the antidepressive effects of KFL in CSDS mice...
February 14, 2019: Metabolic Brain Disease
https://read.qxmd.com/read/30761127/p31-43-gliadin-peptide-forms-oligomers-and-induces-nlrp3-inflammasome-caspase-1-dependent-mucosal-damage-in-small-intestine
#4
María Florencia Gómez Castro, Emanuel Miculán, María Georgina Herrera, Carolina Ruera, Federico Perez, Eduardo Daniel Prieto, Exequiel Barrera, Sergio Pantano, Paula Carasi, Fernando Gabriel Chirdo
Celiac disease (CD) is a chronic enteropathy elicited by a Th1 response to gluten peptides in the small intestine of genetically susceptible individuals. However, it remains unclear what drives the induction of inflammatory responses of this kind against harmless antigens in food. In a recent work, we have shown that the p31-43 peptide (p31-43) from α-gliadin can induce an innate immune response in the intestine and that this may initiate pathological adaptive immunity. The receptors and mechanisms responsible for the induction of innate immunity by p31-43 are unknown and here we present evidence that this may reflect conformational changes in the peptide that allow it to activate the NLRP3 inflammasome...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30756082/the-effects-of-korea-red-ginseng-on-inflammatory-cytokines-and-apoptosis-in-rat-model-with-chronic-nonbacterial-prostatitis
#5
Sang Wook Kang, Je-Hoon Park, Hosik Seok, Hae Jeong Park, Joo-Ho Chung, Chang-Ju Kim, Young Ock Kim, Young Rok Han, DongWhan Hong, Young Sik Kim, Su Kang Kim
Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. To induce CNP, rats were castrated and beta-estradiol (0.25 mg/kg) was subcutaneously (s.c.) injected daily...
2019: BioMed Research International
https://read.qxmd.com/read/30755631/exposure-to-nanoscale-particulate-matter-from-gestation-to-adulthood-impairs-metabolic-homeostasis-in-mice
#6
Nicholas C Woodward, Amanda L Crow, Yang Zhang, Sam Epstein, Jaana Hartiala, Richard Johnson, Heidi Kocalis, Arian Saffari, Ishwarya Sankaranarayanan, Omid Akbari, Gajalakshmi Ramanathan, Jesus A Araujo, Caleb E Finch, Sebastien G Bouret, Constantinos Sioutas, Todd E Morgan, Hooman Allayee
Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM2.5 ) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice...
February 12, 2019: Scientific Reports
https://read.qxmd.com/read/30755185/improved-antibacterial-effects-of-alkali-transformed-saponin-from-quinoa-husks-against-halitosis-related-bacteria
#7
Xiaoyan Sun, Xiushi Yang, Peng Xue, Zhiguo Zhang, Guixing Ren
BACKGROUND: Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8-12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has been reported to exhibit anti-inflammatory and antifungal activity. However, the antibacterial effects of quinoa saponin against halitosis-related bacteria are still unclear. METHODS: In this study, quinoa saponin (QS) and alkali-transformed saponin (ATS) were separated by AB-2 resin to obtain QS-30, QS-80, ATS-30 and ATS-80...
February 12, 2019: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/30753883/alkamides-from-tropaeolum-tuberosum-inhibit-inflammatory-response-induced-by-tnf-%C3%AE-and-nf-%C3%AE%C2%BAb
#8
Apaza T Luis, Tena Pérez Victor, S Erban Andreea Madalina, Alonso Navarro Matías J, Rumbero Angel
ETHNO-PHARMACOLOGICAL RELEVANCE: Tropaeolum tuberosum, commonly known as "Mashua", is one of the plants most frequently used by Andean (Peruvian-Bolivian) people as food and medicine. It is used as a remedy against a wide range of diseases, especially those related with inflammation. OBJECTIVES: This study aims to identify compounds active against inflammatory related conditions. MATERIALS AND METHODS: A bioassay-guided isolation of anti-inflammatory compounds from black and purple tubers of T...
February 9, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30753323/consumption-of-cashew-nuts-does-not-influence-blood-lipids-or-other-markers-of-cardiovascular-disease-in-humans-a-randomized-controlled-trial
#9
David J Baer, Janet A Novotny
Background: The US Food and Drug Administration (FDA) approved a qualified health claim for tree nuts and reduction of cardiovascular disease. However, cashews are excluded from that claim due to their content of saturated fats, which is predominantly stearic acid. Because stearic acid is neutral with respect to blood lipids, several studies have been conducted to test the effect of cashew nuts on blood lipids, and these studies have produced conflicting results. Objectives: The aim of this study was to conduct a highly controlled intervention to determine the effect of cashews fed at the amount specified in the health claim on risk factors for cardiovascular disease...
