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Nicole Chien, Michelle Petrasich, George Chan, Edward Theakston, Anna Ruskova, Nicola Eaddy, Timothy Hawkins, Leanne Berkahn, Richard Doocey, Peter J Browett, Taryn N Green, Maggie L Kalev-Zylinska
Current guidelines recommend that a rapid test be used to assist diagnosis of acute promyelocytic leukaemia (APL), but the choice of an assay is discretionary. PML immunofluorescence (PML IF) identifies the microparticulate pattern of the PML protein localisation, highly specific for APL. The aim of this study was to evaluate clinical utility of PML IF in a real-life setting based on a retrospective records review for all patients who had PML IF performed in our centre between 2000 and 2017. Final analysis included 151 patients, 70 of whom had APL...
March 12, 2019: Pathology
Giovanni Pagano, Philippe J Thomas, Aldo Di Nunzio, Marco Trifuoggi
The extensive use of rare earth elements (REEs) in a number of technologies is expected to impact on human health, including occupational and environmental REE exposures. A body of experimental evidence on REE-associated toxicity has been accumulated in recent decades, thus providing extensive background information on the adverse effects of REE exposures. Unlike experimental studies, the consequences of REE exposures to human health have been subjected to relatively fewer investigations. Geographical studies have been conducted on residents in REE mining districts, reporting on REE bioaccumulation, and associations between REE residential exposures and adverse health effects...
February 4, 2019: Environmental Research
Carly Fleagle Chisholm, Taek Jin Kang, Miao Dong, Kasey Lewis, Madhuri Namekar, Axel T Lehrer, Theodore W Randolph
No United States Food and Drug Administration-licensed vaccines protective against Ebola virus (EBOV) infections are currently available. EBOV vaccine candidates currently in development, as well as most currently licensed vaccines in general, require transport and storage under a continuous cold chain in order to prevent potential decreases in product efficacy. Cold chain requirements are particularly difficult to maintain in developing countries. To improve thermostability and reduce costly cold chain requirements, a subunit protein vaccine against EBOV was formulated as a glassy solid using lyophilization...
January 28, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Laura Tiozzo Fasiolo, Michele Dario Manniello, Fabrizio Bortolotti, Francesca Buttini, Alessandra Rossi, Fabio Sonvico, Paolo Colombo, Georgia Valsami, Gaia Colombo, Paola Russo
Neuroinflammation occurs in the early stages of Alzheimer's disease (AD). Thus, anti-inflammatory drugs in this asymptomatic initial phase could slow down AD progression, provided they enter the brain. Direct nose-to-brain drug transport occurs along olfactory or trigeminal nerves, bypassing the blood-brain barrier. Nasal administration may enable the drug to access the brain. Here, flurbiprofen powders for nose-to-brain drug transport in early AD-related neuroinflammation were studied. Their target product profile contemplates drug powder deposition in the nasal cavity, prompt dissolution in the mucosal fluid and attainment of saturation concentration to maximise diffusion in the tissue...
January 29, 2019: Journal of Drug Targeting
Lipika Chablani, Suprita A Tawde, Archana Akalkotkar, Martin J D'Souza
Breast cancer impacts female population globally and is the second most common cancer for females. With various limitations and adverse effects of current therapies, several immunotherapies are being explored. Development of an effective breast cancer vaccine can be a groundbreaking immunotherapeutic approach. Such approaches are being evaluated by several clinical trials currently. On similar lines, our research study aims to evaluate a particulate breast cancer vaccine delivered via skin. This particulate breast cancer vaccine was prepared by spray drying technique and utilized murine breast cancer whole cell lysate as a source of tumor-associated antigens...
January 2, 2019: AAPS Journal
Cristina García-Caballero, Burke Lieppman, Alicia Arranz-Romera, Irene T Molina-Martínez, Irene Bravo-Osuna, Michael Young, Petr Baranov, Rocío Herrero-Vanrell
Purpose: To evaluate the potential of a poly(lactic-co-glycolic acid) (PLGA)-based slow release formulation of glial cell line-derived neurotrophic factor (GDNF) alone or in combination with melatonin to rescue photoreceptors in a mouse model of retinal degeneration. Methods: GDNF and GDNF/melatonin-loaded PLGA microspheres (MSs) were prepared using a solid-in-oil-in-water emulsion solvent extraction-evaporation technique. A combination of PLGA and vitamin E (VitE) was used to create the microcarriers...
