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clomiphene clomid

Tal D Saar, Stefaan Pacquée, Dean Helmar Conrad, Mikhail Sarofim, Philippe De Rosnay, David Rosen, Greg Cario, Danny Chou
Endometriosis is a common gynecological condition which affects 5-10% of women of reproductive age and up to 50% of women with pelvic pain and infertility. The most commonly affected areas are the pelvic peritoneum, ovaries and rectovaginal septum. Isolated endometriosis of the sciatic nerve is very rare. Our patient suffered from worsening right hip and buttock pain with severe exacerbation during menstruation. Several different imaging modalities (ultrasound of her pelvis and right hip, as well as X-rays and computed tomography scans of her right hip and lumbosacral spine) failed to identify any pathology...
April 2018: Gynecology and minimally invasive therapy
Mohamed A El-Nourya, Mahmoud B El-Begawyb, Mona E Morsyc, Ehab M Al Sherbineyd
AIM: This study aimed to evaluate a new modality of low power laser biostimulation in rat ovaries, in comparison with the conventional medical therapy by clomiphene citrate that depends on up-regulation of the hypothalamic-pituitary-ovarian axis to induce ovulation. STUDY DESIGN: A Prospective experimental study carried out from January 2014 to February 2016. SETTING: University-based photobiology laboratory. MATERIALS AND METHODS: Seventy-two (72) Female-Wistar Albino rats were used in this study, divided into three groups: 17 rats used as a control group, 19 rats received clomiphene citrate (Clomid group), 36 rats exposed to diode laser 660 nm wavelength (laser group)...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
G Chene, N Radosevic-Robin, A S Tardieu, A Cayre, I Raoelfils, P Dechelotte, J Dauplat, F Penault Llorca
Ovarian epithelial dysplasia was initially described in material from prophylactic oophorectomies for BReast CAncer gene (BRCA) mutation. Similar histopathological abnormalities have been revealed after ovulation stimulation. Given that tamoxifen (TAM) has a clomid-like effect and is sometimes used to induce ovulation, we studied the morphological features and immunohistochemical expression patterns of neoplasia-associated markers in adnexectomies previously exposed to TAM for breast cancer. We blindly reviewed 173 histopathological slides of adnexectomies according to three groups - oophorectomie sassociated with TAM exposure (n=42), oophorectomies associated with clomiphene exposure (n=15) and a spontaneously fertile non cancerous control group (n=116)...
2014: European Journal of Histochemistry: EJH
Diana E Chavkin, Thomas A Molinaro, Andrea H Roe, Mary D Sammel, Anuja Dokras
The objective of this study was to determine the clinical pregnancy rate with 2 inseminations compared to a single intrauterine insemination (IUI) in a given cycle using frozen-thawed donor sperm. This was a retrospective study at a university practice; patients were women using donor sperm. We conducted a comparison of single IUI, intracervical insemination (ICI) followed by an IUI on the next day, and double IUI (2 consecutive days); clinical pregnancy rate was the main outcome measure. The cycle-specific and total pregnancy rates were not significantly different between the 3 protocol groups (306 cycles)...
May 2012: Journal of Andrology
Maria I Viola, David Meyer, Thinus Kruger
OBJECTIVES: To determine whether clomiphene citrate (CC) can be implicated as a cause for central retinal vein occlusion (CRVO) and other visual disturbances. METHODS: For this systematic review, we performed a search of the following databases: PubMed (1976 to November 2009), Medline Plus 2009, Cochrane Library (1996 to November 2009), Google and Google Scholar (1996 to November 2009). Thirty-five relevant titles (25 full papers and 10 abstracts) were identified and read by authors...
2011: Gynecologic and Obstetric Investigation
D R Mishell
No abstract text is available yet for this article.
November 1975: Western Journal of Medicine
Ying Huang, Qun Cheng, An-fang Zhou
OBJECTIVE: To observe the clinical effect of Lin'erlai Prescription (LEL) in treating anovulatory infertility of blood and essence asthenia syndrome type (BEAS). METHODS: Sixty patients with anovulatory infertility in Western medical term, and classified as BEAS in Chinese medical term were equally assigned to two groups, they were treated with LEL (the treated group) and clomid (the control group) respectively. The ovulation rate and pregnant rate were observed...
November 2007: Chinese Journal of Integrated Traditional and Western Medicine
P M Zavos, M G Burchett, L A Edgerton
The objective of this study was to determine the effect of clomiphene citrate (clomid) on pituitary responsiveness to gonadotropin releasing hormone (GnRH) in rams and wethers. Doses of 200 mg clomid per ram and 1 mug GnRH per 50 kg body weight were used in studies on 12 rams and 4 wethers. The experimental design involved bleeding each animal at 15-minute intervals for 6.5 hours. At the end of the first hour, GnRH was injected IV. The second GnRH challenge was administered 0.5 hours after an injection of clomid or vehicle (4...
July 1984: Theriogenology
A Mishra, K P Joy
In vitro effects of estradiol-17beta (E(2)), the catecholestrogens 2-hydroxyE(2) (2-OHE(2)) and 2-methoxyE(2), and the nonsteroidal antiestrogen clomiphene citrate (clomid) on oocyte maturation were investigated in the catfish Heteropneustes fossilis. Incubation of postvitellogenic follicles with 2-OHE(2) induced germinal vesicle breakdown (GVBD; 86% at 5 microM for 30 h) and progression of meiosis up to metaphase II, as evident from the presence of Hoechst stained metaphase chromosomes and anti-alpha-tubulin-positive bipolar spindles...
