Han-Soo Kim, Do-Young Choi, So Jeong Yun, Seong-Mi Choi, Jeong Won Kang, Jin Woo Jung, Daehee Hwang, Kwang Pyo Kim, Dong-Wook Kim
Mesenchymal stem cells (MSCs) have emerged as a promising means for treating degenerative or incurable diseases. Recent studies have shown that microvesicles (MVs) from MSCs (MSC-MVs) contribute to recovery of damaged tissues in animal disease models. Here, we profiled the MSC-MV proteome to investigate their therapeutic effects. LC-MS/MS analysis of MSC-MVs identified 730 MV proteins. The MSC-MV proteome included five positive and two variable known markers of MSCs, but no negative marker, as well as 43 surface receptors and signaling molecules controlling self-renewal and differentiation of MSCs...
February 3, 2012: Journal of Proteome Research