2018: Molecular Vision
Ling Yang, Tian Zhao, Ishtvan Boldog, Christoph Janiak, Xiao-Yu Yang, Qiang Li, Yan-Jia Zhou, Yong Xia, Deng-Wang Lai, Yue-Jun Liu
The concentration of benzoic acid was found to exercise efficient control over the formation of either MIL-101(Cr) or MIL-88B(Cr) under otherwise similar hydrothermal synthetic conditions. Nanocrystals of MIL-101(Cr) with ∼100 nm average size and excellent SBET = 3467 m2 g-1 are obtained at lower concentrations of benzoic acid, while at higher concentrations the microparticulated MIL-88B(Cr) product is formed. Hereby a new efficient synthetic method towards the elusive MIL-88B(Cr), yet reported only once without synthetic details, is proposed...
December 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Srabani Mitra, Anasuya Sarkar
The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive mature IL-1β by activated immune cells. Microparticle (MP) shedding has also been recently recognized as a manner of cytokine IL-1β release. However, the understanding of purinergic receptor roles in the MP-mediated IL-1β release process is still rudimentary...
December 13, 2018: Purinergic Signalling
Chuying Ma, Xinggui Tian, Jimin P Kim, Denghui Xie, Xiang Ao, Dingying Shan, Qiaoling Lin, Maria R Hudock, Xiaochun Bai, Jian Yang
A comprehensive understanding of the key microenvironmental signals regulating bone regeneration is pivotal for the effective design of bioinspired orthopedic materials. Here, we identified citrate as an osteopromotive factor and revealed its metabonegenic role in mediating citrate metabolism and its downstream effects on the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Our studies show that extracellular citrate uptake through solute carrier family 13, member 5 (SLC13a5) supports osteogenic differentiation via regulation of energy-producing metabolic pathways, leading to elevated cell energy status that fuels the high metabolic demands of hMSC osteodifferentiation...
November 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
G Tejada, M C Lamas, M Sortino, V A Alvarez, D Leonardi
Oropharyngeal candidiasis is a recurrent oral infection caused by Candida species. Gel formulation containing miconazole nitrate is the most common approach for treating oral candidiasis. However, traditional oral topical antifungal therapies have many limitations, including short contact time with the oral mucosa and the necessity to administrate various doses per day. Thus, the aim of this work was to formulate composited microparticulated systems based on combinations of mucoadhesive cationic, anionic, and nonionic polymers that could protect and modify the drug release rate and therefore avoid a fast dilution of the drug by saliva...
September 20, 2018: AAPS PharmSciTech
Alan J Mearns, Donald J Reish, Matt Bissell, Ann Michelle Morrison, Mary Ann Rempel-Hester, Courtney Arthur, Nicolle Rutherford, Rachel Pryor
This review covers selected 2017 articles on the biological effects of pollutants and human physical disturbances on marine and estuarine plants, animals, ecosystems and habitats. The review, based largely on journal articles, covers field and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, marine debris, dredging and disposal etc...
October 1, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
Chanchan Sun, Bin Liang, Huanjing Sheng, Ruijun Wang, Jiang Zhao, Zesheng Zhang, Min Zhang
In this article, oil-in-water (O/W) emulsions stabilized by natural whey protein concentrate (WPC) and microparticulated whey protein (MWP) and their mixtures with xanthan gum (XG) were prepared to investigate the lipid oxidative stability of O/W emulsions with the same interfacial composition but different interfacial structures. High-performance size exclusion chromatography, Fourier transform infrared spectrometry, X-ray diffraction analysis and steady-state fluorescence spectroscopy were used to reveal the differences in the structures of natural whey protein and the microparticulated whey proteins (MWP, pH 3...
December 2018: International Journal of Biological Macromolecules
Chanchan Sun, Rui Liu, Huanjing Sheng, Ruijun Wang, Zesheng Zhang, Jiang Zhao, Min Zhang
Since lipid digestion is an interfacial process, food emulsions are increasingly being seen as a mechanism for controlling lipid uptake. Oil-in-water emulsions stabilized by whey protein (WP) and protein-xanthan gum (XG) mixtures were designed to investigate the influence of interfacial structures on lipid digestion using an in vitro digestion model. The interfacial layers with different structures were designed using microparticulated whey protein (MWP) and MWP-XG mixtures. The increase in the volume average diameter of proteins indicated that the WPs aggregated to form micro-particles during microparticulation...
