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JOURNAL ARTICLE
Heba M Badawe, Jean Paul Harouz, Petra Raad, Kareem Abu, Anthony Freije, Kamel Ghali, Wassim Abou-Kheir, Massoud L Khraiche
High-intensity focused ultrasound (HIFU) is a non-invasive therapeutic modality that uses precise acoustic energy to ablate cancerous tissues through coagulative necrosis. In this context, we investigate the efficacy of HIFU ablation in two distinct cellular configurations, namely 2D monolayers and 3D spheroids of epithelial breast cancer cell lines (MDA-MB 231 and MCF7). The primary objective is to compare the response of these two in vitro models to HIFU while measuring their ablation percentages and temperature elevation levels...
March 25, 2024: Cancers
#22
JOURNAL ARTICLE
Mohd Azhafiz Abdullah, L F Chuah, Razak Zakariya, Asad Syed, Rozaimi Che Hasan, Shahrul Miza Mahmud, Abdallah M Elgorban, A Bokhari, Muhammad Saeed Akhtar, Hind A Al-Shwaiman
Crucial to the Earth's oceans, ocean currents dynamically react to various factors, including rotation, wind patterns, temperature fluctuations, alterations in salinity and the gravitational pull of the moon. Climate change impacts coastal ecosystems, emphasizing the need for understanding these currents. This study explores multibeam echo sounder (MBES), specifically R2-Sonic 2020, offering detailed seabed information. Investigating coral reefs, rocky reefs and artificial reefs aimed to map seafloor currents movement and their climate change responses...
April 10, 2024: Environmental Research
#23
JOURNAL ARTICLE
Mathilde Puges, Caroline Caradu, Isabelle Svahn, Etienne Gontier, Fatima Mzali, Carole Vignals, Charles Cazanave, Xavier Bérard
BACKGROUND: Vascular graft and endograft infections (VGEIs) are complicated by high morbidity, mortality, and recurrence rates, notably due to biofilm formation on the graft surface, hardly dislodgeable by the sole anti-infectious treatment. The characteristics of this biofilm are still poorly documented. The aim of this study was to evaluate ex vivo biofilm on removed infected vascular grafts and endografts (VGEs). METHODS: Explanted VGEs were prospectively collected from 2019 to 2022 at Bordeaux University Hospital, France...
April 10, 2024: Journal of Vascular Surgery
#24
JOURNAL ARTICLE
Qian Ma, Tao Zhou, Zhong Wang, Yanjie Zhao, Xiaodong Li, Lu Liu, Xiuxiu Zhang, Kouadio Jean Eric-Parfait Kouame, Shuo Chen
Starting from the consideration of the structure of human milk fat globule (MFG), this study aimed to investigate the effects of ultrasonic treatment on milk fat globule membrane (MFGM) and soy lecithin (SL) complexes and their role in mimicking human MFG emulsions. Ultrasonic power significantly affected the structure of the MFGM-SL complex, further promoting the unfolding of the molecular structure of the protein, and then increased solubility and surface hydrophobicity. Furthermore, the microstructure of mimicking MFG emulsions without sonication was unevenly distributed, and the average droplet diameter was large...
April 8, 2024: Ultrasonics Sonochemistry
#25
JOURNAL ARTICLE
Mingjuan Li, Esmeralda D C Bosman, Olivia M Smith, Nicole Lintern, Daniel J de Klerk, Hong Sun, Shuqun Cheng, Weiwei Pan, Gert Storm, Yazan S Khaled, Michal Heger
This first-in-its-class proof-of-concept study explored the use of bionanovesicles for the delivery of photosensitizer into cultured cholangiocarcinoma cells and subsequent treatment by photodynamic therapy (PDT). Two types of bionanovesicles were prepared: cellular vesicles (CVs) were fabricated by sonication-mediated nanosizing of cholangiocarcinoma (TFK-1) cells, whereas cell membrane vesicles (CMVs) were produced by TFK-1 cell and organelle membrane isolation and subsequent nanovesicularization by sonication...
