Xiaoyu Han, Fan Wang, Jieliang Shen, Shuyu Chen, Pengcheng Xiao, Ying Zhu, Weiwei Yi, Zhengyu Zhao, Zhengwei Cai, Wenguo Cui, Dingqun Bai
Conventional coupling agents (such as polyvinylpyrrolidone, methylcellulose, and polyurethane) are unable to efficiently transport drugs through the skin's dual barriers (the epidermal cuticle barrier and the basement membrane barrier between the epidermis and dermis) when exposed to ultrasound, hindering deep and non-invasive transdermal drug delivery. In this study, nanobubbles prepared by the double emulsification method and aminated hyaluronic acid were crosslinked with aldehyde-based hyaluronic acid by dynamic covalent bonding through the Schiff base reaction to produce an innovative ultrasound-nanobubble coupling agent...
October 18, 2023: Advanced Materials