keyword
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#1
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38529636/treatment-modalities-and-outcomes-in-brainstem-cavernous-malformations-a-large-multicenter-observational-cohort-study
#2
JOURNAL ARTICLE
Junlin Lu, Zongze Li, Hao Deng, Guangchao Shi, Wei Wang, Chao You, Wei Zhu, Rui Tian
BACKGROUND: Symptomatic brainstem cavernous malformations (BSCMs) pose a high risk of morbidity and mortality due to recurrent hemorrhage, warranting aggressive management. However, few studies have compared the effectiveness of different treatment modalities for BSCMs. We aimed to assess the association of treatment modalities with recurrent hemorrhage and neurological outcomes in patients with BSCM. METHODS: We conducted a retrospective cohort study using an observational registry database covering population of southwest and southeast China...
March 26, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38505769/understanding-the-mechanism-of-acupuncture-in-acute-cerebral-infraction-through-a-proteomic-analysis-protocol-for-a-prospective-randomized-controlled-trial
#3
JOURNAL ARTICLE
Jiangpeng Cao, Yuanhao Du, Xiumei Yin, Na Zheng, Jiawei Han, Linling Chen, Lanyu Jia
BACKGROUND: Acute cerebral infarction (ACI), being the predominant form of stroke, presents challenges in terms of the limited effectiveness of various treatments in improving the neurological function. Although acupuncture shows promise in addressing ACI, the availability of high-quality evidence regarding its efficacy, safety, and underlying mechanism remains insufficient. In this study, we design a multicenter, prospective, single-blind, randomized controlled trial with the aim of evaluating the efficacy and safety of acupuncture for ACI, making an attempt to unveil the molecular mechanisms by proteomic...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38489544/efficacy-and-safety-of-tirofiban-before-stenting-for-symptomatic-intracranial-atherosclerotic-stenosis-a-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Jun Zhang, Xin Huang, Guoqing Wang, Xianjun Wang, Tao Zhang, Dong Wang, Lifeng Qi, Jiye Liang, Bing Li, Jianfeng Chu, Kai Li, Lili Sun, Yun Song, Wei Zhao, Meimei Zheng, Yao Meng, Hao Yin, Wei Wang, Ju Han
BACKGROUND AND OBJECTIVES: Acute stent thrombosis (AST) is not uncommon and even catastrophic during intracranial stenting angioplasty in patients with symptomatic high-grade intracranial atherosclerotic stenosis (ICAS). The purpose of this study was to investigate whether adjuvant intravenous tirofiban before stenting could reduce the risk of AST and periprocedural ischemic stroke in patients receiving stent angioplasty for symptomatic ICAS. METHODS: A prospective, multicenter, open-label, randomized clinical trial was conducted from September 9, 2020, to February 18, 2022, at 10 medical centers in China...
April 9, 2024: Neurology
https://read.qxmd.com/read/38464864/validation-of-the-openwater-wearable-optical-system-cerebral-hemodynamic-monitoring-during-a-breath-hold-maneuver
#5
JOURNAL ARTICLE
Christopher G Favilla, Sarah Carter, Brad Hartl, Rebecca Gitlevich, Michael T Mullen, Arjun G Yodh, Wesley B Baker, Soren Konecky
SIGNIFICANCE: Bedside cerebral blood flow (CBF) monitoring has the potential to inform and improve care for acute neurologic diseases, but technical challenges limit the use of existing techniques in clinical practice. AIM: Here, we validate the Openwater optical system, a novel wearable headset that uses laser speckle contrast to monitor microvascular hemodynamics. APPROACH: We monitored 25 healthy adults with the Openwater system and concurrent transcranial Doppler (TCD) while performing a breath-hold maneuver to increase CBF...
January 2024: Neurophotonics
https://read.qxmd.com/read/38453193/evaluations-of-virtual-exercise-programmes-for-adults-with-mobility-limitations-a-scoping-review-protocol-incorporating-an-equity-lens-to-inform-the-development-of-strategies-to-optimise-participation-of-under-represented-groups
#6
JOURNAL ARTICLE
Renato Barbosa Dos Santos, Jing Lin, Anchal Badwal, Hardeep Singh, Susan Brenda Jaglal, Christina Sperling, Nancy Margaret Salbach
INTRODUCTION: For individuals with mobility limitations, virtual exercise programmes can address the challenges of in-person participation in community exercise programmes. A synthesis of studies of virtual exercise programmes targeting mobility limitations provided outside of conventional rehabilitation services and strategies used to optimise equitable access and inclusivity in these programmes is lacking. We aim to characterise evaluations of virtual exercise programmes for adults with mobility limitations, and the nature of and extent to which equity, diversity and inclusion considerations are integrated in the research process...