April 2, 2024: Journal of Photochemistry and Photobiology. B, Biology
#26
REVIEW
Hanjie Yang, Min Li, Yuhao Deng, Huantao Wen, Minjie Luo, Wangming Zhang
Medulloblastomas, the most common malignant pediatric brain tumors, can be classified into the wingless, sonic hedgehog (SHH), group 3, and group 4 subgroups. Among them, the SHH subgroup with the TP53 mutation and group 3 generally present with the worst patient outcomes due to their high rates of recurrence and metastasis. A novel and effective treatment for refractory medulloblastomas is urgently needed. To date, the tumor microenvironment (TME) has been shown to influence tumor growth, recurrence, and metastasis through immunosuppression, angiogenesis, and chronic inflammation...
April 2024: Genes, Chromosomes & Cancer
#27
JOURNAL ARTICLE
Denisa Lizonova, Una Trivanovic, Philip Demokritou, Georgios A Kelesidis
Methodologies across the dispersion preparation, characterization, and cellular dosimetry of hydrophilic nanoparticles (NPs) have been developed and used extensively in the field of nanotoxicology. However, hydrophobic NPs pose a challenge for dispersion in aqueous culture media using conventional methods that include sonication followed by mixing in the culture medium of interest and cellular dosimetry. In this study, a robust methodology for the preparation of stable dispersions of hydrophobic NPs for cellular studies is developed by introducing continuous energy over time via stirring in the culture medium followed by dispersion characterization and cellular dosimetry...
March 27, 2024: Nanomaterials
#28
JOURNAL ARTICLE
Yuyang Liu, Shiyin Zhao, Yujiao Li, Jian Huang, Xuheng Yang, Jianfang Wang, Cheng-An Tao
Chemical warfare agents (CWAs) refer to toxic chemical substances used in warfare. Recently, CWAs have been a critical threat for public safety due to their high toxicity. Metal-organic frameworks have exhibited great potential in protecting against CWAs due to their high crystallinity, stable structure, large specific surface area, high porosity, and adjustable structure. However, the metal clusters of most reported MOFs might be highly consumed when applied in CWA hydrolysis. Herein, we fabricated a two-dimensional piezoresponsive UiO-66-F4 and subjected it to CWA simulant dimethyl-4-nitrophenyl phosphate (DMNP) detoxification under sonic conditions...
March 22, 2024: Nanomaterials
#29
JOURNAL ARTICLE
M Giaccherini, M Rende, M Gentiluomo, C Corradi, L Archibugi, S Ermini, E Maiello, L Morelli, C H J van Eijck, G M Cavestro, M Schneider, A Mickevicius, K Adamonis, D Basso, V Hlavac, D Gioffreda, R Talar-Wojnarowska, B Schöttker, M Lovecek, G Vanella, M Gazouli, M Uno, E Malecka-Wojciesko, P Vodicka, M Goetz, M F Bijlsma, M C Petrone, F Bazzocchi, M Kiudelis, A Szentesi, S Carrara, G Nappo, H Brenner, A C Milanetto, P Soucek, V Katzke, G Peduzzi, C Rizzato, C Pasquali, X Chen, G Capurso, T Hackert, B Bueno-de-Mesquita, F G G Uzunoglu, P Hegyi, W Greenhalf, G E E Theodoropoulos, C Sperti, F Perri, M Oliverius, A Mambrini, F Tavano, R Farinella, P G Arcidiacono, M Lucchesi, S Bunduc, J Kupcinskas, G Di Franco, S Stocker, J P Neoptolemos, F Bambi, K Jamroziak, S G G Testoni, M N Aoki, B Mohelnikova-Duchonova, J R Izbicki, R Pezzilli, R T Lawlor, E F Kauffmann, E López de Maturana, N Malats, F Canzian, D Campa
Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls...
