Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo, Joan So, Lei Peng, Xiaoxuan Zhu, Eva Hin Wa Leung, Lina Zhu, Kui Ming Chan, Martin Cheung, Siu Yuen Chan
Nucleosome assembly proteins (NAPs) have been identified as histone chaperons. Testis-Specific Protein, Y-Encoded-Like (TSPYL) is a newly arisen NAP family in mammals. TSPYL2 can be transcriptionally induced by DNA damage and TGFβ causing proliferation arrest. TSPYL1, another TSPYL family member, has been poorly characterized and is the only TSPYL family member known to be causal of a lethal recessive disease in humans. This study shows that TSPYL1 and TSPYL2 play an opposite role in TGFβ signaling...
April 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)