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Diabetes Infertility

Ivana Ságová, Dušan Pávai, Daniela Kantárová, Anton Vaňuga, Jurina Sadloňová, Peter Vaňuga, Milan Dragula
Acromegaly is a rare disorder usually caused by a benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor 1 (IGF1) levels accompanying this disease is associated with complications such as cardiomyopathy, diabetes mellitus, sleep apnoea and arthropathy. Incidence of acromegaly is 3-4 patients per million per year. Klinefelter syndrome (KS) is the most common sex chromosome disorder occuring in about 1/500 live male births. Common physical features include particularly small testes, among other symptoms are tall stature, reduced muscle tone, delayed pubertal development, lack of secondary male sex characteristics and gynecomastia...
2019: Vnitr̆ní Lékar̆ství
Huda Alalami, Thozhukat Sathyapalan, Stephen L Atkin
Women with polycystic ovary syndrome (PCOS) have an adverse metabolic profile with an increased risk of prediabetes and type 2 diabetes (T2DM); however, it is unclear if PCOS is associated with increased cardiovascular events in later years independent of the presence of T2DM. Many therapies have been used to treat the differing facets of PCOS, including those for menstrual irregularity, hirsutism, acne and anovulatory infertility. The aim of this review was to evaluate the cardiovascular profiles associated with the medications used in the management of PCOS and evaluate whether they have cardiovascular benefit, detriment or are neutral...
2019: Therapeutic Advances in Endocrinology and Metabolism
Athira Johnson, Shu-Chun Cheng, David Tsou, Zwe-Ling Kong
Diabetes mellitus together with the oxidative stress affects the process of spermatogenesis and leads to male infertility. Antrodia cinnamomea (AC) is a mushroom found unique in Taiwan and commonly used for the treatment of several types of cancers and inflammatory disorders. This study was aimed to investigate the anti-oxidative and the ameliorative effects of Antrodia cinnamomea ethanol extract (ACEE) on reproduction dysfunction in male diabetic rats. The diabetic condition was induced by administrating the combination of streptozotocin (STZ) (65 mg/kg) and nicotinamide (NA) (230 mg/kg)...
February 21, 2019: Biomedicine & Pharmacotherapy
Igor Alexander Harsch, Thomas Heß, Peter Christopher Konturek
Turner syndrome can be manifest with a considerable genetic and phenotypic variability. This merely accounts for about 50% of patients who do not have the "classic" 45 X genotype. We report the case of a 42-year-old female patient with a 46, X, del (X) q 21 genotype (deletion on the second X chromosome on the long arm). As the patient displayed a non-typical phenotype and was infertile, a diagnosis was established at the age of 24 with no follow-up treatment. As part of our therapy of the individual due to newly manifested diabetes mellitus, our diagnostic workup revealed a severe metabolic syndrome encompassing fatty liver disease, obstructive sleep apnea syndrome and hyperuricemia...
2019: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Anna Buigues, Maria Marchante, Sonia Herraiz, Antonio Pellicer
Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) are primary factors leading to infertility. However, there is a lack of appropriate animal models of DOR usable for assessing new therapeutic strategies. In this study, we aimed to evaluate whether chemotherapy treatment in mice could reproduce features similar of that observed in women with DOR. Twenty-one Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) female mice were allocated to 3 groups (n = 7/group): control, single dose of vehicle (Dimethyl Sulfoxide [DMSO]); DOR, single reduced chemotherapy dose; and POI, single standard chemotherapy dose...
February 21, 2019: Reproductive Sciences
Zeinab Khosravi, Reza Sedaghat, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Diabetes mellitus (DM) is a prevalent metabolic disorder that is associated with development of some complications in male reproductive system including testicular damage, sexual dysfunction, abnormal spermatogenesis, and infertility. Diosgenin is a natural steroidal saponin with anti-diabetic, anti-oxidative, and anti-inflammatory effects. This research study was undertaken to explore the protective effect of diosgenin against diabetes-induced testicular damage in the rat. Ten days following streptozotocin (STZ; i...