June 2006: General and Comparative Endocrinology
T Benie, J Duval, M-L Thieulant
It is well known that the plant kingdom contains numerous bioactive substances affecting the regulation of reproduction. The present study was undertaken to examine the putative contraceptive effects of three traditional plant extracts from Côte d'Ivoire Pharmacopea. It concerns Afrormosia laxiflora (Papilionacea), Pterocarpus erinaceus (Papilionacea) and Cola nitida (Sterculiacea) stem bark. Data showed that treatment of rats with these plant extracts induced ovulation and oestrous cycle blockade at the dioestrous II stage...
August 2003: Phytotherapy Research: PTR
Sally G Haskell
Because of recent concerns about the long-term risks of estrogen replacement therapy in postmenopausal women, there is growing interest in a group of compounds known as selective estrogen receptor modulators (SERMs). The SERMs bind to estrogen receptors and have tissue-specific effects that allow them to function as estrogen agonists in some tissues and estrogen antagonists in other tissues. There are four SERMs currently marketed in the United States. These include the triphenylethylenes--clomiphene citrate (Clomid), tamoxifen, and toremifene--and the benzothiophene, raloxifene...
May 2003: Southern Medical Journal
Ragga Mansour, Mohammed Aboulghar, Gamal I Serour, Hesham G Al-Inany, Ibrahim Fahmy, Yehia Amin
OBJECTIVE: To evaluate the cost effectiveness of a clomiphene citrate (CC)/human menopausal gonadotropin (hMG)/GnRH antagonist protocol versus a long-acting GnRH agonist/hMG protocol. PARTICIPANTS AND METHODS: One hundred eighty nine couples having their first trial of ICSI for male factor infertility were divided into two groups. Group I (no = 33) received CC 100-150 mg/day for five days starting from day 2 of the cycle and 150 IU of hMG/day on days 6-10. GnRH antagonist (Centrorelix) 0...
January 2003: Acta Obstetricia et Gynecologica Scandinavica
Paul G McDonough
No abstract text is available yet for this article.
September 2002: Fertility and Sterility
G Wyshak
OBJECTIVE: The objective of this paper is to present data on prevalence of infertility, causes and treatments based on self-reports of a sample of American college alumnae. METHODS: A sample of 3940 American college alumnae, ages 37 to over 70 years, completed a self-administered questionnaire relating to infertility, its causes, treatment and treatment outcomes. RESULTS: Of the entire sample (n=3940), 3.1% (n=121) had primary infertility; 14...
June 2001: International Journal of Gynaecology and Obstetrics
N K Suri
Oestrogen receptor (ER) and progesterone receptor (PR) binding site levels were determined using an assay system based upon that of King et al. Endometrial samples were obtained from 49 subfertility patients on clomiphene citrate (Clomid) therapy admitted to hospital for dye laparoscopy. An assay system based on that of Kato and Seto using synthetic androgen R1881 was used to measure androgen receptor (AR) binding sites in endometrial tissue obtained in the above patients. It is concluded that a cyclic variation was observed in ER and PR binding sites in women on Clomid therapy...
November 1996: East African Medical Journal
N V Coots, C E McCoy, D L Gehlbach, L E Becker
A 33-year-old woman treated for infertility with multiple courses of clomiphene citrate (Clomid) presented with the complaint of a rash with every course of the medication. Examination revealed petechiae and palpable purpura on her lower extremities which, histologically, were found to be consistent with a neutrophilic drug reaction. The clinical course of this unusual presentation, as well as a brief review of the neutrophilic dermatoses, are provided.
February 1996: Cutis; Cutaneous Medicine for the Practitioner
T F Kruger, A Fisher, Y Swart, J P Van der Merwe, K Smith
PURPOSE: It may sometimes be necessary to regulate cycles in assisted reproduction. Cycles can be regulated with gonadotropin releasing hormone (GnRHa) agonist but other methods can also be used. The aim of this study was to compare the pregnancy rate in a gamete intrafallopian transfer (GIFT) program in patients receiving a contraceptive pill/Clomid/human menopausal gonadotropin (hMG) regimen (study group), with the standard Clomid/hMG regime (control group). Fifty one patients in the study group were carefully matched for patient age, infertility diagnosis (female), semen parameters, number of follicles, and number of oocytes transferred into consideration with a control group...
February 1993: Journal of Assisted Reproduction and Genetics
M F Chrétien, C Guerrier, A Denis, K Malkani
Sterility related to ovarian dystrophy is currently treated by means of standard inductors of ovulation such as Clomid and HMG. In case of failure, patients are recommended in vitro fertilization. In our study of 30 cases of ovarian dystrophy, 9 pregnancies occurred after in vitro fertilization. Slow injections of purified FSH appear to produce similar results but the method is still under evaluation. Our results suggest that after say, two years of failure with classical methods in patients with a long history of sterility, in vitro fertilization may be expected to give good results...
December 1993: Contraception, Fertilité, Sexualité
E Y Adashi, A J Hsueh, S S Yen
Alterations in the concentrations of oestrogen receptors in the uterus, pituitary gland and hypothalamus during the 2 weeks following a single administration of clomiphene citrate (Clomid) to immature, bilaterally ovariectomized rats were investigated. Examination of the uterine wet weight at 1, 7 and 14 days following a single injection of Clomid (100 micrograms, 250 micrograms or 10 mg) indicated significant time- and dose-related increments from a control value of 45 +/- 2 (S.E.M.) mg to a maximum of 123 +/- 3 mg (250 micrograms dose at 14 days)...
December 1980: Journal of Endocrinology
J H Clark, S A McCormack
No abstract text is available yet for this article.
January 1980: Journal of Steroid Biochemistry
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