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https://read.qxmd.com/read/30763694/anti-quorum-sensing-and-anti-biofilm-activities-of-hypericum-perforatum-l-extracts-against-pseudomonas-aeruginosa
#1
Şule Doğan, Barış Gökalsın, İsmail Şenkardeş, Ahmet Doğan, N Cenk Sesal
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae) has been used as a traditional therapeutic for skin wounds, burns, cuts and stomach ailments including stomach ache, ulcers for a long time in many societies. Although many studies about its antibacterial properties can be found, there is a lack of studies about its quorum sensing inhibition properties, which effects bacterial vulnerability directly, on Pseudomonas aeruginosa. AIM OF THE STUDY: Evaluation of anti-quorum sensing (anti-QS) and anti-biofilm activity of ethanol, methanol, acetone and ultra-sonicated extracts of Hypericum perforatum L...
February 11, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30763382/analysis-of-pseudomonas-aeruginosa-biofilm-membrane-vesicles-supports-multiple-mechanisms-of-biogenesis
#2
Adam C Cooke, Alexander V Nello, Robert K Ernst, Jeffrey W Schertzer
Outer Membrane Vesicles (OMVs) are ubiquitous in bacterial environments and enable interactions within and between species. OMVs are observed in lab-grown and environmental biofilms, but our understanding of their function comes primarily from planktonic studies. Planktonic OMVs assist in toxin delivery, cell-cell communication, horizontal gene transfer, small RNA trafficking, and immune system evasion. Previous studies reported differences in size and proteomic cargo between planktonic and agar plate biofilm OMVs, suggesting possible differences in function between OMV types...
2019: PloS One
https://read.qxmd.com/read/30761748/water-dispersible-candle-soot-derived-carbon-nano-onion-clusters-for-imaging-guided-photothermal-cancer-therapy
#3
Wei Sun, Xiaodong Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Yuxin Guo, Ge Gao, Yan-Hong Li, Fu-Gen Wu
Herein, water-dispersible carbon nano-onion clusters (CNOCs) with an average hydrodynamic size of ≈90 nm are prepared by simply sonicating candle soot in a mixture of oxidizing acid. The obtained CNOCs have high photothermal conversion efficiency (57.5%), excellent aqueous dispersibility (stable in water for more than a year without precipitation), and benign biocompatibility. After polyethylenimine (PEI) and poly(ethylene glycol) (PEG) modification, the resultant CNOCs-PEI-PEG have a high photothermal conversion efficiency (56...
February 14, 2019: Small
https://read.qxmd.com/read/30761741/eif5a-regulates-proliferation-and-chemoresistance-in-pancreatic-cancer-through-the-shh-signalling-pathway
#4
Zheng Wang, Jie Jiang, Tao Qin, Ying Xiao, Liang Han
BACKGROUND: Pancreatic cancer (PC) has a very poor prognosis and comparatively short survival. Eukaryotic translation initiation factor 5A (EIF5A) promotes cancer metastasis. Here, we exploited the biological role of EIF5A in PC chemoresistance. METHODS: Expression of EIF5A was analysed in PC cells and tissues by real-time PCR, Western blotting, immunohistochemistry and immunofluorescent. EIF5A expression was specifically suppressed by transfection, and subsequently the alterations of growth behaviour and resistance to anticancer treatment were tested in an orthotopic tumour model...
February 14, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30759718/sonication-of-yeast-biomasses-to-improve-the-ageing-on-lees-technique-in-red-wines
#5
Juan Manuel Del Fresno, Antonio Morata, Carlos Escott, Iris Loira, Rafael Cuerda, José Antonio Suárez-Lepe
Ageing on Lees (AOL) is a technique to improve the aromatic and gustatory complexity of wine, mainly by improving its body and reducing its astringency. However, the autolytic process is slow, resulting in high production costs. This work evaluated the effect of adding sonicated lees and combining it with oak chips, as a new technique to accelerate the AOL process and improve the aromatic quality of aged red wine. Cell disruption due to sonication was verified by optical microscopy. Volatile acidity, total polyphenol index, color intensity, tonality, dissolved oxygen, anthocyanins, and fermentative volatiles were monitored throughout the ageing of the wines...