February 1, 2019: American Journal of Clinical Nutrition
https://read.qxmd.com/read/30747606/no-relation-between-zinc-status-and-inflammatory-biomarkers-in-adolescent-judokas
#10
Artemizia Francisca de Sousa, Laiana Sepúlveda de Andrade Mesquita, Kyria Jayanne Clímaco Cruz, Ana Raquel Soares de Oliveira, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Jéssica Batista Beserra, Nadir do Nascimento Nogueira, Dilina do Nascimento Marreiro
This study aimed to assess the relation between zinc status and inflammation biomarkers in adolescent judokas. This cross-sectional study included 52 male adolescents, aged between 14 and 19 years, who were subdivided into two groups: judoka group (n = 25) and control group (n = 27). Zinc intake was monitored using 3-day food records and the NutWin software version 1.5. The plasma and erythrocyte zinc concentrations were determined by flame atomic absorption spectrophotometry. Analysis of cytokines (IL-1β, IL-6, and TNF-α) was performed...
February 12, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://read.qxmd.com/read/30747184/vitamin-a-inhibits-the-action-of-lps-on-the-intestinal-epithelial-barrier-function-and-tight-junction-proteins
#11
Caimei He, Jun Deng, Xin Hu, Sichun Zhou, Jingtao Wu, Di Xiao, Kwame Oteng Darko, Yanjun Huang, Ting Tao, Mei Peng, Zhiren Wang, Xiaoping Yang
Inflammation caused by either intrinsic or extrinsic toxins results in intestinal barrier dysfunction, contributing to inflammatory bowel disease (IBD) and other diseases. Vitamin A is a widely used food supplement although its mechanistic effect on intestinal structures is largely unknown. The goal of this study was to explore the mechanism by investigating the influence of vitamin A on the intestinal barrier function, represented by tight junctions. IPEC-J2 cells were differentiated on transwell inserts and used as a model of intestinal barrier permeability...
February 12, 2019: Food & Function
https://read.qxmd.com/read/30746696/anti-inflammatory-effects-of-resolvins-in-diabetic-nephropathy-mechanistic-pathways
#12
REVIEW
Habib Yaribeygi, Stephen L Atkin, Luis E Simental-Mendía, George E Barreto, Amirhossein Sahebkar
The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear...
February 11, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30744677/metaproteomics-reveals-persistent-and-phylum-redundant-metabolic-functional-stability-in-adult-human-gut-microbiomes-of-crohn-s-remission-patients-despite-temporal-variations-in-microbial-taxa-genomes-and-proteomes
#13
J Alfredo Blakeley-Ruiz, Alison R Erickson, Brandi L Cantarel, Weili Xiong, Rachel Adams, Janet K Jansson, Claire M Fraser, Robert L Hettich
BACKGROUND: The gut microbiome plays a fundamental role in the human host's overall health by contributing key biological functions such as expanded metabolism and pathogen defense/immune control. In a healthy individual, the gut microbiome co-exists within the human host in a symbiotic, non-inflammatory relationship that enables mutual benefits, such as microbial degradation of indigestible food products into small molecules that the host can utilize, and enhanced pathogen defense. In abnormal conditions, such as Crohn's disease, this favorable metabolic relationship breaks down and a variety of undesirable activities result, including chronic inflammation and other health-related issues...
February 11, 2019: Microbiome
https://read.qxmd.com/read/30744084/antioxidant-%C3%AE-amylase-and-%C3%AE-glucosidase-inhibitory-activities-and-potential-constituents-of-canarium-tramdenum-bark
#14
Nguyen Van Quan, Tran Dang Xuan, Hoang-Dung Tran, Nguyen Thi Dieu Thuy, Le Thu Trang, Can Thu Huong, Yusuf Andriana, Phung Thi Tuyen
The fruits of Canarium tramdenum are commonly used as foods and cooking ingredients in Vietnam, Laos, and the southeast region of China, whilst the leaves are traditionally used for treating diarrhea and rheumatism. This study was conducted to investigate the potential use of this plant bark as antioxidants, and α-amylase and α-glucosidase inhibitors. Five different extracts of C. tramdenum bark (TDB) consisting of the extract (TDBS) and factional extracts hexane (TDBH), ethyl acetate (TDBE), butanol (TDBB), and water (TDBW) were evaluated...