February 19, 2019: International Immunopharmacology
Chinenye Jane Ugwah-Oguejiofor, Charles Ogbonna Okoli, Michael Oguejiofor Ugwah, Millicent Ladi Umaru, Chiedozie Smart Ogbulie, Halilu Emmanuel Mshelia, Mohammed Umar, Anoka Ayembe Njan
Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential toxicity of aqueous extract of aerial parts of Caralluma dalzielii (AECD) through acute and sub-acute oral administration in mice and rats. During acute toxicity study, female mice and rats were orally administered with AECD at single doses of 175, 500 and 2000 mg/kg according to OECD Guidelines 425...
January 2019: Heliyon
Mahmoud R Abdel-Fadeil, Eman S H Abd Allah, Heba M Iraqy, Dalia A Elgamal, Mohammed A Abdel-Ghani
Reproductive dysfunction is a common consequence of both obesity and diabetes. This study investigated the impact of obesity and diabetes, alone or combined, on physiological reproductive parameters in male rats. Twenty-four male Wistar Albino rats were divided into four groups: Control; obese non-diabetic; diabetic; and obese diabetic. Obesity was provoked by consumption of a high-fat diet (HFD) consisting of 40% energy from fat for 90 days. Diabetes was induced by an intraperitoneal injection of streptozotocin at a dose of 40 mg/kg/day for three consecutive days...
February 5, 2019: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Alexander W Pastuszak, Amin S Herati, Michael L Eisenberg, Cenk Cengiz, Peter H Langlois, Taylor P Kohn, Dolores J Lamb, Larry I Lipshultz
STUDY QUESTION: What is the relationship between semen parameters and birth defect (BD) rates in offspring of men evaluated for infertility? SUMMARY ANSWER: Among men undergoing infertility evaluation, there is no significant relationship between semen parameters and defect rates in live or still births, even when considering mode of conception. WHAT IS KNOWN ALREADY: Approximately 15% of couples have fertility difficulties, with up to a 50% male factor contribution...
February 12, 2019: Human Reproduction
Hossein Shateri, Akram Ranjbar, Nejat Kheiripour, Hassan Ghasemi, Yasin Pourfarjam, Elahe Habibitabar, Hamid Gholami, Heresh Moridi
AIMS: Oxidative stress induced by diabetes mellitus (DM) is considered as one of the main causes of infertility in diabetic patients. The aim of the present study was to assess the effect of Tempol - as a synthetic antioxidant- on the testis oxidative stress and sperm parameters in type 2 diabetic (T2D) rats. MAIN METHODS: Twenty male Wistar rats were divided into 4 groups. Control groups (C) and diabetic groups (D); the control and diabetic groups received Tempol (100 mg/kg) for one month...
February 7, 2019: Life Sciences
Jessica A Grieger, Luke E Grzeskowiak, Lisa G Smithers, Tina Bianco-Miotto, Shalem Y Leemaqz, Prabha Andraweera, Lucilla Poston, Lesley M McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts
OBJECTIVES: To determine 1) the association between metabolic syndrome (MetS), time to pregnancy (TTP), and infertility 2) associations between individual and increasing number of MetS components, TTP, and infertility; 3) whether these relationships differ by obesity (BMI, <30kg/m2 vs. ≥30kg/m2 ). DESIGN: Retrospective cohort study. SETTING: Multi-centre (Australia, United Kingdom, New Zealand, Ireland). POPULATION: 5519 low-risk nulliparous pregnant women...
February 7, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Gayathree Murugappan, Shufeng Li, Ruth B Lathi, Valerie L Baker, Michael L Eisenberg
BACKGROUND: The risk of common chronic medical conditions among infertile women is not known. OBJECTIVE: The objective of the study was to study the association between female infertility and the risk of incident chronic disease. STUDY DESIGN: This was a retrospective cohort analysis using the Optum deidentified Clinformatics Datamart from 2003 through 2016. A total of 64,345 infertile women were identified by infertility diagnosis, testing, or treatment and compared with 3,128,345 noninfertile patients seeking routine gynecologic care...
January 30, 2019: American Journal of Obstetrics and Gynecology
Xiangyan Ruan, Meng Li, Alfred O Mueck
BACKGROUND: Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with numerous severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. METHODS: We summarized the literature focused on the symptoms and negative long-term consequences of untreated PCOS and the existing options for the treatment. We reviewed the Pubmed and China National Knowledge Infrastructure databases and the relevant literature for the recent 20 years...
