Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
Erica Saphire, Zhe Li Salie, Zunlong Ke, Peter Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael Holbrook, Benjamin Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, Jens Kuhn, John Briggs, Gabriella Worwa, Carl Davis, Rafi Ahmed
Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP 1,2 ) are the standard of care for Ebola virus disease (EVD). Anti-GP 1,2 mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV in vitro . However, their neutralization mechanism is poorly understood because they target a GP 1,2 epitope that has evaded structural characterization. Moreover, their in vivo efficacy has only been evaluated in the mouse model of EVD. Using x-ray crystallography and cryo-electron tomography of 3A6 complexed with its stalk- GP 1,2 MPER epitope we reveal a novel mechanism in which 3A6 elevates the stalk or stabilizes a conformation of GP 1,2 that is lifted from the virion membrane...
December 22, 2023: Research Square
#22
JOURNAL ARTICLE
Kelly Sansom, Amy Reynolds, Daniel Windred, Andrew Phillips, Satvinder S Dhaliwal, Jennifer Walsh, Kathleen Maddison, Bhajan Singh, Peter Eastwood, Nigel McArdle
STUDY OBJECTIVES: Little is known about the inter-relationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension. METHODS: 602 adults (age mean(SD) =56.96(5.51) years, female=60%) from the Raine Study who were not evening or night shift workers were assessed for OSA (in-laboratory polysomnography; apnea hypopnea index (AHI) ≥15events/hour), hypertension (doctor diagnosed; or systolic blood pressure ≥140mmHg and/or diastolic ≥90mmHg) and sleep (wrist actigraphy for ≥5 days)...
January 5, 2024: Sleep
#23
JOURNAL ARTICLE
Patrick McArdle, Christopher Yung, Nathan Tomlin, John Lehman, Michelle Stephens
We have developed a low-cost micro-diffuse reflectance infrared Fourier transform spectroscopic (micro-DRIFTS) setup for measuring the reflectance of small area diffuse samples. The system performance is characterized and then demonstrated on small area vertically aligned carbon nanotube (VACNT) samples. We find that our system can measure samples with a spatial resolution of approximately 140 µm with sensitivities of 10s of ppm in the 2 µm - 18 µm spectral window. Our uncertainty budget is presented along with how our measured reflectance can be equated to directional-hemispherical reflectance...
December 18, 2023: Optics Express
#24
JOURNAL ARTICLE
Anastasia Glazyrina, Elena Zholobova, Ekaterina Iakovleva, Polina Bobkova, Ekaterina Krasnaya, Karina Kovygina, Olga Romanova, Oleg Blyuss, Konstantin Tutelman, Polina Petrova, Anastasiia Bairashevskaia, Mikhail Rumyantsev, Anatoliy A Korsunskiy, Elena Kondrikova, Anzhelika Nargizyan, Valeriya Yusupova, Evgeniya Korobyants, Anna Sologub, Seda Kurbanova, Aleksandr Suvorov, Louise Sigfrid, Danilo Buonsenso, Diego G Peroni, Andrew James McArdle, Pasquale Comberiati, Daniel Munblit
BACKGROUND: Even though the incidence of Multisystem Inflammatory Syndrome in children (MIS-C) is decreasing cases are still reported across the world. Studying the consequences of MIS-C enhances our understanding of the disease's prognosis. The objective of this study was to assess short- and medium-term clinical outcomes of MIS-C. METHODS: Prospective observational cohort study at Municipal Children's Hospital Morozovskaya, Moscow, Russia. All children meeting the Royal College of Paediatrics and Child Health (RCPCH), Centers for Disease Control and Prevention (CDC), or the World Health Organization (WHO) MIS-C case definition admitted to the hospital between 17 May and 26 October 2020 were included in the study...
January 4, 2024: Italian Journal of Pediatrics
#25
JOURNAL ARTICLE
Yasmine Makhlouf, Vivek Kumar Singh, Stephanie Craig, Aoife McArdle, Dominique French, Maurice B Loughrey, Nicola Oliver, Juvenal Baena Acevedo, Paul O'Reilly, Jacqueline A James, Perry Maxwell, Manuel Salto-Tellez
The immune response associated with oncogenesis and potential oncological ther- apeutic interventions has dominated the field of cancer research over the last decade. T-cell lymphocytes in the tumor microenvironment are a crucial aspect of cancer's adaptive immunity, and the quantification of T-cells in specific can- cer types has been suggested as a potential diagnostic aid. However, this is cur- rently not part of routine diagnostics. To address this challenge, we present a new method called True-T , which employs artificial intelligence-based techniques to quantify T-cells in colorectal cancer (CRC) using immunohistochemistry (IHC) images...
December 2024: Computational and Structural Biotechnology Journal
#26
JOURNAL ARTICLE
Anna Pedrinolla, Masoud Isanejad, Cinzia Antognelli, Desirée Bartolini, Consuelo Borras, Valentina Cavedon, Gabriele Di Sante, Anna Migni, Cristina Mas-Bargues, Chiara Milanese, Claudia Baschirotto, Roberto Modena, Alessandra Pistilli, Mario Rende, Federico Schena, Anna Maria Stabile, Nicola Vincenzo Telesa, Sara Tortorella, Kay Hemmings, Jose Vina, Eivind Wang, Anne McArdle, Malcolm J Jackson, Massimo Venturelli, Francesco Galli
OBJECTIVE: Protein-energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly...