February 12, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30759322/four-year-follow-up-results-of-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#6
Yong-Sook Park, Na Young Jung, Young Cheol Na, Jin Woo Chang
BACKGROUND: Following the emergence of magnetic resonance-guided focused ultrasound as a promising tool for movement disorder surgery, thalamotomy for essential tremor using this technique has become a useful tool based on its efficacy and lack of adverse effects. Here, we summarize the 4-year results of previous reports focusing on the durability of effectiveness of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. METHODS: From October 2013 to August 2014, 15 patients with intractable essential tremor were enrolled...
February 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30758380/cryo-assisted-exfoliation-of-atomically-thin-2d-sb-2-se-3-nanosheets-for-photo-induced-theranostics
#7
Linxin Fan, Doudou Huang, Yichuan Wang, Zhaohua Miao, Yan Ma, Qingliang Zhao, Zhengbao Zha
A liquid-phase exfoliation approach, combined with cryogenic fracturing and bath/probe sonication, is developed to prepare atomically thin 2D anisotropic Sb2Se3 nanosheets for simultaneous photoacoustic imaging and photothermal therapy.
February 13, 2019: Chemical Communications: Chem Comm
https://read.qxmd.com/read/30756105/liquid-phase-exfoliation-of-carbonate-intercalated-layered-double-hydroxides
#8
Jose A Carrasco, Andrew Harvey, Damien Hanlon, Vicent Lloret, Dave McAteer, Roger Sanchis-Gual, Andreas Hirsch, Frank Hauke, Gonzalo Abellán, Jonathan N Coleman, Eugenio Coronado
Direct exfoliation of a carbonate layered double hydroxide (LDH) has been achieved by using a novel horn-probe sonic tip, avoiding the development of time-consuming anion-exchange reactions. The most suitable solvents were chosen based on the Hildebrand solubility parameters and the thickness of the exfoliated nanosheets confirmed unambiguously the successful delamination.
February 13, 2019: Chemical Communications: Chem Comm
https://read.qxmd.com/read/30755389/effect-of-ultrasound-on-the-dissolution-of-magnesium-hydroxide-ph-stat-and-nanoscale-observation
#9
Xiaojia Tang, Miao Liu, Qian Tang, Zhongyuan Du, Subei Bai, Yimin Zhu
It has been previously confirmed that the dissolution of magnesium hydroxide was a crucial procedure in its application process. Note that the ultrasound is an effective method for enhancing solid dissolution. In this study, the enhancement of ultrasound on the dissolution of magnesium hydroxide was investigated by the pH-stat method. The titrating results indicated that the promotion effect of ultrasound was only be observed at some certain cases, such as lower pH value. Meanwhile, the activation energy data obtained based on Shrinking Core Model for sonication case ranged from 6...
January 18, 2019: Ultrasonics Sonochemistry
https://read.qxmd.com/read/30753753/the-intrinsic-mechanochemical-reactivity-of-vinyl-addition-polynorbornene
#10
Daniel Lee, Victoria Kensy, Chris Maroon, Brian K Long, Andrew Jackson Boydston
Herein we report the discovery of the intrinsic mechanochemical activity of vinyl-addition polynorbornene (VA-PNB), which has strained bicyclic ring repeat units along the polymer backbone. VA-PNBs with three different side chains were found to undergo ring-opening olefination upon sonication in dilute solutions. The sonicated polymers exhibited spectroscopic signatures consistent with conversion of the bicyclic norbornane repeat units to the ring-open isomer typical of polynorbornene made by ring-opening metathesis polymerization (ROMP-PNB)...
February 12, 2019: Angewandte Chemie
https://read.qxmd.com/read/30747231/combined-inhibition-of-sonic-hedgehog-signaling-and-histone-deacetylase-is-an-effective-treatment-for-liver-cancer
#11
Jingmin Li, Heng Cai, Hongxing Li, Yanguo Liu, Yirong Wang, Yan Shi, Yan Sun, Haoran Song, Dong Wang
Clinical trials have revealed that inhibition of sonic Hedgehog (SHH) signaling or histone deacetylase (HDAC) holds promise as a treatment for liver cancer. Based on our previous results, it was hypothesized that dual inhibition of SHH and HDAC may contribute to more efficient targeting of this disease. The effect of SHH inhibitor vismodegib as a single‑agent or in combination with HDAC inhibitor entinostat was evaluated by Cell Counting Kit‑8 (CCK‑8) and flow cytometric assays, as well as immunoblotting...
