Huijun Sun, Jie Dong, Zhaoyue Fu, Xueyan Lu, Xutao Chen, Hui Lei, Xifeng Xiao, Shuqiang Chen, Jie Lu, Danjie Su, Yujing Xiong, Zheng Fang, Jiaqin Mao, Lihua Chen, Xiaohong Wang
Intrauterine adhesion (IUA), commonly known as Asherman's syndrome, is a disease characterized by the formation of fibrous scar tissue within the uterine cavity, which can lead to severe clinical complications and significantly compromise the reproductive health and fertility of women. Unfortunately, severe cases of IUA currently lack effective treatment. This study presents a novel approach that utilizes TSG6-modified exosomes (Exos) in conjunction with an injectable thermosensitive hydrogel (CS/GP) to mitigate the occurrence of IUA by reducing endometrium fibrosis in a mouse IUA model...
April 8, 2024: Advanced Materials