March 7, 2024: BMJ Open
https://read.qxmd.com/read/38436197/arterial-blood-gas-analysis-predicts-futile-recanalization-in-mechanical-thrombectomy-treated-acute-ischemic-stroke-patients-a-multicenter-study
#7
MULTICENTER STUDY
A Onalan, E Gurkas, C K Akpinar, H Dogan, T Acar, B Acar, O Aykac, Z Uysal Kocabas, F Balgetir, A O Ozdemir
UNLABELLED: OBJECTIVE: It is known that providing recanalization alone in large vessel occlusions is not sufficient to provide a good 90-day clinical outcome. It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. However, the effects of blood gas parameters before and after mechanical thrombectomy on clinical outcomes are not clear. The objective of this study is to assess the effectiveness of serial blood gas measures in accurately predicting futile recanalization at an early stage...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38434200/effectiveness-and-safety-of-auricular-acupuncture-on-adjuvant-analgesia-in-patients-with-total-knee-arthroplasty-a-randomized-sham-controlled-trial
#8
JOURNAL ARTICLE
Xingshuo Zhang, Hao Chen, Jingqiao Li, Xingang Liu, Xuesong Wang, Pingju Xue, Miao Lin, Jidong Li, Yanfen She
OBJECTIVE: This study aimed to evaluate the effectiveness and safety of auricular acupuncture (AA) on postoperative analgesia, the degree of postoperative nausea, and the effect of inflammation after total knee arthroplasty (TKA). METHODS: This was a single-center, placebo-controlled, randomized clinical trial. In total, 96 patients were randomly divided into an AA group with an indwelling intradermal needle ( n  = 48) and a sham auricular acupuncture (SAA) group with a non-penetrating placebo needle ( n  = 48)...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38429754/clopidogrel-with-indobufen-or-aspirin-in-minor-ischemic-stroke-or-high-risk-transient-ischemic-attack-a-randomized-controlled-clinical-study
#9
RANDOMIZED CONTROLLED TRIAL
Xudong Liu, Xuxian Lv, Yanfang Peng, Jianing Wang, Junjie Lei, Chaogang Tang, Shijian Luo, Weihua Mai, Yiming Cai, Qian Fan, Chenhao Liu, Lei Zhang
BACKGROUND: Ischemic stroke and transient ischemic attack (TIA) are the most prevalent cerebrovascular diseases. The conventional antiplatelet drugs are associated with an inherent bleeding risk, while indobufen is a new antiplatelet drug and has the similar mechanism of antiplatelet aggregation as aspirin with more safety profile. However, there have been no studies evaluating the combination therapy of indobufen and clopidogrel for antiplatelet therapy in cerebrovascular diseases. OBJECTIVE: The CARMIA study aims to investigate the effectiveness and safety of a new dual antiplatelet therapy consisting of indobufen and clopidogrel comparing with the conventional dual antiplatelet therapy consisting of aspirin and clopidogrel in patients with minor ischemic stroke or high-risk TIA...
March 1, 2024: BMC Neurology
https://read.qxmd.com/read/38425785/high-frequency-multimodal-training-with-a-focus-on-tai-chi-in-people-with-parkinson-s-disease-a-pilot-study
#10
JOURNAL ARTICLE
Ketevan Toloraia, Ute Gschwandtner, Peter Fuhr
BACKGROUND AND OBJECTIVES: Cognitive decline is an important and common complication in patients with Parkinson's disease (PD) since it significantly reduces the quality of life. A breakthrough in treating and preventing cognitive decline in PD remains to be achieved. This study aimed to evaluate the effectiveness of high-frequency and intensive multimodal training in improving motor and cognitive function. METHODS: Twenty-eight patients diagnosed with idiopathic PD completed a comprehensive neuropsychological test battery and were neurologically examined...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38424473/circuit-specific-deep-brain-stimulation-provides-insights-into-movement-control
#11
REVIEW
Aryn H Gittis, Roy V Sillitoe
Deep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie motor control...
February 29, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38424472/predictive-processing-a-circuit-approach-to-psychosis
#12
REVIEW
Georg B Keller, Philipp Sterzer
Predictive processing is a computational framework that aims to explain how the brain processes sensory information by making predictions about the environment and minimizing prediction errors. It can also be used to explain some of the key symptoms of psychotic disorders such as schizophrenia. In recent years, substantial advances have been made in our understanding of the neuronal circuitry that underlies predictive processing in cortex. In this review, we summarize these findings and how they might relate to psychosis and to observed cell type-specific effects of antipsychotic drugs...
February 29, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38413218/microrna-29b-3p-degenerates-terminally-differentiated-dopaminergic-sh-sy5y-cells-by-perturbation-of-mitochondrial-functions
#13
JOURNAL ARTICLE
Sana Sarkar, Anuj Pandey, Sanjeev Kumar Yadav, Pragati Raghuwanshi, Mohammed Haris Siddiqui, Saripella Srikrishna, Aditya Bhushan Pant, Sanjay Yadav
Mitochondrial dysfunction is the main cause of gradual deterioration of structure and function of neuronal cells, eventually resulting in neurodegeneration. Studies have revealed a complex interrelationship between neurotoxicant exposure, mitochondrial dysfunction, and neurodegenerative diseases. Alteration in the expression of microRNAs (miRNAs) has also been linked with disruption in mitochondrial homeostasis and bioenergetics. In our recent research (Cellular and Molecular Neurobiology (2023) https://doi...
