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Epithelial to mesenchymal transition lung

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https://read.qxmd.com/read/30781783/garcinol-sensitizes-nsclc-cells-to-standard-therapies-by-regulating-emt-modulating-mirnas
#1
Mohd Farhan, Arshi Malik, Mohammad Fahad Ullah, Sarah Afaq, Mohd Faisal, Ammad Ahmad Farooqi, Bernhard Biersack, Rainer Schobert, Aamir Ahmad
Garcinol, a dietary factor obtained from Garcinia indica , modulates several key cellular signaling pathways as well as the expression of miRNAs. Acquired resistance to standard therapies, such as erlotinib and cisplatin, is a hallmark of non-small cell lung cancer (NSCLC) cells that often involves miRNA-regulated epithelial-to-mesenchymal transition (EMT). We used A549 cells that were exposed to transforming growth factor beta 1 (TGF-β1), resulting in A549M cells with mesenchymal and drug resistant phenotype, and report that garcinol sensitized resistant cells with mesenchymal phenotype to erlotinib as well as cisplatin with significant decrease in their IC50 values...
February 13, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30781674/yifei-tongluo-a-chinese-herbal-formula-suppresses-tumor-growth-and-metastasis-and-exerts-immunomodulatory-effect-in-lewis-lung-carcinoma-mice
#2
Qiuchen Qi, Yanhong Hou, Ang Li, Yueyue Sun, Siying Li, Zhongxi Zhao
This study was aimed to investigate the anti-tumor, anti-metastasis and immunomodulatory effects of Yifei Tongluo (YFTL), a Chinese herbal formula, in Lewis lung carcinoma mice and to explore the underlying mechanisms. LLC cells were inoculated subcutaneously in C57BL/6 mice to establish the Lewis lung carcinoma model. We observed that YFTL effectively inhibited tumor growth and prolonged the overall survival of tumor-bearing mice. Additionally, YFTL treatment resulted in a significantly decreased number of surface lung metastatic lesions compared with the model control group...
February 18, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30779728/circrna-circ_0067934-overexpression-correlates-with-poor-prognosis-and-promotes-thyroid-carcinoma-progression
#3
Huihui Wang, Xiaoguang Yan, Haijun Zhang, Xiaorong Zhan
BACKGROUND Circular RNAs are important regulators in human cancers, including thyroid carcinoma. The circ_0067934 RNA is reported to participate in hepatocellular carcinoma, esophageal squamous cell carcinoma, and lung cancer. Whether it regulates thyroid carcinoma remains unclear. The purpose of this study was to research potential mechanisms of circ_0067934 in thyroid tumors to provide potential new diagnostic and treatment targets. MATERIAL AND METHODS The expression level of circ_0067934 in thyroid tumors, adjacent tissues, and cell lines was measured by qRT-PCR...
February 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30779215/macrophage-er%C3%AE-promoted-invasion-of-endometrial-cancer-cell-by-mtor-kif5b-mediated-epithelial-to-mesenchymal-transition
#4
Xuanxuan Jing, Jin Peng, Yu Dou, Jintang Sun, Chao Ma, Qingjie Wang, Lin Zhang, Xia Luo, Beihua Kong, Yun Zhang, Lijie Wang, Xun Qu
Tumor associated macrophages (TAMs) exert tumor-promoting effects. There have been reports that Estrogen receptors (ERs) are expressed on the infiltrating macrophages of endometriosis, ovarian cancer and lung cancer. However, the role of ERs in macrophages is not well characterized. In this study, we first identified that ERα expression on the macrophages of human endometrial cancer was positively correlated with cancer progression. Conditioned medium from selective ERα agonist-treated M2 macrophages induced the epithelial to mesenchymal transition (EMT) in endometrial cancer cells...
February 18, 2019: Immunology and Cell Biology
https://read.qxmd.com/read/30772441/tox3-inhibits-cancer-cell-migration-and-invasion-via-transcriptional-regulation-of-snai1-and-snai2-in-clear-cell-renal-cell-carcinoma
#5
Bo Jiang, Wei Chen, Haixiang Qin, Wenli Diao, Binghua Li, Wenmin Cao, Zhenxing Zhang, Wei Qi, Jie Gao, Mengxia Chen, Xiaozhi Zhao, Hongqian Guo
Studies on the mechanism of clear cell renal cell carcinoma (ccRCC) progression are lacking. In this study, TOX3 was identified as a novel cancer suppressor gene in ccRCC. Hypermethylation of CpG probes in the promoter region was associated with the functional loss of TOX3 in ccRCC cancer tissues. Downregulation of TOX3 mRNA was strongly associated with poor clinical outcomes in ccRCC. Immunohistochemistry confirmed TOX3 was downregulated in primary tumors without metastasis (n=126) and further downregulated in primary metastatic tumors (n=23) compared with adjacent noncancerous tissues (n=92)...