April 12, 2024: Mutagenesis
#30
JOURNAL ARTICLE
Kiran K Mali, Yogeshkumar N Gavhane, Rita D Chakole
Smart nanomedicinal treatment for cancer manifests a solubility challenge with inherent nanoscale size and nonspecific release with stimuli-responsive potential. This is the limelight in novel chemotherapy to pursue physiochemical differences between the tumor microenvironment (TME) and normal cells, which introduces active groups of nanocarriers responding to various stimuli, endowing them with concise responses to various tumor-related signals. The nanogels were successfully prepared by a modified solvent evaporation technique...
April 11, 2024: AAPS PharmSciTech
#31
JOURNAL ARTICLE
Yongmin Kwon, Chanhee Kim, Giltsu Choi
Phytochrome B (phyB), a plant photoreceptor, forms a membraneless organelle known as a photobody. Here, we present a protocol for the isolation of phyB photobodies through fluorescence-activated particle sorting from mature transgenic Arabidopsis leaves expressing phyB-GFP. This protocol involves the isolation of nuclei from frozen ground leaves using sucrose gradient centrifugation, the disruption of nuclear envelopes by sonication, and the subsequent isolation of phyB photobodies through fluorescence-activated particle sorting...
2024: Methods in Molecular Biology
#32
JOURNAL ARTICLE
Shuze Wang, Saikat Chakraborty, Yujuan Fu, Mary P Lee, Jie Liu, Joerg Waldhaus
In the mammalian auditory system, frequency discrimination depends on numerous morphological and physiological properties of the organ of Corti, which gradually change along the apex-to-base (tonotopic) axis of the organ. For example, the basilar membrane stiffness changes tonotopically, thus affecting the tuning properties of individual hair cells. At the molecular level, those frequency-specific characteristics are mirrored by gene expression gradients; however, the molecular mechanisms controlling tonotopic gene expression in the mouse cochlea remain elusive...
April 4, 2024: Developmental Cell
#33
JOURNAL ARTICLE
Georgia da Silva Feltran, Amanda Fantini de Andrade, Célio Jr da C Fernandes, Rodrigo A Foganholi da Silva, Willian F Zambuzzi
During the morphological changes occurring in osteoblast differentiation, Sonic hedgehog (Shh) plays a crucial role. While some progress has been made in understanding this process, the epigenetic mechanisms governing the expression of Hh signaling members in response to bone morphogenetic protein 7 (BMP7) signaling in osteoblasts remain poorly understood. To delve deeper into this issue, we treated pre-osteoblasts (pObs) with 100 ng/mL of BMP7 for up to 21 days. Initially, we validated the osteogenic phenotype by confirming elevated expression of well-defined gene biomarkers, including Runx2, Osterix, Alkaline Phosphatase (Alp), and bone sialoprotein (Bsp)...
April 9, 2024: Cell Biology International
#34
JOURNAL ARTICLE
Paloma Martínez-Merino, Miguel A Hernández-Rodríguez, José C Piñero, Carlos D S Brites, Rodrigo Alcántara, Javier Navas
Transition metal dichalcogenides, including WSe2 , have gained significant attention as promising nanomaterials for various applications due to their unique properties. In this study, we explore the temperature-dependent photoluminescent properties of WSe2 nanomaterials to investigate their potential as luminescent nanothermometers. We compare the performance of WSe2 quantum dots and nanorods synthesized using sonication synthesis and hot injection methods. Our results show a distinct temperature dependence of the photoluminescence, and conventional ratiometric luminescence thermometry demonstrates comparable relative thermal sensitivity (0...
April 9, 2024: Nanoscale
#35
JOURNAL ARTICLE
Rona Geffen, Christoph Braun
This study introduces Geometric Sound as a subfield of spatial sound featuring audio stimuli which are sonic holograms of mathematically defined 3D shapes. The effects of Geometric Sound on human physiology were investigated through EEG, heart rate, blood pressure, and a combination of questionnaires monitoring 50 healthy participants in two separate experiments. The impact of Geometric Sound on Faraday wave pattern morphology was further studied. The shapes examined, pyramid, cube, and sphere, exhibited varying significant effects on autonomic nervous system markers, brainwave power amplitude, topology, and connectivity patterns, in comparison to both the control (traditional stereo), and recorded baseline where no sound was presented...