February 27, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38410194/gastric-filling-ultrasonography-to-evaluate-gastric-motility-in-patients-with-parkinson-s-disease
#14
JOURNAL ARTICLE
Xianwei Zou, Xiaqing Chen, Yanxia Wen, Xiaofeng Jing, Man Luo, Fengyue Xin, Yao Tang, Mengfei Hu, Jian Liu, Fan Xu
BACKGROUND: Delayed gastric emptying is a common non-motor symptom of Parkinson's disease (PD). However, there is currently no objective evaluation and diagnostic method for this condition. OBJECTIVES: The purpose of this study was to evaluate the feasibility of gastric-filling ultrasonography for gastric motility in patients with PD and the relationship between gastric dynamics and gastrointestinal symptoms and motor symptoms of PD. DESIGN SETTING AND PATIENTS: We performed a case-control study with 38 patients with PD and 34 healthy controls...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38382543/keeping-your-brain-in-balance-homeostatic-regulation-of-network-function
#15
REVIEW
Wei Wen, Gina G Turrigiano
To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity to maintain stable function. This dynamic fine-tuning is accomplished through a rich array of cellular homeostatic plasticity mechanisms that stabilize important cellular and network features such as firing rates, information flow, and sensory tuning properties. Further, these functional network properties can be stabilized by different forms of homeostatic plasticity, including mechanisms that target excitatory or inhibitory synapses, or that regulate intrinsic neuronal excitability...
February 21, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38375124/evaluation-of-neurological-and-auditory-development-in-children-with-congenital-heart-disease-using-essence-q-questionnaire-and-auditory-brainstem-response-abr-test
#16
JOURNAL ARTICLE
Asadollah Tanasan, Fatemeh Eghalian, Helen Behmanesh, Salman Khazaei, Farhad Farahani, Firozeh Hosseini
OBJECTIVES: The progress of cardiac surgery in children and the increase in the survival of children with Congenital Heart Disease (CHD) has led to consider another issue called a neurodevelopmental disorder. In this study, 53 children with CHD were evaluated in terms of development with the Essence Q questionnaire, Otoacoustic Emission (OAE), and Auditory Brainstem Response (ABR) regarding these patients' hearing and risk factors. The Essence Q scores were also examined. MATERIALS & METHODS: In this prospective, cross-sectional study, the researchers included 53 children diagnosed with CHD...
2024: Iranian Journal of Child Neurology
https://read.qxmd.com/read/38374040/the-efficacy-of-virtual-reality-technology-for-the-postoperative-rehabilitation-of-patients-with-cervical-spondylotic-myelopathy-csm-a-study-protocol-for-a-randomized-controlled-trial
#17
JOURNAL ARTICLE
Jiajun Wu, Zhongchuan Sun, Zhichao Ge, Dong Zhang, Jianghan Xu, Rilin Zhang, Xuecheng Liu, Qing Zhao, Hao Sun
BACKGROUND: Patients with cervical spondylosis myelopathy (CSM) may experience severe neurological dysfunction due to untimely spinal cord compression after surgery. These disorders may lead to sensory and motion disorders, causing considerable psychological distress. Recent studies found that virtual reality (VR) technology can be an effective tool for treating spinal cord injuries. Owing to this discovery, we developed an exploratory research project to investigate the impact of this intervention on the postoperative recovery of patients with CSM...
February 19, 2024: Trials
https://read.qxmd.com/read/38360566/harmony-in-the-molecular-orchestra-of-hearing-developmental-mechanisms-from-the-ear-to-the-brain
#18
REVIEW
Sonja J Pyott, Gabriela Pavlinkova, Ebenezer N Yamoah, Bernd Fritzsch
Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing...
February 15, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38360565/a-whole-brain-topographic-ontology
#19
REVIEW
Michael Arcaro, Margaret Livingstone
It is a common view that the intricate array of specialized domains in the ventral visual pathway is innately prespecified. What this review postulates is that they are not. We explore the origins of domain specificity, hypothesizing that the adult brain emerges from an interplay between a domain-general map-based architecture, shaped by intrinsic mechanisms, and experience. We argue that the most fundamental innate organization of cortex in general, and not just the visual pathway, is a map-based topography that governs how the environment maps onto the brain, how brain areas interconnect, and ultimately, how the brain processes information...
February 15, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38355477/intravenous-lipid-emulsion-for-local-anaesthetic-systemic-toxicity-in-pregnant-women-a-scoping-review
#20
REVIEW
Makoto Tsuji, Masafumi Nii, Marie Furuta, Shinji Baba, Takahide Maenaka, Shigetaka Matsunaga, Hiroaki Tanaka, Atsushi Sakurai
BACKGROUND: Local anaesthetic systemic toxicity (LAST) is a rare but life-threatening complication that can occur after local anaesthetic administration. Various clinical guidelines recommend an intravenous lipid emulsion as a treatment for local anaesthetic-induced cardiac arrest. However, its therapeutic application in pregnant patients has not yet been established. This scoping review aims to systematically identify and map the evidence on the efficacy and safety of intravenous lipid emulsion for treating LAST during pregnancy...
February 14, 2024: BMC Pregnancy and Childbirth
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