February 9, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30743984/formulations-of-curcumin-nanoparticles-for-brain-diseases
#15
REVIEW
María L Del Prado-Audelo, Isaac H Caballero-Florán, Jorge A Meza-Toledo, Néstor Mendoza-Muñoz, Maykel González-Torres, Benjamín Florán, Hernán Cortés, Gerardo Leyva-Gómez
Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms "curcumin" and "curcumin brain diseases", which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions...
February 8, 2019: Biomolecules
https://read.qxmd.com/read/30741729/a-further-assessment-of-a-role-for-toll-like-receptor-4-in-the-reinforcing-and-reinstating-effects-of-opioids
#16
Kai Yue, Gianluigi Tanda, Jonathan L Katz, Claudio Zanettini
The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids in rats and to reduce other preclinical indicators of abuse potential. However, under the self-administration conditions studied, the effects of TLR4 antagonists were not reinforcer selective, questioning the involvement of those receptors and their mediated inflammatory response specifically in opioid abuse. The objectives of the current study were to further characterize the reinforcer specificity of TLR4 antagonism in opioid self-administration and to explore its effects in a preclinical model of craving/relapse...
February 7, 2019: Behavioural Pharmacology
https://read.qxmd.com/read/30741253/sexual-transmission-of-american-trypanosomes-from-males-and-females-to-naive-mates
#17
Adriana B Almeida, Perla F Araújo, Francisco M Bernal, Ana de Cassia Rosa, Sebastião A Valente, Antonio R L Teixeira
American trypanosomiasis is transmitted to humans by triatomine bugs through the ingestion of contaminated food, by blood transfusions or accidently in hospitals and research laboratories. In addition, the Trypanosoma cruzi infection is transmitted congenitally from a chagasic mother to her offspring, but the male partner's contribution to in utero contamination is unknown. The findings of nests and clumps of amastigotes and of trypomastigotes in the theca cells of the ovary, in the goniablasts and in the lumen of seminiferous tubules suggest that T...
January 27, 2019: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/30739283/analyses-of-the-possible-anti-tumor-effect-of-yokukansan
#18
Cheolsun Han, Miho Kawata, Yusuke Hamada, Takashige Kondo, Junna Wada, Katsunori Asano, Hitoshi Makabe, Katsuhide Igarashi, Naoko Kuzumaki, Michiko Narita, Hiroyuki Kobayashi, Minoru Narita
The Kampo medicine yokukansan (YKS) has a wide variety of properties such as anxiolytic, anti-inflammatory and analgesic effects, and is also thought to regulate tumor suppression. In this study, we investigated the anti-tumor effect of YKS. We used Lewis lung carcinoma (LLC)-bearing mice that were fed food pellets containing YKS and then performed a fecal microbiota analysis, a microarray analysis for microRNAs (miRNAs) and an in vitro anti-tumor assay. The fecal microbiota analysis revealed that treatment with YKS partly reversed changes in the microbiota composition due to LLC implantation...
February 9, 2019: Journal of Natural Medicines
https://read.qxmd.com/read/30737369/defective-proteostasis-in-celiac-disease-as-a-new-therapeutic-target
#19
REVIEW
Luigi Maiuri, Valeria R Villella, Mauro Piacentini, Valeria Raia, Guido Kroemer
Cystic fibrosis (CF) is a disease caused by loss-of-function mutations affecting the CF transmembrane conductance regulator (CFTR), a chloride channel. Recent evidence indicates that CFTR is inhibited by a gluten/gliadin-derived peptide (P31-43), causing an acquired state of CFTR inhibition within the gut that contributes to the pathogenesis of celiac disease (CD). Of note, CFTR inhibition does not only cause intra- and extracellular ion imbalances but also affects proteostasis by activating transglutaminase-2 (TGM2) and by disabling autophagy...
February 8, 2019: Cell Death & Disease
https://read.qxmd.com/read/30737049/the-inflammatory-potential-of-diet-is-related-to-incident-frailty-and-slow-walking-in-older-adults
#20
Martin Laclaustra, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon, Jose R Banegas, Auxiliadora Graciani, Esther Garcia-Esquinas, Esther Lopez-Garcia
BACKGROUND: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes. METHODS: Data were taken from 1948 community-dwelling individuals ≥60 years old from the Seniors-ENRICA cohort, who were recruited in 2008-2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an "a priori" pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an "a posteriori" pattern score which was statistically derived from an epidemiological study...
January 24, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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