2024: Evidence-based Complementary and Alternative Medicine: ECAM
#36
Karol Bomsztyk, Daniel Mar, Oleg Denisenko, Suzanne Powell, Monika Vishnoi, Jennifer Delegard, Anoop Patel, Richard G Ellenbogen, Rohan Ramakrishna, Robert Rostomily
Precision oncology is driven by molecular biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O6-methylguanine-DNA methyltransferase ( MGMT ) gene DNA promoter methylation is an important prognostic and treatment clinical biomarker. Time consuming pre-analytical steps such as biospecimen storage before fixing, sampling, and processing are major sources of errors and batch effects, that are further confounded by intra-tumor heterogeneity of MGMT promoter methylation...
March 27, 2024: bioRxiv
#37
JOURNAL ARTICLE
Chandra Sekhar Bongu, Muhammad Arsalan, Edreese H Alsharaeh
The nanocomposites of hexagonal boron nitride, molybdenum disulfide, and graphene (h-BN/G/MoS2 ) are promising energy storage materials. The originality of the current work is the first-ever synthesis of 2D-layered ternary nanocomposites of boron nitrate, graphene, and molybdenum disulfide (h-BN/G/MoS2 ) using ball milling and the sonication method and the investigation of their applicability for supercapacitor applications. The morphological investigation confirms the well-dispersed composite material production, and the ternary composite appears to be made of h-BN and MoS2 wrapping graphene...
April 2, 2024: ACS Omega
#38
JOURNAL ARTICLE
Jhenifer Cristina Carvalho Santos, Jefferson Luiz Gomes Correa, Maria Luiza Bianchetti Furtado, Larissa Carolina de Morais, Soraia Vilela Borges, Cassiano Rodrigues de Oliveira, Jaime Vilela de Resende, Letícia Fernandes de Oliveira
The use of extracts rich in bioactive compounds is becoming increasingly common in the food, cosmetics, and pharmaceutical industries for the production of functional products. Araticum is a potential fruit to be analyzed due to its content of phenolic compounds, carotenoids and vitamins, with antioxidant properties. Therefore, this study aimed to investigate the effect of ultrasound on total phenolic compounds, total carotenoids, ascorbic acid, color, turbidity and rheology in araticum juice. Response surface methodology based on a central composite design was applied...
April 3, 2024: Ultrasonics Sonochemistry
#39
JOURNAL ARTICLE
Jamshid Behin, Hessamodin Shahabazi
The level of knowledge on the non-thermal contribution of ultrasonic wave's energy to perform physico-chemical phenomena is one of the bottlenecks for the commercialization purposes. Under constant nominal power of transducer (Pn ), the input electrical power (Pin ) is less and sensitive to the medium's physical properties. This study attempts to assess the conversion of acoustic to thermal power experimentally and numerically using COMSOL Multiphysis@ for a 24 kHz horn-type sonicator through a medium without any sono-chemical effect...
April 3, 2024: Ultrasonics Sonochemistry
#40
REVIEW
Zhiqiang Zhu, Tianao Chen, Yongqi Wu, Xizhi Wu, Zhongliang Lang, Fangsheng Huang, Pingan Zhu, Ting Si, Ronald X Xu
In the field of tissue engineering, local hypoxia in large-cell structures (larger than 1 mm3 ) poses a significant challenge. Oxygen-releasing biomaterials supply an innovative solution through oxygen delivery in a sustained and controlled manner. Compared to traditional methods such as emulsion, sonication, and agitation, microfluidic technology offers distinct benefits for oxygen-releasing material production, including controllability, flexibility, and applicability. It holds enormous potential in the production of smart oxygen-releasing materials...
April 3, 2024: Acta Biomaterialia
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