December 22, 2023: BMJ Open
#27
JOURNAL ARTICLE
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Jillian G Baker, Nicholas M Barnes, Ross Bathgate, Jean-Martin Beaulieu, Annette G Beck-Sickinger, Maik Behrens, Kenneth E Bernstein, Bernhard Bettler, Nigel J M Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Helen M Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Michael L Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Lukas Grätz, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Deron Herr, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P IJzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Davide Malfacini, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin C Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E Müller, Philip M Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, G Enrico Rovati, Chiara Ruzza, Gareth J Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Khuraijam Dhanachandra Singh, Craig M Smith, Leigh A Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P Tan, David Thal, Walter Wally Thomas, Pieter B M W M Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Tom Lloyd Williams, Trent M Woodruff, Chengcan Yao, Richard D Ye
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties...
October 2023: British Journal of Pharmacology
#28
JOURNAL ARTICLE
Walaa Karazi, Jacqueline Coppers, Daphne Maas, Edith Cup, Bart Bloemen, Nicole Voet, Jan T Groothuis, Tomàs Pinós, Ramon Marti Seves, Ros Quinlivan, Nicoline Løkken, John Vissing, Salman Bhai, Andrew Wakelin, Stacey Reason, Nicol C Voermans
BACKGROUND: Glycogen storage disease type 5 (GSD) is an autosomal recessive inherited metabolic myopathy caused by a deficiency of the enzyme muscle glycogen phosphorylase. Individuals with GSD5 experience physical activity intolerance. OBJECTIVE: This patient-led study aimed to capture the daily life experiences of GSD5, with a focus on adapting to and coping with their physical activity intolerance. METHODS: An online survey was composed in close collaboration with patient organizations...
December 15, 2023: Journal of Neuromuscular Diseases
#29
Haizhen Wang, Cyrus Nikain, Jaime Amengual, Maxwell La Forest, Yong Yu, Meng C Wang, Russell Watts, Richard Lehner, Yunping Qiu, Min Cai, Irwin J Kurland, Ira J Goldberg, Sujith Rajan, M Mahmood Hussain, Jeffrey L Brodsky, Edward A Fisher
OBJECTIVES: Triglyceride (TG) association with apolipoprotein B100 (apoB100) serves to form very low density lipoproteins (VLDL) in the liver. The repertoire of factors that facilitate this association is incompletely defined. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discovered as a factor participating in cytoplasmic lipid droplets (LDs) in tissues that do not form VLDL. We hypothesized that in the liver, in addition to promoting cytosolic LD formation, FITM2 would also transfer TG from its site of synthesis in the ER membrane to nascent VLDL particles within the ER lumen...
December 7, 2023: bioRxiv
#30
Hira Kalsoom, Haseeb Mukhtar, Rizwana Kitchlew Latif
McArdle's disease (Glycogen storage disease type V) is a rare inherited autosomal recessive disease involving defect in enzyme, glycogen phosphorylase (PYGM) which results in accumulation of glycogen mainly affecting skeletal muscles. It commonly presents in childhood and rarely in adults with symptoms like exercise intolerance, muscle weakness, cramps and fatigue. Herein, we report an unusual case of a 22 years old male in Pakistan with probable McArdle's Disease presenting with repeated episodes of generalized cramping muscle pain, exercise intolerance and haematuria...
December 2023: JPMA. the Journal of the Pakistan Medical Association
#31
Joanna von Berg, Patrick F McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L Pulit, Steven J Kittner, Braxton D Mitchell, Jeroen de Ridder, Sander W van der Laan
Large genome-wide association studies (GWAS) employing case-control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify loci influencing age at onset (AAO) of ischemic stroke. Analyses were conducted in a Discovery cohort of 10,857 ischemic stroke cases using a linear regression framework. We meta-analyzed all SNPs with p-value < 1×10 -5 in a sex-combined or sex-stratified analysis using summary data from two additional replication cohorts...
December 1, 2023: medRxiv
#32
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Emanuela Turla, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of Schizochytrium sp. (strain CABIO-A-2) oil as a novel food (NF) pursuant to Regulation (EU) 2015/2283. S . sp. is a single-cell microalga. The NF is a mixture of triglycerides in which docosahexaenoic acid (DHA) represents 38%-44% of fatty acids. The applicant proposed to use the NF in infant formulae (IF) and follow-on formulae (FOF). The use levels proposed by the applicant were derived from Regulation (EU) 2016/127, which states the mandatory addition of DHA to IF and FOF at the level of 20-50 mg/100 kcal...