September 19, 2018: Food & Function
Yukari Miyadera, Takafumi Naito, Takahiro Yamada, Junichi Kawakami
BACKGROUND: Daptomycin, a cyclic lipopeptide antibiotic, displays high plasma protein binding. This study developed the simple method of liquid chromatographic separation using a core-shell octadecylsilyl microparticulate coupled to tandem mass spectrometry for the quantitation of total and free daptomycin in human plasma. METHODS: Free daptomycin in plasma was obtained by centrifugal ultrafiltration. Deproteinized plasma specimens were directly separated using a core-shell octadecylsilyl microparticulate with isocratic elution...
October 2018: Therapeutic Drug Monitoring
Ruben Gracia, Cristina Yus, Olga Abian, Gracia Mendoza, Silvia Irusta, Victor Sebastian, Vanesa Andreu, Manuel Arruebo
Bovine Serum Albumin (BSA) and Horseradish Peroxidase (HRP) have been encapsulated within microparticulated matrices composed of Eudragit RS100 by the water-in-oil-in-water double emulsion solvent evaporation method. Good encapsulation efficiencies were achieved for BSA and HRP, 88.4 and 95.8%, respectively. The stability of the loaded proteins was confirmed by using circular dichroism and fluorescence. The gastroresistance of the protein-loaded microparticles was evaluated under simulated gastric conditions demonstrating the preservation of the structural integrity of the proteins loaded inside the particles...
November 2018: International Journal of Biological Macromolecules
Lizziane Maria Belloto de Francisco, Diana Pinto, Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Rafaela Said Dos Santos, Paulo Costa, Francisca Rodrigues, M Beatriz P P Oliveira, Bruno Sarmento, Marcos Luciano Bruschi
Correction for 'Development of a microparticulate system containing Brazilian propolis by-product and gelatine for ascorbic acid delivery: evaluation of intestinal cell viability and radical scavenging activity' by Lizziane Maria Belloto de Francisco et al., Food Funct., 2018, DOI: 10.1039/c8fo00863a.
August 15, 2018: Food & Function
Lizziane Maria Belloto de Francisco, Diana Pinto, Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Rafaela Said Dos Santos, Paulo Costa, Francisca Rodrigues, M Beatriz P P Oliveira, Bruno Sarmento, Marcos Luciano Bruschi
The use of propolis by-product (PBP) microparticles (MP) as delivery systems can be a promising tool to surpass drawbacks related to low stability of ascorbic acid (AA). The objective of this study was to develop and characterize MP prepared with PBP containing AA. The MP was characterized regarding morphology, particle size, polydispersity index (PDI), association efficiency (AE), drug loading (DL), infrared and Raman spectroscopy as well as antioxidant and radical scavenging activity, in vitro release, and cellular studies...
August 15, 2018: Food & Function
Sandra Jankovic, Georgia Tsakiridou, Felix Ditzinger, Niklas J Koehl, Daniel J Price, Alexandra-Roxana Ilie, Lida Kalantzi, Kristof Kimpe, René Holm, Anita Nair, Brendan Griffin, Christoph Saal, Martin Kuentz
OBJECTIVES: Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water-soluble drugs. KEY FINDINGS: An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches...
July 5, 2018: Journal of Pharmacy and Pharmacology
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2018: Inflammatory Bowel Diseases
Francesco Mainini, David S Larsen, Gill A Webster, Sarah L Young, Michael R Eccles
MIS416 is a microparticulate formulation derived from propionibacterium acnes cell wall skeletons with intrinsic adjuvant activity. Conjugates of MIS416-SS-peptide containing a disulfide linkage facilitate the cytoplasmic delivery and release of peptides in antigen-presenting cells (APCs). We hypothesized that MIS416-siRNA (small interfering RNA) conjugates, containing a disulfide linkage between MIS416 and the siRNA, would allow cytoplasmic release of siRNA in APCs. MIS416-SS-siStat3 conjugates added to cell culture medium of monolayers of DCs in culture flasks successfully targeted Stat3 mRNA in DCs in vitro without transfection, downregulating Stat3 mRNA and protein levels...
August 2018: Nucleic Acid Therapeutics
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