February 14, 2019: Cancer Letters
https://read.qxmd.com/read/30771899/cancer-upregulated-gene-cug-2-elevates-yap1-expression-leading-to-enhancement-of-epithelial-mesenchymal-transition-in-human-lung-cancer-cells
#6
Sirichat Kaowinn, Natpaphan Yawut, Sang Seok Koh, Young-Hwa Chung
Although our previous studies have showed that a novel oncogene, cancer upregulated gene (CUG)2 induced epithelial-mesenchymal transition (EMT), the detailed molecular mechanism remains unknown. Because several lines of evidence documented that Yes-Associated Protein (YAP)1 is closely associated with cancer stem cell (CSC)-like phenotypes including EMT, stemness, and drug resistance, we wondered if YAP1 is involved in CUG2-induced EMT. We herein found that the overexpression of CUG2 increased YAP1 expression at the transcriptional as well as protein levels...
February 13, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30767589/multifocal-synchronous-upper-urinary-tract-carcinosarcoma-sarcomatoid-carcinoma-with-rhabdomyoblastic-differentiation
#7
Kosuke Takemura, Toru Motoi, Akiko Tonooka, Nobuaki Funata, Yasukazu Nakanishi, Madoka Kataoka, Masaya Ito, Kazumasa Sakamoto, Hiroaki Suzuki, Ken-Ichi Tobisu, Fumitaka Koga
Carcinosarcoma of the upper urinary tract is very rare. In this article, we report a case of upper urinary tract carcinosarcoma with rhabdomyoblastic differentiation showing distinct transition between the epithelial and mesenchymal components confirmed by morphology and immunohistochemistry. An 81-year-old female underwent radical nephroureterectomy under the diagnosis of left ureteral urothelial carcinoma (UC). Multiple invasive tumors showed combined histology with UC and rhabdomyosarcomatous elements (pT2-ureter and pT3-renal pelvis, pN0, u-lt0, ly0, v0, RM0)...
February 15, 2019: International Journal of Surgical Pathology
https://read.qxmd.com/read/30767202/fractionated-ionizing-radiation-facilitates-interferon-%C3%AE-signaling-and-anticancer-activity-in-lung-adenocarcinoma-cells
#8
Szu-Yuan Wu, Chia-Ling Chen, Po-Chun Tseng, Chi-Yun Chiu, Yung-En Lin, Chiou-Feng Lin
Fractionated ionizing radiation (FIR) is a radiotherapy regimen that is regularly performed as part of lung cancer treatment. In contrast to the growth inhibition caused by DNA damage, immunomodulation in post-irradiated cancer cells is not well documented. Interferon (IFN)-γ confers anticancer activity by triggering both growth inhibition and cytotoxicity. This study investigated the priming effects of FIR with immunomodulation on the anticancer IFN-γ. Cell morphology, cell growth, and cytotoxicity were observed in FIR-treated A549 lung adenocarcinoma...
February 14, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30767087/autophagy-inhibition-with-chloroquine-reverts-paclitaxel-resistance-and-attenuates-metastatic-potential-in-human-nonsmall-lung-adenocarcinoma-a549-cells-via-ros-mediated-modulation-of-%C3%AE-catenin-pathway
#9
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Paclitaxel is one of the most commonly used drugs for the treatment of nonsmall cell lung cancer (NSCLC). However acquired resistance to paclitaxel, epithelial to mesenchymal transition and cancer stem cell formation are the major obstacles for successful chemotherapy with this drug. Some of the major reasons behind chemoresistance development include increased ability of the cancer cells to survive under stress conditions by autophagy, increased expression of drug efflux pumps, tubulin mutations etc. In this study we found that inhibition of autophagy with chloroquine prevented development of paclitaxel resistance in A549 cells with time and potentiated the effect of paclitaxel by increased accumulation of superoxide-producing damaged mitochondria, with elevated ROS generation, it also increased the apoptotic rate and sub G0/ G1 phase arrest with time in A549 cells treated with paclitaxel and attenuated the metastatic potential and cancer stem cell population of the paclitaxel-resistant cells by ROS mediated modulation of the Wnt/β-catenin signaling pathway, thereby increasing paclitaxel sensitivity...