January 29, 2019: Current Pharmaceutical Design
Wendy E Hoy, Christopher M Reid, Molla Huq, Beverly J McLeod, Susan A Mott
Introduction: We conducted a double-blind randomised controlled trial in a remote-living Australian Aboriginal group at high risk for chronic disease to assess whether pharmacological treatment with angiotensin converting enzyme inhibitor (ACEi) could delay the onset of albuminuria, hypertension or diabetes in people currently free of those conditions. Methods: Eligibility criteria in 2008 were age ≥18yr, blood pressure ≤140/90 mm/Hg, urinary albumin creatinine ratio (ACR) < 3...
June 2019: Contemporary Clinical Trials Communications
Yan Cao, Li Li, Kaihui Shen, Jianguo Liu
While it has been acknowledged that exposure to endocrine-disrupting chemicals (EDCs) is associated with human diseases, the overall disease burden attributable to the exposure to a specific EDC has rarely been evaluated. Based on existing models for assessing probabilities of causation and a comprehensive review of available data, we analyzed the burden of three diseases, i.e., male infertility, adult obesity, and diabetes, among the general Chinese population resulting from exposure to phthalates. Our estimation indicates that exposure to phthalates is associated with ~2...
April 20, 2019: Science of the Total Environment
Azam Kouhkan, Mohammad E Khamseh, Ashraf Moini, Reihaneh Pirjani, Arezoo Arabipoor, Zahra Zolfaghari, Roya Hosseini, Hamid Reza Baradaran
Background: The aim of the present study was to determine the maternal pre-pregnancy body mass index (BMI), first-trimester fasting blood sugar (FBS), and the combination of (BMI+FBS) cut-points for at-risk pregnant women conceived by assisted reproductive technology (ART) to better predict the risk of developing gestational diabetes mellitus (GDM) in infertile women. Materials and Methods: In this nested case-control study, 270 singleton pregnant women consisted of 135 (GDM) and 135 (non-GDM) who conceived using ART were assessed...
April 2019: International Journal of Fertility & Sterility
Jianzhong Zhang, Bin Yang, Zhonglin Cai, Hongjun Li, Taoli Han, Ying Wang
The objective of the current study was to explore the role of body mass index (BMI) in sperm quality and erectile function in Chinese males of infertile couples. A total of 28 fertility centers in different regions of China were enrolled. Patient data were collected from June 1, 2017, through October 31, 2017. Semen analyses and demographic data were collected and the five-item International Index of Erectile Function (IIEF-5) questionnaire was used to evaluate the erectile function in participants with different BMIs...
January 2, 2019: American Journal of Men's Health
Camila Florencia Zuccato, Antonela Sofia Asad, Alejandro Javier Nicola Candia, María Florencia Gottardo, Mariela Alejandra Moreno Ayala, María Susana Theas, Adriana Seilicovich, Marianela Candolfi
Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role in the cellular stress response. The first reported and better characterized MDP is humanin (HN), which exerts robust protective effects against a myriad of cytotoxic stimuli in many cell types. These effects have led to the evaluation of HN and its analogs as therapeutic targets for several chronic diseases...
December 24, 2018: Expert Opinion on Therapeutic Targets
Stephen H Tsang, Alicia R P Aycinena, Tarun Sharma
Bardet-Biedl syndrome (BBS) is an autosomal recessive disease with a prevalence of about 1/125,000. The syndrome involves mixed rod-cone dystrophy (which becomes obvious by 6&#x00A0;years of age). About two thirds of patients have postaxial polydactyly, and sometimes syndactyly, brachydactyly, and/or clinodactyly may be present. Hypogonadism and renal involvement occur in about 40%, mental retardation in about 50%, and truncal obesity in about 70%; it is present early, along with insulin resistance, type 2 diabetes, dyslipidemia, and hypertension...
2018: Advances in Experimental Medicine and Biology
Francine Bono-Neri, Cara Romano, Anne Isedeh
Cystic fibrosis (CF) is an autosomal recessive genetic disorder resulting from a mutation in the gene which encodes a cellular transmembrane protein channel known as the CF transmembrane conductance regulator. Located systemically on the surface of numerous cells, these altered channels yield multisystem dysfunction. Typical manifestations seen are chronic, progressive, obstructive lung disease, pancreatic insufficiency, CF-related diabetes mellitus, malabsorption and malnutrition, liver disease, and infertility...
October 24, 2018: Journal of Pediatric Health Care
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