December 2023: EFSA journal
#33
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Emanuela Turla, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of Schizochytrium sp. (TKD-1) oil as a novel food (NF) pursuant to Regulation (EU) 2015/2283. Schizochytrium sp. is a single-cell microalga. The strain TKD-1, used by the applicant (ATK Biotech Co. Ltd.), belongs to the species Schizochytrium limacinum . The NF is a mixture of triglycerides in which docosahexaenoic acid (DHA) represents 53%-61% of fatty acids...
December 2023: EFSA journal
#34
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karen-Ildico Hirsch-Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Julia Bornhorst, Francesco Cubadda, Aymeric Dopter, Rex FitzGerald, Agnès de Sesmaisons Lecarré, Pedro das Neves Ferreira, Lucia Fabiani, Zsuzsanna Horvath, Leonard Matijević, Androniki Naska
Following a request from the European Commission (EC), the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for manganese. Systematic reviews of the literature of human and animal data were conducted to assess evidence regarding excess manganese intake (including authorised manganese salts) and the priority adverse health effect, i.e. manganese-induced neurotoxicity. Available human and animal studies support neurotoxicity as a critical effect, however, data are not sufficient and suitable to characterise a dose-response relationship and identify a reference point for manganese-induced neurotoxicity...
December 2023: EFSA journal
#35
JOURNAL ARTICLE
Michael McArdle
Life expectancy has more than doubled in the last century, and a new cohort of elderly and increasingly frail patients is presenting to emergency departments with new clinical challenges. When this patient cohort presents after injury, all aspects of clinical practice have to be recalibrated to provide safe and appropriate care. The prevalence of chronic disease, levels of organ failure, multiple comorbidities, greater use of anticoagulation and incidence of recurrent low- and high-impact trauma may delay and obscure diagnosis and, ultimately, increase mortality...
December 7, 2023: BMJ Case Reports
#36
JOURNAL ARTICLE
Matthias Schiedel, Darius J B McArdle, Gilda Padalino, Anthony K N Chan, Josephine Forde-Thomas, Michael McDonough, Helen Whiteland, Manfred Beckmann, Rosa Cookson, Karl F Hoffmann, Stuart J Conway
Schistosomiasis is a disease affecting >200 million people worldwide, but its treatment relies on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we have conducted the first systematic analysis of bromodomain-containing proteins (BCPs) in a causative species, Schistosoma mansoni . Having identified 29 putative bromodomains (BRDs) in 22 S. mansoni proteins, we selected Sm BRD3, a tandem BRD-containing BCP that shows high similarity to the human bromodomain and extra terminal domain (BET) family, for further studies...
December 4, 2023: Journal of Medicinal Chemistry
#37
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Carmen Peláez, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on lacto-N-fucopentaose I (LNFP-I)/2'-fucosyllactose (2'-FL) mixture as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human-identical milk oligosaccharides (HiMO) LNFP-I and 2'-FL, but it also contains d-lactose, lacto-N-tetraose, difucosyllactose, 3-fucosyllactose, LNFP-I fructose isomer, 2'-fucosyl-d-lactulose, l-fucose and 2'-fucosyl-d-lactitol, and a small fraction of other related saccharides...
December 2023: EFSA journal
#38
JOURNAL ARTICLE
Amani Kais, Erica McArdle, Rafka Chaiban, Ruifeng Cui, Chadi A Makary, Hassan H Ramadan
OBJECTIVE: Periorbital cellulitis in children are commonly caused by acute rhinosinusitis (ARS). This study investigated the association of ARS and the severity of periorbital cellulitis in children. STUDY DESIGN: Retrospective case-control study of children with periorbital cellulitis with ARS versus periorbital cellulitis without ARS. SETTING: Patients were seen at West Virginia University Children's Hospitals between August 2011 to August 2022...
November 30, 2023: International Journal of Pediatric Otorhinolaryngology
#39
JOURNAL ARTICLE
Anna Slipsager, Linda Kahr Andersen, Nicol Cornelia Voermans, Alejandro Lucia, Walaa Karazi, Alfredo Santalla, John Vissing, Nicoline Løkken
McArdle disease is an autosomal recessive inherited disease caused by pathogenic variants in the PYGM gene, resulting in virtual absence of the myophosphorylase enzyme in skeletal muscle. Patients experience physical activity intolerance, muscle pain, and muscle fatigue. This study aimed to investigate other fatigue domains with the Multidimensional Fatigue Inventory (MFI-20) along with an investigation of potential contributing factors, including relevant disease and lifestyle-related factors. We conducted a survey in an international cohort of patients with McArdle disease...
November 11, 2023: Neuromuscular Disorders: NMD
#40
JOURNAL ARTICLE
G McArdle, R Davies, I V Lerner, I V Yurkevich
We investigate nonequilibrium transport properties of a quantum dot in the Coulomb blockade regime under the condition of negligible inelastic scattering during the dwelling time of the electrons in the dot. Using the quantum kinetic equation we show that the absence of thermalization leads to a double step in the distribution function of electrons on the dot, provided that it is symmetrically coupled to the leads. This drastically changes nonlinear transport through the dot resulting in an additional (compared to the thermalized case) jump in the conductance at voltages close to the charging energy, which could serve as an experimental manifestation of the absence of thermalization...
November 17, 2023: Physical Review Letters
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