January 23, 2019: Oncology Reports
https://read.qxmd.com/read/30745233/sonochemical-synthesis-of-a-nanodandelion-tin-iv-complex-with-carbacylamidophosphate-ligand-as-anti-alzheimer-agent-molecular-docking-study
#12
Mona Eini Roumiani, Niloufar Dorosti
The dandelion-shaped nanostructure of an organotin complex with formula Sn(CH3 )2 Cl2 }NC5 H4 C(O)NHP(O)[NHC6 H11 ]2 }2 (C1 ) was synthesized by means of a sonochemical method. Nano-structures were characterized by elemental analysis, NMR, SEM-EDS, XRD, UV-Vis, and FT-IR spectroscopy. The thermal stability of the complex C1 has been studied by thermal gravimetric analysis (TGA), and compared to the bulk form (C2 ). Both the morphology and the size of the ultrasound-assisted synthesized organotin complex have been investigated using scanning electron microscopy (SEM) by changing such parameters as the concentration of initial reactants and the sonication frequency...
January 23, 2019: Ultrasonics Sonochemistry
https://read.qxmd.com/read/30744607/ligustrazin-increases-lung-cell-autophagy-and-ameliorates-paraquat-induced-pulmonary-fibrosis-by-inhibiting-pi3k-akt-mtor-and-hedgehog-signalling-via-increasing-mir-193a-expression
#13
Ming-Wei Liu, Mei-Xian Su, Deng-Yun Tang, Li Hao, Xiang-Han Xun, Yun-Qiao Huang
BACKGROUND: Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however, on the signalling pathways involved in PQ-induced lung fibrosis have not yet been investigated sufficiently. Here, we examined the impacts of ligustrazin on lung fibrosis, in particular ROS-related autophagy and pro-fibrotic signalling pathways, using a murine model of PQ-induced lung fibrosis...
February 11, 2019: BMC Pulmonary Medicine
https://read.qxmd.com/read/30744560/hepatic-sonic-hedgehog-protein-expression-measured-by-computer-assisted-morphometry-significantly-correlates-with-features-of-non-alcoholic-steatohepatitis
#14
Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D Goodman, Zobair M Younossi
BACKGROUND: Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnosis and determine whether quantification of staining by computer assisted morphometry (CAM) can be used to assess severity of ballooning degeneration. METHODS: SHH was detected by immunohistochemistry (IHC) on paraffin-embedded liver sections in subjects (N = 69) with biopsy proven NAFLD and no liver disease (control)...
February 11, 2019: BMC Gastroenterology
https://read.qxmd.com/read/30741721/pten-induced-partial-epithelial-mesenchymal-transition-drives-diabetic-kidney-disease
#15
Yajuan Li, Qingsong Hu, Chunlai Li, Ke Liang, Yu Xiang, Heidi Hsiao, Tina K Nguyen, Peter K Park, Sergey D Egranov, Chandrashekar R Ambati, Nagireddy Putluri, David H Hawke, Leng Han, Mien-Chie Hung, Farhad R Danesh, Liuqing Yang, Chunru Lin
Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb)...
February 11, 2019: Journal of Clinical Investigation
https://read.qxmd.com/read/30739022/activation-of-zero-valent-iron-through-ball-milling-synthesis-of-hybrid-fe-0-fe-3-o-4-fecl-2-microcomposite-for-enhanced-nitrobenzene-reduction
#16
Zhe Yang, Xiaowen Ma, Chao Shan, Xiaohong Guan, Weiming Zhang, Lu Lv, Bingcai Pan
To activate zero-valent iron (ZVI) for efficient nitrobenzene (NB) reduction, a hybrid Fe0 /Fe3 O4 /FeCl2 microcomposite (hZVIbm ) was synthesized via simple ball-milling of the ternary mixture of ZVI, Fe3 O4 , and FeCl2 ·4H2 O (hZVI). SEM-EDX and time-of-flight secondary ion mass spectroscopy (ToF-SIMS) indicated the hZVIbm microcomposite (10-20 μm) consisted of Fe0 core covered by ∼3.3 μm-thick shell decorated with Fe3 O4 /FeCl2 fine particles (0.1-2 μm). Efficient removal (>95%) of NB (200 mg/L) was achieved by hZVIbm (2...