February 14, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30766750/flotillin1-promotes-emt-of-human-small-cell-lung-cancer-via-tgf-%C3%AE-signaling-pathway
#10
Lianmei Zhao, Jie Li, Yueping Liu, Wei Zhou, Yanan Shan, Xinyi Fan, Xinliang Zhou, Baoen Shan, Yongmei Song, Qimin Zhan
Objective: Small cell lung carcinoma (SCLC) is considered one of the most aggressive types of lung cancer due to its rapid growth and early metastasis. No tumor markers or therapeutic targets have been demonstrated to be specific or effective in SCLC to date. This study aims to evaluate the potential of Flotillin1 (Flot1) as a target of SCLC treatment. Methods: Flot1 expression level in the tissue of SCLC and other tissue of lung disease was detected using immunohistochemical staining...
November 2018: Cancer Biology & Medicine
https://read.qxmd.com/read/30764900/heme-oxygenase-1-inhibits-tumor-metastasis-mediated-by-notch1-pathway-in-murine-mammary-carcinoma
#11
Qiang Li, Qi Liu, Wanpeng Cheng, Huiyan Wei, Wenqian Jiang, Fang E, Yuan Yu, Jianfeng Jin, Chaoxia Zou
Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated indices for Epithelial-mesenchymal transition (EMT), migration and proliferation of 4T1 cells were evaluated...
February 14, 2019: Oncology Research
https://read.qxmd.com/read/30763256/nm23-h1-inhibits-hypoxia-induced-epithelial-mesenchymal-transition-and-stemness-in-non-small-cell-lung-cancer-cells
#12
Cun-En Wu, Yu-Wen Zhuang, Jin-Yong Zhou, Shen-Lin Liu, Xi Zou, Jian Wu, Rui-Ping Wang, Peng Shu
The Nm23 gene has been acknowledged to play a crucial role in lung cancer metastasis inhibitory cascades controlled by multiple factors. Low expression or allelic deletion of nm23-H1 is strongly linked to widespread metastasis and poor differentiation of non-small cell lung cancer (NSCLC). In this study, nm23-H1 was down regulated in epithelial-mesenchymal transition (EMT) and stemness enhancement under cobalt chloride (CoCl2)-induced hypoxia in NSCLC cells. Moreover, knocking down of nm23-H1 by shRNA apparently promoted hypoxia induced EMT and stemness, which was entirely suppressed via over expression of nm23-H1...
February 14, 2019: Biological Chemistry
https://read.qxmd.com/read/30762593/case-series-of-met-exon-14-skipping-mutation-positive-non-small-cell-lung-cancers-with-response-to-crizotinib-and-cabozantinib
#13
Samantha X Y Wang, Bing M Zhang, Heather A Wakelee, Michael Z Koontz, MingGui Pan, Maximilian Diehn, Christian A Kunder, Joel W Neal
The mesenchymal-to-epithelial transition (MET) gene is altered and becomes a driver mutation in up to 5% of non-small-cell lung cancer (NSCLC). We report our institutional experience treating patients with MET exon 14 skipping (METex14) mutations, including responses to the MET inhibitors crizotinib and cabozantinib. We identified cases of NSCLC with METex14 mutations using an institutionally developed or commercial next-generation sequencing assay. We assessed patient and disease characteristics by retrospective chart review...
February 12, 2019: Anti-cancer Drugs
https://read.qxmd.com/read/30760700/loss-of-madd-expression-inhibits-cellular-growth-and-metastasis-in-anaplastic-thyroid-cancer
#14
Shikha Saini, Lakshmi Sripada, Kiara Tulla, Prabhakaran Kumar, Fei Yue, Nicholas Kunda, Ajay V Maker, Bellur S Prabhakar
Anaplastic Thyroid Cancer (ATC) is an aggressive malignancy with limited therapeutic options and dismal patient survival. We have previously shown MADD to be differentially overexpressed in multiple cancer histologies and to contribute to tumor cell growth and survival. Therefore, we targeted MADD by gene silencing, explored its effect on cellular proliferation and metastases and examined its therapeutic potential in an orthotopic ATC model in athymic nude mice. When compared to untreated control and scramble siRNA, MADD siRNA treatment inhibited the proliferative capacity of 8505C, C643 and HTH7 cells in vitro and 8505C-derived-orthotopic tumor growth in vivo...
February 13, 2019: Cell Death & Disease
https://read.qxmd.com/read/30760238/hypoxia-induced-cancer-stemness-acquisition-is-associated-with-cxcr4-activation-by-its-aberrant-promoter-demethylation
#15
Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y Park, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim
BACKGROUND: A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. However, hypoxia-induced changes in the expression and function of candidate stem cell markers and their possible molecular mechanism is still not understood. METHODS: Lung cell lines were analyzed in normoxic or hypoxic conditions. For screening among the stem cell markers, a transcriptome analysis using next-generation sequencing was performed...
