Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P Acker, Syed M Qadri
BACKGROUND: Thrombospondin-1 (TSP-1), a Ca2+ -binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD47, orchestrates a wide array of cellular functions including cytoskeletal organization, migration, cell-cell interaction, cell proliferation, autophagy, and apoptosis. In the present study, we investigated the impact of TSP-1/CD47 signaling on Ca2+ dynamics, survival, and deformability of human red blood cells (RBCs)...
September 18, 2020: Cell Communication and Signaling: CCS