January 31, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30738452/-clinicopathological-observation-of-primary-renal-non-hodgkin-s-lymphoma-a-report-of-two-cases
#17
Yang-Yang Sun, Xiao-Li Zhou, Wei Gao, Yu-Qing Cheng
OBJECTIVE: To investigate the clinicopathological and immunohistochemical features as well as diagnosis, differential diagnosis,treatment and prognosis of patients with primary renal non-hodgkin's lymphoma (PRNHL). METHODS: Clinical data of 2 patients with PRNHL from January 2013 to October 2017 were retrospectively analyzed. RESULTS: One of the two male patients PRNHL aged 51 years old, admitted to hospital for swelling and pain in the right waist, B-ultra sonic examination showed a very solid upper right renal space occupying lesion...
February 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/30738163/efficacy-of-a-novel-sequential-enzymatic-hydrolysis-of-lignocellulosic-biomass-and-inhibition-characteristics-of-monosugars
#18
Sibashish Baksi, Akash K Ball, Ujjaini Sarkar, Debopam Banerjee, Alexander Wentzel, Heinz A Preisig, Jagdish C Kuniyal, Cansu Birgen, Sudeshna Saha, Bernd Wittgens, Sidsel Markussen
Efficient production of sugar monomers from lignocellulose is often hampered by serious bottle-necks in biomass hydrolysis. The present study reveals that ultra-sonication assisted pretreatment following autoclaving, termed as combined pretreatment, can lead to more efficient delignification of lignocellulosic biomass and an open, deformed polysaccharide matrix, found favorable for subsequent enzymatic hydrolysis, is formed. The pattern of inhibition for the enzymatic hydrolysis reaction on combined-pretreated saw dust is identified...
February 6, 2019: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30737565/can-we-ablate-liver-lesions-close-to-large-portal-and-hepatic-veins-with-mr-guided-hifu-an-experimental-study-in-a-porcine-model
#19
Ulrik Carling, Leonid Barkhatov, Henrik M Reims, Tryggve Storås, Frederic Courivaud, Airazat M Kazaryan, Per Steinar Halvorsen, Eric Dorenberg, Bjørn Edwin, Per Kristian Hol
OBJECTIVES: Invasive treatment of tumors adjacent to large hepatic vessels is a continuous clinical challenge. The primary aim of this study was to examine the feasibility of ablating liver tissue adjacent to large hepatic and portal veins with magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU). The secondary aim was to compare sonication data for ablations performed adjacent to hepatic veins (HV) versus portal veins (PV). MATERIALS AND METHODS: MRgHIFU ablations were performed in six male land swine under general anesthesia...
February 8, 2019: European Radiology
https://read.qxmd.com/read/30737122/a-comparative-study-of-seer-sonorheometry-versus-standard-coagulation-tests-rotational-thromboelastometry-and-multiple-electrode-aggregometry-in-cardiac-surgery
#20
Ekaterina Baryshnikova, Umberto Di Dedda, Marco Ranucci
OBJECTIVES: Coagulation point-of-care tests for the diagnosis and management of bleeding commonly are used in cardiac surgery. Recently, a new viscoelastic point-of-care device, Quantra (HemoSonics, Charlottesville, VA), which is based on sonic estimation of elasticity via resonance sonorheometry, entered the market. Prior studies have compared the Quantra parameters with conventional coagulation tests and thromboelastography or rotational thromboelastography, but no study has assessed the correlation of the platelet-derived Quantra parameter platelet contribution to stiffness (PCS) with platelet function assays...
January 4, 2019: Journal of Cardiothoracic and Vascular Anesthesia
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