February 13, 2019: BMC Cancer
https://read.qxmd.com/read/30755817/dysregulated-enpp1-increases-the-malignancy-of-human-lung-cancer-by-inducing-epithelial-mesenchymal-transition-phenotypes-and-stem-cell-features
#16
Min Hu, Wenzheng Guo, Yueling Liao, Dongliang Xu, Beibei Sun, Hongyong Song, Tong Wang, Yanbin Kuang, Bo Jing, Kaimi Li, Jing Ling, Feng Yao, Jiong Deng
Induction of cancer stem cell (CSC) characters and epithelial mesenchymal transition (EMT) features are crucial in tumor initiation, progression and metastasis. However, underlying mechanisms remain incompletely understood. Here, we showed that ENPP1 plays an important role in inducing and maintaining EMT phenotypes and CSC features in lung cancer. ENPP1 is upregulated in lung cancer cells. ENPP1-knockdown in lung cancer HCC827 cells and A549 cells resulted in suppressed colonogenic formation, anchorage-independent growth in vitro, and tumorigenicity in vivo...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755599/lncrna-zeb1-as1-promotes-pulmonary-fibrosis-through-zeb1-mediated-epithelial-mesenchymal-transition-by-competitively-binding-mir-141-3p
#17
Weibin Qian, Xinrui Cai, Qiuhai Qian, Wei Peng, Jie Yu, Xinying Zhang, Li Tian, Can Wang
Long non-coding RNAs (lncRNAs) have been reported to be involved in various pathophysiological processes in many diseases. However, the role and mechanism of lncRNAs in pulmonary fibrosis have not been explicitly delineated. In the present study, we found that lncRNA ZEB1 antisense RNA 1 (ZEB1-AS1) is upregulated in the lungs of BLM-induced rats and TGF-β1-induced RLE-6TN cells, and positively correlated with the levels of ZEB1, an epithelial-mesenchymal transition (EMT) master regulator. Knockdown of ZEB1-AS1 alleviated BLM-induced fibrogenesis, in vivo, via inhibiting EMT progress...
February 12, 2019: Cell Death & Disease
https://read.qxmd.com/read/30755243/shmt1-inhibits-the-metastasis-of-hcc-by-repressing-nox1-mediated-ros-production
#18
Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang, Kangsheng Tu
BACKGROUND: Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in human cancers including lung cancer, ovarian cancer and intestinal cancer. However, the expression, function and the underlying mechanisms of SHMT1 in HCC remain uncovered. METHODS: qRT-PCR, immunohistochemistry and immunoblotting were performed to detect the expression of SHMT1 in HCC tissues and cell lines...
February 12, 2019: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/30747209/lncrna-h19-promotes-viability-and-epithelial-mesenchymal-transition-of-lung-adenocarcinoma-cells-by-targeting-mir-29b-3p-and-modifying-stat3
#19
Lihua Liu, Linlin Liu, Sijing Lu
Considering the joint contribution of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs) to tumorigenesis, the aim of the present study was to investigate whether and how lncRNA H19 targets miR‑29b‑3p to affect the progression of lung adenocarcinoma by the modulation of signal transducer and activator of transcription 3 (STAT3). A total of 305 lung adenocarcinoma tissues and four human lung adenocarcinoma cell lines (i.e. Calu‑3, NCI‑H1975, A549 and NCI‑H23) were used. pcDNA3.1‑H19, short interfering RNA (si‑)H19, miR‑29b‑3p mimic, miR‑29b‑3p inhibitor and negative control (NC) were transfected into the cells, and the proliferation, viability and apoptosis of the cells were determined using a Cell Counting Kit‑8 assay, colony formation assay and flow cytometry, respectively...
January 24, 2019: International Journal of Oncology
https://read.qxmd.com/read/30746122/radon-induced-mitochondrial-dysfunction-in-human-bronchial-epithelial-cells-and-epithelial-mesenchymal-transition-with-long-term-exposure
#20
Qian Xu, Lijun Fang, Bin Chen, Hong Zhang, Qianqian Wu, Hongbo Zhang, Aiqing Wang, Jian Tong, Shasha Tao, Hailin Tian
Radon is a naturally occurring radionuclide, which has a wide environmental distributed. It emits multiple high linear energy transfer (LET) alpha particles during radiative decay, and has been regarded as a human carcinogen by the International Agency for Research on Cancer. Currently, residential radon exposure is considered as the second highest cause of lung cancer and the leading cause among nonsmokers. Radon exposure leads to genomic instability, which causes the accumulation of multiple genetic changes and leads to cancer development...
January 1, 2019: Toxicology Research
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